The tapeworm interactome: inferring confidence scored protein-protein interactions from the proteome of Hymenolepis microstoma

Table 4 Closeness centrality

Gene model	Degree	BC	CC	Description
HmN_000704800	38*	0.135**	0.315	Cyclin-dependent kinase 2
HmN_000144900	33*	0.068**	0.302	Cyclin-dependent kinase 2
HmN_000799800	52*	0.129**	0.297	Heat shock protein 71 kDa protein 90 alpha
HmN_003006230	46*	0.135**	0.290	DNA-directed RNA polymerase subunit RBP1
HmN_000846600	30	0.037**	0.288	Transitional endoplasmic reticulum ATPase
HmN_003022520	30	0.037**	0.288	Transitional endoplasmic reticulum ATPase
HmN_003022580	30	0.037**	0.288	Transitional endoplasmic reticulum ATPase
HmN_000772200	88*	0.131**	0.284	Cell division cycle 5 protein
HmN_000015300	79*	0.101**	0.283	Pre mRNA processing factor 19
HmN_003006810	28	0.074**	0.281	Histone acetyltransferase p300
HmN_003048860	24	0.097**	0.277	Actin
HmN_000372000	17	0.030**	0.271	DNA replication licensing factor MCM2
HmN_000063500	34*	0.014	0.269	Cullin 1
HmN_000629900	34*	0.014	0.269	Cullin 1
HmN_003003610	34*	0.014	0.269	Cullin 1
HmN_003003620	34*	0.014	0.269	Cullin 1
HmN_003003820	39*	0.034**	0.268	Eukaryotic initiation factor 4A-III
HmN_003003830	39*	0.034**	0.268	Eukaryotic initiation factor 4A-III
HmN_000547600	12	0.047**	0.267	Tubulin gamma chain-1
HmN_000536300	24	0.047**	0.265	Histone H2B
HmN_000476900	23	0.025	0.265	Splicing factor 3b subunit 3
HmN_000109300	14	0.011	0.264	Cyclin dependent kinase 7
HmN_000744000	16	0.025	0.263	Chaperonin containing TCP1 subunit 2 (beta)
HmN_000541900	13	0.018	0.262	Replication protein A 70 kDa DNA-binding subunit
HmN_000463400	22	0.028	0.262	SNW domain containing protein 1

The top twenty-five protein ranked by closeness centrality. Proteins that are also top 20 protein hubs (Table 2) are denoted with * and top 20 betweenness centrality (Table 3) with **. BC: betweenness centrality; CC: closeness centrality

ISSN: 1471-2164