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  1. Methylation at CpG dinucleotides in genomic DNA is a fundamental epigenetic mechanism of gene expression control in vertebrates. Proteins with a methyl-CpG-binding domain (MBD) can bind to single methylated Cp...

    Authors: Tim C Roloff, H Hilger Ropers and Ulrike A Nuber
    Citation: BMC Genomics 2003 4:1
  2. In order to contribute to the establishment of a complete map of transcribed regions of the human genome, we constructed a testicular cDNA library for the cynomolgus monkey, and attempted to find novel transcr...

    Authors: Naoki Osada, Munetomo Hida, Jun Kusuda, Reiko Tanuma, Makoto Hirata, Yumiko Suto, Momoki Hirai, Keiji Terao, Sumio Sugano and Katsuyuki Hashimoto
    Citation: BMC Genomics 2002 3:36
  3. Complete sequencing and annotation of the 96.2 kb Bacillus anthracis plasmid, pXO2, predicted 85 open reading frames (ORFs). Bacillus cereus and Bacillus thuringiensis isolates that ranged in genomic similarity t...

    Authors: James Pannucci, Richard T Okinaka, Erin Williams, Robert Sabin, Lawrence O Ticknor and Cheryl R Kuske
    Citation: BMC Genomics 2002 3:34
  4. The CyaB protein from Aeromonas hydrophila has been shown to possess adenylyl cyclase activity. While orthologs of this enzyme have been found in some bacteria and archaea, it shows no detectable relationship to ...

    Authors: Lakshminarayan M Iyer and L Aravind
    Citation: BMC Genomics 2002 3:33
  5. Co-regulation of genes may imply involvement in similar biological processes or related function. Many clusters of co-regulated genes have been identified using microarray experiments. In this study, we examin...

    Authors: Wei Ding, Luquan Wang, Ping Qiu, Mitchel Kostich, Jonathan Greene and Marco Hernandez
    Citation: BMC Genomics 2002 3:32
  6. T7 based linear amplification of RNA is used to obtain sufficient antisense RNA for microarray expression profiling. We optimized and systematically evaluated the fidelity and reproducibility of different ampl...

    Authors: Hongjuan Zhao, Trevor Hastie, Michael L Whitfield, Anne-Lise Børresen-Dale and Stefanie S Jeffrey
    Citation: BMC Genomics 2002 3:31
  7. Multiple candidate regions as sites for Schizophrenia and Bipolar susceptibility genes have been reported, suggesting heterogeneity of susceptibility genes or oligogenic inheritance. Linkage analysis has sugge...

    Authors: Manjula Maheshwari, SL Christian, C Liu, JA Badner, S Detera-Wadleigh, ES Gershon and Richard A Gibbs
    Citation: BMC Genomics 2002 3:30
  8. The EST database provides a rich resource for gene discovery and in silico expression analysis. We report a novel computational approach to identify co-expressed genes using EST database, and its application to I...

    Authors: Lawrence Benbow, Lynn Wang, Maureen Laverty, Suxing Liu, Ping Qiu, Richard W Bond, Eric Gustafson, Joseph A Hedrick, Mitchell Kostich, Jonathan R Greene and Luquan Wang
    Citation: BMC Genomics 2002 3:29
  9. Microarray technology is a powerful methodology for identifying differentially expressed genes. However, when thousands of genes in a microarray data set are evaluated simultaneously by fold changes and signif...

    Authors: Yuanyuan Xiao, Mark R Segal, Douglas Rabert, Andrew H Ahn, Praveen Anand, Lakshmi Sangameswaran, Donglei Hu and C Anthony Hunt
    Citation: BMC Genomics 2002 3:28
  10. Gonadotropin releasing hormone (GnRH) is responsible for stimulation of gonadotropic hormone (GtH) in the hypothalamus-pituitary-gonadal axis (HPG). The regulatory mechanisms responsible for brain specificity ...

    Authors: Jacob Torgersen, Rasoul Nourizadeh-Lillabadi, Harald Husebye and Peter Aleström
    Citation: BMC Genomics 2002 3:25
  11. The Blau syndrome (MIM 186580), an autosomal dominant granulomatous disease, was previously mapped to chromosome 16p12-q21. However, inconsistent physical maps of the region and consequently an unknown order o...

    Authors: Xiaoju Wang, Helena Kuivaniemi, Gina Bonavita, Charlene J Williams and Gerard Tromp
    Citation: BMC Genomics 2002 3:24
  12. The dinucleotide relative abundance profile can be regarded as a genomic signature because, despite diversity between species, it varies little between 50 kilobase or longer windows on a given genome. Both the...

    Authors: Robert W Jernigan and Robert H Baran
    Citation: BMC Genomics 2002 3:23
  13. Analysis of cell-selective gene expression for families of proteins of therapeutic interest is crucial when deducing the influence of genes upon complex traits and disease susceptibility. Presently, there is n...

    Authors: Grant Dewson, Edward C Conley and Peter Bradding
    Citation: BMC Genomics 2002 3:22
  14. Based on sequence similarity, the superfamily of G protein-coupled receptors (GPRs) can be subdivided into several subfamilies, the members of which often share similar ligands. The sequence data provided by t...

    Authors: Timo Wittenberger, Susanne Hellebrand, Antonia Munck, Hans-Jürgen Kreienkamp, H Chica Schaller and Wolfgang Hampe
    Citation: BMC Genomics 2002 3:17
  15. High density cDNA microarray technology provides a powerful tool to survey the activity of thousands of genes in normal and diseased cells, which helps us both to understand the molecular basis of the disease ...

    Authors: Limei Hu, Jing Wang, Keith Baggerly, Hua Wang, Gregory N Fuller, Stanley R Hamilton, Kevin R Coombes and Wei Zhang
    Citation: BMC Genomics 2002 3:16
  16. Freshwater planarians are widely used as models for investigation of pattern formation and studies on genetic variation in populations. Despite extensive information on the biology and genetics of planaria, th...

    Authors: Denis V Rebrikov, Maria E Bulina, Ekaterina A Bogdanova, Loura L Vagner and Sergey A Lukyanov
    Citation: BMC Genomics 2002 3:15
  17. Suppression Subtractive Hybridization PCR (SSH PCR) is a sophisticated cDNA subtraction method to enrich and isolate differentially expressed genes. Despite its popularity, the method has not been thoroughly s...

    Authors: Wan Ji, Matthew B Wright, Li Cai, Angel Flament and Klaus Lindpaintner
    Citation: BMC Genomics 2002 3:12
  18. The centromere is a specialized locus that mediates chromosome movement during mitosis and meiosis. This chromosomal domain comprises a uniquely packaged form of heterochromatin that acts as a nucleus for the ...

    Authors: Javier Figueroa, Carlos Pendón and Manuel M Valdivia
    Citation: BMC Genomics 2002 3:11
  19. Genome wide transcriptome maps can provide tools to identify candidate genes that are over-expressed or silenced in certain disease tissue and increase our understanding of the structure and organization of th...

    Authors: Ping Qiu, Lawrence Benbow, Suxing Liu, Jonathan R Greene and Luquan Wang
    Citation: BMC Genomics 2002 3:10
  20. Animal and yeast proteins containing long coiled-coil domains are involved in attaching other proteins to the large, solid-state components of the cell. One subgroup of long coiled-coil proteins are the nuclea...

    Authors: Frank Gindullis, Annkatrin Rose, Shalaka Patel and Iris Meier
    Citation: BMC Genomics 2002 3:9
  21. Gene expression profiling among different tissues is of paramount interest in various areas of biomedical research. We have developed a novel method (DADA, D igital A nalysis of cD NA A bundance), that calculates...

    Authors: Peter Hof, Claudia Ortmeier, Kirstin Pape, Birgit Reitmaier, Johannes Regenbogen, Andreas Goppelt and Joern-Peter Halle
    Citation: BMC Genomics 2002 3:7
  22. Familial atrial fibrillation, an autosomal dominant disease, was previously mapped to chromosome 10q22. One of the genes mapped to the 10q22 region is DLG5, a member of the MAGUKs (Membrane Associated Gyanylat...

    Authors: Gopi Shah, Ramon Brugada, Oscar Gonzalez, Grazyna Czernuszewicz, Richard A Gibbs, Linda Bachinski and Robert Roberts
    Citation: BMC Genomics 2002 3:6
  23. Inhibitor of Apoptosis (IAP) proteins are key intrinsic regulators of apoptosis induced by a variety of triggers. We isolated the rat Inhibitor of Apoptosis genes 1, 2 and 3 and characterized their tissue dist...

    Authors: Martin Holcik, Charles A Lefebvre, Keiko Hicks and Robert G Korneluk
    Citation: BMC Genomics 2002 3:5
  24. Mucolipidosis type IV (MLIV) is an autosomal recessive lysosomal storage disorder characterized by severe neurologic and ophthalmologic abnormalities. Recently the MLIV gene, MCOLN1, has been identified as a new ...

    Authors: John L Falardeau, John C Kennedy, James S Acierno Jr, Mei Sun, Stefanie Stahl, Ehud Goldin and Susan A Slaugenhaupt
    Citation: BMC Genomics 2002 3:3
  25. The phospholipase D (PLD) family has been identified in plants by recent molecular studies, fostered by the emerging importance of plant PLDs in stress physiology and signal transduction. However, the presence...

    Authors: Marek Eliáš, Martin Potocký, Fatima Cvrčková and Viktor Žárský
    Citation: BMC Genomics 2002 3:2
  26. Two-hybrid screening for proteins that interact with the core domain of human topoisomerase I identified two novel proteins, BTBD1 and BTBD2, which share 80% amino acid identities.

    Authors: Lixin Xu, Lihong Yang, Keiko Hashimoto, Melvin Anderson, Glenda Kohlhagen, Yves Pommier and Peter D'Arpa
    Citation: BMC Genomics 2002 3:1
  27. Non-allelic homologous recombination between paralogous repeats is increasingly being recognized as a major mechanism causing both pathogenic microdeletions and duplications, and structural polymorphism in the...

    Authors: Matthew E Hurles
    Citation: BMC Genomics 2001 2:11
  28. The yeast yCCR4 factor belongs to the CCR4-NOT transcriptional regulatory complex, in which it interacts, through its leucine-rich repeat (LRR) motif with yPOP2. Recently, yCCR4 was shown to be a component of ...

    Authors: Anne Dupressoir, Anne-Pierre Morel, Willy Barbot, Marie-Paule Loireau, Laura Corbo and Thierry Heidmann
    Citation: BMC Genomics 2001 2:9
  29. Studies suggest that the related proteins nucleoplasmin and nucleophosmin (also called B23, NO38 or numatrin) are nuclear chaperones that mediate the assembly of nucleosomes and ribosomes, respectively, and th...

    Authors: Gregory M Shackleford, Amit Ganguly and Craig A MacArthur
    Citation: BMC Genomics 2001 2:8
  30. The tropomodulins (TMODs) are a family of proteins that cap the pointed ends of actin filaments. Four TMODs have been identified in humans, with orthologs in mice. Mutations in actin or actin-binding proteins ...

    Authors: Patrick R Cox, Teepu Siddique and Huda Y Zoghbi
    Citation: BMC Genomics 2001 2:7
  31. DAZAP1 (DAZ Associated Protein 1) was originally identified by a yeast two-hybrid system through its interaction with a putative male infertility factor, DAZ (Deleted in Azoospermia). In vitro, DAZAP1 interacts w...

    Authors: Tiane Dai, Yanira Vera, Eduardo C Salido and Pauline H Yen
    Citation: BMC Genomics 2001 2:6
  32. Single nucleotide polymorphisms (SNPs) are the foundation of powerful complex trait and pharmacogenomic analyses. The availability of large SNP databases, however, has emphasized a need for inexpensive SNP gen...

    Authors: A Fawad Faruqi, Seiyu Hosono, Mark D Driscoll, Frank B Dean, Osama Alsmadi, Rajanikanta Bandaru, Gyanendra Kumar, Brian Grimwade, Qiuling Zong, Zhenyu Sun, Yuefen Du, Stephen Kingsmore, Tim Knott and Roger S Lasken
    Citation: BMC Genomics 2001 2:4
  33. A partial cDNA clone from dog thyroid presenting a very significant similarity with an uncharacterized mouse EST sequence was isolated fortuitously. We report here the identification of the complete mRNA and o...

    Authors: Christiane Christophe-Hobertus, Claude Szpirer, Richard Guyon and Daniel Christophe
    Citation: BMC Genomics 2001 2:3
  34. Receptor protein tyrosine phosphatase rho (RPTPρ, gene symbol PTPRT) is a member of the type IIB RPTP family. These transmembrane molecules have been linked to signal transduction, cell adhesion and neurite ex...

    Authors: Julie A Besco, Adrienne Frostholm, Magdalena C Popesco, Arthur HM Burghes and Andrej Rotter
    Citation: BMC Genomics 2001 2:1
  35. Cystinosis is an autosomal recessive disorder characterised by an intralysosomal accumulation of cystine, and affected individuals progress to end-stage renal failure before the age of ten. The causative gene, CT...

    Authors: Stéphanie Cherqui, Vasiliki Kalatzis, Lionel Forestier, Isabelle Poras and Corinne Antignac
    Citation: BMC Genomics 2000 1:2
  36. Capping protein (CP), a heterodimer of α and β subunits, is found in all eukaryotes. CP binds to the barbed ends of actin filaments in vitro and controls actin assembly and cell motility in vivo. Vertebrates have...

    Authors: Marilyn C Hart, Yulia O Korshunova and John A Cooper
    Citation: BMC Genomics 2000 1:1

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