Table 4 Proteins associated to S. pyogenes Pathogenesis (GO: GO:0009405). Domains that are shared between S. aureus and S. pyogenes are underlined. Proteins that are shared are written in bold
Protein | Description |
|---|---|
PF02821 | Streptokinase, breaks down blood cloths |
PF01640 | Peptidase C10 family |
PF01123 | Enterotoxin type B, super antigen involved in food poisoning |
PF02876 | Staphylococcal/Streptococcal toxin, beta-grasp domain |
PF03734 | L,D-transpeptidase catalytic domain, peptidoglycan binding |
PF00746; PF01391 | LPXTG cell wall anchor motif; Collagen helix, rod like structure, coagulation-fibrinolytic binding in blood, Scl1 adhesin specifically recognizes the wound microenvironment [36] |
PF00746; PF02370 | LPXTG cell wall anchor motif; M protein repeat, binds IgA, major virulence factor involved in host cell invasion and resistance to phagocytosis [37] |
PF00746; PF08017 | LPXTG cell wall anchor motif; Fibronogen binding protein, members of this family include the fibrinogen receptor, FbsA which mediates platelet aggregation |
PF00746; PF02986 | LPXTG cell wall anchor motif; Fibronectin binding repeat, mediate adherence to host cells, enable the colonisation of wound tissue and blood clots |
PF00092; PF00746; PF02986 | Von Willebrand factor type A domain domains participate in numerous biological events (e.g. cell adhesion, migration, homing, pattern formation, and signal transduction); LPXTG cell wall anchor motif; Fibronectin binding repeat |