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  1. Human mesenchymal stem cells (MSC) with the capacity to differentiate into osteoblasts provide potential for the development of novel treatment strategies, such as improved healing of large bone defects. Howev...

    Authors: Birgit Kulterer, Gerald Friedl, Anita Jandrositz, Fatima Sanchez-Cabo, Andreas Prokesch, Christine Paar, Marcel Scheideler, Reinhard Windhager, Karl-Heinz Preisegger and Zlatko Trajanoski
    Citation: BMC Genomics 2007 8:70
  2. Genetical genomics is a very powerful tool to elucidate the basis of complex traits and disease susceptibility. Despite its relevance, however, statistical modeling of expression quantitative trait loci (eQTL)...

    Authors: Miguel Pérez-Enciso, José R Quevedo and Antonio Bahamonde
    Citation: BMC Genomics 2007 8:69
  3. Recent studies have shown that when individuals are grouped on the basis of genetic similarity, group membership corresponds closely to continental origin. There has been considerable debate about the implicat...

    Authors: Dominic J Allocco, Qing Song, Gary H Gibbons, Marco F Ramoni and Isaac S Kohane
    Citation: BMC Genomics 2007 8:68
  4. Plant promoter architecture is important for understanding regulation and evolution of the promoters, but our current knowledge about plant promoter structure, especially with respect to the core promoter, is ...

    Authors: Yoshiharu Y Yamamoto, Hiroyuki Ichida, Minami Matsui, Junichi Obokata, Tetsuya Sakurai, Masakazu Satou, Motoaki Seki, Kazuo Shinozaki and Tomoko Abe
    Citation: BMC Genomics 2007 8:67
  5. The hematopoietic stem cells (HSCs) niche of the bone marrow is comprised of HSCs, osteoblasts, endothelial cells and a stromal component of non-hematopoietic multipotent cells of mesenchymal origin named "mes...

    Authors: Enrico Pedemonte, Federica Benvenuto, Simona Casazza, Gianluigi Mancardi, Jorge R Oksenberg, Antonio Uccelli and Sergio E Baranzini
    Citation: BMC Genomics 2007 8:65
  6. For expression profiling to have a practical impact in the management of immune-related disease it is essential that it can be applied to peripheral blood cells. Early studies have used total peripheral blood ...

    Authors: Paul A Lyons, Maria Koukoulaki, Alexander Hatton, Karen Doggett, Hayley B Woffendin, Afzal N Chaudhry and Kenneth GC Smith
    Citation: BMC Genomics 2007 8:64
  7. Myostatin, a muscle-specific member of the Transforming Growth Factor beta family, negatively regulates muscle development. Double-muscled (DM) cattle have a loss-of-function mutation in their myostatin gene r...

    Authors: Isabelle Cassar-Malek, Florent Passelaigue, Carine Bernard, Jean Léger and Jean-François Hocquette
    Citation: BMC Genomics 2007 8:63
  8. Asbestos has been shown to cause chromosomal damage and DNA aberrations. Exposure to asbestos causes many lung diseases e.g. asbestosis, malignant mesothelioma, and lung cancer, but the disease-related process...

    Authors: Penny Nymark, Pamela M Lindholm, Mikko V Korpela, Leo Lahti, Salla Ruosaari, Samuel Kaski, Jaakko Hollmén, Sisko Anttila, Vuokko L Kinnula and Sakari Knuutila
    Citation: BMC Genomics 2007 8:62
  9. The non-human primate (NHP) research community has been intensely interested in obtaining whole-genome expression arrays for their work. Recently, novel approaches were used to generate the DNA sequence inform...

    Authors: Fenghai Duan, Eliot R Spindel, Yu-Hua Li and Robert B Norgren Jr
    Citation: BMC Genomics 2007 8:61
  10. The genome of Mycobacterium tuberculosis harbors four copies of a cluster of genes termed mce operons. Despite extensive research that has demonstrated the importance of these operons on infection outcome, their ...

    Authors: Nicola Casali and Lee W Riley
    Citation: BMC Genomics 2007 8:60
  11. One of the least common types of alternative splicing is the complete retention of an intron in a mature transcript. Intron retention (IR) is believed to be the result of intron, rather than exon, definition a...

    Authors: Noboru Jo Sakabe and Sandro José de Souza
    Citation: BMC Genomics 2007 8:59
  12. Bacterial invasion during sepsis induces disregulated systemic responses that could lead to fatal lung failure. The purpose of this study was to relate the temporal dynamics of gene expression to the pathophys...

    Authors: Hua Zhu, Yuhong Tang, Lacramioara Ivanciu, Michael Centola, Cristina Lupu, Fletcher B Taylor Jr and Florea Lupu
    Citation: BMC Genomics 2007 8:58
  13. Trypanosomatids exhibit a unique gene organization into large directional gene clusters (DGCs) in opposite directions. The transcription "strand switch region" (SSR) separating the two large DGCs that constitu...

    Authors: Jacques Puechberty, Christine Blaineau, Sabrina Meghamla, Lucien Crobu, Michel Pagès and Patrick Bastien
    Citation: BMC Genomics 2007 8:57
  14. Allopolyploidy is a preeminent process in plant evolution that results from the merger of distinct genomes in a common nucleus via inter-specific hybridization. Allopolyploid formation is usually related to genom...

    Authors: Warren Albertin, Karine Alix, Thierry Balliau, Philippe Brabant, Marlène Davanture, Christian Malosse, Benoît Valot and Hervé Thiellement
    Citation: BMC Genomics 2007 8:56
  15. Gamma-proteobacteria, such as Escherichia coli, can use a variety of respiratory substrates employing numerous aerobic and anaerobic respiratory systems controlled by multiple transcription regulators. Thus, in E...

    Authors: Dmitry A Ravcheev, Anna V Gerasimova, Andrey A Mironov and Mikhail S Gelfand
    Citation: BMC Genomics 2007 8:54
  16. Cervical carcinoma develops as a result of multiple genetic alterations. Different studies investigated genomic alterations in cervical cancer mainly by means of metaphase comparative genomic hybridization (mC...

    Authors: Judith N Kloth, Jan Oosting, Tom van Wezel, Karoly Szuhai, Jeroen Knijnenburg, Arko Gorter, Gemma G Kenter, Gert Jan Fleuren and Ekaterina S Jordanova
    Citation: BMC Genomics 2007 8:53
  17. Passerines (perching birds) are widely studied across many biological disciplines including ecology, population biology, neurobiology, behavioural ecology and evolutionary biology. However, understanding the m...

    Authors: Jon Slate, Matthew C Hale and Timothy R Birkhead
    Citation: BMC Genomics 2007 8:52
  18. Comparative genomic studies of the mitochondrion-lacking protist group Diplomonadida (diplomonads) has been lacking, although Giardia lamblia has been intensively studied. We have performed a sequence survey proj...

    Authors: Jan O Andersson, Åsa M Sjögren, David S Horner, Colleen A Murphy, Patricia L Dyal, Staffan G Svärd, John M Logsdon Jr, Mark A Ragan, Robert P Hirt and Andrew J Roger
    Citation: BMC Genomics 2007 8:51
  19. Expressed sequence tags (ESTs) have been used for rapid gene discovery in a variety of organisms and provide a valuable resource for whole genome annotation. Although the genome of one marsupial, the opossum Mono...

    Authors: Michelle L Baker, Sandra Indiviglio, April M Nyberg, George H Rosenberg, Kerstin Lindblad-Toh, Robert D Miller and Anthony T Papenfuss
    Citation: BMC Genomics 2007 8:50
  20. Identification of coordinately regulated genes according to the level of their expression during the time course of a process allows for discovering functional relationships among genes involved in the process.

    Authors: Cuong C To and Jiri Vohradsky
    Citation: BMC Genomics 2007 8:49
  21. Operon structures play an important role in transcriptional regulation in prokaryotes. However, there have been fewer studies on complicated operon structures in which the transcriptional units vary with chang...

    Authors: Shujiro Okuda, Shuichi Kawashima, Kazuo Kobayashi, Naotake Ogasawara, Minoru Kanehisa and Susumu Goto
    Citation: BMC Genomics 2007 8:48
  22. Molecular markers serve three important functions in physical map assembly. First, they provide anchor points to genetic maps facilitating functional genomic studies. Second, they reduce the overlap required f...

    Authors: Young-Sun Yim, Patricia Moak, Hector Sanchez-Villeda, Theresa A Musket, Pamela Close, Patricia E Klein, John E Mullet, Michael D McMullen, Zheiwei Fang, Mary L Schaeffer, Jack M Gardiner, Edward H Coe Jr and Georgia L Davis
    Citation: BMC Genomics 2007 8:47
  23. Human stem cells are viewed as a possible source of neurons for a cell-based therapy of neurodegenerative disorders, such as Parkinson's disease. Several protocols that generate different types of neurons from...

    Authors: Sergey V Anisimov, Nicolaj S Christophersen, Ana S Correia, Jia-Yi Li and Patrik Brundin
    Citation: BMC Genomics 2007 8:46
  24. Var genes encode a family of virulence factors known as PfEMP1 (Plasmodium falciparum erythrocyte membrane protein 1) which are responsible for both antigenic variation and cytoadherence of infected erythrocytes....

    Authors: Susan M Kraemer, Sue A Kyes, Gautam Aggarwal, Amy L Springer, Siri O Nelson, Zoe Christodoulou, Leia M Smith, Wendy Wang, Emily Levin, Christopher I Newbold, Peter J Myler and Joseph D Smith
    Citation: BMC Genomics 2007 8:45
  25. Comparative teleost studies are of great interest since they are important in aquaculture and in evolutionary issues. Comparing genomes of fully sequenced model fish species with those of farmed fish species t...

    Authors: Elena Sarropoulou, Rafaella Franch, Bruno Louro, Deborah M Power, Luca Bargelloni, Antonios Magoulas, Fabrice Senger, Matina Tsalavouta, Tomaso Patarnello, Francis Galibert, Georgios Kotoulas and Robert Geisler
    Citation: BMC Genomics 2007 8:44
  26. Rhesus macaques serve a critical role in the study of human biomedical research. While both Indian and Chinese rhesus macaques are commonly used, genetic differences between these two subspecies affect aspects...

    Authors: Betsy Ferguson, Summer L Street, Hollis Wright, Carlo Pearson, Yibing Jia, Shaun L Thompson, Patrick Allibone, Christopher J Dubay, Eliot Spindel and Robert B Norgren Jr
    Citation: BMC Genomics 2007 8:43
  27. Many lines of evidence suggest that poly(ADP-ribose) polymerase-1 (Parp-1) is involved in transcriptional regulation of various genes as a coactivator or a corepressor by modulating chromatin structure. Howeve...

    Authors: Hideki Ogino, Tadashige Nozaki, Akemi Gunji, Miho Maeda, Hiroshi Suzuki, Tsutomu Ohta, Yasufumi Murakami, Hitoshi Nakagama, Takashi Sugimura and Mitsuko Masutani
    Citation: BMC Genomics 2007 8:41
  28. Noncoding RNA species play a diverse set of roles in the eukaryotic cell. While much recent attention has focused on smaller RNA species, larger noncoding transcripts are also thought to be highly abundant in ...

    Authors: John N Hutchinson, Alexander W Ensminger, Christine M Clemson, Christopher R Lynch, Jeanne B Lawrence and Andrew Chess
    Citation: BMC Genomics 2007 8:39
  29. Human myelogenous leukemia characterized by either the non random t(8; 21)(q22; q22) or t(16; 21)(q24; q22) chromosome translocations differ for both their biological and clinical features. Some of these featu...

    Authors: Stefano Rossetti, André T Hoogeveen, Ping Liang, Cornel Stanciu, Peter van der Spek and Nicoletta Sacchi
    Citation: BMC Genomics 2007 8:38
  30. The midgut of hematophagous insects, such as disease transmitting mosquitoes, carries out a variety of essential functions that mostly relate to blood feeding. The midgut of the female malaria vector mosquito Ano...

    Authors: Emma Warr, Ruth Aguilar, Yuemei Dong, Vassiliki Mahairaki and George Dimopoulos
    Citation: BMC Genomics 2007 8:37
  31. Neisseria gonorrhoeae can survive during oxygen starvation by reducing nitrite to nitrous oxide catalysed by the nitrite and nitric oxide reductases, AniA and NorB. The oxygen-sensing transcription factor, FNR, i...

    Authors: Rebekah N Whitehead, Tim W Overton, Lori AS Snyder, Simon J McGowan, Harry Smith, Jeff A Cole and Nigel J Saunders
    Citation: BMC Genomics 2007 8:35
  32. Pyrethroid resistance in Anopheles funestus populations has led to an increase in malaria transmission in southern Africa. Resistance has been attributed to elevated activities of cytochrome P450s but the molecul...

    Authors: Charles S Wondji, John Morgan, Maureen Coetzee, Richard H Hunt, Keith Steen, William C Black IV, Janet Hemingway and Hilary Ranson
    Citation: BMC Genomics 2007 8:34
  33. Prostate cancer is the most frequently diagnosed cancer in American men, and few effective treatment options are available to patients who develop hormone-refractory prostate cancer. The molecular changes that...

    Authors: Steven N Quayle, Heidi Hare, Allen D Delaney, Martin Hirst, Dorothy Hwang, Jacqueline E Schein, Steven JM Jones, Marco A Marra and Marianne D Sadar
    Citation: BMC Genomics 2007 8:32
  34. Improvement of Citrus, the most economically important fruit crop in the world, is extremely slow and inherently costly because of the long-term nature of tree breeding and an unusual combination of reproductive ...

    Authors: Javier Terol, Ana Conesa, Jose M Colmenero, Manuel Cercos, Francisco Tadeo, Javier Agustí, Enriqueta Alós, Fernando Andres, Guillermo Soler, Javier Brumos, Domingo J Iglesias, Stefan Götz, Francisco Legaz, Xavier Argout, Brigitte Courtois, Patrick Ollitrault…
    Citation: BMC Genomics 2007 8:31
  35. Rapid progress in high-throughput biotechnologies (e.g. microarrays) and exponential accumulation of gene functional knowledge make it promising for systematic understanding of complex human diseases at functi...

    Authors: Jing Zhu, Jing Wang, Zheng Guo, Min Zhang, Da Yang, Yanhui Li, Dong Wang and Guohua Xiao
    Citation: BMC Genomics 2007 8:30
  36. An important mechanism for gene regulation utilizes small non-coding RNAs called microRNAs (miRNAs). These small RNAs play important roles in tissue development, cell differentiation and proliferation, lipid a...

    Authors: Yang Wang, Tingting Weng, Deming Gou, Zhongming Chen, Narendranath Reddy Chintagari and Lin Liu
    Citation: BMC Genomics 2007 8:29
  37. Until recently, few genomic reagents specific for non-human primate research have been available. To address this need, we have constructed a macaque-specific high-density oligonucleotide microarray by using h...

    Authors: James C Wallace, Marcus J Korth, Bryan Paeper, Sean C Proll, Matthew J Thomas, Charles L Magness, Shawn P Iadonato, Charles Nelson and Michael G Katze
    Citation: BMC Genomics 2007 8:28
  38. The C. elegans Promoterome is a powerful resource for revealing the regulatory mechanisms by which transcription is controlled pan-genomically. Transcription factors will form the core of any systems biology mode...

    Authors: John S Reece-Hoyes, Jane Shingles, Denis Dupuy, Christian A Grove, Albertha JM Walhout, Marc Vidal and Ian A Hope
    Citation: BMC Genomics 2007 8:27
  39. Amyotrophic lateral sclerosis (ALS) is a fatal disorder caused by the progressive degeneration of motoneurons in brain and spinal cord. Despite identification of disease-linked mutations, the diversity of proc...

    Authors: Carsten W Lederer, Antonietta Torrisi, Maria Pantelidou, Niovi Santama and Sebastiano Cavallaro
    Citation: BMC Genomics 2007 8:26
  40. Regulatory networks often employ the model that attributes changes in gene expression levels, as observed across different cellular conditions, to changes in the activity of transcription factors (TFs). Althou...

    Authors: Theo A Knijnenburg, Johannes H de Winde, Jean-Marc Daran, Pascale Daran-Lapujade, Jack T Pronk, Marcel JT Reinders and Lodewyk FA Wessels
    Citation: BMC Genomics 2007 8:25
  41. Nuclear receptors are hormone-regulated transcription factors whose signaling controls numerous aspects of development and physiology. Many receptors recognize DNA hormone response elements formed by direct re...

    Authors: David Laperriere, Tian-Tian Wang, John H White and Sylvie Mader
    Citation: BMC Genomics 2007 8:23
  42. Transcription regulatory networks are composed of protein-DNA interactions between transcription factors and their target genes. A long-term goal in genome biology is to map protein-DNA interaction networks of...

    Authors: M Inmaculada Barrasa, Philippe Vaglio, Fabien Cavasino, Laurent Jacotot and Albertha JM Walhout
    Citation: BMC Genomics 2007 8:21

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