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  1. Gastrointestinal nematodes constitute a major cause of morbidity and mortality in grazing ruminants. Individual animals or breeds, however, are known to differ in their resistance to infection. Gene expression...

    Authors: Orla M Keane, Amonida Zadissa, Theresa Wilson, Dianne L Hyndman, Gordon J Greer, David B Baird, Alan F McCulloch, Allan M Crawford and John C McEwan
    Citation: BMC Genomics 2006 7:42
    Content type: Research article Published on:

  2. EST libraries are used in various biological studies, from microarray experiments to proteomic and genetic screens. These libraries usually contain many uncharacterized ESTs that are typically ignored since th...

    Authors: Paul Shafer, David M Lin and Golan Yona
    Citation: BMC Genomics 2006 7:41
    Content type: Software Published on:

  3. Genes and proteins are organized into functional modular networks in which the network context of a gene or protein has implications for cellular function. Highly connected hub proteins, largely responsible fo...

    Authors: Marc RJ Carlson, Bin Zhang, Zixing Fang, Paul S Mischel, Steve Horvath and Stanley F Nelson
    Citation: BMC Genomics 2006 7:40
    Content type: Research article Published on:

  5. Plant seeds are complex organs in which maternal tissues, embryo and endosperm, follow distinct but coordinated developmental programs. Some morphogenetic and metabolic processes are exclusively associated wit...

    Authors: Cristian Becerra, Pere Puigdomenech and Carlos M Vicient
    Citation: BMC Genomics 2006 7:38
    Content type: Methodology article Published on:

  6. The ribosome is a central player in the translation system, which in mammals consists of four RNA species and 79 ribosomal proteins (RPs). The control mechanisms of gene expression and the functions of RPs are...

    Authors: Kyota Ishii, Takanori Washio, Tamayo Uechi, Maki Yoshihama, Naoya Kenmochi and Masaru Tomita
    Citation: BMC Genomics 2006 7:37
    Content type: Research article Published on:

  7. Genome research in farm animals will expand our basic knowledge of the genetic control of complex traits, and the results will be applied in the livestock industry to improve meat quality and productivity, as ...

    Authors: Tae-Hun Kim, Nam-Soon Kim, Dajeong Lim, Kyung-Tai Lee, Jung-Hwa Oh, Hye-Sook Park, Gil-Won Jang, Hyung-Yong Kim, Mina Jeon, Bong-Hwan Choi, Hae-Young Lee, HY Chung and Heebal Kim
    Citation: BMC Genomics 2006 7:36
    Content type: Research article Published on:

  8. Spotted cDNA microarrays generally employ co-hybridization of fluorescently-labeled RNA targets to produce gene expression ratios for subsequent analysis. Direct comparison of two RNA samples in the same micro...

    Authors: Bernardo R Peixoto, Ricardo ZN Vêncio, Camila M Egidio, Luisa Mota-Vieira, Sergio Verjovski-Almeida and Eduardo M Reis
    Citation: BMC Genomics 2006 7:35
    Content type: Methodology article Published on:

  9. Low density arrays (LDAs) have recently been introduced as a novel approach to gene expression profiling. Based on real time quantitative RT-PCR (QRT-PCR), these arrays enable a more focused and sensitive appr...

    Authors: Andrew B Goulter, Daniel W Harmer and Kenneth L Clark
    Citation: BMC Genomics 2006 7:34
    Content type: Research article Published on:

  11. Secretion stress is caused by compromised folding, modification or transport of proteins in the secretory pathway. In fungi, induction of genes in response to secretion stress is mediated mainly by the unfolde...

    Authors: Mikko Arvas, Tiina Pakula, Karin Lanthaler, Markku Saloheimo, Mari Valkonen, Tapani Suortti, Geoff Robson and Merja Penttilä
    Citation: BMC Genomics 2006 7:32
    Content type: Research article Published on:

  12. Several studies have compared various features of heritable disease genes with other so called non-disease genes, but they have yielded some conflicting results. A potential problem in those studies is that th...

    Authors: Zhidong Tu, Li Wang, Min Xu, Xianghong Zhou, Ting Chen and Fengzhu Sun
    Citation: BMC Genomics 2006 7:31
    Content type: Research article Published on:

  13. The restriction fragment length polymorphism (RFLP) is a common laboratory method for the genotyping of single nucleotide polymorphisms (SNPs). Here, we describe a web-based software, named SNP-RFLPing, which ...

    Authors: Hsueh-Wei Chang, Cheng-Hong Yang, Phei-Lang Chang, Yu-Huei Cheng and Li-Yeh Chuang
    Citation: BMC Genomics 2006 7:30
    Content type: Software Published on:

  14. Well known for its gene density and the large number of mapped diseases, the human sub-chromosomal region Xq28 has long been a focus of genome research. Over 40 of approximately 300 X-linked diseases map to th...

    Authors: Anja Kolb-Kokocinski, Alexander Mehrle, Stephanie Bechtel, Jeremy C Simpson, Petra Kioschis, Stefan Wiemann, Ruth Wellenreuther and Annemarie Poustka
    Citation: BMC Genomics 2006 7:29
    Content type: Research article Published on:

  16. Genotyping technology has advanced such that genome-wide association studies of complex diseases based upon dense marker maps are now technically feasible. However, the cost of such projects remains high. Pool...

    Authors: George Kirov, Ivan Nikolov, Lyudmila Georgieva, Valentina Moskvina, Michael J Owen and Michael C O'Donovan
    Citation: BMC Genomics 2006 7:27
    Content type: Methodology article Published on:

  17. Most plasmids depend on the host replication machinery and possess partitioning genes. These properties confine plasmids to a limited range of hosts, yielding a close and presumably stable relationship between...

    Authors: Mark WJ van Passel, Aldert Bart, Angela CM Luyf, Antoine HC van Kampen and Arie van der Ende
    Citation: BMC Genomics 2006 7:26
    Content type: Research article Published on:

  18. MicroRNAs have been identified as crucial regulators in both animals and plants. Here we report on a comprehensive comparative study of all known miRNA families in animals. We expand the MicroRNA Registry 6.0 ...

    Authors: Jana Hertel, Manuela Lindemeyer, Kristin Missal, Claudia Fried, Andrea Tanzer, Christoph Flamm, Ivo L Hofacker and Peter F Stadler
    Citation: BMC Genomics 2006 7:25
    Content type: Research article Published on:

  19. The application of DNA microarray technology in post-genomic analysis of bacterial genome sequences has allowed the generation of huge amounts of data related to regulatory networks. This data along with liter...

    Authors: Jan Baumbach, Karina Brinkrolf, Lisa F Czaja, Sven Rahmann and Andreas Tauch
    Citation: BMC Genomics 2006 7:24
    Content type: Database Published on:

  20. Cnidarian – dinoflagellate intracellular symbioses are one of the most important mutualisms in the marine environment. They form the trophic and structural foundation of coral reef ecosystems, and have played ...

    Authors: Mauricio Rodriguez-Lanetty, Wendy S Phillips and Virginia M Weis
    Citation: BMC Genomics 2006 7:23
    Content type: Research article Published on:

  21. The horizontal transfer of expressed genes from Bacteria into Ciliates which live in close contact with each other in the rumen (the foregut of ruminants) was studied using ciliate Expressed Sequence Tags (EST...

    Authors: Guénola Ricard, Neil R McEwan, Bas E Dutilh, Jean-Pierre Jouany, Didier Macheboeuf, Makoto Mitsumori, Freda M McIntosh, Tadeusz Michalowski, Takafumi Nagamine, Nancy Nelson, Charles J Newbold, Eli Nsabimana, Akio Takenaka, Nadine A Thomas, Kazunari Ushida, Johannes HP Hackstein…
    Citation: BMC Genomics 2006 7:22
    Content type: Research article Published on:

  22. The knowledge about complete bacterial genome sequences opens the way to reconstruct the qualitative topology and global connectivity of transcriptional regulatory networks. Since iron is essential for a varie...

    Authors: Iris Brune, Hendrikje Werner, Andrea T Hüser, Jörn Kalinowski, Alfred Pühler and Andreas Tauch
    Citation: BMC Genomics 2006 7:21
    Content type: Research article Published on:

  24. In chickens, three mutant alleles have been reported at the C locus, including the albino mutation, and the recessive white mutation, which is characterized by white plumage and pigmented eyes. The albino mutatio...

    Authors: Chung-Ming Chang, Jean-Luc Coville, Gérard Coquerelle, David Gourichon, Ahmad Oulmouden and Michèle Tixier-Boichard
    Citation: BMC Genomics 2006 7:19
    Content type: Research article Published on:

  26. The crown-of-thorns starfish, Acanthaster planci (L.), has been blamed for coral mortality in a large number of coral reef systems situated in the Indo-Pacific region. Because of its high fecundity and the long d...

    Authors: Nina Yasuda, Masami Hamaguchi, Miho Sasaki, Satoshi Nagai, Masaki Saba and Kazuo Nadaoka
    Citation: BMC Genomics 2006 7:17
    Content type: Research article Published on:

  27. Approximately 40% of mammalian mRNA sequences contain AUG trinucleotides upstream of the main coding sequence, with a quarter of these AUGs demarcating open reading frames of 20 or more codons. In order to inv...

    Authors: Mark L Crowe, Xue-Qing Wang and Joseph A Rothnagel
    Citation: BMC Genomics 2006 7:16
    Content type: Research article Published on:

  28. Cancer is a major medical problem in modern societies. However, the incidence of this disease in non-human primates is very low. To study whether genetic differences between human and chimpanzee could contribu...

    Authors: Xose S Puente, Gloria Velasco, Ana Gutiérrez-Fernández, Jaume Bertranpetit, Mary-Claire King and Carlos López-Otín
    Citation: BMC Genomics 2006 7:15
    Content type: Research article Published on:

  29. Chlamydiae species are of much importance from a clinical viewpoint. Their diversity both in terms of their numbers as well as clinical involvement are presently believed to be significantly underestimated. Th...

    Authors: Emma Griffiths, Michael S Ventresca and Radhey S Gupta
    Citation: BMC Genomics 2006 7:14
    Content type: Research article Published on:

  30. On porcine chromosome 7, the region surrounding the Major Histocompatibility Complex (MHC) contains several Quantitative Trait Loci (QTL) influencing many traits including growth, back fat thickness and carcas...

    Authors: Julie Demars, Juliette Riquet, Katia Feve, Mathieu Gautier, Mireille Morisson, Olivier Demeure, Christine Renard, Patrick Chardon and Denis Milan
    Citation: BMC Genomics 2006 7:13
    Content type: Research article Published on:

  31. Structural genes of the phenyl-propanoid pathway which encode flavonoid 3'- and 3',5'-hydroxylases (F3'H and F3'5'H) have long been invoked to explain the biosynthesis of cyanidin- and delphinidin-based anthoc...

    Authors: Simone D Castellarin, Gabriele Di Gaspero, Raffaella Marconi, Alberto Nonis, Enrico Peterlunger, Sophie Paillard, Anne-Francoise Adam-Blondon and Raffaele Testolin
    Citation: BMC Genomics 2006 7:12
    Content type: Research article Published on:

  33. The massive scale of microarray derived gene expression data allows for a global view of cellular function. Thus far, comparative studies of gene expression between species have been based on the level of expr...

    Authors: Bas E Dutilh, Martijn A Huynen and Berend Snel
    Citation: BMC Genomics 2006 7:10
    Content type: Research article Published on:

  34. Epithelia are barrier-forming tissues that protect the organism against external noxious stimuli. Despite the similarity in function of epithelia, only few common protective mechanisms that are employed by the...

    Authors: Joost B Vos, Nicole A Datson, Antoine H van Kampen, Angela C Luyf, Renate M Verhoosel, Patrick L Zeeuwen, Diana Olthuis, Klaus F Rabe, Joost Schalkwijk and Pieter S Hiemstra
    Citation: BMC Genomics 2006 7:9
    Content type: Research article Published on:

  35. Virus taxonomy is based on morphologic characteristics, as there are no widely used non-phenotypic measures for comparison among virus families. We examined whether there is phylogenetic signal in virus nucleo...

    Authors: David T Pride, Trudy M Wassenaar, Chandrabali Ghose and Martin J Blaser
    Citation: BMC Genomics 2006 7:8
    Content type: Research article Published on:

  36. To have an insight into the Mayetiola destructor (Hessian fly) genome, we performed an in silico comparative genomic analysis utilizing genetic mapping, genomic sequence and EST sequence data along with data avai...

    Authors: Neil F Lobo, Susanta K Behura, Rajat Aggarwal, Ming-Shun Chen, Frank H Collins and Jeff J Stuart
    Citation: BMC Genomics 2006 7:7
    Content type: Research article Published on:

  38. Complex traits, which are under the influence of multiple and possibly interacting genes, have become a subject of new statistical methodological research. One of the greatest challenges facing human geneticis...

    Authors: Vessela N Kristensen, Anya Tsalenko, Jurgen Geisler, Anne Faldaas, Grethe Irene Grenaker, Ole Christian Lingjærde, Ståle Fjeldstad, Zohar Yakhini, Per Eystein Lønning and Anne-Lise Børresen-Dale
    Citation: BMC Genomics 2006 7:5
    Content type: Methodology article Published on:

  39. The N-acetylation of L-glutamate is regarded as a universal metabolic strategy to commit glutamate towards arginine biosynthesis. Until recently, this reaction was thought to be catalyzed by either of two enzy...

    Authors: Ying Xu, Nicolas Glansdorff and Bernard Labedan
    Citation: BMC Genomics 2006 7:4
    Content type: Research article Published on:

  41. Chemical and radiological toxicities related to uranium acute exposure have been widely studied in nuclear fuel workers and military personnel. It is well known that uranyl nitrate induces acute renal failure ...

    Authors: Magali Taulan, Francois Paquet, Angel Argiles, Jacques Demaille and Marie-Catherine Romey
    Citation: BMC Genomics 2006 7:2
    Content type: Research article Published on:

  42. Bread wheat (Triticum aestivum) is an important staple food. However, wheat gluten proteins cause celiac disease (CD) in 0.5 to 1% of the general population. Among these proteins, the α-gliadins contain several p...

    Authors: Teun WJM van Herpen, Svetlana V Goryunova, Johanna van der Schoot, Makedonka Mitreva, Elma Salentijn, Oscar Vorst, Martijn F Schenk, Peter A van Veelen, Frits Koning, Loek JM van Soest, Ben Vosman, Dirk Bosch, Rob J Hamer, Luud JWJ Gilissen and Marinus JM Smulders
    Citation: BMC Genomics 2006 7:1
    Content type: Research article Published on:

  43. In addition to their cytotoxic nature, reactive oxygen species (ROS) are also signal molecules in diverse cellular processes in eukaryotic organisms. Linking genome-wide transcriptional changes to cellular phy...

    Authors: István Pócsi, Márton Miskei, Zsolt Karányi, Tamás Emri, Patricia Ayoubi, Tünde Pusztahelyi, György Balla and Rolf A Prade
    Citation: BMC Genomics 2005 6:182
    Content type: Research article Published on:

  44. Salamanders of the genus Ambystoma are a unique model organism system because they enable natural history and biomedical research in the laboratory or field. We developed Sal-Site to integrate new and existing am...

    Authors: Jeramiah J Smith, Srikrishna Putta, John A Walker, D Kevin Kump, Amy K Samuels, James R Monaghan, David W Weisrock, Chuck Staben and S Randal Voss
    Citation: BMC Genomics 2005 6:181
    Content type: Commentary Published on:

  45. Quantitative Polymerase Chain Reaction (qPCR) is a well-established method for quantifying levels of gene expression, but has not been routinely applied to the detection of constitutional copy number alteratio...

    Authors: Rosanna Weksberg, Simon Hughes, Laura Moldovan, Anne S Bassett, Eva WC Chow and Jeremy A Squire
    Citation: BMC Genomics 2005 6:180
    Content type: Research article Published on:

  47. Macrophages play an integral role in the host immune system, bridging innate and adaptive immunity. As such, they are finely attuned to extracellular and intracellular stimuli and respond by rapidly initiating...

    Authors: Graeme R Grimes, Stuart Moodie, John S Beattie, Marie Craigon, Paul Dickinson, Thorsten Forster, Andrew D Livingston, Muriel Mewissen, Kevin A Robertson, Alan J Ross, Garwin Sing and Peter Ghazal
    Citation: BMC Genomics 2005 6:178
    Content type: Database Published on:

  48. Fungi can undergo autophagic- or apoptotic-type programmed cell death (PCD) on exposure to antifungal agents, developmental signals, and stress factors. Filamentous fungi can also exhibit a form of cell death ...

    Authors: Natalie D Fedorova, Jonathan H Badger, Geoff D Robson, Jennifer R Wortman and William C Nierman
    Citation: BMC Genomics 2005 6:177
    Content type: Research article Published on:

  49. Spiroplasma citri BR3-3X and S. kunkelii CR2-3X cause serious diseases worldwide on citrus and maize species, respectively. S. citri BR3-3X harbors a plasmid, pBJS-Original (pBJS-O), that encodes the s piroplasma...

    Authors: Bharat D Joshi, Michael Berg, Janet Rogers, Jacqueline Fletcher and Ulrich Melcher
    Citation: BMC Genomics 2005 6:175
    Content type: Research article Published on:

  50. Two closely related species Burkholderia mallei (Bm) and Burkholderia pseudomallei (Bp) are serious human health hazards and are potential bio-warfare agents, whereas another closely related species Burkholderia ...

    Authors: H Stanley Kim, Mark A Schell, Yan Yu, Ricky L Ulrich, Saul H Sarria, William C Nierman and David DeShazer
    Citation: BMC Genomics 2005 6:174
    Content type: Research article Published on:

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BMC Genomics

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