Cuomo CA, Guldener U, Xu JR, Trail F, Turgeon BG, Di Pietro A, Walton JD, Ma LJ, Baker SE, Rep M, Adam G, Antoniw J, Baldwin T, Calvo S, Chang Y-L, DeCaprio D, Gale KR, Gnerre S, Goswami RS, Hammond-Kosack K, Harris LJ, Hilburn K, Kennell JC, Kroken S, Magnuson JK, Mannhaupt G, Mauceli E, Mewes H-W, Mitterbauer R, Muehlbauer G, et al: The Fusarium graminearum genome reveals a link between localized polymorphism and pathogen specialization. Science. 2007, 317: 1400-1402. 10.1126/science.1143708.
Article
CAS
PubMed
Google Scholar
Walter S, Nicholson P, Doohan FM: Action and reaction of host and pathogen during Fusarium head blight disease. New Phytol. 2010, 185: 54-66. 10.1111/j.1469-8137.2009.03041.x.
Article
CAS
PubMed
Google Scholar
Pestka JJ: Deoxynivalenol: mechanisms of action, human exposure, and toxicological relevance. Arch Toxicol. 2010, 84: 663-679. 10.1007/s00204-010-0579-8.
Article
CAS
PubMed
Google Scholar
The European Commission: Commission recommendation (EC) no. 1881/2006 of 19 December 2006 setting maximum levels for certain contaminants in foodstuffs. Off J Eur Union. 2006, 364: 5-24.
Google Scholar
Brenchley R, Spannagl M, Pfeifer M, Barker GL, D’Amore R, Allen AM, McKenzie N, Kramer M, Kerhornou A, Bolser D, Kay S, Waite D, Trick M, Bancroft I, Gu Y, Huo N, Luo M-C, Sehgal S, Gill B, Kianian S, Anderson O, Kersey P, Dvorak J, McCombie WR, Hall A, Mayer FKX, Edwards KJ, Bevan MW, Hall N: Analysis of the bread wheat genome using whole-genome shotgun sequencing. Nature. 2012, 491: 705-710. 10.1038/nature11650.
Article
PubMed Central
CAS
PubMed
Google Scholar
Paux E, Roger D, Badaeva E, Gay G, Bernard M, Sourdille P, Feuillet C: Characterizing the composition and evolution of homoeologous genomes in hexaploid wheat through BAC-end sequencing on chromosome 3B. Plant J. 2006, 48: 463-474. 10.1111/j.1365-313X.2006.02891.x.
Article
CAS
PubMed
Google Scholar
Buerstmayr H, Ban T, Anderson JA: QTL mapping and marker-assisted selection for fusarium head blight resistance in wheat: a review. Plant Breed. 2009, 128: 1-26. 10.1111/j.1439-0523.2008.01550.x.
Article
CAS
Google Scholar
Waldron BL, Moreno-Sevilla B, Anderson JA, Stack RW, Frohberg RC: RFLP mapping of QTL for fusarium head blight resistance in wheat. Crop Sci. 1999, 39: 805-811. 10.2135/cropsci1999.0011183X003900030032x.
Article
CAS
Google Scholar
Buerstmayr H, Lemmens M, Hartl L, Doldi L, Steiner B, Stierschneider M, Ruckenbauer P: Molecular mapping of QTLs for fusarium head blight resistance in spring wheat. I. Resistance to fungal spread (Type II resistance). Theor Appl Genet. 2002, 104: 84-91. 10.1007/s001220200009.
Article
CAS
PubMed
Google Scholar
Buerstmayr H, Steiner B, Hartl L, Griesser M, Angerer N, Lengauer D, Miedaner T, Schneider B, Lemmens M: Molecular mapping of QTLs for fusarium head blight resistance in spring wheat. II. Resistance to fungal penetration and spread. Theor Appl Genet. 2003, 107: 503-508. 10.1007/s00122-003-1272-6.
Article
CAS
PubMed
Google Scholar
Lemmens M, Scholz U, Berthiller F, Dall’Asta C, Koutnik A, Schuhmacher R, Adam G, Buerstmayr H, Mesterhazy A, Krska R, Ruckenbauer P: The ability to detoxify the mycotoxin deoxynivalenol colocalizes with a major quantitative trait locus for fusarium head blight resistance in wheat. Mol Plant-Microbe Interact. 2005, 18: 1318-1324. 10.1094/MPMI-18-1318.
Article
CAS
PubMed
Google Scholar
Gunnaiah R, Kushalappa AC, Duggavathi R, Fox S, Somers DJ: Integrated metabolo-proteomic approach to decipher the mechanisms by which wheat QTL (Fhb1) contributes to resistance against Fusarium graminearum. PloS one. 2012, 7: e40695-10.1371/journal.pone.0040695.
Article
PubMed Central
CAS
PubMed
Google Scholar
Zhuang Y, Gala A, Yen Y: Identification of functional genic components of major Fusarium head blight resistance quantitative trait loci in wheat cultivar Sumai 3. Mol Plant-Microbe Interact. 2013, 26: 442-450. 10.1094/MPMI-10-12-0235-R.
Article
CAS
PubMed
Google Scholar
Schweiger W, Steiner B, Ametz C, Siegwart G, Wiesenberger G, Berthiller F, Lemmens M, Jia H, Adam G, Muehlbauer GJ, Kreil DP, Buerstmayr H: Transcriptomic characterization of two major fusarium resistance QTL, Fhb1 and Qfhs.ifa-5A, identifies novel candidate genes. Mol Plant Pathol. 2013, 14: 772-785. 10.1111/mpp.12048.
Article
PubMed Central
CAS
PubMed
Google Scholar
Schreiber A, Hayden M, Forrest K, Kong S, Langridge P, Baumann U: Transcriptome-scale homoeolog-specific transcript assemblies of bread wheat. BMC Genom. 2012, 13: 492-10.1186/1471-2164-13-492.
Article
CAS
Google Scholar
Mochida K, Yoshida T, Sakurai T, Ogihara Y, Shinozaki K: TriFLDB: a database of clustered full-length coding sequences from Triticeae with applications to comparative grass genomics. Plant Physiol. 2009, 150: 1135-1146. 10.1104/pp.109.138214.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kubalakova M, Vrana J, Cihalikova J, Simkova H, Dolezel J: Flow karyotyping and chromosome sorting in bread wheat (Triticum aestivum L.). Theor Appl Genet. 2002, 104: 1362-1372. 10.1007/s00122-002-0888-2.
Article
PubMed
Google Scholar
Poland JA, Brown PJ, Sorrells ME, Jannink JL: Development of high-density genetic maps for barley and wheat using a novel two-enzyme genotyping-by-sequencing approach. PloS one. 2012, 7: e32253-10.1371/journal.pone.0032253.
Article
PubMed Central
CAS
PubMed
Google Scholar
Philippe R, Choulet F, Paux E, van Oeveren J, Tang J, Wittenberg AH, Janssen A, van Eijk MJ, Stormo K, Alberti A, Wincker P, Akhunov E, van der Vossen E, Feuillet C: Whole genome profiling provides a robust framework for physical mapping and sequencing in the highly complex and repetitive wheat genome. BMC genom. 2012, 13: 47-
Article
CAS
Google Scholar
The International Barley Genome Sequencing Consortium: A physical, genetic and functional sequence assembly of the barley genome. Nature. 2012, 491: 711-716.
Google Scholar
Adhikari BN, Savory EA, Vaillancourt B, Childs KL, Hamilton JP, Day B, Buell CR: Expression profiling of Cucumis sativus in response to infection by Pseudoperonospora cubensis. PloS one. 2012, 7: e34954-10.1371/journal.pone.0034954.
Article
PubMed Central
CAS
PubMed
Google Scholar
Bagnaresi P, Biselli C, Orru L, Urso S, Crispino L, Abbruscato P, Piffanelli P, Lupotto E, Cattivelli L, Vale G: Comparative transcriptome profiling of the early response to Magnaporthe oryzae in durable resistant vs susceptible rice (Oryza sativa L.) genotypes. PloS one. 2012, 7: e51609-10.1371/journal.pone.0051609.
Article
PubMed Central
CAS
PubMed
Google Scholar
Wong P, Walter M, Lee W, Mannhaupt G, Munsterkotter M, Mewes HW, Adam G, Guldener U: FGDB: revisiting the genome annotation of the plant pathogen fusarium graminearum. Nuc Acids Res. 2011, 39: D637-D639. 10.1093/nar/gkq1016.
Article
CAS
Google Scholar
Trapnell C, Roberts A, Goff L, Pertea G, Kim D, Kelley DR, Pimentel H, Salzberg SL, Rinn JL, Pachter L: Differential gene and transcript expression analysis of RNA-seq experiments with TopHat and cufflinks. Nat Protoc. 2012, 7: 562-578.
Article
PubMed Central
CAS
PubMed
Google Scholar
Benjamini Y, Hochberg Y: Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc Ser B Stat Methodol. 1995, 57: 289-300.
Google Scholar
Alexa A, Rahnenführer J, Lengauer T: Improved scoring of functional groups from gene expression data by decorrelating GO graph structure. Bioinformatics. 2006, 22: 1600-1607. 10.1093/bioinformatics/btl140.
Article
CAS
PubMed
Google Scholar
Bolton MD: Primary metabolism and plant defense—fuel for the fire. Mol Plant-Microbe Interact. 2009, 22: 487-497. 10.1094/MPMI-22-5-0487.
Article
CAS
PubMed
Google Scholar
Seifi HS, Van Bockhaven J, Angenon G, Hofte M: Glutamate metabolism in plant disease and defense: friend or foe?. Mol Plant-Microbe Interact. 2013, 26: 475-485. 10.1094/MPMI-07-12-0176-CR.
Article
CAS
PubMed
Google Scholar
Langfelder P, Horvath S: WGCNA: an R package for weighted correlation network analysis. BMC bioinformatics. 2008, 9: 559-10.1186/1471-2105-9-559.
Article
PubMed Central
PubMed
Google Scholar
Langfelder P, Horvath S: Eigengene networks for studying the relationships between co-expression modules. BMC Syst Biol. 2007, 1: 54-10.1186/1752-0509-1-54.
Article
PubMed Central
PubMed
Google Scholar
Langfelder P, Luo R, Oldham MC, Horvath S: Is my network module preserved and reproducible?. PLoS Comput Biol. 2011, 7: e1001057-10.1371/journal.pcbi.1001057.
Article
PubMed Central
CAS
PubMed
Google Scholar
Freeman L: Centrality in social networks: conceptual clarification. Soc Networks. 1979, 1: 215-239.
Article
Google Scholar
Wasserman SFK: Social network analysis : methods and applications. 1994, Cambridge, New York: Cambridge University Press
Book
Google Scholar
Hage P, Harary F: Eccentricity and centrality in networks. Soc Networks. 1995, 17: 57-63. 10.1016/0378-8733(94)00248-9.
Article
Google Scholar
Jeong H, Mason SP, Barabasi AL, Oltvai ZN: Lethality and centrality in protein networks. Nature. 2001, 411: 41-42. 10.1038/35075138.
Article
CAS
PubMed
Google Scholar
Filteau M, Pavey SA, St-Cyr J, Bernatchez L: Gene coexpression networks reveal key drivers of phenotypic divergence in lake whitefish. Mol Biol Evol. 2013, 30: 1384-1396. 10.1093/molbev/mst053.
Article
CAS
PubMed
Google Scholar
Ferreira RM, Rybarczyk-Filho JL, Dalmolin RJ, Castro MA, Moreira JC, Brunnet LG, de Almeida RM: Preferential duplication of intermodular hub genes: an evolutionary signature in eukaryotes genome networks. PloS one. 2013, 8: e56579-10.1371/journal.pone.0056579.
Article
PubMed Central
CAS
PubMed
Google Scholar
Csardi G, Nepusz T: The igraph software package for complex network research. InterJournal. 2006, Complex Systems: 1695-
Google Scholar
Bonacich P: Power and centrality: a family of measures. Am J Sociol. 1987, 92: 1170-1182. 10.1086/228631.
Article
Google Scholar
Larkin MA, Blackshields G, Brown NP, Chenna R, McGettigan PA, McWilliam H, Valentin F, Wallace IM, Wilm A, Lopez R, Thompson JD, Gibson TJ, Higgins DG: Clustal w and clustal x version 2.0. Bioinformatics. 2007, 23: 2947-2948. 10.1093/bioinformatics/btm404.
Article
CAS
PubMed
Google Scholar
Schweiger W, Pasquet JC, Nussbaumer T, Kovalsky Paris MP, Wiesenberger G, Macadre C, Ametz C, Berthiller F, Lemmens M, Saindrenan P, Mewes HW, Mayer KF, Dufresne M, Adam G: Functional characterization of two clusters of Brachypodium distachyon UDP-glycosyltransferases encoding putative deoxynivalenol detoxification genes. Mol Plant-Microbe Interact. 2013, 26: 781-792. 10.1094/MPMI-08-12-0205-R.
Article
CAS
PubMed
Google Scholar
Eulgem T, Rushton PJ, Robatzek S, Somssich IE: The WRKY superfamily of plant transcription factors. Trends Plant Sci. 2000, 5: 199-206. 10.1016/S1360-1385(00)01600-9.
Article
CAS
PubMed
Google Scholar
Vogt T, Jones P: Glycosyltransferases in plant natural product synthesis: characterization of a supergene family. Trends Plant Sci. 2000, 5: 1360-1385.
Google Scholar
Poppenberger B, Berthiller F, Lucyshyn D, Sieberer T, Schuhmacher R, Krska R, Kuchler K, Glossl J, Luschnig C, Adam G: Detoxification of the fusarium mycotoxin deoxynivalenol by a UDP-glucosyltransferase from Arabidopsis thaliana. J Biol Chem. 2003, 278: 47905-47914. 10.1074/jbc.M307552200.
Article
CAS
PubMed
Google Scholar
Schweiger W, Boddu J, Shin S, Poppenberger B, Berthiller F, Lemmens M, Muehlbauer GJ, Adam G: Validation of a candidate deoxynivalenol-inactivating UDP-glucosyltransferase from barley by heterologous expression in yeast. Mol Plant-Microbe Interact. 2010, 23: 977-986. 10.1094/MPMI-23-7-0977.
Article
CAS
PubMed
Google Scholar
Jia H, Cho S, Muehlbauer GJ: Transcriptome analysis of a wheat near-isogenic line pair carrying fusarium head blight–resistant and –susceptible alleles. Mol Plant-Microbe Interact. 2009, 22: 1366-1378. 10.1094/MPMI-22-11-1366.
Article
CAS
PubMed
Google Scholar
Foroud NA, Ouellet T, Laroche A, Oosterveen B, Jordan MC, Ellis BE, Eudes F: Differential transcriptome analyses of three wheat genotypes reveal different host response pathways associated with fusarium head blight and trichothecene resistance. Plant Pathol. 2012, 61: 296-314. 10.1111/j.1365-3059.2011.02512.x.
Article
CAS
Google Scholar
Gottwald S, Samans B, Luck S, Friedt W: Jasmonate and ethylene dependent defence gene expression and suppression of fungal virulence factors: two essential mechanisms of fusarium head blight resistance in wheat?. BMC genomics. 2012, 13: 369-10.1186/1471-2164-13-369.
Article
PubMed Central
CAS
PubMed
Google Scholar
Walter S, Brennan J, Trognitz F, Trognitz B, Leonard G, Egan D, Doohan F: Components of the gene network associated with genotype-dependent response of wheat to the fusarium mycotoxin deoxynivalenol. Funct Integr Genomics. 2008, 8: 421-427. 10.1007/s10142-008-0089-4.
Article
CAS
PubMed
Google Scholar
Lulin M, Yi S, Aizhong C, Zengjun Q, Liping X, Peidu C, Dajun L, Xiu EW: Molecular cloning and characterization of an up-regulated UDP-glucosyltransferase gene induced by DON from Triticum aestivum L. cv. Wangshuibai. Mol Biol Rep. 2010, 37: 785-795. 10.1007/s11033-009-9606-3.
Article
PubMed
Google Scholar
Ansari KI, Walter S, Brennan JM, Lemmens M, Kessans S, McGahern A, Egan D, Doohan FM: Retrotransposon and gene activation in wheat in response to mycotoxigenic and non-mycotoxigenic-associated fusarium stress. Theor Appl Genet. 2007, 114: 927-937. 10.1007/s00122-006-0490-0.
Article
CAS
PubMed
Google Scholar
Ding L, Xu H, Yi H, Yang L, Kong Z, Zhand L, Xue S, Jia H: Resistance to hemi-biotrophic F. graminearum infection is associated with coordinated and ordered expression of diverse defense signaling pathways. PloS one. 2011, 6: e19008-10.1371/journal.pone.0019008.
Article
PubMed Central
CAS
PubMed
Google Scholar
Emmert-Streib F, Dehmer M: Networks for systems biology: conceptual connection of data and function. IET Syst Biol. 2011, 5: 185-207. 10.1049/iet-syb.2010.0025.
Article
CAS
PubMed
Google Scholar
Todeschini R, Consonni V: Handbook of Molecular Descriptors. 2008, Weilheim: WILEY-VCH
Google Scholar
Mueller LA, Kugler KG, Dander A, Graber A, Dehmer M: QuACN: an R package for analyzing complex biological networks quantitatively. Bioinformatics. 2011, 27: 140-141. 10.1093/bioinformatics/btq606.
Article
CAS
PubMed
Google Scholar
Seong KY, Zhao X, Xu JR, Guldener U, Kistler HC: Conidial germination in the filamentous fungus Fusarium graminearum. Fung Genet Biol. 2008, 45: 389-399. 10.1016/j.fgb.2007.09.002.
Article
CAS
Google Scholar
Pritsch C, Muehlbauer GJ, Bushnell WR, Somers DA, Vance CP: Fungal development and induction of defense response genes during early infection of wheat spikes by Fusarium graminearum. Mol Plant-Microbe Interact. 2000, 13: 159-169. 10.1094/MPMI.2000.13.2.159.
Article
CAS
PubMed
Google Scholar
Dixon DP, Cummins I, Cole DJ, Edwards R: Glutathione-mediated detoxification systems in plants. Curr Opin Plant Biol. 1998, 1: 258-266. 10.1016/S1369-5266(98)80114-3.
Article
CAS
PubMed
Google Scholar
Essmann J, Schmitz-Thom I, Schon H, Sonnewald S, Weis E, Scharte J: RNA interference-mediated repression of cell wall invertase impairs defense in source leaves of tobacco. Plant physiol. 2008, 147: 1288-1299. 10.1104/pp.108.121418.
Article
PubMed Central
CAS
PubMed
Google Scholar
Fernandez O, Bethencourt L, Quero A, Sangwan RS, Clement C: Trehalose and plant stress responses: friend or foe?. Trends Plant Sci. 2010, 15: 409-417. 10.1016/j.tplants.2010.04.004.
Article
CAS
PubMed
Google Scholar
Luo Y, Li W-M, Wang W: Trehalose: protector of antioxidant enzymes or reactive oxygen species scavenger under heat stress?. Environ Exper Bot. 2008, 63: 378-384. 10.1016/j.envexpbot.2007.11.016.
Article
CAS
Google Scholar
Renard-Merlier D, Randoux B, Nowak E, Farcy F, Durand R, Reignault P: Iodus 40, salicylic acid, heptanoyl salicylic acid and trehalose exhibit different efficacies and defence targets during a wheat/powdery mildew interaction. Phytochem. 2007, 68: 1156-1164. 10.1016/j.phytochem.2007.02.011.
Article
CAS
Google Scholar
Suharsono U, Fujisawa Y, Kawasaki T, Iwasaki Y, Satoh H, Shimamoto K: The heterotrimeric G protein alpha subunit acts upstream of the small GTPase Rac in disease resistance of rice. Proc Natl Acad Sci U S A. 2002, 99: 13307-13312. 10.1073/pnas.192244099.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lieberherr D, Thao NP, Nakashima A, Umemura K, Kawasaki T, Shimamoto K: A sphingolipid elicitor-inducible mitogen-activated protein kinase is regulated by the small GTPase OsRac1 and heterotrimeric G-protein in rice 1[w]. Plant Physiol. 2005, 138: 1644-1652. 10.1104/pp.104.057414.
Article
PubMed Central
CAS
PubMed
Google Scholar
Trusov Y, Rookes JE, Chakravorty D, Armour D, Schenk PM, Botella JR: Heterotrimeric G proteins facilitate arabidopsis resistance to necrotrophic pathogens and are involved in jasmonate signaling. Plant Physiol. 2006, 140: 210-220.
Article
PubMed Central
CAS
PubMed
Google Scholar
Li G, Yen Y: Jasmonate and ethylene signaling pathway may mediate fusarium head blight resistance in wheat. Crop Sci. 2008, 48: 1888-1896. 10.2135/cropsci2008.02.0097.
Article
Google Scholar
Gillespie ME, Brandt AS, Scofield SR: Ethylene-signaling is essential for basal resistance to Fusarium head blight in wheat. Proceedings of the National Fusarium Head Blight Forum: 4-6 December 2012; Orlando, FL. Edited by: Canty S. 2012, East Lansing, MI/Lexington, KY: US Wheat & Barley Scab Initiative, 135-
Google Scholar
Gardiner S, Boddu J, Berthiller F, Hametner C, Stupar R, Adam G, Muehlbauer G: Transcriptome analysis of the barley-deoxynivalenol interaction: evidence for a role of glutathione in deoxynivalenol detoxification. Mol Plant-Microbe Interact. 2010, 23: 962-976. 10.1094/MPMI-23-7-0962.
Article
CAS
PubMed
Google Scholar
Wu XR, Kenzior A, Willmot D, Scanlon S, Chen Z, Topin A, He SH, Acevedo A, Folk WR: Altered expression of plant lysyl tRNA synthetase promotes tRNA misacylation and translational recoding of lysine. Plant J. 2007, 50: 627-636. 10.1111/j.1365-313X.2007.03076.x.
Article
CAS
PubMed
Google Scholar
Dennison KL, Spalding EP: Glutamate-gated calcium fluxes in arabidopsis. Plant Physiol. 2000, 124: 1511-1514. 10.1104/pp.124.4.1511.
Article
PubMed Central
CAS
PubMed
Google Scholar
Lecourieux D, Mazars C, Pauly N, Ranjeva R, Pugin A: Analysis and effects of cytosolic free calcium increases in response to elicitors in Nicotiana plumbaginifolia cells. Plant Cell. 2002, 14: 2627-2641. 10.1105/tpc.005579.
Article
PubMed Central
CAS
PubMed
Google Scholar
Kang S, Kim HB, Lee H, Choi JY, Heu S, Oh CJ, Kwon SI, An CS: Overexpression in arabidopsis of a plasma membrane-targeting glutamate receptor from small radish increases glutamate-mediated Ca2+ influx and delays fungal infection. Mol Cells. 2006, 21: 418-427.
CAS
PubMed
Google Scholar
Dong H, Beer SV: Riboflavin induces disease resistance in plants by activating a novel signal transduction pathway. Phytopathol. 2000, 90 (8): 801-811. 10.1094/PHYTO.2000.90.8.801.
Article
CAS
Google Scholar
Zhang S, Yang X, Sun M, Sun F, Deng S, Dong H: Riboflavin-induced priming for pathogen defense in Arabidopsis thaliana. J Integr Plant Biol. 2009, 51: 167-174. 10.1111/j.1744-7909.2008.00763.x.
Article
PubMed
Google Scholar