Fig. 6
H2A.Z, H2B.Z, H3.3 and H2A.X distribution and gene coverage vary with gene expression within the cell cycle. Using the same strategy as shown in Fig. 5, genes with different amounts of H2A.Z, H2B.Z, H3.3 or H2A.X coverage were compared to sets of genes upregulated at intervals during cell cycle. Plots show -log2(p-value) of enrichment for genes with different levels of histone variant coverage. Genes with 0–20% H2A.Z or H2B.Z coverage are enriched in G1-regulated genes upregulated between hours 4 and 6 of cell cycle, while genes with 20–40% coverage are enriched in G1-regulated genes upregulated between hours 5 and 7. The pattern of histone variant H2A.Z, H2B.Z coverage differs in SM-regulated genes with enrichment of genes with significant coverage over the entire gene. Note that the enrichment scales for G1 and S/M are different. p-value of < 0.05 in the hypergeometric test was considered significant and is indicated by the dotted grey line