Fig. 5
From: Comparative analysis of the transcriptomes of EDL, psoas, and soleus muscles from mice
Isoforms associated with fast-twitch fibers are expressed in all three muscles. Expression levels of (a) Myosin light chains, (b) troponin, and (c) tropomyosin isoforms in EDL, psoas, and soleus. Fast-twitch myosin light chain isoforms (Myl1, Mylk2, and Mylpf), troponin isoforms (Tnnc2, Tnni2, and Tnnt3), and tropomyosin 1 (Tpm1) are the expressed in all three muscles, but the expression levels are notably higher in EDL and psoas. At least 97-fold higher expression of slow myosin light chain isoforms Myl2 and Myl3, 137-fold expression upregulation of slow troponin isoforms Tnnc1, Tnni1, and Tnnt1, and 31-fold expression upregulation in Tpm3 are observed in soleus compared to EDL and psoas. Tpm2 is preferentially expressed in slow muscles, but 2.4 fold up-regulated was observed in psoas compared to EDL (p-adj = 6.37e− 10). d Genes coding for proteins that interact at the Z-disk are downregulated in EDL. The calpain 3 (Capn3), desmin (Des), filamin-C (Flnc), nebulin (Neb), obscurin (Obscn), and titin (Ttn) follow a similar expression signature, where all six genes are significantly downregulated in EDL compared to the psoas. * p-adj < 0.01. Adjusted p values were calculated using DESeq2