Fig. 4

A. Cosine similarity of the somatic mutational spectrum across the 7 tumors. B. Contribution of known human mutational signatures to somatic mutations identified in each tumor using bootstrapping refitting in 1000 iterations. The color of the dot shows the percentage of iterations in which the signature is found (contribution > 0). The size of the dot represents the average contribution of that signature (in the iterations in which the contribution was higher than 0). C. Mutational signatures extracted from the 7 tumors using nonnegative matrix factorization method