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  1. Atherosclerosis affects aorta, coronary, carotid, and iliac arteries most frequently than any other body vessel. There may be common molecular pathways sustaining this process. Plaque presence and diffusion is...

    Authors: Stefano Cagnin, Michele Biscuola, Cristina Patuzzo, Elisabetta Trabetti, Alessandra Pasquali, Paolo Laveder, Giuseppe Faggian, Mauro Iafrancesco, Alessandro Mazzucco, Pier Franco Pignatti and Gerolamo Lanfranchi
    Citation: BMC Genomics 2009 10:13
    Content type: Research article Published on:

  2. Cold adapted or psychrophilic organisms grow at low temperatures, where most of other organisms cannot grow. This adaptation requires a vast array of sequence, structural and physiological adjustments. To unde...

    Authors: Raghu Prasad Rao Metpally and Boojala Vijay B Reddy
    Citation: BMC Genomics 2009 10:11
    Content type: Research article Published on:

  3. The first week of human pre-embryo development is characterized by the induction of totipotency and then pluripotency. The understanding of this delicate process will have far reaching implication for in vitro...

    Authors: Said Assou, Doris Cerecedo, Sylvie Tondeur, Véronique Pantesco, Outi Hovatta, Bernard Klein, Samir Hamamah and John De Vos
    Citation: BMC Genomics 2009 10:10
    Content type: Research article Published on:

  4. The promoter is a critical necessary transcriptional cis-regulatory element. In addition to its role as an assembly site for the basal transcriptional apparatus, the promoter plays a key part in mediating tempora...

    Authors: Qianqian Zhu and Marc S Halfon
    Citation: BMC Genomics 2009 10:9
    Content type: Research article Published on:

  5. Transcriptional regulatory elements are central to development and interspecific phenotypic variation. Current regulatory element prediction tools rely heavily upon conservation for prediction of putative elem...

    Authors: David M McGaughey, Zachary E Stine, Jimmy L Huynh, Ryan M Vinton and Andrew S McCallion
    Citation: BMC Genomics 2009 10:8
    Content type: Research article Published on:

  6. The control of gene expression in eukaryotic cells occurs both transcriptionally and post-transcriptionally. Although many genes are now known to be regulated at the translational level, in general, the mechan...

    Authors: Craig Lawless, Richard D Pearson, Julian N Selley, Julia B Smirnova, Christopher M Grant, Mark P Ashe, Graham D Pavitt and Simon J Hubbard
    Citation: BMC Genomics 2009 10:7
    Content type: Research article Published on:

  7. Haemophilus influenzae requires heme for aerobic growth and possesses multiple mechanisms to obtain this essential nutrient. Although an understanding of the heme acquisition mechanisms of H. influenzae is emergi...

    Authors: Paul W Whitby, Thomas W Seale, Timothy M VanWagoner, Daniel J Morton and Terrence L Stull
    Citation: BMC Genomics 2009 10:6
    Content type: Research article Published on:

  8. Fourmidable is an infrastructure to curate and share the emerging genetic, molecular, and functional genomic data and protocols for ants.

    Authors: Yannick Wurm, Paolo Uva, Frédéric Ricci, John Wang, Stephanie Jemielity, Christian Iseli, Laurent Falquet and Laurent Keller
    Citation: BMC Genomics 2009 10:5
    Content type: Database Published on:

  9. Single nucleotide polymorphisms (SNPs) are ideal genetic markers due to their high abundance and the highly automated way in which SNPs are detected and SNP assays are performed. The number of SNPs identified ...

    Authors: Hindrik HD Kerstens, Sonja Kollers, Arun Kommadath, Marisol del Rosario, Bert Dibbits, Sylvia M Kinders, Richard P Crooijmans and Martien AM Groenen
    Citation: BMC Genomics 2009 10:4
    Content type: Research article Published on:

  10. Persistent colonization of the human stomach by Helicobacter pylori is associated with asymptomatic gastric inflammation (gastritis) and an increased risk of duodenal ulceration, gastric ulceration, and non-cardi...

    Authors: Mark S McClain, Carrie L Shaffer, Dawn A Israel, Richard M Peek Jr and Timothy L Cover
    Citation: BMC Genomics 2009 10:3
    Content type: Research article Published on:

  11. Peripheral blood is an accessible and informative source of transcriptomal information for many human disease and pharmacogenomic studies. While there can be significant advantages to analyzing RNA isolated fr...

    Authors: Kristina Vartanian, Rachel Slottke, Timothy Johnstone, Amanda Casale, Stephen R Planck, Dongseok Choi, Justine R Smith, James T Rosenbaum and Christina A Harrington
    Citation: BMC Genomics 2009 10:2
    Content type: Methodology article Published on:

  12. Genomic resources for the majority of free-living vertebrates of ecological and evolutionary importance are scarce. Therefore, linkage maps with high-density genome coverage are needed for progress in genomics...

    Authors: Sonja Jaari, Meng-Hua Li and Juha Merilä
    Citation: BMC Genomics 2009 10:1
    Content type: Research article Published on:

  13. Oxidative stress is a common stress encountered by living organisms and is due to an imbalance between intracellular reactive oxygen and nitrogen species (ROS, RNS) and cellular antioxidant defence. To defend ...

    Authors: David Thybert, Stéphane Avner, Céline Lucchetti-Miganeh, Angélique Chéron and Frédérique Barloy-Hubler
    Citation: BMC Genomics 2008 9:637
    Content type: Database Published on:

  15. Mismatched oligonucleotides are widely used on microarrays to differentiate specific from nonspecific hybridization. While many experiments rely on such oligos, the hybridization behavior of various degrees of...

    Authors: Michael Seringhaus, Joel Rozowsky, Thomas Royce, Ugrappa Nagalakshmi, Justin Jee, Michael Snyder and Mark Gerstein
    Citation: BMC Genomics 2008 9:635
    Content type: Methodology article Published on:

  16. Biomphalaria glabrata is an intermediate snail host for Schistosoma mansoni, one of the important schistosomes infecting man. B. glabrata/S. mansoni provides a useful model system for investigating the intimate i...

    Authors: Anne E Lockyer, Jenny Spinks, Richard A Kane, Karl F Hoffmann, Jennifer M Fitzpatrick, David Rollinson, Leslie R Noble and Catherine S Jones
    Citation: BMC Genomics 2008 9:634
    Content type: Research article Published on:

  17. Quantitative polymerase chain reaction (QPCR) is a widely applied analytical method for the accurate determination of transcript abundance. Primers for QPCR have been designed on a genomic scale but non-specif...

    Authors: Athanasia Spandidos, Xiaowei Wang, Huajun Wang, Stefan Dragnev, Tara Thurber and Brian Seed
    Citation: BMC Genomics 2008 9:633
    Content type: Research article Published on:

  18. One of the most striking features of mammalian and birds chromosomes is the variation in the guanine-cytosine (GC) content that occurs over scales of hundreds of kilobases to megabases; this is known as the "i...

    Authors: Christelle Melodelima and Christian Gautier
    Citation: BMC Genomics 2008 9:632
    Content type: Research article Published on:

  19. The recently constructed river buffalo whole-genome radiation hybrid panel (BBURH5000) has already been used to generate preliminary radiation hybrid (RH) maps for several chromosomes, and buffalo-bovine comparat...

    Authors: M Elisabete J Amaral, Jason R Grant, Penny K Riggs, Nedenia B Stafuzza, Edson A Rodrigues Filho, Tom Goldammer, Rosemarie Weikard, Ronald M Brunner, Kelli J Kochan, Anthony J Greco, Jooha Jeong, Zhipeng Cai, Guohui Lin, Aparna Prasad, Satish Kumar, G Pardha Saradhi…
    Citation: BMC Genomics 2008 9:631
    Content type: Research article Published on:

  20. Skeletal muscle mass can be markedly reduced through a process called atrophy, as a consequence of many diseases or critical physiological and environmental situations. Atrophy is characterised by loss of cont...

    Authors: Enrica Calura, Stefano Cagnin, Anna Raffaello, Paolo Laveder, Gerolamo Lanfranchi and Chiara Romualdi
    Citation: BMC Genomics 2008 9:630
    Content type: Research article Published on:

  21. We have recently released a comprehensive, manually curated database of mammalian protein complexes called CORUM. Combining CORUM with other resources, we assembled a dataset of over 2700 mammalian complexes. ...

    Authors: Philip Wong, Sonja Althammer, Andrea Hildebrand, Andreas Kirschner, Philipp Pagel, Bernd Geissler, Pawel Smialowski, Florian Blöchl, Matthias Oesterheld, Thorsten Schmidt, Normann Strack, Fabian J Theis, Andreas Ruepp and Dmitrij Frishman
    Citation: BMC Genomics 2008 9:629
    Content type: Research article Published on:

  23. Acute changes in environmental parameters (e.g., O2, pH, UV, osmolarity, nutrients, etc.) evoke a common transcriptomic response in yeast referred to as the "environmental stress response" (ESR) or "common enviro...

    Authors: Liang-Chuan Lai, Matthew T Kissinger, Patricia V Burke and Kurt E Kwast
    Citation: BMC Genomics 2008 9:627
    Content type: Research article Published on:

  24. Mus spretus diverged from Mus musculus over one million years ago. These mice are genetically and phenotypically divergent. Despite the value of utilizing M. musculus and M. spretus for quantitative trait locus (...

    Authors: Kimberly L Mahler, Jessica L Fleming, Amy M Dworkin, Nicholas Gladman, Hee-Yeon Cho, Jian-Hua Mao, Allan Balmain and Amanda Ewart Toland
    Citation: BMC Genomics 2008 9:626
    Content type: Research article Published on:

  25. Phosphorylation by protein kinases is a common event in many cellular processes. Further, many kinases perform specialized roles and are regulated by non-kinase domains tethered to kinase domain. Perturbation ...

    Authors: Krishanpal Anamika, Juliette Martin and Narayanaswamy Srinivasan
    Citation: BMC Genomics 2008 9:625
    Content type: Research article Published on:

  26. MicroRNAs (miRNAs) play key roles in mammalian gene expression and several cellular processes, including differentiation, development, apoptosis and cancer pathomechanisms. Recently the biological importance o...

    Authors: Priyanka Pandey, Benedikt Brors, Prashant K Srivastava, Andrea Bott, Susanne NE Boehn, Herrmann-Josef Groene and Norbert Gretz
    Citation: BMC Genomics 2008 9:624
    Content type: Research article Published on:

  27. Increasing evidence shows that whole genomes of eukaryotes are almost entirely transcribed into both protein coding genes and an enormous number of non-protein-coding RNAs (ncRNAs). Therefore, revealing the un...

    Authors: Lin Wan, Dayong Li, Donglei Zhang, Xue Liu, Wenjiang J Fu, Lihuang Zhu, Minghua Deng, Fengzhu Sun and Minping Qian
    Citation: BMC Genomics 2008 9:623
    Content type: Research article Published on:

  28. Sodium channels are heteromultimeric, integral membrane proteins that belong to a superfamily of ion channels. The mutations in genes encoding for sodium channel proteins have been linked with several inherite...

    Authors: Sunil Sagar, Mandeep Kaur, Adam Dawe, Sundararajan Vijayaraghava Seshadri, Alan Christoffels, Ulf Schaefer, Aleksandar Radovanovic and Vladimir B Bajic
    Citation: BMC Genomics 2008 9:622
    Content type: Database Published on:

  29. Many plant genomes are resistant to whole-genome assembly due to an abundance of repetitive sequence, leading to the development of gene-rich sequencing techniques. Two such techniques are hypomethylated parti...

    Authors: William Nelson, Meizhong Luo, Jianxin Ma, Matt Estep, James Estill, Ruifeng He, Jayson Talag, Nicholas Sisneros, David Kudrna, HyeRan Kim, Jetty SS Ammiraju, Kristi Collura, Arvind K Bharti, Joachim Messing, Rod A Wing, Phillip SanMiguel…
    Citation: BMC Genomics 2008 9:621
    Content type: Research article Published on:

  31. Seed oil accumulates primarily as triacylglycerol (TAG). While the biochemical pathway for TAG biosynthesis is known, its regulation remains unclear. Previous research identified microsomal diacylglycerol acyl...

    Authors: Nirmala Sharma, Maureen Anderson, Arvind Kumar, Yan Zhang, E Michael Giblin, Suzanne R Abrams, L Irina Zaharia, David C Taylor and Pierre R Fobert
    Citation: BMC Genomics 2008 9:619
    Content type: Research article Published on:

  32. The Tephritidae family of insects includes the most important agricultural pests of fruits and vegetables, belonging mainly to four genera (Bactrocera, Ceratitis, Anastrepha and Rhagoletis). The olive fruit fly,

    Authors: Antonios A Augustinos, Elias E Stratikopoulos, Eleni Drosopoulou, Evdoxia G Kakani, Penelope Mavragani-Tsipidou, Antigone Zacharopoulou and Kostas D Mathiopoulos
    Citation: BMC Genomics 2008 9:618
    Content type: Research article Published on:

  33. The bacterial cell wall is the target of many antibiotics and cell envelope constituents are critical to host-pathogen interactions. To combat resistance development and virulence, a detailed knowledge of the ...

    Authors: Judith Hübscher, Lucas Lüthy, Brigitte Berger-Bächi and Patricia Stutzmann Meier
    Citation: BMC Genomics 2008 9:617
    Content type: Research article Published on:

  34. The fish pathogen Aliivibrio salmonicida is the causative agent of cold-water vibriosis in marine aquaculture. The Gram-negative bacterium causes tissue degradation, hemolysis and sepsis in vivo.

    Authors: Erik Hjerde, Marit Sjo Lorentzen, Matthew TG Holden, Kathy Seeger, Steinar Paulsen, Nathalie Bason, Carol Churcher, David Harris, Halina Norbertczak, Michael A Quail, Suzanne Sanders, Scott Thurston, Julian Parkhill, Nils Peder Willassen and Nicholas R Thomson
    Citation: BMC Genomics 2008 9:616
    Content type: Research article Published on:

  35. The Burkholderia cepacia complex (BCC) is a versatile group of Gram negative organisms that can be found throughout the environment in sources such as soil, water, and plants. While BCC bacteria can be involved i...

    Authors: Amanda D Goudie, Karlene H Lynch, Kimberley D Seed, Paul Stothard, Savita Shrivastava, David S Wishart and Jonathan J Dennis
    Citation: BMC Genomics 2008 9:615
    Content type: Research article Published on:

  38. Compound microsatellites are a special variation of microsatellites in which two or more individual microsatellites are found directly adjacent to each other. Until now, such composite microsatellites have not...

    Authors: Robert Kofler, Christian Schlötterer, Evita Luschützky and Tamas Lelley
    Citation: BMC Genomics 2008 9:612
    Content type: Research article Published on:

  39. Starvation triggers a complex array of adaptative metabolic responses including energy-metabolic responses, a process which must imply tissue specific alterations in gene expression and in which the liver play...

    Authors: Colette Désert, Michel J Duclos, Pierre Blavy, Frédéric Lecerf, François Moreews, Christophe Klopp, Marc Aubry, Frédéric Herault, Pascale Le Roy, Cécile Berri, Madeleine Douaire, Christian Diot and Sandrine Lagarrigue
    Citation: BMC Genomics 2008 9:611
    Content type: Research article Published on:

  40. Nucleotide sequences and the gene arrangements of mitochondrial genomes are effective tools for resolving phylogenetic problems. Hemipteroid insects are known to possess highly reorganized mitochondrial genome...

    Authors: Jimeng Hua, Ming Li, Pengzhi Dong, Ying Cui, Qiang Xie and Wenjun Bu
    Citation: BMC Genomics 2008 9:610
    Content type: Research article Published on:

  42. Lipopolysaccharide (LPS) is a cell wall component of Gram-negative bacteria with proved role in pathogenesis of sepsis. Brain injury was observed with both patients dead from sepsis and animal septic models. H...

    Authors: Gang Yue, Guanfang Shi, Marco A Azaro, Qifeng Yang, Guohong Hu, Minjie Luo, Kingsley Yin, Robert G Nagele, Daniel H Fine, Jin-Ming Yang and Honghua Li
    Citation: BMC Genomics 2008 9:608
    Content type: Research article Published on:

  43. Streptococcus agalactiae (group B Streptococcus; GBS) is a significant bacterial pathogen of neonates and an emerging pathogen of adults. Though transcriptional regulators are abundantly encoded on the GBS genome...

    Authors: Joshua D Bryan, Roxanne Liles, Urska Cvek, Marjan Trutschl and Daniel Shelver
    Citation: BMC Genomics 2008 9:607
    Content type: Research article Published on:

  44. Lymphotoxin signaling via the lymphotoxin-β receptor (LTβR) has been implicated in biological processes ranging from development of secondary lymphoid organs, maintenance of spleen architecture, host defense a...

    Authors: Agnes Lovas, Dörte Radke, Daniela Albrecht, Z Buket Yilmaz, Ulrich Möller, Andreas JR Habenicht and Falk Weih
    Citation: BMC Genomics 2008 9:606
    Content type: Research article Published on:

  46. Environmental signals usually enhance secondary metabolite production in Streptomycetes by initiating complex signal transduction system. It is known that different sigma factors respond to different types of str...

    Authors: Yoon Jung Kim, Myung Hee Moon, Jae Yang Song, Colin P Smith, Soon-Kwang Hong and Yong Keun Chang
    Citation: BMC Genomics 2008 9:604
    Content type: Research article Published on:

  47. Massively parallel DNA sequencing instruments are enabling the decoding of whole genomes at significantly lower cost and higher throughput than classical Sanger technology. Each of these technologies have been...

    Authors: Jean-Marc Aury, Corinne Cruaud, Valérie Barbe, Odile Rogier, Sophie Mangenot, Gaelle Samson, Julie Poulain, Véronique Anthouard, Claude Scarpelli, François Artiguenave and Patrick Wincker
    Citation: BMC Genomics 2008 9:603
    Content type: Research article Published on:

  49. Expression of a large number of yeast genes is repressed by glucose. The zinc finger protein Mig1 is the main effector in glucose repression, but yeast also has two related proteins: Mig2 and Mig3. We have use...

    Authors: Jakub Orzechowski Westholm, Niklas Nordberg, Eva Murén, Adam Ameur, Jan Komorowski and Hans Ronne
    Citation: BMC Genomics 2008 9:601
    Content type: Research article Published on:

  50. Members of the genus Rhodococcus are frequently found in soil and other natural environments and are highly resistant to stresses common in those environments. The accumulation of storage compounds permits cells ...

    Authors: Martín A Hernández, William W Mohn, Eliana Martínez, Enrique Rost, Adrián F Alvarez and Héctor M Alvarez
    Citation: BMC Genomics 2008 9:600
    Content type: Research article Published on:

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BMC Genomics

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