Selected articles from BGRS\SB-2018: genomics

Genomics research at Bioinformatics of Genome Regulation and Structure\ Systems Biology (BGRS\SB) conferences in Novosibirsk

Authors: Yuriy L. Orlov, Alex V. Kochetov, Guoliang Li and Nikolay A. Kolchanov

Hierarchical cooperation of transcription factors from integration analysis of DNA sequences, ChIP-Seq and ChIA-PET data

Chromosomal architecture, which is constituted by chromatin loops, plays an important role in cellular functions. Gene expression and cell identity can be regulated by the chromatin loop, which is formed by pr...

Authors: Ruimin Wang, Yunlong Wang, Xueying Zhang, Yaliang Zhang, Xiaoyong Du, Yaping Fang and Guoliang Li

ImtRDB: a database and software for mitochondrial imperfect interspersed repeats annotation

Mitochondria is a powerhouse of all eukaryotic cells that have its own circular DNA (mtDNA) encoding various RNAs and proteins. Somatic perturbations of mtDNA are accumulating with age thus it is of great impo...

Authors: Viktor N. Shamanskiy, Valeria N. Timonina, Konstantin Yu. Popadin and Konstantin V. Gunbin

High-density genotyping reveals signatures of selection related to acclimation and economically important traits in 15 local sheep breeds from Russia

Domestication and centuries of selective breeding have changed genomes of sheep breeds to respond to environmental challenges and human needs. The genomes of local breeds, therefore, are valuable sources of ge...

Authors: Andrey A. Yurchenko, Tatiana E. Deniskova, Nikolay S. Yudin, Arsen V. Dotsev, Timur N. Khamiruev, Marina I. Selionova, Sergey V. Egorov, Henry Reyer, Klaus Wimmers, Gottfried Brem, Natalia A. Zinovieva and Denis M. Larkin

LINC01420 RNA structure and influence on cell physiology

It was shown that the major part of human genome is transcribed and produces a large number of long noncoding RNAs (lncRNAs). Today there are many evidences that lncRNAs play important role in the regulation o...

Authors: Daria O. Konina, Alexandra Yu. Filatova and Mikhail Yu. Skoblov

Delineating the role of c-FLIP/NEMO interaction in the CD95 network via rational design of molecular probes

Structural homology modeling supported by bioinformatics analysis plays a key role in uncovering new molecular interactions within gene regulatory networks. Here, we have applied this powerful approach to anal...

Authors: Nikita V. Ivanisenko, Jörn H. Buchbinder, Johannes Espe, Max Richter, Miriam Bollmann, Laura K. Hillert, Vladimir A. Ivanisenko and Inna N. Lavrik

The differences in brain stem transcriptional profiling in hypertensive ISIAH and normotensive WAG rats

The development of essential hypertension is associated with a wide range of mechanisms. The brain stem neurons are essential for the homeostatic regulation of arterial pressure as they control baroreflex and ...

Authors: Larisa A. Fedoseeva, Leonid O. Klimov, Nikita I. Ershov, Vadim M. Efimov, Arcady L. Markel, Yuriy L. Orlov and Olga E. Redina

SNPs associated with barley resistance to isolates of Pyrenophora teres f. teres

Net blotch caused by Pyrenophra teres f. teres is a major foliar disease of barley. Infection can result in significant yield losses of susceptible cultivars of up to 40%. Of the two forms of net blotch (P. teres

Authors: Irina V. Rozanova, Nina M. Lashina, Zakhar S. Mustafin, Sofia A. Gorobets, Vadim M. Efimov, Olga S. Afanasenko and Elena K. Khlestkina