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Fig. 4 | BMC Genomics

Fig. 4

From: Integrated proteomic and transcriptomic profiling identifies aberrant gene and protein expression in the sarcomere, mitochondrial complex I, and the extracellular matrix in Warmblood horses with myofibrillar myopathy

Fig. 4

Immunofluorescent staining of cross-sections of muscle from an MFM horse. Horizontal and vertical arrows indicate the same fiber in all 4 images. Bar = 40 μm. A. Fibers with more intense CSRP3 staining or aggregates of CSRP3 correspond to type 2A fibers in D (vertical and horizontal arrows). B. Fibers with desmin aggregates corresponded to type 2A fibers in D (horizontal arrow). Some (vertical arrow) but not all fibers with desmin aggregates also had CSRP3 aggregates. C. Merged CSRP3 and desmin showing colocalization of CSRP3 with desmin aggregates (horizontal arrow) in some but not all fibers (vertical arrow). D. Fiber type stain showing type 1 fibers (blue), type 2A fibers (yellow) and type 2X fibers (brown)

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BMC Genomics

ISSN: 1471-2164

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