Fig. 6

Tanglegram and heatmaps of the top 500 ΔmtDNA ‘species’ DE genes in females. Hierarchical clustering dendrograms and heatmaps of RNA-seq reaction norms (left) and development time expression (right) [55] are compared, revealing extensive crossing over and also consistent regions where there is phenetic resemblance between dendrograms (where parallel lines join genes with the same ID). DE genes are not limited to any particular ontogenetic gene expression period. Arbitrarily colored lines represent genes that are adjacent in both dendrograms. The same effects were evident when the top 50, 100, or 200 genes were used in the analysis. The order of genotypes in the leftmost heatmap (RNA-seq data) is OreR, Zim53, siI and sm21 (left to right). The developmental time course is color coded: embryo (violet), larval (red), pupal (black), and male (sand) and females (green) adult stages are shown