Fig. 1From: Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product familyBiosynthesis of lanthipeptides. a Installation of lanthionine or methyllanthionine thioether crosslinks in the four different classes of lanthipeptides. Dha: dehydroalanine, Dhb: dehydrobutyrine, Lan: lanthionine, MeLan: methyllanthionine. b Domain structure of the enzymes that install the thioether crosslinks in the different classes of lanthipeptides. The cyclase domains shared between the classes belong to the Pfam family PF05147. The black lines in the cyclase domains represent the location of the zinc-binding residuesBack to article page