Fig. 4

Mapping DE gene enrichments using SAFE and a PPI network analysis. The network topology used in these analyses is based on the network of [49]. The network topology is identical in a-f. Highly connected genes are present at the center of the network. Poorly connected (~ 2 to 20 gene) sub networks are shown at the bottom and top right of each figure. Enriched regions of DE genes in the PPI network are displayed as a heat component. Red is enriched, violet is not enriched. Contrasts are as follows: ΔmtDNA ‘haplotype’ (a, d), ΔmtDNA ‘species’ (b, e), and G x G ‘broadscale epistasis’ (c, f). Female analyses are shown in A, B, and C, male analyses are shown in D, E, and F Contrasts show both conserved and private regions of enrichment across contrasts. The six remaining haplotype pairwise comparisons (for females as an example) are shown in Additional file 8: Figure S2