King GL, Kunisaki M, Nishio Y, Inoguchi T, Shiba T, et al: Biochemical and molecular mechanisms in the development of diabetic vascular complications. Diabetes. 1996, 45: S105-S108.
Article
PubMed
Google Scholar
Hoogeveen EK, Kostense PJ, Beks PJ, MacKaay AJC, Jakobs C, et al: Hyperhomocysteinemia is associated with an increased risk of cardiovascular disease, especially in non-insulin-dependent diabetes mellitus - a population-based. Arterioscler Thromb Vasc Biol. 1998, 18: 133-138. 10.1161/01.ATV.18.1.133.
Article
PubMed
Google Scholar
Meigs JB, Jacques PF, Selhub J, Singer DE, Nathan DM, et al: Fasting plasma homocysteine levels in the insulin resistance syndrome - the Framingham offspring study. Diabetes Care. 2001, 24: 1403-1410. 10.2337/diacare.24.8.1403.
Article
PubMed
Google Scholar
Buysschaert M, Dramais AS, Wallemacq PE, Hermans MP: Hyperhomocysteinemia in type 2 diabetes: relationship to macroangiopathy, nephropathy, and insulin resistance. Diabetes Care. 2000, 23: 1816-1822. 10.2337/diacare.23.12.1816.
Article
PubMed
Google Scholar
Kark JD, Selhub J, Bostom A, Adler B, Rosenberg IH: Plasma homocysteine and all-cause mortality in diabetes. Lancet. 1999, 353: 1936-1937.
Article
PubMed
Google Scholar
Hoogeveen EK, Kostense PJ, Jakobs C, Dekker JM, Nijpels G, et al: Hyperhomocysteinemia increases risk of death, especially in type 2 diabetes - 5-year follow-up of the Hoorn study. Circulation. 2000, 101: 1506-1511. 10.1161/01.CIR.101.13.1506.
Article
PubMed
Google Scholar
Agullo-Ortuno MT, Albaladejo MD, Parra S, Rodriguez-Manotas M, Fenollar M, et al: Plasmatic homocysteine concentration and its relationship with complications associated to diabetes mellitus. Clin Chim Acta. 2002, 326: 105-112. 10.1016/S0009-8981(02)00287-5.
Article
PubMed
Google Scholar
Emoto M, Kanda H, Shoji T, Kawagishi T, Komatsu M, et al: Impact of insulin resistance and nephropathy on homocysteine in type 2 diabetes. Diabetes Care. 2001, 24: 533-538. 10.2337/diacare.24.3.533.
Article
PubMed
Google Scholar
Smulders YM, Rakic M, Slaats EH, Treskes M, Sijbrands EJ, et al: Fasting and post-methionine homocysteine levels in NIDDM. Determinants and correlations with retinopathy, albuminuria, and cardiovascular disease. Diabetes Care. 1999, 22: 125-132. 10.2337/diacare.22.1.125.
Article
PubMed
Google Scholar
Araki A, Sako Y, Ito H: Plasma homocysteine concentrations in Japanese patients with non-insulin-dependent diabetes mellitus: effect of parenteral methylcobalamin treatment. Atherosclerosis. 1993, 103: 149-157. 10.1016/0021-9150(93)90258-V.
Article
PubMed
Google Scholar
Folsom AR, Nieto FJ, McGovern PG, Tsai MY, Malinow MR, et al: Prospective study of coronary heart disease incidence in relation to fasting total homocysteine, related genetic polymorphisms, and B vitamins: the Atherosclerosis Risk in Communities (ARIC) study. Circulation. 1998, 98: 204-210. 10.1161/01.CIR.98.3.204.
Article
PubMed
Google Scholar
Mazza A, Bossone E, Mazza F, Distante A: Reduced serum homocysteine levels in type 2 diabetes. Nutr Metab Cardiovasc Dis. 2005, 15: 118-124. 10.1016/j.numecd.2004.03.001.
Article
PubMed
Google Scholar
Oishi K, Nagake Y, Yamasaki H, Fukuda S, Ichikawa H, et al: The significance of serum homocysteine levels in diabetic patients on haemodialysis. Nephrol Dial Transplant. 2000, 15: 851-855. 10.1093/ndt/15.6.851.
Article
PubMed
Google Scholar
Lander ES: The new genomics: global views of biology. Science. 1996, 274: 536-539. 10.1126/science.274.5287.536.
Article
PubMed
Google Scholar
Jacques PF, Bostom AG, Williams RR, Ellison RC, Eckfeldt JH, et al: Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation. 1996, 93: 7-9. 10.1161/01.CIR.93.1.7.
Article
PubMed
Google Scholar
Zintzaras E, Chatzoulis DZ, Karabatsas CH, Stefanidis I: The relationship between C677T methylenetetrahydrofolate reductase gene polymorphism and retinopathy in type 2 diabetes: a meta-analysis. J Hum Genet. 2005, 50: 267-275. 10.1007/s10038-005-0250-z.
Article
PubMed
Google Scholar
Hemati T, Moghadami-Tabrizi N, Davari-Tanha F, Salmanian B, Javadian P: High plasma homocysteine and insulin resistance in patients with polycystic ovarian syndrome. Iranian Journal of Reproductive Medicine. 2011, 9: 223-228.
PubMed Central
PubMed
Google Scholar
Nafiye Y, Sevtap K, Muammer D, Emre O, Senol K, et al: The effect of serum and intrafollicular insulin resistance parameters and homocysteine levels of nonobese, nonhyperandrogenemic polycystic ovary syndrome patients on in vitro fertilization outcome. Fertil Steril. 2010, 93: 1864-1869. 10.1016/j.fertnstert.2008.12.024.
Article
PubMed
Google Scholar
Malek-Khosravi S, Kaboudi M, Kaboudi B, Atefi G: Plasma homocysteine concentrations and insulin resistance in preeclampsia. Hypertens Pregnancy. 2009, 28: 13-22. 10.1080/10641950802233049.
Article
PubMed
Google Scholar
Patterson S, Flatt PR, Brennan L, Newsholme P, McClenaghan NH: Detrimental actions of metabolic syndrome risk factor, homocysteine, on pancreatic beta-cell glucose metabolism and insulin secretion. J Endocrinol. 2006, 189: 301-310. 10.1677/joe.1.06537.
Article
PubMed
Google Scholar
Patterson S, Flatt PR, McClenaghan NH: Homocysteine-induced impairment of insulin secretion from clonal pancreatic BRIN-BD11 beta-cells is not prevented by catalase. Pancreas. 2007, 34: 144-151. 10.1097/01.mpa.0000240613.43345.51.
Article
PubMed
Google Scholar
Scullion SMJ, Gurgul-Convey E, Elsner M, Lenzen S, Flatt PR, et al: Enhancement of homocysteine toxicity to insulin-secreting BRIN-BD11 cells in combination with alloxan. J Endocrinol. 2012, 214: 233-238. 10.1530/JOE-11-0461.
Article
PubMed
Google Scholar
Russo GT, Di Benedetto A, Magazzù D, Giandalia A, Giorda CB, et al: Mild hyperhomocysteinemia, C677T polymorphism on methylenetetrahydrofolate reductasegene and the risk of macroangiopathy in type 2 diabetes: a prospective study. Acta Diabetol. 2011, 48: 95-101. 10.1007/s00592-009-0169-5.
Article
PubMed
Google Scholar
Kelly PJ, Rosand J, Kistler JP, Shih VE, Silveira S, et al: Homocysteine, MTHFR 677CT polymorphism, and risk of ischemic stroke: results of a meta-analysis. Neurology. 2002, 59: 529-536. 10.1212/WNL.59.4.529.
Article
PubMed
Google Scholar
Ndrepepa G, Kastrati A, Braun S, Koch W, Kolling K, et al: Circulating homocysteine levels in patients with type 2 diabetes mellitus. Nutr Metab Cardiovasc Dis. 2008, 18: 66-73. 10.1016/j.numecd.2006.03.007.
Article
PubMed
Google Scholar
Bluthner M, Bruntgens A, Schmidt S, Strojek K, Grzeszczak W, et al: Association of methylenetetrahydrofolate reductase gene polymorphism and diabetic nephropathy in type 2 diabetes?. Nephrol Dial Transplant. 1999, 14: 56-57. 10.1093/ndt/14.1.56.
Article
PubMed
Google Scholar
Benes P, Kankova K, Muzik J, Groch L, Benedik J, et al: Methylenetetrahydrofolate reductase polymorphism, type II diabetes mellitus, coronary artery disease, and essential hypertension in the Czech population. Mol Genet Metab. 2001, 73: 188-195. 10.1006/mgme.2001.3188.
Article
PubMed
Google Scholar
Yilmaz H, Agachan B, Ergen A, Karaalib ZE, Isbir T: Methylene tetrahydrofolate reductase C677T mutation and left ventricular hypertrophy in Turkish patients with type II diabetes mellitus. J Biochem Mol Biol. 2004, 37: 234-238. 10.5483/BMBRep.2004.37.2.234.
Article
PubMed
Google Scholar
Erdogan M, Karadeniz M, Eroglu Z, Tezcanli B, Selvi N, et al: The relationship of the peroxisome proliferator-activated receptor-gamma 2 exon 2 and exon 6 gene polymorphism in Turkish type 2 diabetic patients with and without nephropathy. Diabetes Res Clin Pract. 2007, 78: 355-359. 10.1016/j.diabres.2007.06.005.
Article
PubMed
Google Scholar
Tutuncu NB, Erbas T, Alikasifoglu M, Tuncbilek E: Thermolabile methylenetetrahydrofolate reductase enzyme genotype is frequent in type 2 diabetic patients with normal fasting homocysteine levels. J Intern Med. 2005, 257: 446-453. 10.1111/j.1365-2796.2005.01480.x.
Article
PubMed
Google Scholar
Soares AL, Fernandes AP, Cardoso JE, Sousa MO, Lasmar MC, et al: Plasma total homocysteine levels and methylenetetrahydrofolate reductase gene polymorphism in patients with type 2 diabetes mellitus. Pathophysiol Haemost Thromb. 2007, 36: 275-281. 10.1159/000252825.
Article
Google Scholar
Angeline T, Thiruvarutselvi G, Isabel W, Aruna RM, Devi R, et al: MTHFR (Ala 222 Val) polymorphism and AMI in patients with type II diabetes mellitus. Indian J Clin Biochem. 2009, 24: 137-141. 10.1007/s12291-009-0025-y.
Article
PubMed Central
PubMed
Google Scholar
Mehri S, Koubaa N, Nakbi A, Hammami S, Chaaba R, et al: Relationship between genetic polymorphisms of angiotensin-converting enzyme and methylenetetrahydrofolate reductase as risk factors for type 2 diabetes in Tunisian patients. Clin Biochem. 2010, 43: 259-266. 10.1016/j.clinbiochem.2009.10.008.
Article
PubMed
Google Scholar
Sun JH, Xu YC, Zhu YL, Lu HY: Genetic polymorphism of methylenetetrahydrofolate reductase as a risk factor for diabetic nephropathy in Chinese type 2 diabetic patients. Diabetes Res Clin Pract. 2004, 64: 185-190. 10.1016/j.diabres.2003.10.022.
Article
PubMed
Google Scholar
Mtiraoui N, Ezzidi I, Chaieb M, Marmouche H, Aouni Z, et al: MTHFR C677T and A1298C gene polymorphisms and hyperhomocysteinemia as risk factors of diabetic nephropathy in type 2 diabetes patients. Diabetes Res Clin Pract. 2007, 75: 99-106. 10.1016/j.diabres.2006.05.018.
Article
PubMed
Google Scholar
Sun J, Xu Y, Zhu Y, Lu H, Deng H, et al: The relationship of methylenetetrahydrofolate reductase gene polymorphism and plasma homocysteine levels in type 2 diabetes mellitus patients with diabetic retinopathy. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2003, 20: 131-134.
PubMed
Google Scholar
Movva S, Alluri RV, Venkatasubramanian S, Vedicherla B, Vattam KK, et al: Association of methylene tetrahydrofolate reductase C677T genotype with type 2 diabetes mellitus patients with and without renal complications. Genet Test Mol Biomarkers. 2011, 15: 257-261. 10.1089/gtmb.2010.0118.
Article
PubMed
Google Scholar
Bazzaz JT, Shojapoor M, Nazem H, Amiri P, Fakhrzadeh H, et al: Methylenetetrahydrofolate reductase gene polymorphism in diabetes and obesity. Mol Biol Rep. 2010, 37: 105-109. 10.1007/s11033-009-9545-z.
Article
Google Scholar
Benrahma H, Abidi O, Melouk L, Ajjemami M, Rouba H, et al: Association of the C677T Polymorphism in the Human Methylenetetrahydrofolate Reductase (MTHFR) gene with the genetic predisposition for Type 2 diabetes mellitus in a Moroccan Population. Genet Test Mol Biomarkers. 2012, 16: 383-387. 10.1089/gtmb.2011.0179.
Article
PubMed
Google Scholar
Sharaf SM, Gawish HH, Elsherbiny EM: Methylenetetrahydrofolate Reductase (Mthfr C677t) Gene Polymorphism Effect on Development of Diabetic Nephropathy in Egyptien Patients with Type 2 Diabetes Mellitus. Life Science Journal-Acta Zhengzhou University Overseas Edition. 2012, 9: 874-880.
Google Scholar
Higgins JP, Thompson SG: Quantifying heterogeneity in a meta-analysis. Stat Med. 2002, 21: 1539-1558. 10.1002/sim.1186.
Article
PubMed
Google Scholar
Song YQ, Yeung E, Liu AY, VanderWeele TJ, Chen LW, et al: Pancreatic beta-cell function and type 2 diabetes risk: quantify the causal effect using a Mendelian randomization approach based on meta-analyses. Hum Mol Genet. 2012, 21: 5010-5018. 10.1093/hmg/dds339.
Article
PubMed Central
PubMed
Google Scholar
Glymour MM, Tchetgen EJT, Robins JM: Credible mendelian randomization studies: approaches for evaluating the instrumental variable assumptions. Am J Epidemiol. 2012, 175: 332-339. 10.1093/aje/kwr323.
Article
PubMed Central
PubMed
Google Scholar
Tanaka T, Scheet P, Giusti B, Bandinelli S, Piras MG, et al: Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations. Am J Hum Genet. 2009, 84: 477-482. 10.1016/j.ajhg.2009.02.011.
Article
PubMed Central
PubMed
Google Scholar
Huang T, Tucker KL, Lee YC, Crott JW, Parnell LD, et al: Methylenetetrahydrofolate reductase variants associated with hypertension and cardiovascular disease interact with dietary polyunsaturated fatty acids to modulate plasma homocysteine in puerto rican adults. J Nutr. 2011, 141: 654-659. 10.3945/jn.110.134353.
Article
PubMed Central
PubMed
Google Scholar
Thompson JR, Minelli C, Abrams KR, Tobin MD, Riley RD: Meta-analysis of genetic studies using Mendelian randomization - a multivariate approach. Stat Med. 2005, 24: 2241-2254. 10.1002/sim.2100.
Article
PubMed
Google Scholar
Wald DS, Law M, Morris JK: Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. Br Med J. 2002, 325: 1202-1206K. 10.1136/bmj.325.7374.1202.
Article
Google Scholar
Mazza A, Motti C, Nulli A, Pastore A, Andreotti F, et al: Serum homocysteine, MTHFR gene polymorphism, and carotid intimal-medial thickness in NIDDM subjects. J Thromb Thrombolysis. 1999, 8: 207-212. 10.1023/A:1008962220476.
Article
PubMed
Google Scholar
Hermans MP, Gala JL, Buysschaert M: The MTHFR C677T polymorphism confers a high risk for stroke in both homozygous and heterozygous T allele carriers with Type 2 diabetes. Diabet Med. 2006, 23: 529-536. 10.1111/j.1464-5491.2006.01841.x.
Article
PubMed
Google Scholar
Scaglione L, Gambino R, Rolfo E, Lillaz E, Gai M, et al: Plasma homocysteine, methylenetetrahydrofolate reductase gene polymorphism and carotid intima-media thickness in Italian type 2 diabetic patients. Eur J Clin Invest. 2002, 32: 24-28.
Article
PubMed
Google Scholar
Ozmen B, Ozmen D, Turgan N, Habif S, Mutaf I, et al: Association between homocysteinemia and renal function in patients with type 2 diabetes mellitus. Ann Clin Lab Sci. 2002, 32: 279-286.
PubMed
Google Scholar
Tessari P, Coracina A, Kiwanuka E, Vedovato M, Vettore M, et al: Effects of insulin on methionine and homocysteine kinetics in type 2 diabetes with nephropathy. Diabetes. 2005, 54: 2968-2976. 10.2337/diabetes.54.10.2968.
Article
PubMed
Google Scholar
Helfenstein T, Fonseca FAH, Relvas WGM, Santos AO, Dabela ML, et al: Prevalence of myocardial infarction is related to hyperhomocysteinemia but not influenced by C677T methylenetetrahydrofolate reductase and A2756G methionine synthase polymorphisms in diabetic and non-diabetic subjects. Clin Chim Acta. 2005, 355: 165-172. 10.1016/j.cccn.2004.12.002.
Article
PubMed
Google Scholar
Koubaa N, Nakbi A, Smaoui A, Abid N, Chaaba R, et al: yperhomocysteinemia and elevated ox-LDL in Tunisian type 2 diabetic patients: role of genetic and dietary factors. Clin Biochem. 2007, 40: 1007-1014. 10.1016/j.clinbiochem.2007.05.017.
Article
PubMed
Google Scholar
Ratnam S, Maclean KN, Jacobs RL, Brosnan ME, Kraus JP, et al: Hormonal regulation of cystathionine beta-synthase expression in liver. J Biol Chem. 2002, 277: 42912-42918. 10.1074/jbc.M206588200.
Article
PubMed
Google Scholar
Dicker-Brown A, Fonseca VA, Fink LA, Kern PA: The effect of glucose and insulin on the activity of methylene tetrahydrofolate reductase and cystathionine-beta-synthase: studies in hepatocytes. Atherosclerosis. 2001, 158: 297-301. 10.1016/S0021-9150(01)00442-7.
Article
PubMed
Google Scholar
Kluijtmans LA, van den Heuvel LP, Boers GH, Frosst P, Stevens EM, et al: Molecular genetic analysis in mild hyperhomocysteinemia: a common mutation in the methylenetetrahydrofolate reductase gene is a genetic risk factor for cardiovascular disease. Am J Hum Genet. 1996, 58: 35-41.
PubMed Central
PubMed
Google Scholar
Moczulski D, Fojcik H, Zukowska-Szczechowska E, Szydlowska I, Grzeszczak W: Effects of the C677T and A1298C polymorphisms of the MTHFR gene on the genetic predisposition for diabetic nephropathy. Nephrol Dial Transplant. 2003, 18: 1535-1540. 10.1093/ndt/gfg211.
Article
PubMed
Google Scholar
Chango A, Potier De Courcy G, Boisson F, Guilland JC, Barbe F, et al: 5,10-methylenetetrahydrofolate reductase common mutations, folate status and plasma homocysteine in healthy French adults of the Supplementation en Vitamines et Mineraux Antioxydants (SU.VI.MAX) cohort. Br J Nutr. 2000, 84: 891-896.
PubMed
Google Scholar
Kluijtmans LA, Young IS, Boreham CA, Murray L, McMaster D, et al: Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults. Blood. 2003, 101: 2483-2488. 10.1182/blood.V101.7.2483.
Article
PubMed
Google Scholar
Brown KS, Kluijtmans LA, Young IS, Murray L, McMaster D, et al: The 5,10-methylenetetrahydrofolate reductase C677T polymorphism interacts with smoking to increase homocysteine. Atherosclerosis. 2004, 174: 315-322. 10.1016/j.atherosclerosis.2004.01.023.
Article
PubMed
Google Scholar
Maeda M, Yamamoto I, Fukuda M, Nishida M, Fujitsu J, et al: MTHFR gene polymorphism as a risk factor for diabetic retinopathy in type 2 diabetic patients without serum creatinine elevation. Diabetes Care. 2003, 26: 547-548. 10.2337/diacare.26.2.547.
Article
PubMed
Google Scholar
Ksiazek P, Bednarek-Skublewska A, Buraczynska M: The C677T methylenetetrahydrofolate reductase gene mutation and nephropathy in type 2 diabetes mellitus. Med Sci Monit. 2004, 10: BR47-51.
PubMed
Google Scholar
Ioannidis JPA, Ntzani EE, Trikalinos TA: 'Racial' differences in genetic effects for complex diseases. Nat Genet. 2004, 36: 1312-1318. 10.1038/ng1474.
Article
PubMed
Google Scholar
Ioannidis JPA, Trikalinos TA, Ntzani EE, Contopoulos-Ioannidis DG: Genetic associations in large versus small studies: an empirical assessment. Lancet. 2003, 361: 567-571. 10.1016/S0140-6736(03)12516-0.
Article
PubMed
Google Scholar
Pfeiffer CM, Huff DL, Smith SJ, Miller DT, Gunter EW: Comparison of plasma total homocysteine measurements in 14 laboratories: an international study. Clin Chem. 1999, 45: 1261-1268.
PubMed
Google Scholar
Song Y, Cook NR, Albert CM, Van Denburgh M, Manson JE: Effect of homocysteine-lowering treatment with folic Acid and B vitamins on risk of type 2 diabetes in women: a randomized, controlled trial. Diabetes. 2009, 58 (8): 1921-8. 10.2337/db09-0087.
Article
PubMed Central
PubMed
Google Scholar