van den Berghe G: The role of the liver in metabolic homeostasis: implications for inborn errors of metabolism. J Inherit Metab Dis. 1991, 14 (4): 407-420.
Article
CAS
PubMed
Google Scholar
Kersten S, Seydoux J, Peters JM, Gonzalez FJ, Desvergne B, Wahli W: Peroxisome proliferator-activated receptor alpha mediates the adaptive response to fasting. J Clin Invest. 1999, 103 (11): 1489-1498.
Article
CAS
PubMed Central
PubMed
Google Scholar
Stenberg P, Luthman K, Artursson P: Virtual screening of intestinal drug permeability. J Control Release. 2000, 65 (1-2): 231-243.
Article
CAS
PubMed
Google Scholar
Lee VH: Membrane transporters. Eur J Pharm Sci. 2000, 11 Suppl 2: S41-50.
Article
CAS
PubMed
Google Scholar
Steffansen B, Nielsen CU, Brodin B, Eriksson AH, Andersen R, Frokjaer S: Intestinal solute carriers: an overview of trends and strategies for improving oral drug absorption. Eur J Pharm Sci. 2004, 21 (1): 3-16.
Article
CAS
PubMed
Google Scholar
Tsuji A, Tamai I: Carrier-mediated intestinal transport of drugs. Pharm Res. 1996, 13 (7): 963-977.
Article
CAS
PubMed
Google Scholar
Anderle P, Huang Y, Sadee W: Intestinal membrane transport of drugs and nutrients: genomics of membrane transporters using expression microarrays. Eur J Pharm Sci. 2004, 21 (1): 17-24.
Article
CAS
PubMed
Google Scholar
Hediger MA, Romero MF, Peng JB, Rolfs A, Takanaga H, Bruford EA: The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins. Pflugers Arch. 2004, 447 (5): 465-468.
Article
CAS
PubMed
Google Scholar
Wacher VJ, Salphati L, Benet LZ: Active secretion and enterocytic drug metabolism barriers to drug absorption. Adv Drug Deliv Rev. 2001, 46 (1-3): 89-102.
Article
CAS
PubMed
Google Scholar
Kaminsky LS, Zhang QY: The small intestine as a xenobiotic-metabolizing organ. Drug Metab Dispos. 2003, 31 (12): 1520-1525.
Article
CAS
PubMed
Google Scholar
Danielson PB: The cytochrome P450 superfamily: biochemistry, evolution and drug metabolism in humans. Curr Drug Metab. 2002, 3 (6): 561-597.
Article
CAS
PubMed
Google Scholar
Banoglu E: Current status of the cytosolic sulfotransferases in the metabolic activation of promutagens and procarcinogens. Curr Drug Metab. 2000, 1 (1): 1-30.
Article
CAS
PubMed
Google Scholar
Weinshilboum RM, Otterness DM, Aksoy IA, Wood TC, Her C, Raftogianis RB: Sulfation and sulfotransferases 1: Sulfotransferase molecular biology: cDNAs and genes. FASEB J. 1997, 11 (1): 3-14.
CAS
PubMed
Google Scholar
Tukey RH, Strassburg CP: Human UDP-Glucuronosyltransferases: Metabolism, Expression, and Disease. Annual Review of Pharmacology and Toxicology. 2000, 40 (1): 581-616.
Article
CAS
PubMed
Google Scholar
Tew KD, Ronai Z: GST function in drug and stress response. Drug Resistance Updates. 1999, 2 (3): 143-
Article
CAS
PubMed
Google Scholar
Moscow JA, Dixon KH: Glutathione-related enzymes, glutathione and multidrug resistance. Cytotechnology. 1993, 12 (1-3): 155-170.
Article
CAS
PubMed
Google Scholar
Vatsis KP, Weber WW, Bell DA, Dupret JM, Evans DA, Grant DM, Hein DW, Lin HJ, Meyer UA, Relling MV: Nomenclature for N-acetyltransferases. Pharmacogenetics. 1995, 5 (1): 1-17.
Article
CAS
PubMed
Google Scholar
Arand M, Cronin A, Adamska M, Oesch F: Epoxide hydrolases: structure, function, mechanism, and assay. Methods Enzymol. 2005, 400: 569-588.
Article
CAS
PubMed
Google Scholar
Borst P, Elferink RO: Mammalian ABC transporters in health and disease. Annu Rev Biochem. 2002, 71: 537-592.
Article
CAS
PubMed
Google Scholar
Ferraris RP, Carey HV: Intestinal transport during fasting and malnutrition. AnnuRevNutr. 2000, 20: 195-219.
CAS
Google Scholar
Miyauchi S, Gopal E, Fei YJ, Ganapathy V: Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids. J Biol Chem. 2004, 279 (14): 13293-13296.
Article
CAS
PubMed
Google Scholar
Markovich D, Murer H: The SLC13 gene family of sodium sulphate/carboxylate cotransporters. Pflugers Arch. 2004, 447 (5): 594-602.
Article
CAS
PubMed
Google Scholar
Endo S, Nomura T, Chan BS, Lu R, Pucci ML, Bao Y, Schuster VL: Expression of PGT in MDCK cell monolayers: polarized apical localization and induction of active PG transport. Am J Physiol Renal Physiol. 2002, 282 (4): F618-622.
Article
CAS
PubMed
Google Scholar
Mount DB, Romero MF: The SLC26 gene family of multifunctional anion exchangers. Pflugers Arch. 2004, 447 (5): 710-721.
Article
CAS
PubMed
Google Scholar
Eide DJ: The SLC39 family of metal ion transporters. Pflugers Arch. 2004, 447 (5): 796-800.
Article
CAS
PubMed
Google Scholar
Gill RK, Saksena S, Alrefai WA, Sarwar Z, Goldstein JL, Carroll RE, Ramaswamy K, Dudeja PK: Expression and membrane localization of MCT isoforms along the length of the human intestine. Am J Physiol Cell Physiol. 2005, 289 (4): C846-852.
Article
CAS
PubMed
Google Scholar
McKie AT, Barlow DJ: The SLC40 basolateral iron transporter family (IREG1/ferroportin/MTP1). Pflugers Arch. 2004, 447 (5): 801-806.
Article
CAS
PubMed
Google Scholar
Martel F: Recent advances on the importance of the serotonin transporter SERT in the rat intestine. Pharmacol Res. 2006, 54 (2): 73-76.
Article
CAS
PubMed
Google Scholar
Liuzzi JP, Cousins RJ: Mammalian zinc transporters. Annu Rev Nutr. 2004, 24: 151-172.
Article
CAS
PubMed
Google Scholar
Bartoloni L, Antonarakis SE: The human sugar-phosphate/phosphate exchanger family SLC37. Pflugers Arch. 2004, 447 (5): 780-783.
Article
CAS
PubMed
Google Scholar
Steinberg SJ, Wang SJ, Kim DG, Mihalik SJ, Watkins PA: Human very-long-chain acyl-CoA synthetase: cloning, topography, and relevance to branched-chain fatty acid metabolism. Biochem Biophys Res Commun. 1999, 257 (2): 615-621.
Article
CAS
PubMed
Google Scholar
Kamiyama S, Sasaki N, Goda E, Ui-Tei K, Saigo K, Narimatsu H, Jigami Y, Kannagi R, Irimura T, Nishihara S: Molecular Cloning and Characterization of a Novel 3'-Phosphoadenosine 5'-Phosphosulfate Transporter, PAPST2. J Biol Chem. 2006, 281 (16): 10945-10953.
Article
CAS
PubMed
Google Scholar
Palmieri F: The mitochondrial transporter family (SLC25): physiological and pathological implications. Pflugers Arch. 2004, 447 (5): 689-709.
Article
CAS
PubMed
Google Scholar
Ishida N, Kawakita M: Molecular physiology and pathology of the nucleotide sugar transporter family (SLC35). Pflugers Arch. 2004, 447 (5): 768-775.
Article
CAS
PubMed
Google Scholar
Alberti S, Schuster G, Parini P, Feltkamp D, Diczfalusy U, Rudling M, Angelin B, Bjorkhem I, Pettersson S, Gustafsson JA: Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXR{beta}-deficient mice. J Clin Invest. 2001, 107 (5): 565-573.
Article
CAS
PubMed Central
PubMed
Google Scholar
Lund E, Andersson O, Zhang J, Babiker A, Ahlborg G, Diczfalusy U, Einarsson K, Sjovall J, Bjorkhem I: Importance of a Novel Oxidative Mechanism for Elimination of Intracellular Cholesterol in Humans. Arterioscler Thromb Vasc Biol. 1996, 16 (2): 208-212.
Article
CAS
PubMed
Google Scholar
Jia G, Takahashi R, Zhang Z, Tsuji Y, Sone H: Aldo-keto reductase 1 family B7 is the gene induced in response to oxidative stress in the livers of Long-Evans Cinnamon rats. Int J Oncol. 2006, 29 (4): 829-838.
CAS
PubMed Central
PubMed
Google Scholar
Wang N, Silver DL, Thiele C, Tall AR: ATP-binding Cassette Transporter A1 (ABCA1) Functions as a Cholesterol Efflux Regulatory Protein. J Biol Chem. 2001, 276 (26): 23742-23747.
Article
CAS
PubMed
Google Scholar
Yu L, Li-Hawkins J, Hammer RE, Berge KE, Horton JD, Cohen JC, Hobbs HH: Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. J Clin Invest. 2002, 110 (5): 671-680.
Article
CAS
PubMed Central
PubMed
Google Scholar
Kislinger T, Cox B, Kannan A, Chung C, Hu P, Ignatchenko A, Scott MS, Gramolini AO, Morris Q, Hallett MT, Rossant J, Hughes TR, Frey B, Emili A: Global survey of organ and organelle protein expression in mouse: combined proteomic and transcriptomic profiling. Cell. 2006, 125 (1): 173-186.
Article
CAS
PubMed
Google Scholar
Cox B, Kislinger T, Wigle DA, Kannan A, Brown K, Okubo T, Hogan B, Jurisica I, Frey B, Rossant J, Emili A: Integrated proteomic and transcriptomic profiling of mouse lung development and Nmyc target genes. Mol Syst Biol. 2007, 3:
Google Scholar
Lenaerts K, Sokolovic M, Bouwman FG, Lamers WH, Mariman EC, Renes J: Starvation induces phase-specific changes in the proteome of mouse small intestine. J Proteome Res. 2006, 5 (9): 2113-2122.
Article
CAS
PubMed
Google Scholar
Chappell VL, Thompson MD, Jeschke MG, Chung DH, Thompson JC, Wolf SE: Effects of incremental starvation on gut mucosa. Dig Dis Sci. 2003, 48 (4): 765-769.
Article
PubMed
Google Scholar
Samsom M, Fraser R, Smout AJ, Verhagen MA, Adachi K, Horowitz M, Dent J: Characterization of small intestinal pressure waves in ambulant subjects recorded with a novel portable manometric system. Dig Dis Sci. 1999, 44 (11): 2157-2164.
Article
CAS
PubMed
Google Scholar
Lordal M, Wallen H, Hjemdahl P, Beck O, Hellstrom PM: Concentration-dependent stimulation of intestinal phase III of migrating motor complex by circulating serotonin in humans. Clin Sci (Lond). 1998, 94 (6): 663-670.
Article
CAS
Google Scholar
Liu MC, Sakakibara Y, Liu CC: Bacterial expression, purification, and characterization of a novel mouse sulfotransferase that catalyzes the sulfation of eicosanoids. Biochem Biophys Res Commun. 1999, 254 (1): 65-69.
Article
CAS
PubMed
Google Scholar
Makkar RS, Contreras MA, Paintlia AS, Smith BT, Haq E, Singh I: Molecular organization of peroxisomal enzymes: protein-protein interactions in the membrane and in the matrix. Arch Biochem Biophys. 2006, 451 (2): 128-140.
Article
CAS
PubMed
Google Scholar
Pajor AM: Sodium-coupled transporters for Krebs cycle intermediates. Annu Rev Physiol. 1999, 61: 663-682.
Article
CAS
PubMed
Google Scholar
Venkateswaran A, Laffitte BA, Joseph SB, Mak PA, Wilpitz DC, Edwards PA, Tontonoz P: Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXRalpha. PNAS. 2000, 97 (22): 12097-12102.
Article
CAS
PubMed Central
PubMed
Google Scholar
Repa JJ, Berge KE, Pomajzl C, Richardson JA, Hobbs H, Mangelsdorf DJ: Regulation of ATP-binding Cassette Sterol Transporters ABCG5 and ABCG8 by the Liver X Receptors alpha and beta. J Biol Chem. 2002, 277 (21): 18793-18800.
Article
CAS
PubMed
Google Scholar
Fu X, Menke JG, Chen Y, Zhou G, MacNaul KL, Wright SD, Sparrow CP, Lund EG: 27-Hydroxycholesterol Is an Endogenous Ligand for Liver X Receptor in Cholesterol-loaded Cells. J Biol Chem. 2001, 276 (42): 38378-38387.
Article
CAS
PubMed
Google Scholar
Bauer M, Hamm AC, Bonaus M, Jacob A, Jaekel J, Schorle H, Pankratz MJ, Katzenberger JD: Starvation response in mouse liver shows strong correlation with life-span-prolonging processes. Physiol Genomics. 2004, 17 (2): 230-244.
Article
CAS
PubMed
Google Scholar
Guengerich FP: Cytochrome P-450 3A4: regulation and role in drug metabolism. Annu Rev Pharmacol Toxicol. 1999, 39: 1-17.
Article
CAS
PubMed
Google Scholar
Townsend DM, Tew KD, Tapiero H: The importance of glutathione in human disease. Biomed Pharmacother. 2003, 57 (3-4): 145-155.
Article
CAS
PubMed
Google Scholar
Battiston L, Moretti M, Tulissi P, Micheli L, Marchi P, Mazzoran L, Lunazzi G, Pozzato G: Hepatic glutathione determination after ethanol administration in rat: evidence of the first-pass metabolism of ethanol. Life Sci. 1995, 56 (4): 241-248.
Article
CAS
PubMed
Google Scholar
Szkudelski T, Okulicz M, Bialik I, Szkudelska K: The influence of fasting on liver sulfhydryl groups, glutathione peroxidase and glutathione-S-transferase activities in the rat. J Physiol Biochem. 2004, 60 (1): 1-6.
Article
CAS
PubMed
Google Scholar
Di Simplicio P, Rossi R, Falcinelli S, Ceserani R, Formento ML: Antioxidant status in various tissues of the mouse after fasting and swimming stress. Eur J Appl Physiol Occup Physiol. 1997, 76 (4): 302-307.
Article
CAS
PubMed
Google Scholar
Bartlett K, Eaton S: Mitochondrial {beta}-oxidation. Eur J Biochem. 2004, 271 (3): 462-469.
Article
CAS
PubMed
Google Scholar
Beutler E, Gelbart T, Pegelow C: Erythrocyte glutathione synthetase deficiency leads not only to glutathione but also to glutathione-S-transferase deficiency. J Clin Invest. 1986, 77 (1): 38-41.
Article
CAS
PubMed Central
PubMed
Google Scholar
Kensler TW, Wakabayashi N, Biswal S: Cell Survival Responses to Environmental Stresses Via the Keap1-Nrf2-ARE Pathway. Annual Review of Pharmacology and Toxicology. 2007, 47 (1): 89-116.
Article
CAS
PubMed
Google Scholar
Patsouris D, Reddy JK, Muller M, Kersten S: Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression. Endocrinology. 2006, 147 (3): 1508-1516.
Article
CAS
PubMed
Google Scholar
Kok T, Wolters H, Bloks VW, Havinga R, Jansen PL, Staels B, Kuipers F: Induction of hepatic ABC transporter expression is part of the PPARalpha-mediated fasting response in the mouse. Gastroenterology. 2003, 124 (1): 160-171.
Article
CAS
PubMed
Google Scholar
Vamecq J, Latruffe N: Medical significance of peroxisome proliferator-activated receptors. Lancet. 1999, 354 (9173): 141-148.
Article
CAS
PubMed
Google Scholar
Knight BL, Patel DD, Humphreys SM, Wiggins D, Gibbons GF: Inhibition of cholesterol absorption associated with a PPAR alpha-dependent increase in ABC binding cassette transporter A1 in mice. J Lipid Res. 2003, 44 (11): 2049-2058.
Article
CAS
PubMed
Google Scholar
Santamarina-Fojo S, Peterson K, Knapper C, Qiu Y, Freeman L, Cheng JF, Osorio J, Remaley A, Yang XP, Haudenschild C, Prades C, Chimini G, Blackmon E, Francois T, Duverger N, Rubin EM, Rosier M, Denefle P, Fredrickson DS, Brewer HB: Complete genomic sequence of the human ABCA1 gene: analysis of the human and mouse ATP-binding cassette A promoter. Proc Natl Acad Sci U S A. 2000, 97 (14): 7987-7992.
Article
CAS
PubMed Central
PubMed
Google Scholar
Lee SS, Pineau T, Drago J, Lee EJ, Owens JW, Kroetz DL, Fernandez-Salguero PM, Westphal H, Gonzalez FJ: Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol Cell Biol. 1995, 15 (6): 3012-3022.
Article
CAS
PubMed Central
PubMed
Google Scholar
Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, Hornik K, Hothorn T, Huber W, Iacus S, Irizarry R, Leisch F, Li C, Maechler M, Rossini AJ, Sawitzki G, Smith C, Smyth G, Tierney L, Yang JY, Zhang J: Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 2004, 5 (10): R80-
Article
PubMed Central
PubMed
Google Scholar
Wu Z, Irizarry RA, Gentleman R, Martinez-Murillo F, Spencer F: A Model-Based Background Adjustment for Oligonucleotide Expression Arrays. Journal of the American Statistical Association. 2004, 99 (468): 909-917.
Article
Google Scholar
Smyth GK: Limma: linear models for microarray data. Bioinformatics and Computational Biology Solutions using R and Bioconductor. Edited by: R. Gentleman VCSDRIWH. 2005, New York , Springer, 1: 397-420.
Chapter
Google Scholar
Kendziorski CM, Newton MA, Lan H, Gould MN: On parametric empirical Bayes methods for comparing multiple groups using replicated gene expression profiles. Stat Med. 2003, 22 (24): 3899-3914.
Article
CAS
PubMed
Google Scholar
Kooperberg C, Aragaki A, Strand AD, Olson JM: Significance testing for small microarray experiments. Stat Med. 2005, 24 (15): 2281-2298.
Article
PubMed
Google Scholar
Gottardo R, Pannucci JA, Kuske CR, Brettin T: Statistical analysis of microarray data: a Bayesian approach. Biostatistics. 2003, 4 (4): 597-620.
Article
PubMed
Google Scholar
Smyth GK: Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol. 2004, 3: Article3-
PubMed
Google Scholar
Kussmann M, Raymond F, Affolter M: OMICS-driven biomarker discovery in nutrition and health. J Biotechnol. 2006, 124 (4): 758-787.
Article
CAS
PubMed
Google Scholar
Afman L, Muller M: Nutrigenomics: from molecular nutrition to prevention of disease. J Am Diet Assoc. 2006, 106 (4): 569-576.
Article
CAS
PubMed
Google Scholar
Muller M, Kersten S: Nutrigenomics: goals and strategies. Nat Rev Genet. 2003, 4 (4): 315-322.
Article
PubMed
Google Scholar