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Table 3 Potentially essential proteins as acetylation targets for maintaining normal hepatic metabolism

From: Protein acetylation in mitochondria plays critical functions in the pathogenesis of fatty liver disease

Protein accession numberProtein nameAll/Up/DownaProtein subcellular localizationNo. of interactive nodes in PPIbNo. of associated pathwaysSignaling pathways
E1BMH4EHHADH2/1/1mitochondria5311Fatty acid degradation; Valine, leucine and isoleucine degradation; Tryptophan metabolism; Peroxisome; beta-Alanine metabolism; Butanoate metabolism; PPAR signaling pathway; Propanoate metabolism; Fatty acid metabolism; Lysine degradation; Carbon metabolism;
Q3SZ00HADHA14/12/2mitochondria4811Fatty acid degradation; Valine, leucine and isoleucine degradation; Tryptophan metabolism; beta-Alanine metabolism; Butanoate metabolism; Propanoate metabolism; Fatty acid elongation; Fatty acid metabolism; Biosynthesis of unsaturated fatty acids; Carbon metabolism; Lysine degradation;
Q29RZ0ACAT110/10/0mitochondria2012Synthesis and degradation of ketone bodies; Fatty acid degradation; Valine, leucine and isoleucine degradation; Tryptophan metabolism; Butanoate metabolism; Terpenoid backbone biosynthesis; Propanoate metabolism; Glyoxylate and dicarboxylate metabolism; Pyruvate metabolism; Fatty acid metabolism; Lysine degradation; Carbon metabolism;
Q32LG3MDH26/6/0mitochondria205Glyoxylate and dicarboxylate metabolism; Cysteine and methionine metabolism; Pyruvate metabolism; Citrate cycle (TCA cycle); Carbon metabolism;
P12344GOT211/10/1mitochondria14112-Oxocarboxylic acid metabolism; Alanine, aspartate and glutamate metabolism; Biosynthesis of amino acids; Arginine biosynthesis; Tyrosine metabolism; Arginine and proline metabolism; Phenylalanine, tyrosine and tryptophan biosynthesis; Fat digestion and absorption; Cysteine and methionine metabolism; Carbon metabolism; Phenylalanine metabolism;
F1ML89CPS111/10/1mitochondria125Nitrogen metabolism; Alanine, aspartate and glutamate metabolism; Biosynthesis of amino acids; Arginine biosynthesis; Carbon metabolism;
Q2KIE6HMGCS211/10/1mitochondria114Synthesis and degradation of ketone bodies; Valine, leucine and isoleucine degradation; Butanoate metabolism; Terpenoid backbone biosynthesis;
  1. a Number of all differentially acetylated sites (All) in the protein, higher acetylated sites (Up) and lower acetylated sites (Down) in the protein, separated by slash
  2. b Number of the nodes that were showing the reciprocally interactive proteins in the protein-protein interaction (PPI) network obtained by STRING analysis (shown as in Fig. 6 and/or Fig. S3)