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  1. The cynomolgus monkey (Macaca fascicularis) is one of the most widely used surrogate animal models for an increasing number of human diseases and vaccines, especially immune-system-related ones. Towards a better ...

    Authors: Wei-Hua Chen, Xue-Xia Wang, Wei Lin, Xiao-Wei He, Zhen-Qiang Wu, Ying Lin, Song-Nian Hu and Xiao-Ning Wang
    Citation: BMC Genomics 2006 7:82
  2. Due to the lack of availability of large genomic sequences for peach or other Prunus species, the degree of synteny conservation between the Prunus species and Arabidopsis has not been systematically assessed. Us...

    Authors: Sook Jung, Dorrie Main, Margaret Staton, Ilhyung Cho, Tatyana Zhebentyayeva, Pere Arús and Albert Abbott
    Citation: BMC Genomics 2006 7:81
  3. In vitro systems have inherent limitations in their ability to model whole organism gene responses, which must be identified and appropriately considered when developing predictive biomarkers of in vivo toxicity....

    Authors: Edward Dere, Darrell R Boverhof, Lyle D Burgoon and Timothy R Zacharewski
    Citation: BMC Genomics 2006 7:80
  4. The past three decades have witnessed a dramatic increase in interest in the whitefly Bemisia tabaci, owing to its nature as a taxonomically cryptic species, the damage it causes to a large number of herbaceous p...

    Authors: Dena Leshkowitz, Shirley Gazit, Eli Reuveni, Murad Ghanim, Henryk Czosnek, Cindy McKenzie, Robert L Shatters Jr and Judith K Brown
    Citation: BMC Genomics 2006 7:79
  5. Microsatellites are the tandem repeats of nucleotide motifs of size 1–6 bp observed in all known genomes. These repeats show length polymorphism characterized by either insertion or deletion (indels) of the re...

    Authors: Vattipally B Sreenu, Pankaj Kumar, Javaregowda Nagaraju and Hampapathalu A Nagarajaram
    Citation: BMC Genomics 2006 7:78
  6. Massively Parallel Signature Sequencing (MPSS) technology was recently developed as a high-throughput technology for measuring the concentration of mRNA transcripts in a sample. It has previously been observed...

    Authors: Junfeng Chen and Magnus Rattray
    Citation: BMC Genomics 2006 7:77
  7. Shewanella oneidensis MR-1 is a facultative, gram-negative bacterium capable of coupling the oxidation of organic carbon to a wide range of electron acceptors such as oxygen, nitrate and metals, and has potential...

    Authors: Weimin Gao, Yongqing Liu, Carol S Giometti, Sandra L Tollaksen, Tripti Khare, Liyou Wu, Dawn M Klingeman, Matthew W Fields and Jizhong Zhou
    Citation: BMC Genomics 2006 7:76
  8. Expression of the LIM-homeobox gene Lhx2 in murine hematopoietic cells allows for the generation of hematopoietic stem cell (HSC)-like cell lines. To address the molecular basis of Lhx2 function, we generated HSC...

    Authors: Karin Richter, Valtteri Wirta, Lina Dahl, Sara Bruce, Joakim Lundeberg, Leif Carlsson and Cecilia Williams
    Citation: BMC Genomics 2006 7:75
  9. Staphylococcus aureus or MRSA (Methicillin Resistant S. aureus), is an acquired pathogen and the primary cause of nosocomial infections worldwide. In S. aureus, teichoic acid is an essential component of the cell...

    Authors: Ziliang Qian, Yanbin Yin, Yong Zhang, Lingyi Lu, Yixue Li and Ying Jiang
    Citation: BMC Genomics 2006 7:74
  10. Cre-loxP recombination refers to the process of site-specific recombination mediated by two loxP sequences and the Cre recombinase protein. Transgenic experiments exploit integrative recombination, where a donor ...

    Authors: Perseus I Missirlis, Duane E Smailus and Robert A Holt
    Citation: BMC Genomics 2006 7:73
  11. DNA microarrays have proven powerful for functional genomics studies. Several technologies exist for the generation of whole-genome arrays. It is well documented that 25mer probes directed against different re...

    Authors: Danielle L Leiske, Anis Karimpour-Fard, Patrick S Hume, Benjamin D Fairbanks and Ryan T Gill
    Citation: BMC Genomics 2006 7:72
  12. The Stanley Medical Research Institute online genomics database (SMRIDB) is a comprehensive web-based system for understanding the genetic effects of human brain disease (i.e. bipolar, schizophrenia, and depre...

    Authors: Brandon W Higgs, Michael Elashoff, Sam Richman and Beata Barci
    Citation: BMC Genomics 2006 7:70
  13. During the last two decades progress in the genetics of aging in invertebrate models such as C. elegans and D. melanogaster has clearly demonstrated the existence of regulatory pathways that control the rate of a...

    Authors: Fabrice Girardot, Christelle Lasbleiz, Véronique Monnier and Hervé Tricoire
    Citation: BMC Genomics 2006 7:69
  14. Thymidylate synthase (TS) is a critical target for cancer chemotherapy and is one of the most extensively studied biomarkers for fluoropyrimidine-based chemotherapy. In addition to its critical role in enzyme ...

    Authors: Yaguang Xi, Go Nakajima, John C Schmitz, Edward Chu and Jingfang Ju
    Citation: BMC Genomics 2006 7:68
  15. Prostate cancer (CaP) is a disease with multifactorial etiology that includes both genetic and environmental components. The knowledge of the genetic basis of CaP has increased over the past years, mainly in t...

    Authors: Simon Hughes, Maisa Yoshimoto, Ben Beheshti, Richard S Houlston, Jeremy A Squire and Andrew Evans
    Citation: BMC Genomics 2006 7:65
  16. Transcriptome data from quantitative PCR (Q-PCR) and DNA microarrays are typically obtained from a fixed amount of RNA collected per sample. Therefore, variations in tissue cellularity and RNA yield across sam...

    Authors: Jun Kanno, Ken-ichi Aisaki, Katsuhide Igarashi, Noriyuki Nakatsu, Atsushi Ono, Yukio Kodama and Taku Nagao
    Citation: BMC Genomics 2006 7:64
  17. Cotton (Gossypium hirsutum) is the most important fiber crop grown in 90 countries. In 2004–2005, US farmers planted 79% of the 5.7-million hectares of nuclear transgenic cotton. Unfortunately, genetically modifi...

    Authors: Seung-Bum Lee, Charalambos Kaittanis, Robert K Jansen, Jessica B Hostetler, Luke J Tallon, Christopher D Town and Henry Daniell
    Citation: BMC Genomics 2006 7:61
  18. The mitochondrial DNA of kinetoplastid flagellates is distinctive in the eukaryotic world due to its massive size, complex form and large sequence content. Comprised of catenated maxicircles that contain rRNA ...

    Authors: Scott J Westenberger, Gustavo C Cerqueira, Najib M El-Sayed, Bianca Zingales, David A Campbell and Nancy R Sturm
    Citation: BMC Genomics 2006 7:60
  19. DNA microarrays are rapidly becoming a fundamental tool in discovery-based genomic and biomedical research. However, the reliability of the microarray results is being challenged due to the existence of differ...

    Authors: Yulei Wang, Catalin Barbacioru, Fiona Hyland, Wenming Xiao, Kathryn L Hunkapiller, Julie Blake, Frances Chan, Carolyn Gonzalez, Lu Zhang and Raymond R Samaha
    Citation: BMC Genomics 2006 7:59
  20. Contrasting biological, chemical and hydrogeological analyses highlights the fundamental processes that shape different environments. Generating and interpreting the biological sequence data was a costly and t...

    Authors: Robert A Edwards, Beltran Rodriguez-Brito, Linda Wegley, Matthew Haynes, Mya Breitbart, Dean M Peterson, Martin O Saar, Scott Alexander, E Calvin Alexander Jr and Forest Rohwer
    Citation: BMC Genomics 2006 7:57
  21. We have studied alterations of gene expression associated with naturally-occurring early life stage mortality (M74) in Baltic salmon using a cDNA microarray and real time PCR. M74-affected fry have several typ...

    Authors: Kristiina AM Vuori, Heikki Koskinen, Aleksei Krasnov, Paula Koivumäki, Sergey Afanasyev, Pekka J Vuorinen and Mikko Nikinmaa
    Citation: BMC Genomics 2006 7:56
  22. The Cleavage Stimulation Factor (CstF) is a required protein complex for eukaryotic mRNA 3'-processing. CstF interacts with 3'-processing downstream elements (DSEs) through its 64-kDa subunit, CstF-64; however...

    Authors: Jesse Salisbury, Keith W Hutchison and Joel H Graber
    Citation: BMC Genomics 2006 7:55
  23. For many years gene mapping studies have been performed through linkage analyses based on pedigree data. Recently, linkage disequilibrium methods based on unrelated individuals have been advocated as powerful ...

    Authors: Simon Boitard, Jihad Abdallah, Hubert de Rochambeau, Christine Cierco-Ayrolles and Brigitte Mangin
    Citation: BMC Genomics 2006 7:54
  24. A number of different quantitative trait loci (QTL) for various phenotypic traits, including milk production, functional, and conformation traits in dairy cattle as well as growth and body composition traits i...

    Authors: Rosemarie Weikard, Tom Goldammer, Pascal Laurent, James E Womack and Christa Kuehn
    Citation: BMC Genomics 2006 7:53
  25. Immune responses to sandfly saliva have been shown to protect animals against Leishmania infection. Yet very little is known about the molecular characteristics of salivary proteins from different sandflies, part...

    Authors: Jennifer M Anderson, Fabiano Oliveira, Shaden Kamhawi, Ben J Mans, David Reynoso, Amy E Seitz, Phillip Lawyer, Mark Garfield, MyVan Pham and Jesus G Valenzuela
    Citation: BMC Genomics 2006 7:52
  26. We compared the relative precision and accuracy of expression measurements obtained from three different state-of-the-art commercial short and long-oligonucleotide microarray platforms (Affymetrix GeneChip™, G...

    Authors: Aurélien de Reyniès, Daniela Geromin, Jean-Michel Cayuela, Fabien Petel, Philippe Dessen, François Sigaux and David S Rickman
    Citation: BMC Genomics 2006 7:51
  27. The best studied insect-symbiont system is that of aphids and their primary bacterial endosymbiont Buchnera aphidicola. Buchnera inhabits specialized host cells called bacteriocytes, provides nutrients to the aph...

    Authors: Alex CC Wilson, Helen E Dunbar, Gregory K Davis, Wayne B Hunter, David L Stern and Nancy A Moran
    Citation: BMC Genomics 2006 7:50
  28. The development of microarray resources for the chicken is an important step in being able to profile gene expression changes occurring in birds in response to different challenges and stimuli. The creation of...

    Authors: Jacqueline Smith, David Speed, Paul M Hocking, Richard T Talbot, Winfried GJ Degen, Virgil EJC Schijns, Elizabeth J Glass and David W Burt
    Citation: BMC Genomics 2006 7:49
  29. Despite significant efforts from the research community, an extensive portion of the proteins encoded by human genes lack an assigned cellular function. Most metazoan proteins are composed of structural and/or...

    Authors: Danielle Kemmer, Raf M Podowski, David Arenillas, Jonathan Lim, Emily Hodges, Peggy Roth, Erik LL Sonnhammer, Christer Höög and Wyeth W Wasserman
    Citation: BMC Genomics 2006 7:48
  30. The ability of an oocyte to develop into a viable embryo depends on the accumulation of specific maternal information and molecules, such as RNAs and proteins. A serial analysis of gene expression (SAGE) was c...

    Authors: Anja Knoll-Gellida, Michèle André, Tamar Gattegno, Jean Forgue, Arie Admon and Patrick J Babin
    Citation: BMC Genomics 2006 7:46
  31. The medical community requires computational tools that distinguish missense genetic differences having phenotypic impact within the vast number of sense mutations that do not. Tools that do this will become i...

    Authors: Eric A Gaucher, Danny W De Kee and Steven A Benner
    Citation: BMC Genomics 2006 7:44
  32. Aeromonas salmonicida has been isolated from numerous fish species and shows wide variation in virulence and pathogenicity. As part of a larger research program to identify virulence genes and candidates for vacc...

    Authors: John HE Nash, Wendy A Findlay, Christian C Luebbert, Oksana L Mykytczuk, Simon J Foote, Eduardo N Taboada, Catherine D Carrillo, Jessica M Boyd, Duncan J Colquhoun, Michael E Reith and Laura L Brown
    Citation: BMC Genomics 2006 7:43
  33. Gastrointestinal nematodes constitute a major cause of morbidity and mortality in grazing ruminants. Individual animals or breeds, however, are known to differ in their resistance to infection. Gene expression...

    Authors: Orla M Keane, Amonida Zadissa, Theresa Wilson, Dianne L Hyndman, Gordon J Greer, David B Baird, Alan F McCulloch, Allan M Crawford and John C McEwan
    Citation: BMC Genomics 2006 7:42
  34. EST libraries are used in various biological studies, from microarray experiments to proteomic and genetic screens. These libraries usually contain many uncharacterized ESTs that are typically ignored since th...

    Authors: Paul Shafer, David M Lin and Golan Yona
    Citation: BMC Genomics 2006 7:41
  35. Genes and proteins are organized into functional modular networks in which the network context of a gene or protein has implications for cellular function. Highly connected hub proteins, largely responsible fo...

    Authors: Marc RJ Carlson, Bin Zhang, Zixing Fang, Paul S Mischel, Steve Horvath and Stanley F Nelson
    Citation: BMC Genomics 2006 7:40
  36. The ribosome is a central player in the translation system, which in mammals consists of four RNA species and 79 ribosomal proteins (RPs). The control mechanisms of gene expression and the functions of RPs are...

    Authors: Kyota Ishii, Takanori Washio, Tamayo Uechi, Maki Yoshihama, Naoya Kenmochi and Masaru Tomita
    Citation: BMC Genomics 2006 7:37

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