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  1. A well-informed choice of genetic locus is central to the efficacy of DNA barcoding. Current DNA barcoding in animals involves the use of the 5' half of the mitochondrial cytochrome oxidase 1 gene (CO1) to diagno...

    Authors: Arong Luo, Aibing Zhang, Simon YW Ho, Weijun Xu, Yanzhou Zhang, Weifeng Shi, Stephen L Cameron and Chaodong Zhu
    Citation: BMC Genomics 2011 12:84
    Content type: Research article Published on:

  2. Zinc Finger Nucleases (ZFNs) have tremendous potential as tools to facilitate genomic modifications, such as precise gene knockouts or gene replacements by homologous recombination. ZFNs can be used to advance...

    Authors: Deepak Reyon, Jessica R Kirkpatrick, Jeffry D Sander, Feng Zhang, Daniel F Voytas, J Keith Joung, Drena Dobbs and Clark R Coffman
    Citation: BMC Genomics 2011 12:83
    Content type: Database Published on:

  3. Hematophagy is a common trait of insect vectors of disease. Extensive genome-wide transcriptional changes occur in mosquitoes after blood meals, and these are related to digestive and reproductive processes, a...

    Authors: Mariangela Bonizzoni, W Augustine Dunn, Corey L Campbell, Ken E Olson, Michelle T Dimon, Osvaldo Marinotti and Anthony A James
    Citation: BMC Genomics 2011 12:82
    Content type: Research article Published on:

  4. Due to their high level of genotypic and phenotypic variability, Mus spretus strains were introduced in laboratories to investigate the genetic determinism of complex phenotypes including quantitative trait loci....

    Authors: Nisrine Boumahrou, Claudia Bevilacqua, Christian Beauvallet, Guy Miranda, Sanda Andrei, Emmanuelle Rebours, Jean-Jacques Panthier, Sylvain Bellier and Patrice Martin
    Citation: BMC Genomics 2011 12:80
    Content type: Research article Published on:

  5. Segmental duplication and deletion were implicated for a region containing the human immunoglobulin heavy chain variable (IGHV) gene segments, 1.9III/hv3005 (possible allelic variants of IGHV3-30) and hv3019b9...

    Authors: Sreemanta Pramanik, Xiangfeng Cui, Hui-Yun Wang, Nyam-Osor Chimge, Guohong Hu, Li Shen, Richeng Gao and Honghua Li
    Citation: BMC Genomics 2011 12:78
    Content type: Research article Published on:

  6. Genetic markers are pivotal to modern genomics research; however, discovery and genotyping of molecular markers in oat has been hindered by the size and complexity of the genome, and by a scarcity of sequence ...

    Authors: Rebekah E Oliver, Gerard R Lazo, Joseph D Lutz, Marc J Rubenfield, Nicholas A Tinker, Joseph M Anderson, Nicole H Wisniewski Morehead, Dinesh Adhikary, Eric N Jellen, P Jeffrey Maughan, Gina L Brown Guedira, Shiaoman Chao, Aaron D Beattie, Martin L Carson, Howard W Rines, Donald E Obert…
    Citation: BMC Genomics 2011 12:77
    Content type: Research article Published on:

  7. Heat shock response in eukaryotes is transcriptionally regulated by conserved heat shock transcription factors (Hsfs). Hsf genes are represented by a large multigene family in plants and investigation of the H...

    Authors: Yong-Xiang Lin, Hai-Yang Jiang, Zhang-Xin Chu, Xiu-Li Tang, Su-Wen Zhu and Bei-Jiu Cheng
    Citation: BMC Genomics 2011 12:76
    Content type: Research article Published on:

  8. The prevalence of invasive fungal infections (IFIs) has increased steadily worldwide in the last few decades. Particularly, there has been a global rise in the number of infections among immunosuppressed peopl...

    Authors: Ana Karina R Abadio, Erika S Kioshima, Marcus M Teixeira, Natalia F Martins, Bernard Maigret and Maria Sueli S Felipe
    Citation: BMC Genomics 2011 12:75
    Content type: Research article Published on:

  9. Although primarily known as the site of ribosome subunit production, the nucleolus is involved in numerous and diverse cellular processes. Recent large-scale proteomics projects have identified thousands of hu...

    Authors: Michelle S Scott, François-Michel Boisvert, Angus I Lamond and Geoffrey J Barton
    Citation: BMC Genomics 2011 12:74
    Content type: Research article Published on:

  10. Copepods are highly diverse and abundant, resulting in extensive ecological radiation in marine ecosystems. Calanus sinicus dominates continental shelf waters in the northwest Pacific Ocean and plays an important...

    Authors: Wang Minxiao, Sun Song, Li Chaolun and Shen Xin
    Citation: BMC Genomics 2011 12:73
    Content type: Research article Published on:

  13. M. catarrhalis is a gram-negative, gamma-proteobacterium and an opportunistic human pathogen associated with otitis media (OM) and exacerbations of chronic obstructive pulmonary disease (COPD). With direct and in...

    Authors: Jeremiah J Davie, Josh Earl, Stefan PW de Vries, Azad Ahmed, Fen Z Hu, Hester J Bootsma, Kim Stol, Peter WM Hermans, Robert M Wadowsky, Garth D Ehrlich, John P Hays and Anthony A Campagnari
    Citation: BMC Genomics 2011 12:70
    Content type: Research article Published on:

  14. Sessile bivalves of the genus Mytilus are suspension feeders relatively tolerant to a wide range of environmental changes, used as sentinels in ecotoxicological investigations and marketed worldwide as seafood. M...

    Authors: Paola Venier, Laura Varotto, Umberto Rosani, Caterina Millino, Barbara Celegato, Filippo Bernante, Gerolamo Lanfranchi, Beatriz Novoa, Philippe Roch, Antonio Figueras and Alberto Pallavicini
    Citation: BMC Genomics 2011 12:69
    Content type: Research article Published on:

  15. Eukaryotic translation initiation factor 4G (eIF4G) is thought to influence the translational efficiencies of cellular mRNAs by its roles in forming an eIF4F-mRNA-PABP mRNP that is competent for attachment of ...

    Authors: Eun-Hee Park, Fan Zhang, Jonas Warringer, Per Sunnerhagen and Alan G Hinnebusch
    Citation: BMC Genomics 2011 12:68
    Content type: Research article Published on:

  16. Chinese hamster ovary (CHO) cells are among the most widely used hosts for therapeutic protein production. Yet few genomic resources are available to aid in engineering high-producing cell lines.

    Authors: Stephanie Hammond, Jeffrey C Swanberg, Mihailo Kaplarevic and Kelvin H Lee
    Citation: BMC Genomics 2011 12:67
    Content type: Research article Published on:

  17. Methods for gene-class testing, such as Gene Set Enrichment Analysis (GSEA), incorporate biological knowledge into the analysis and interpretation of microarray data by comparing gene expression patterns to pa...

    Authors: Michael A Thomas, Luobin Yang, Barbara J Carter and Rebecca D Klaper
    Citation: BMC Genomics 2011 12:66
    Content type: Research article Published on:

  18. Scanning the genome with high density SNP markers has become a standard approach for identifying regions of the genome showing substantial between-population genetic differentiation, and thus evidence of diver...

    Authors: Pamela Wiener, Mohammad A Edriss, John L Williams, David Waddington, Andrew Law, John A Woolliams and Beatriz Gutiérrez-Gil
    Citation: BMC Genomics 2011 12:65
    Content type: Research article Published on:

  20. After several years in the juvenile phase, trees undergo flowering transition to become mature (florally competent) trees. This transition depends on the balanced expression of a complex network of genes that ...

    Authors: Jin-Zhi Zhang, Xiao-Yan Ai, Lei-Ming Sun, Dong-Liang Zhang, Wen-Wu Guo, Xiu-Xin Deng and Chun-Gen Hu
    Citation: BMC Genomics 2011 12:63
    Content type: Research article Published on:

  21. Heliconius butterflies are an excellent system for studies of adaptive convergent and divergent phenotypic traits. Wing colour patterns are used as signals to both predators and potential mates and are inherited ...

    Authors: Alison K Surridge, Sara Lopez-Gomollon, Simon Moxon, Luana S Maroja, Tina Rathjen, Nicola J Nadeau, Tamas Dalmay and Chris D Jiggins
    Citation: BMC Genomics 2011 12:62
    Content type: Research article Published on:

  22. Most evolutionary developmental biology ("evo-devo") studies of emerging model organisms focus on small numbers of candidate genes cloned individually using degenerate PCR. However, newly available sequencing ...

    Authors: Ben Ewen-Campen, Nathan Shaner, Kristen A Panfilio, Yuichiro Suzuki, Siegfried Roth and Cassandra G Extavour
    Citation: BMC Genomics 2011 12:61
    Content type: Research article Published on:

  24. Many plants have large and complex genomes with an abundance of repeated sequences. Many plants are also polyploid. Both of these attributes typify the genome architecture in the tribe Triticeae, whose members...

    Authors: Frank M You, Naxin Huo, Karin R Deal, Yong Q Gu, Ming-Cheng Luo, Patrick E McGuire, Jan Dvorak and Olin D Anderson
    Citation: BMC Genomics 2011 12:59
    Content type: Methodology article Published on:

  26. The bi-directional communication between the oocyte and its companion cumulus cells (CCs) is crucial for development and functions of both cell types. Transcripts that are exclusively expressed either in oocyt...

    Authors: A Regassa, F Rings, M Hoelker, U Cinar, E Tholen, C Looft, K Schellander and D Tesfaye
    Citation: BMC Genomics 2011 12:57
    Content type: Research article Published on:

  27. The whitefly Trialeurodes vaporariorum is an economically important crop pest in temperate regions that has developed resistance to most classes of insecticides. However, the molecular mechanisms underlying resis...

    Authors: Nikos Karatolos, Yannick Pauchet, Paul Wilkinson, Ritika Chauhan, Ian Denholm, Kevin Gorman, David R Nelson, Chris Bass, Richard H ffrench-Constant and Martin S Williamson
    Citation: BMC Genomics 2011 12:56
    Content type: Research article Published on:

  28. Searching for associations between genetic variants and complex diseases has been a very active area of research for over two decades. More than 51,000 potential associations have been studied and published, a...

    Authors: Urko M Marigorta, Oscar Lao, Ferran Casals, Francesc Calafell, Carlos Morcillo-Suárez, Rui Faria, Elena Bosch, François Serra, Jaume Bertranpetit, Hernán Dopazo and Arcadi Navarro
    Citation: BMC Genomics 2011 12:55
    Content type: Research article Published on:

  29. Cancer is commonly associated with widespread disruption of DNA methylation, chromatin modification and miRNA expression. In this study, we established a robust discovery pipeline to identify epigenetically de...

    Authors: Toby Hulf, Tennille Sibbritt, Erik D Wiklund, Saul Bert, Dario Strbenac, Aaron L Statham, Mark D Robinson and Susan J Clark
    Citation: BMC Genomics 2011 12:54
    Content type: Methodology article Published on:

  30. Single nucleotide polymorphisms (SNPs) have become the marker of choice for genome-wide association studies. In order to provide the best genome coverage for the analysis of performance and production traits, ...

    Authors: Shikai Liu, Zunchun Zhou, Jianguo Lu, Fanyue Sun, Shaolin Wang, Hong Liu, Yanliang Jiang, Huseyin Kucuktas, Ludmilla Kaltenboeck, Eric Peatman and Zhanjiang Liu
    Citation: BMC Genomics 2011 12:53
    Content type: Research article Published on:

  31. The toxigenic fungal plant pathogen Fusarium graminearum compromises wheat production worldwide. Azole fungicides play a prominent role in controlling this pathogen. Sequencing of its genome stimulated the develo...

    Authors: Rayko Becher, Fabian Weihmann, Holger B Deising and Stefan GR Wirsel
    Citation: BMC Genomics 2011 12:52
    Content type: Research article Published on:

  33. High-throughput screening using RNAi is a powerful gene discovery method but is often complicated by false positive and false negative results. Whereas false positive results associated with RNAi reagents has ...

    Authors: Matthew Booker, Anastasia A Samsonova, Young Kwon, Ian Flockhart, Stephanie E Mohr and Norbert Perrimon
    Citation: BMC Genomics 2011 12:50
    Content type: Research article Published on:

  34. Rice blast is the most threatening disease to cultivated rice. Magnaporthe oryzae, its causal agent, is likely to encounter environmental challenges during invasive growth in its host plants that require shifts i...

    Authors: Sandra M Mathioni, André Beló, Christopher J Rizzo, Ralph A Dean and Nicole M Donofrio
    Citation: BMC Genomics 2011 12:49
    Content type: Research article Published on:

  35. The bumblebee Bombus terrestris is an ecologically and economically important pollinator and has become an important biological model system. To study fundamental evolutionary questions at the genomic level, a hi...

    Authors: Eckart Stolle, Lena Wilfert, Regula Schmid-Hempel, Paul Schmid-Hempel, Michael Kube, Richard Reinhardt and Robin FA Moritz
    Citation: BMC Genomics 2011 12:48
    Content type: Research article Published on:

  36. MicroRNAs (miRNAs) constitute a class of single-stranded RNAs which play a crucial role in regulating development and controlling gene expression by targeting mRNAs and triggering either translation repression...

    Authors: Mariana C Simões, Jonathan Lee, Appolinaire Djikeng, Gustavo C Cerqueira, Adhemar Zerlotini, Rosiane A da Silva-Pereira, Andrew R Dalby, Philip LoVerde, Najib M El-Sayed and Guilherme Oliveira
    Citation: BMC Genomics 2011 12:47
    Content type: Research article Published on:

  37. The piRNA pathway operates in animal germ lines to ensure genome integrity through retrotransposon silencing. The Piwi protein-associated small RNAs (piRNAs) guide Piwi proteins to retrotransposon transcripts,...

    Authors: Philipp Berninger, Lukasz Jaskiewicz, Mohsen Khorshid and Mihaela Zavolan
    Citation: BMC Genomics 2011 12:46
    Content type: Research article Published on:

  39. The ubiquitin(Ub)-proteasome pathway is implicated in the regulation of a variety of cellular functions and plays a major role in stress response in eukaryotic cells, by targeting misfolded and damaged protein...

    Authors: Laura Gatti, Kwang L Hoe, Jacqueline Hayles, Sabina C Righetti, Nives Carenini, Laura Dal Bo, Dong U Kim, Han O Park and Paola Perego
    Citation: BMC Genomics 2011 12:44
    Content type: Research article Published on:

  40. Identifying the functional importance of the millions of single nucleotide polymorphisms (SNPs) in the human genome is a difficult challenge. Therefore, a reverse strategy, which identifies functionally import...

    Authors: Muna Affara, Benjamin J Dunmore, Deborah A Sanders, Nicola Johnson, Cristin G Print and D Stephen Charnock-Jones
    Citation: BMC Genomics 2011 12:43
    Content type: Research article Published on:

  41. Comprehensive sequence characterization across the MHC is important for successful organ transplantation and genetic association studies. To this end, we have developed an automated sample preparation, molecul...

    Authors: Rachel L Erlich, Xiaoming Jia, Scott Anderson, Eric Banks, Xiaojiang Gao, Mary Carrington, Namrata Gupta, Mark A DePristo, Matthew R Henn, Niall J Lennon and Paul IW de Bakker
    Citation: BMC Genomics 2011 12:42
    Content type: Methodology article Published on:

  42. The changes in storage reserve accumulation during maize (Zea mays L.) grain maturation are well established. However, the key molecular determinants controlling carbon flux to the grain and the partitioning of c...

    Authors: Hans Hartings, Massimiliano Lauria, Nadia Lazzaroni, Raul Pirona and Mario Motto
    Citation: BMC Genomics 2011 12:41
    Content type: Research article Published on:

  43. Tuberculosis is an infectious bacterial disease in humans caused primarily by Mycobacterium tuberculosis, and infects one-third of the world's total population. Mycobacterium bovis bacillus Calmette-Guérin (BCG) ...

    Authors: Jianhua Zheng, Candong Wei, Lina Zhao, Liguo Liu, Wenchuan Leng, Weijun Li and Qi Jin
    Citation: BMC Genomics 2011 12:40
    Content type: Research article Published on:

  44. Gummosis and root rot caused by Phytophthora are among the most economically important diseases in citrus. Four F1 resistant hybrids (Pool R), and four F1 susceptible hybrids (Pool S) to P. parasitica, were selec...

    Authors: Leonardo P Boava, Mariângela Cristofani-Yaly, Valéria S Mafra, Karen Kubo, Luciano T Kishi, Marco A Takita, Marcelo Ribeiro-Alves and Marcos A Machado
    Citation: BMC Genomics 2011 12:39
    Content type: Research article Published on:

  45. Rhizopus oryzae is a zygomycete filamentous fungus, well-known as a saprobe ubiquitous in soil and as a pathogenic/spoilage fungus, causing Rhizopus rot and mucomycoses.

    Authors: Evy Battaglia, Isabelle Benoit, Joost van den Brink, Ad Wiebenga, Pedro M Coutinho, Bernard Henrissat and Ronald P de Vries
    Citation: BMC Genomics 2011 12:38
    Content type: Research article Published on:

  46. Despite virtually identical DNA sequences between the sexes, sexual dimorphism is a widespread phenomenon in nature. To a large extent the systematic differences between the sexes must therefore arise from pro...

    Authors: Sara Naurin, Bengt Hansson, Dennis Hasselquist, Yong-Hwan Kim and Staffan Bensch
    Citation: BMC Genomics 2011 12:37
    Content type: Research article Published on:

  47. Estrogen receptors alpha (ERα) and beta (ERβ) are transcription factors (TFs) that mediate estrogen signaling and define the hormone-responsive phenotype of breast cancer (BC). The two receptors can be found c...

    Authors: Oli MV Grober, Margherita Mutarelli, Giorgio Giurato, Maria Ravo, Luigi Cicatiello, Maria Rosaria De Filippo, Lorenzo Ferraro, Giovanni Nassa, Maria Francesca Papa, Ornella Paris, Roberta Tarallo, Shujun Luo, Gary P Schroth, Vladimir Benes and Alessandro Weisz
    Citation: BMC Genomics 2011 12:36
    Content type: Research article Published on:

  48. Although nowaday it is broadly accepted that mitochondrial DNA (mtDNA) may undergo recombination, the frequency of such recombination remains controversial. Its estimation is not straightforward, as recombinat...

    Authors: Svenja Sammler, Christoph Bleidorn and Ralph Tiedemann
    Citation: BMC Genomics 2011 12:35
    Content type: Research article Published on:

  49. Pathogen-associated molecular patterns (PAMPs) are structural components of pathogens such as lipopolysaccharide (LPS) and peptidoglycan (PGN) from bacterial cell walls. PAMP-recognition by the host results in...

    Authors: Sebastian Boltaña, Felipe Reyes-Lopez, Davinia Morera, Frederick Goetz and Simon A MacKenzie
    Citation: BMC Genomics 2011 12:34
    Content type: Research article Published on:

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BMC Genomics

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