Hotamisligil GS: Inflammation and metabolic disorders. Nature. 2006, 444 (7121): 860-867. 10.1038/nature05485.
Article
CAS
PubMed
Google Scholar
Rosen ED, Spiegelman BM: Adipocytes as regulators of energy balance and glucose homeostasis. Nature. 2006, 444 (7121): 847-853. 10.1038/nature05483.
Article
PubMed Central
CAS
PubMed
Google Scholar
Maury E, Brichard SM: Adipokine dysregulation, adipose tissue inflammation and metabolic syndrome. Mol Cell Endocrinol. 2010, 314 (1): 1-16. 10.1016/j.mce.2009.07.031.
Article
CAS
PubMed
Google Scholar
Hosogai N, Fukuhara A, Oshima K, Miyata Y, Tanaka S, Segawa K, Furukawa S, Tochino Y, Komuro R, Matsuda M, Shimomura I: Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes. 2007, 56 (4): 901-911. 10.2337/db06-0911.
Article
CAS
PubMed
Google Scholar
Schönherr E, Hausser HJ: Extracellular matrix and cytokines: a functional unit. Dev Immunol. 2000, 7 (2–4): 89-101.
Article
PubMed Central
PubMed
Google Scholar
Okuda S, Languino LR, Ruoslahti E, Border WA: Elevated expression of transforming growth factor-beta and proteoglycan production in experimental glomerulonephritis. Possible role in expansion of the mesangial extracellular matrix. J Clin Invest. 1990, 86 (2): 453-462. 10.1172/JCI114731.
Article
PubMed Central
CAS
PubMed
Google Scholar
Border WA, Noble NA: Transforming growth factor-beta in glomerular injury. Exp Nephrol. 1994, 2 (1): 13-17.
CAS
PubMed
Google Scholar
Tsochatzis EA, Papatheodoridis GV, Archimandritis AJ: Adipokines in nonalcoholic steatohepatitis: from pathogenesis to implications in diagnosis and therapy. Mediators Inflamm. 2009, 831670: 1-9. Published online
Article
Google Scholar
Schram K, Sweeney G: Implications of myocardial matrix remodeling by adipokines in obesity-related heart failure. Trends Cardiovasc Med. 2008, 18 (6): 199-205. 10.1016/j.tcm.2008.10.001.
Article
CAS
PubMed
Google Scholar
Kleemann R, van Erk M, Verschuren L, van den Hoek AM, Koek M, Wielinga PY, Jie A, Pellis L, Bobeldijk-Pastorova I, Kelder T, Toet K, Wopereis S, Cnubben N, Evelo C, van Ommen B, Kooistra T: Time-resolved and tissue-specific systems analysis of the pathogenesis of insulin resistance. PLoS One. 2010, 5 (1): e8817-10.1371/journal.pone.0008817.
Article
PubMed Central
PubMed
Google Scholar
Khan T, Muise ES, Iyengar P, Wang ZV, Chandalia M, Abate N, Zhang BB, Bonaldo P, Chua S, Scherer PE: Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol Cell Biol. 2009, 29 (6): 1575-1591. 10.1128/MCB.01300-08.
Article
PubMed Central
CAS
PubMed
Google Scholar
Wang B, Wood IS, Trayhurn P: Dysregulation of the expression and secretion of inflammation-related adipokines by hypoxia in human adipocytes. Pflugers Arch. 2007, 455 (3): 479-492. 10.1007/s00424-007-0301-8.
Article
PubMed Central
CAS
PubMed
Google Scholar
Fitzgibbons TP, Kogan S, Aouadi M, Hendricks GM, Straubhaar J, Czech MP: Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation. Am J Physiol Heart Circ Physiol. 2011, 301 (4): H1425-H1437. 10.1152/ajpheart.00376.2011.
Article
PubMed Central
CAS
PubMed
Google Scholar
MacLaren RE, Cui W, Lu H, Simard S, Cianflone K: Association of adipocyte genes with ASP expression: a microarray analysis of subcutaneous and omental adipose tissue in morbidly obese subjects. BMC Med Genomics. 2010, 3: 3-10.1186/1755-8794-3-3.
Article
PubMed Central
PubMed
Google Scholar
Halberg N, Khan T, Trujillo ME, Wernstedt-Asterholm I, Attie AD, Sherwani S, Wang ZV, Landskroner-Eiger S, Dineen S, Magalang UJ, Brekken RA, Scherer PE: Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue. Mol Cell Biol. 2009, 29 (16): 4467-4483. 10.1128/MCB.00192-09.
Article
PubMed Central
CAS
PubMed
Google Scholar
Do GM, Kwon EY, Kim E, Kim HS, Choi MS: Hepatic transcription response to high-fat treatment in mice: microarray comparison of individual vs. pooled RNA samples. Biotechnol J. 2010, 5: 970-973. 10.1002/biot.201000046.
Article
CAS
PubMed
Google Scholar
Bioinformatics and Computational Biology Solutions using R and Bioconductor. Edited by: Gentleman R, Carey V, Huber W, Irizarry R, Dudoit S. 2005, Springer, New York
Google Scholar
Schmittgen TD, Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 2008, 3: 1101-1108. 10.1038/nprot.2008.73.
Article
CAS
PubMed
Google Scholar
Huang DW, Sherman BT, Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009, 4: 44-57.
Article
CAS
Google Scholar
Do GM, Oh HY, Kwon EY, Cho YY, Shin SK, Park HJ, Jeon SM, Kim E, Hur CG, Park TS, Sung MK, McGregor RA, Choi MS: Long-term adaptation of global transcription and metabolism in the liver of high-fat diet-fed C57BL/6 J mice. Mol Nutr Food Res. 2011, 55 (Suppl 2): S173-S185.
Article
CAS
PubMed
Google Scholar
Divoux A, Clément K: Architecture and the extracellular matrix: the still unappreciated components of the adipose tissue. Obes Rev. 2011, 12 (5): e494-e503. 10.1111/j.1467-789X.2010.00811.x.
Article
CAS
PubMed
Google Scholar
Zhang F, Basinski MB, Beals JM, Briggs SL, Churgay LM, Clawson DK, DiMarchi RD, Furman TC, Hale JE, Hsiung HM, Schoner BE, Smith DP, Zhang XY, Wery JP, Schevitz RW: Crystal structure of the obese protein leptin-E100. Nature. 1997, 387 (6629): 206-209. 10.1038/387206a0.
Article
CAS
PubMed
Google Scholar
Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Wool EA, Monroe CA, Tepper RI: Identification and expression cloning of a leptin receptor, OB-R. Cell. 1995, 83 (7): 1263-1271. 10.1016/0092-8674(95)90151-5.
Article
CAS
PubMed
Google Scholar
Zarkesh-Esfahani H, Pockley G, Metcalfe RA, Bidlingmaier M, Wu Z, Ajami A, Weetman AP, Strasburger CJ, Ross RJ: High-dose leptin activates human leukocytes via receptor expression on monocytes. J Immunol. 2001, 167 (8): 4593-4599.
Article
CAS
PubMed
Google Scholar
Loffreda S, Yang SQ, Lin HZ, Karp CL, Brengman ML, Wang DJ, Klein AS, Bulkley GB, Bao C, Noble PW, Lane MD, Diehl AM: Leptin regulates proinflammatory immune responses. FASEB J. 1998, 12 (1): 57-65.
CAS
PubMed
Google Scholar
Oka T, Nishimura Y, Zang L, Hirano M, Shimada Y, Wang Z, Umemoto N, Kuroyanagi J, Nishimura N, Tanaka T: Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity. BMC Physiol. 2010, 21 (10): 21-
Article
Google Scholar
Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Ahima RS, Lazar MA: The hormone resistin links obesity to diabetes. Nature. 2001, 409 (6818): 307-312. 10.1038/35053000.
Article
CAS
PubMed
Google Scholar
Steppan CM, Lazar MA: The current biology of resistin. J Intern Med. 2004, 255 (4): 439-447. 10.1111/j.1365-2796.2004.01306.x.
Article
CAS
PubMed
Google Scholar
Jackson MB, Osei SY, Ahima RS: The endocrine role of adipose tissue: focus on adiponectin and resistin. Curr Opin Endocrin Diab. 2005, 12: 163-170. 10.1097/01.med.0000159113.87201.e8.
Article
CAS
Google Scholar
Kawanami D, Maemura K, Takeda N, Harada T, Nojiri T, Imai Y, Manabe I, Utsunomiya K, Nagai R: Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions. Biochem Biophys Res Commun. 2004, 314 (2): 415-419. 10.1016/j.bbrc.2003.12.104.
Article
CAS
PubMed
Google Scholar
Kadowaki S, Li SH, Wang CH, Fedak PW, Li RK, Weisel RD, Mickle DA: Resistin promotes endothelial cell activation: further evidence of adipokine-endothelial interaction. Circulation. 2003, 108 (6): 736-740. 10.1161/01.CIR.0000084503.91330.49.
Article
Google Scholar
Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K: Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest. 2006, 116 (7): 1784-1792. 10.1172/JCI29126.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bolduc C, Yoshioka M, St-Amand J: Acute molecular mechanisms responsive to feeding and meal constitution in mesenteric adipose tissue. Obesity (Silver Spring). 2010, 18 (2): 410-413. 10.1038/oby.2009.257.
Article
Google Scholar
Sumiyoshi M, Sakanaka M, Kimura Y: Chronic intake of high-fat and high-sucrose diets differentially affects glucose intolerance in mice. J Nutr. 2006, 136 (3): 582-587.
CAS
PubMed
Google Scholar
Park SY, Cho YR, Kim HJ, Higashimori T, Danton C, Lee MK, Dey A, Rothermel B, Kim YB, Kalinowski A, Russell KS, Kim JK: Unraveling the temporal pattern of diet-induced insulin resistance in individual organs and cardiac dysfunction in C57BL/6 mice. Diabetes. 2005, 54 (12): 3530-3540. 10.2337/diabetes.54.12.3530.
Article
CAS
PubMed
Google Scholar
Flier JS, Cook KS, Usher P, Spiegelman BM: Severely impaired adipsin expression in genetic and acquired obesity. Science. 1987, 237 (4813): 405-8. 10.1126/science.3299706.
Article
CAS
PubMed
Google Scholar
Maslowska M, Vu H, Phelis S, Sniderman AD, Rhode BM, Blank D, Cianflone K: Plasma acylation stimulating protein, adipsin and lipids in non-obese and obese populations. Eur J Clin Invest. 1999, 29 (8): 679-686. 10.1046/j.1365-2362.1999.00514.x.
Article
CAS
PubMed
Google Scholar
Napolitano A, Lowell BB, Damm D, Leibel RL, Ravussin E, Jimerson DC, Lesem MD, Van Dyke DC, Daly PA, Chatis P: Concentrations of adipsin in blood and rates of adipsin secretion by adipose tissue in humans with normal, elevated and diminished adipose tissue mass. Int J Obes Relat Metab Disord. 1994, 18 (4): 213-218.
CAS
PubMed
Google Scholar
Cianflone K, Xia Z, Chen LY: Critical review of acylation-stimulating protein physiology in humans and rodents. Biochim Biophys Acta. 2003, 1609 (2): 127-143. 10.1016/S0005-2736(02)00686-7.
Article
CAS
PubMed
Google Scholar
Caesar R, Manieri M, Kelder T, Boekschoten M, Evelo C, Müller M, Kooistra T, Cinti S, Kleemann R, Drevon CA: A combined transcriptomics and lipidomics analysis of subcutaneous, epididymal and mesenteric adipose tissue reveals marked functional differences. PLoS One. 2010, 5 (7): e11525-10.1371/journal.pone.0011525.
Article
PubMed Central
PubMed
Google Scholar
Morton NM, Nelson YB, Michailidou Z, Di Rollo EM, Ramage L, Hadoke PW, Seckl JR, Bunger L, Horvat S, Kenyon CJ, Dunbar DR: A stratified transcriptomics analysis of polygenic fat and lean mouse adipose tissues identifies novel candidate obesity genes. PLoS One. 2011, 6 (9): e23944-10.1371/journal.pone.0023944.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lin Y, Lee H, Berg AH, Lisanti MP, Shapiro L, Scherer PE: The lipopolysaccharide-activated toll-like receptor (TLR)-4 induces synthesis of the closely related receptor TLR-2 in adipocytes. J Biol Chem. 2000, 275 (32): 24255-24263. 10.1074/jbc.M002137200.
Article
CAS
PubMed
Google Scholar
Batra A, Pietsch J, Fedke I, Glauben R, Okur B, Stroh T, Zeitz M, Siegmund B: Leptin-dependent toll-like receptor expression and responsiveness in preadipocytes and adipocytes. Am J Pathol. 2007, 170 (6): 1931-1941. 10.2353/ajpath.2007.060699.
Article
PubMed Central
CAS
PubMed
Google Scholar
Takaoka A, Yanai H, Kondo S, Duncan G, Negishi H, Mizutani T, Kano S, Honda K, Ohba Y, Mak TW, Taniguchi T: Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors. Nature. 2005, 434 (7030): 243-249. 10.1038/nature03308.
Article
CAS
PubMed
Google Scholar
Beutler B: Tlr4: central component of the sole mammalian LPS sensor. Curr Opin Immunol. 2000, 12 (1): 20-26. 10.1016/S0952-7915(99)00046-1.
Article
CAS
PubMed
Google Scholar
Miyake K: Roles for accessory molecules in microbial recognition by Toll-like receptors. J Endotoxin Res. 2006, 12 (4): 195-204. 10.1179/096805106X118807.
Article
CAS
PubMed
Google Scholar
Akashi-Takamura S, Miyake K: TLR accessory molecules. Curr Opin Immunol. 2008, 20 (4): 420-425. 10.1016/j.coi.2008.07.001.
Article
CAS
PubMed
Google Scholar
Ogata H, Su I, Miyake K, Nagai Y, Akashi S, Mecklenbräuker I, Rajewsky K, Kimoto M, Tarakhovsky A: The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells. J Exp Med. 2000, 192 (1): 23-29. 10.1084/jem.192.1.23.
Article
PubMed Central
CAS
PubMed
Google Scholar
Pierleoni C, Verdenelli F, Castellucci M, Cinti S: Fibronectins and basal lamina molecules expression in human subcutaneous white adipose tissue. Eur J Histochem. 1998, 42 (3): 183-188.
CAS
PubMed
Google Scholar
Lijnen HR: Angiogenesis and obesity. Cardiovasc Res. 2008, 78 (2): 286-293. 10.1093/cvr/cvm007.
Article
CAS
PubMed
Google Scholar
Wynn TA: Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases. J Clin Invest. 2007, 117 (3): 524-529. 10.1172/JCI31487.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kolb M, Margetts PJ, Sime PJ, Gauldie J: Proteoglycans decorin and biglycan differentially modulate TGF-beta-mediated fibrotic responses in the lung. Am J Physiol Lung Cell Mol Physiol. 2001, 280 (6): L1327-L1334.
CAS
PubMed
Google Scholar
Rada JA, Cornuet PK, Hassell JR: Regulation of corneal collagen fibrillogenesis in vitro by corneal proteoglycan (lumican and decorin) core proteins. Exp Eye Res. 1993, 56 (6): 635-648. 10.1006/exer.1993.1081.
Article
CAS
PubMed
Google Scholar
Chavey C, Mari B, Monthouel MN, Bonnafous S, Anglard P, Van Obberghen E, Tartare-Deckert S: Matrix metalloproteinases are differentially expressed in adipose tissue during obesity and modulate adipocyte differentiation. J Biol Chem. 2003, 278 (14): 11888-11896. 10.1074/jbc.M209196200. Epub
Article
CAS
PubMed
Google Scholar
McGrath ME: The lysosomal cysteine proteases. Annu Rev Biophys Biomol Struct. 1999, 28: 181-204. 10.1146/annurev.biophys.28.1.181.
Article
CAS
PubMed
Google Scholar
Fiebiger E, Maehr R, Villadangos J, Weber E, Erickson A, Bikoff E, Ploegh HL, Lennon-Duménil AM: Invariant chain controls the activity of extracellular cathepsin L. J Exp Med. 2002, 196 (9): 1263-1269. 10.1084/jem.20020762.
Article
PubMed Central
CAS
PubMed
Google Scholar
Taleb S, Lacasa D, Bastard JP, Poitou C, Cancello R, Pelloux V, Viguerie N, Benis A, Zucker JD, Bouillot JL, Coussieu C, Basdevant A, Langin D, Clement K: Cathepsin S, a novel biomarker of adiposity: relevance to atherogenesis. FASEB J. 2005, 19 (11): 1540-1542.
CAS
PubMed
Google Scholar
Nadler ST, Stoehr JP, Schueler KL, Tanimoto G, Yandell BS, Attie AD: The expression of adipogenic genes is decreased in obesity and diabetes mellitus. Proc Natl Acad Sci USA. 2000, 97 (21): 11371-11376. 10.1073/pnas.97.21.11371.
Article
PubMed Central
CAS
PubMed
Google Scholar
Rausch ME, Weisberg S, Vardhana P, Tortoriello DV: Obesity in C57BL/6 J mice is characterized by adipose tissue hypoxia and cytotoxic T-cell infiltration. Int J Obes (Lond). 2008, 32 (3): 451-463. 10.1038/sj.ijo.0803744.
Article
CAS
Google Scholar
Ye J, Gao Z, Yin J, He Q: Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab. 2007, 293 (4): E1118-E1128. 10.1152/ajpendo.00435.2007.
Article
CAS
PubMed
Google Scholar