Fig. 7

Global transcriptome assessment of preimplantation embryos in mice, human and bovine. A Heatmaps showing the gene expression levels of mouse embryos among 1-cell, 2-cell, 4-cell, 8-cell, morula and blastocyst stages. Each column represents a replicate. B Volcano plot of differentially expressed genes (DEGs) of mouse embryos between 2C vs. 1C, 4C vs. 2C, 8C vs. 4C, Mor vs. 8C and Bla vs. Mor (FC > 2, FDR < 0.05). C The expression of DEGs in mouse embryos during 1-cell to blastocyst stage. D Heatmaps showing the gene expression levels of human embryos among 1-cell, 2-cell, 4-cell, 8-cell, morula and blastocyst stage. Each column represents a replicate. E Volcano plot of differentially expressed genes (DEGs) of human embryos between 2C vs. 1C, 4C vs. 2C, 8C vs. 4C, Mor vs. 8C and Bla vs. Mor (FC > 2, FDR < 0.05). F The expression of DEGs of human embryos from 1-cell to blastocyst stage. G Heatmaps showing the gene expression levels of bovine embryo among oocytes, 1-cell, 2-cell, 4-cell, 8-cell, morula and blastocyst. Each column represents a replicate. H Volcano plot of differentially expressed genes (DEGs) of bovine embryos between 2C vs. 1C, 4C vs. 2C, 8C vs. 4C, 16C vs. 8C, Mor vs. 16C and Bla vs. Mor (FC > 2, FDR < 0.05). I The expression of DEGs in human embryos from oocytes to blastocyst stage. Mor, Morula; Bla, Blastocyst. J Schematic overview of the timing of zygotic genome activation in pigs, mice, humans and bovines