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  1. The histidine metabolism and transport (his) genes are controlled by a variety of RNA-dependent regulatory systems among diverse taxonomic groups of bacteria including T-box riboswitches in Firmicutes and Actinob...

    Authors: German A. Ashniev, Natalia V. Sernova, Aleksei E. Shevkoplias, Ivan D. Rodionov, Irina A. Rodionova, Alexey G. Vitreschak, Mikhail S. Gelfand and Dmitry A. Rodionov
    Citation: BMC Genomics 2022 23(Suppl 6):558
    Content type: Research Published on:

    This article is part of a Supplement: Volume 23 Supplement 6

  3. Dendrobium catenatum/D. officinale (here after D. catenatum), a well-known economically important traditional medicinal herb, produces a variety of bioactive metabolites including polysaccharides, alkaloids, and ...

    Authors: Zhicai Wang, Meili Zhao, Xiaojie Zhang, Xuming Deng, Jian Li and Meina Wang
    Citation: BMC Genomics 2022 23:612
    Content type: Research Published on:

  4. Emerging transcriptome-wide high-throughput screenings reveal the landscape and functions of RNAs, such as circular RNAs (circRNAs), in human cancer. In addition, the post-transcriptional RNA internal modifica...

    Authors: Wei Zhao, Jingwen Liu, Jie Wu, Xiaozhou Ma, Xi Wang, Leyu Zhang, Zhe Han, Jianming Yang, Yameng Cui, Xin Hu and Jiayin Deng
    Citation: BMC Genomics 2022 23:611
    Content type: Research Published on:

  5. Nematodes are parasitic animals that cause over 100 billion US dollars loss in agricultural business. The whole-genomes of two Streptomyces strains, Streptomyces spectabilis KCTC9218T and Streptomyces sp. AN09196...

    Authors: Jeong Sang Yi, Jung Min Kim, Min-Kyoung Kang, Jong Hoon Kim, Hang Su Cho, Yeon Hee Ban, Myoung Chong Song, Kwang-Hee Son and Yeo Joon Yoon
    Citation: BMC Genomics 2022 23:610
    Content type: Research Published on:

  6. For over a century, scientists have studied host-pathogen interactions between the crayfish plague disease agent Aphanomyces astaci and freshwater crayfish. It has been hypothesised that North American crayfish h...

    Authors: Ljudevit Luka Boštjančić, Caterina Francesconi, Christelle Rutz, Lucien Hoffbeck, Laetitia Poidevin, Arnaud Kress, Japo Jussila, Jenny Makkonen, Barbara Feldmeyer, Miklós Bálint, Klaus Schwenk, Odile Lecompte and Kathrin Theissinger
    Citation: BMC Genomics 2022 23:600
    Content type: Research article Published on:

    The Data note to this article has been published in BMC Research Notes 2022 15:281

  7. Bacillus Calmette–Guérin (BCG) refers to a group of vaccine strains with unique genetic characteristics. BCG is the only available vaccine for preventing tuberculosis (TB). Genetic and biochemical variations a...

    Authors: Mahla Asadian, Seyed Mehdi Hassanzadeh, Azadeh Safarchi and Masoumeh Douraghi
    Citation: BMC Genomics 2022 23:609
    Content type: Research Published on:

  8. Functional genomics uses unbiased systematic genome-wide gene disruption or analyzes natural variations such as gene expression profiles of different tissues from multicellular organisms to link gene functions...

    Authors: Sabrina Lehmann, Bibi Atika, Daniela Grossmann, Christian Schmitt-Engel, Nadi Strohlein, Upalparna Majumdar, Tobias Richter, Matthias Weißkopf, Salim Ansari, Matthias Teuscher, Muhammad Salim Hakeemi, Jianwei Li, Bernhard Weißbecker, Martin Klingler, Gregor Bucher and Ernst A. Wimmer
    Citation: BMC Genomics 2022 23:608
    Content type: Research Published on:

  9. The development of the ovaries is an important factor that affects egg production performance in geese. Ovarian development is regulated by genes that are expressed dynamically and stage-specifically. The tran...

    Authors: Xiaoyu Zhao, Yingping Wu, Haiying Li, Jiahui Li, Yingying Yao, Yan Cao and Zhiyong Mei
    Citation: BMC Genomics 2022 23:607
    Content type: Research Published on:

  10. Rice sheath blight, which is caused by Rhizoctonia solani, is the most destructive disease affecting rice production, but the resistance mechanism to this pathogen has not been fully elucidated.

    Authors: Yan Wang, Hang Luo, Haining Wang, Zongjing Xiang, Songhong Wei and Wenjing Zheng
    Citation: BMC Genomics 2022 23:606
    Content type: Research Published on:

  11. Morinda officinalis How (MO) is a perennial herb distributed in tropical and subtropical regions, which known as one of the “Four Southern Herbal Medicines”. The extent of genetic variability and the population s...

    Authors: Zhenhua Luo, Zien Chen, Mengyun Liu, Li Yang, Zhimin Zhao, Depo Yang and Ping Ding
    Citation: BMC Genomics 2022 23:605
    Content type: Research Published on:

  12. Flavonols are the largest subgroup of flavonoids, possessing multiple functions in plants including protection against ultraviolet radiation, antimicrobial activities, and flower pigmentation together with ant...

    Authors: Hanna M. Schilbert and Beverley J. Glover
    Citation: BMC Genomics 2022 23:604
    Content type: Research Published on:

  14. It is currently assumed that around 100 million years ago, the common ancestor to the Fabales, Fagales, Rosales and Cucurbitales in Gondwana, developed a root nodule symbiosis with a nitrogen-fixing bacterium....

    Authors: Fede Berckx, Thanh Van Nguyen, Cyndi Mae Bandong, Hsiao-Han Lin, Takashi Yamanaka, Sae Katayama, Daniel Wibberg, Jochen Blom, Jörn Kalinowski, Masaki Tateno, Jessica Simbahan, Chi-Te Liu, Andreas Brachmann and Katharina Pawlowski
    Citation: BMC Genomics 2022 23:602
    Content type: Research Published on:

  15. Due to the prolonged usage of Bt-based biopesticides and Bt-transgenic crops worldwide, insects are continually developing resistance against Cry toxins. This resistance may occur if any mechanistic step in th...

    Authors: Tushar K. Dutta, Abhishek Mandal, Artha Kundu, Victor Phani, Chetna Mathur, Arudhimath Veeresh and Rohini Sreevathsa
    Citation: BMC Genomics 2022 23:601
    Content type: Research Published on:

  16. Somatic copy number alterations (SCNAs) are an important class of genomic alteration in cancer. They are frequently observed in cancer samples, with studies showing that, on average, SCNAs affect 34% of a canc...

    Authors: Sam Abujudeh, Sebastian S. Zeki, Meta C.J. van Lanschot, Mark Pusung, Jamie M.J. Weaver, Xiaodun Li, Ayesha Noorani, Andrew J. Metz, Jan Bornschein, Lawrence Bower, Ahmad Miremadi, Rebecca C. Fitzgerald, Edward R. Morrissey and Andy G. Lynch
    Citation: BMC Genomics 2022 23:599
    Content type: Research article Published on:

  17. Dehydration responsive element binding protein (DREB) is a significant transcription factor class known to be implicated in abiotic stresses. In this study, we systematically conducted a genome-wide identifica...

    Authors: Ying Wu, Liting Zhang, Libing Nie, Yushan Zheng, Shidong Zhu, Jinfeng Hou, Renjie Li, Guohu Chen, Xiaoyan Tang, Chenggang Wang and Lingyun Yuan
    Citation: BMC Genomics 2022 23:598
    Content type: Research Published on:

  18. Monochasma savatieri Franch. ex Maxim is a medicinally valuable herb. However, the collection and protection of the wild germplasm resources of M. savatieri are still insufficient, and their genetic diversity and...

    Authors: Wanling Yang, Zhiyi Bai, Fuqiang Wang, Mingzhu Zou, Xinru Wang, Jiankun Xie and Fantao Zhang
    Citation: BMC Genomics 2022 23:597
    Content type: Research Published on:

  19. Explored the molecular science of anther development is important for improving productivity and overall yield of crops. Although the role of regulatory RNAs, including long non-coding RNAs (lncRNAs) and micro...

    Authors: Lingshan Kong, Yanjing Zhuo, Jieru Xu, Xiangxu Meng, Yue Wang, Wenxiu Zhao, Hanggui Lai, Jinhui Chen and Jian Wang
    Citation: BMC Genomics 2022 23:596
    Content type: Research Published on:

  20. Longissimus muscle samples were collected from lambs exposed in utero to mycotoxins [E-, endophyte-free tall fescue seed without ergot alkaloids (negative control) or E + , endophyte-infected tall fescue seed ...

    Authors: M. A. Greene, A. N. S. Udoka, R. R. Powell, R. E. Noorai, T. Bruce and S. K. Duckett
    Citation: BMC Genomics 2022 23:595
    Content type: Research Published on:

  21. Carcass backfat thickness (BFT), carcass lean percentage (CLP) and carcass fat percentage (CFP) are important to the commercial pig industry. Nevertheless, the genetic architecture of BFT, CLP and CFP is still...

    Authors: Huiyu Wang, Xiaoyi Wang, Dawei Yan, Hao Sun, Qiang Chen, Mingli Li, Xinxing Dong, Yuchun Pan and Shaoxiong Lu
    Citation: BMC Genomics 2022 23:594
    Content type: Research Published on:

  22. Maize kernel row number (KRN) is one of the most important yield traits and has changed greatly during maize domestication and selection. Elucidating the genetic basis of KRN will be helpful to improve grain y...

    Authors: Xiaohong Fei, Yifei Wang, Yunxiao Zheng, Xiaomeng Shen, Lizhu E, Junqiang Ding, Jinsheng Lai, Weibin Song and Haiming Zhao
    Citation: BMC Genomics 2022 23:593
    Content type: Research Published on:

  23. Hypertension-induced cardiac hypertrophy is one of the most common pre-conditions that accompanies heart failure. This study aimed to identify the key pathogenic genes in the disease process.

    Authors: Rui Zhang, Xuan Xu, Xi Chen, Chunshu Hao, Zhenjun Ji, Pengfei Zuo, Mingming Yang, Genshan Ma and Yongjun Li
    Citation: BMC Genomics 2022 23:592
    Content type: Research Published on:

  24. Insect metamorphosis from larvae to pupae is one of the most important stages of insect life history. Relatively comprehensive information related to gene transcription profiles during lepidopteran metamorphos...

    Authors: Xinxin Gao, Jihong Zhang, Peipei Wu, Ruihao Shu, Huan Zhang, Qilian Qin and Qian Meng
    Citation: BMC Genomics 2022 23:591
    Content type: Research Published on:

  25. Carcass traits are important in pig breeding programs for improving pork production. Understanding the genetic variants underlies complex phenotypes can help explain trait variation in pigs. In this study, we ...

    Authors: Rongrong Ding, Zhanwei Zhuang, Yibin Qiu, Xingwang Wang, Jie Wu, Shenping Zhou, Donglin Ruan, Cineng Xu, Linjun Hong, Ting Gu, Enqin Zheng, Gengyuan Cai, Wen Huang, Zhenfang Wu and Jie Yang
    Citation: BMC Genomics 2022 23:590
    Content type: Research Published on:

  26. In the life history of Daphnia, the reproductive mode of parthenogenesis and sexual reproduction alternate in aquatic ecosystem, which are often affected by environmental and genetic factors. Recently, the sex-bi...

    Authors: Ziyan Wang, Feiyun Zhang, Qide Jin, Yeping Wang, Wenping Wang and Daogui Deng
    Citation: BMC Genomics 2022 23:589
    Content type: Research Published on:

  28. The cardiovascular developmental process is a tightly regulated network involving multiple genes. The current understanding of the molecular mechanism behind cardiovascular development is insufficient and requ...

    Authors: Chune Zhou, Wei Zhao, Shuqiang Zhang, Junguo Ma, Yousef Sultan and Xiaoyu Li
    Citation: BMC Genomics 2022 23:587
    Content type: Research Published on:

  29. Porcine Epidemic Diarrhea Virus (PEDV) is a coronavirus that seriously affects the swine industry. MicroRNAs and long noncoding RNAs are two relevant non-coding RNAs (ncRNAs) class and play crucial roles in a ...

    Authors: Xiaojie Shi, Qi Zhang, Jingjing Wang, Yuting Zhang, Yuchao Yan, Yi Liu, Naling Yang, Quanqiong Wang and Xingang Xu
    Citation: BMC Genomics 2022 23:586
    Content type: Research Published on:

  30. Quantitative real time PCR (qPCR) is a powerful tool to evaluate mRNA expression level. However, reliable qPCR results require normalization with validated reference gene(s). In this study, we investigated sta...

    Authors: Jeongah Song, Jeonghee Cho, Jeongsik Park and Jeong Ho Hwang
    Citation: BMC Genomics 2022 23:585
    Content type: Research Published on:

  31. Mitochondrial genomes are the most sequenced genomes after bacterial and fungal genomic DNA. However, little information on mitogenomes is available for multiple metazoan taxa, such as Culicoides, a globally dist...

    Authors: Yoamel Milián-García, Christopher A. Hempel, Lauren A. A. Janke, Robert G. Young, Tara Furukawa-Stoffer, Aruna Ambagala, Dirk Steinke and Robert H. Hanner
    Citation: BMC Genomics 2022 23:584
    Content type: Research Published on:

  32. Patatin-like phospholipase domain containing 5 (PNPLA5) is a newly-discovered lipase. Although the PNPLA family plays critical roles in diverse biological processes, the biological functions of PNPLA5 mostly u...

    Authors: Zhi-Guo Liu, Yan-Qing Hu, Kui Li, Yu-Lian Mu and Tian-Wen Wu
    Citation: BMC Genomics 2022 23:583
    Content type: Research Published on:

  33. Exome sequencing is becoming a routine in health care, because it increases the chance of pinpointing the genetic cause of an individual patient's condition and thus making an accurate diagnosis. It is importa...

    Authors: Vera Belova, Anna Shmitko, Anna Pavlova, Robert Afasizhev, Valery Cheranev, Anastasia Tabanakova, Natalya Ponikarovskaya, Denis Rebrikov and Dmitriy Korostin
    Citation: BMC Genomics 2022 23:582
    Content type: Research Published on:

  35. High temperature induces early bolting in lettuce (Lactuca sativa L.), which affects both quality and production. However, the molecular mechanism underlying high temperature-induced bolting is still limited.

    Authors: Jinghong Hao, Junwei Yang, Xiaofeng Liu, Gaoyang Pan, Yunfeng Li, Xiaolan Zhang, Yingyan Han, Shuangxi Fan and Zhaoyang Zhou
    Citation: BMC Genomics 2022 23:580
    Content type: Research Published on:

  36. Sequencing viruses in many specimens is hindered by excessive background material from hosts, microbiota, and environmental organisms. Consequently, enrichment of target genomic material is necessary for pract...

    Authors: Kevin S. Kuchinski, Jun Duan, Chelsea Himsworth, William Hsiao and Natalie A. Prystajecky
    Citation: BMC Genomics 2022 23:579
    Content type: Research Published on:

  37. Berberine hydrochloride is the main effective component of Coptis spp. used in Chinese herbal medicine and its underlying molecular mechanisms, responsible for inducing effects in crustacean species, are not f...

    Authors: Tian-heng Gao, Ming-ming Han, Hui Zhou, Chen-xi Zhu, Ying Yang, Zakaria Zuraini, Yan-Xia Guo and Qi-chen Jiang
    Citation: BMC Genomics 2022 23:578
    Content type: Research Published on:

  38. As a valuable medicinal plant, Rhodiola has a very long history of folk medicine used as an important adaptogen, tonic, and hemostatic. However, our knowledge of the chloroplast genome level of Rhodiola is limite...

    Authors: Kaihui Zhao, Lianqiang Li, Hong Quan, Junbo Yang, Zhirong Zhang, Zhihua Liao and Xiaozhong Lan
    Citation: BMC Genomics 2022 23:577
    Content type: Research Published on:

  40. Genetics studies in the porcine immune system have enhanced selection practices for disease resistance phenotypes and increased the efficacy of porcine models in biomedical research; however limited functional...

    Authors: Ryan J. Corbett, Andrea M. Luttman, Juber Herrera-Uribe, Haibo Liu, Nancy E. Raney, Jenna M. Grabowski, Crystal L. Loving, Christopher K. Tuggle and Catherine W. Ernst
    Citation: BMC Genomics 2022 23:575
    Content type: Research Published on:

  41. Echinoderms are established models in experimental and developmental biology, however genomic resources are still lacking for many species. Here, we present the draft genome of Ophioderma brevispinum, an emerging...

    Authors: Vladimir Mashanov, Denis Jacob Machado, Robert Reid, Cory Brouwer, Janice Kofsky and Daniel A. Janies
    Citation: BMC Genomics 2022 23:574
    Content type: Research article Published on:

  43. Mammals rely on the circadian clock network to regulate daily systemic metabolism and physiological activities. The liver is an important peripheral organ in mammals, and it has a unique circadian rhythm regul...

    Authors: Yujia Chu, Jingjing Li, Lei Feng, Guoting Zhang, Hui Wu, Tinglei Jiang, Hui Wang and Jiang Feng
    Citation: BMC Genomics 2022 23:572
    Content type: Research Published on:

  44. Skeletal muscle tissue is among the largest organ systems in mammals, essential for survival and movement. Embryonic muscle development determines the quantity and quality of muscles after the birth of an indi...

    Authors: Jun’an Shi, Wendong Li, Anfang Liu, Lingtong Ren, Pusen Zhang, Ting Jiang, Yuqing Han and Lingbin Liu
    Citation: BMC Genomics 2022 23:571
    Content type: Research Published on:

  45. Saposhnikovia divaricata (Turcz.) Schischk. is a perennial herb whose dried roots are commonly used as a source of traditional medicines. To elucidate the organelle-genome-based phylogeny of Saposhnikovia species...

    Authors: Yang Ni, Jingling Li, Haimei Chen, Jingwen Yue, Pinghua Chen and Chang Liu
    Citation: BMC Genomics 2022 23:570
    Content type: Research Published on:

  46. To understand the dynamics of infectious diseases, genomic epidemiology is increasingly advocated, with a need for rapid generation of genetic sequences during outbreaks for public health decision making. Here...

    Authors: David F. Nieuwenhuijse, Anne van der Linden, Robert H. G. Kohl, Reina S. Sikkema, Marion P. G. Koopmans and Bas B. Oude Munnink
    Citation: BMC Genomics 2022 23:569
    Content type: Research article Published on:

  47. Brassinosteroids (BRs) are a group of essential steroid hormones involved in diverse developmental and physiological processes in plants. The Brassinazole-resistant 1 (BZR1) transcription factors are key compo...

    Authors: Chunliu Zuo, Lan Zhang, Xinyue Yan, Xinyue Guo, Qing Zhang, Songyang Li, Yanling Li, Wen Xu, Xiaoming Song, Jinpeng Wang and Min Yuan
    Citation: BMC Genomics 2022 23:568
    Content type: Research Published on:

  48. Acer pseudosieboldianum is a kind of excellent color-leafed plants, and well known for its red leaves in autumn. At the same time, A. pseudosieboldianum is one of the native tree species in the northeast of China...

    Authors: Jia-Lin Li, Zhuo Weng, Xin-Yu Li, Bo Xu, Yu-Fu Gao and Li-Ping Rong
    Citation: BMC Genomics 2022 23:567
    Content type: Research Published on:

  49. The genus Verbascum L. (Scrophulariaceae) is distributed in Africa, Europe, and parts of Asia, with the Mediterranean having the most species variety. Several researchers have already worked on the phylogenetic a...

    Authors: Xiang Dong, Elijah Mbandi Mkala, Elizabeth Syowai Mutinda, Jia-Xin Yang, Vincent Okelo Wanga, Millicent Akinyi Oulo, Victor Omondi Onjolo, Guang-Wan Hu and Qing-Feng Wang
    Citation: BMC Genomics 2022 23:566
    Content type: Research Published on:

  50. Past selection events left footprints in the genome of domestic animals, which can be traced back by stretches of homozygous genotypes, designated as runs of homozygosity (ROHs). The analysis of common ROH reg...

    Authors: Jan Berghöfer, Nadia Khaveh, Stefan Mundlos and Julia Metzger
    Citation: BMC Genomics 2022 23:564
    Content type: Research Published on:

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