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  2. Cleavage of messenger RNA (mRNA) precursors is an essential step in mRNA maturation. The signal recognized by the cleavage enzyme complex has been characterized as an A rich region upstream of the cleavage sit...

    Authors: Dorota Retelska, Christian Iseli, Philipp Bucher, C Victor Jongeneel and Felix Naef
    Citation: BMC Genomics 2006 7:176
    Content type: Research article Published on:

  3. Transcriptomic techniques are now being applied in ecotoxicology and toxicology to measure the impact of stressors and develop understanding of mechanisms of toxicity. Microarray technology in particular offer...

    Authors: Lars-Henrik Heckmann, Richard Connon, Thomas H Hutchinson, Steve J Maund, Richard M Sibly and Amanda Callaghan
    Citation: BMC Genomics 2006 7:175
    Content type: Research article Published on:

  4. High-throughput genotyping technologies represent a highly efficient way to accelerate genetic mapping and enable association studies. As a first step toward this goal, we aimed to develop a resource of candid...

    Authors: Nathalie Pavy, Lee S Parsons, Charles Paule, John MacKay and Jean Bousquet
    Citation: BMC Genomics 2006 7:174
    Content type: Research article Published on:

  5. Shigella bacteria cause dysentery, which remains a significant threat to public health. Shigella flexneri is the most common species in both developing and developed countries. Five Shigella genomes have been seq...

    Authors: Huan Nie, Fan Yang, Xiaobing Zhang, Jian Yang, Lihong Chen, Jing Wang, Zhaohui Xiong, Junping Peng, Lilian Sun, Jie Dong, Ying Xue, Xingye Xu, Shuxia Chen, Zhijian Yao, Yan Shen and Qi Jin
    Citation: BMC Genomics 2006 7:173
    Content type: Research article Published on:

  6. The sheep is an important model animal for testing novel fracture treatments and other medical applications. Despite these medical uses and the well known economic and cultural importance of the sheep, relativ...

    Authors: Jochen Hecht, Heiner Kuhl, Stefan A Haas, Sebastian Bauer, Albert J Poustka, Jasmin Lienau, Hanna Schell, Asita C Stiege, Volkhard Seitz, Richard Reinhardt, Georg N Duda, Stefan Mundlos and Peter N Robinson
    Citation: BMC Genomics 2006 7:172
    Content type: Research article Published on:

  7. Mature saturated brine (crystallizers) communities are largely dominated (>80% of cells) by the square halophilic archaeon "Haloquadratum walsbyi". The recent cultivation of the strain HBSQ001 and thesequencing o...

    Authors: Boris A Legault, Arantxa Lopez-Lopez, Jose Carlos Alba-Casado, W Ford Doolittle, Henk Bolhuis, Francisco Rodriguez-Valera and R Thane Papke
    Citation: BMC Genomics 2006 7:171
    Content type: Research article Published on:

  8. Prediction of secondary structures in the expressed sequences of bacterial genomes allows to investigate spontaneous folding of the corresponding RNA. This is particularly relevant in untranslated mRNA regions...

    Authors: Mauro Petrillo, Giustina Silvestro, Pier Paolo Di Nocera, Angelo Boccia and Giovanni Paolella
    Citation: BMC Genomics 2006 7:170
    Content type: Research article Published on:

  9. The square halophilic archaeon Haloquadratum walsbyi dominates NaCl-saturated and MgCl2 enriched aquatic ecosystems, which imposes a serious desiccation stress, caused by the extremely low water activity. The gen...

    Authors: Henk Bolhuis, Peter Palm, Andy Wende, Michaela Falb, Markus Rampp, Francisco Rodriguez-Valera, Friedhelm Pfeiffer and Dieter Oesterhelt
    Citation: BMC Genomics 2006 7:169
    Content type: Research article Published on:

  10. Pollen of the European white birch (Betula pendula, syn. B. verrucosa) is an important cause of hay fever. The main allergen is Bet v 1, member of the pathogenesis-related class 10 (PR-10) multigene family. To es...

    Authors: Martijn F Schenk, Ludovicus JWJ Gilissen, Gerhard D Esselink and Marinus JM Smulders
    Citation: BMC Genomics 2006 7:168
    Content type: Research article Published on:

  12. NCI60 cell lines are derived from cancers of 9 tissue origins and have been invaluable in vitro models for cancer research and anti-cancer drug screen. Although extensive studies have been carried out to assess t...

    Authors: Huixia Wang, Shuguang Huang, Jianyong Shou, Eric W Su, Jude E Onyia, Birong Liao and Shuyu Li
    Citation: BMC Genomics 2006 7:166
    Content type: Research article Published on:

  16. Pseudomonas aeruginosa is a genetically complex bacterium which can adopt and switch between a free-living or biofilm lifestyle, a versatility that enables it to thrive in many different environments and contribu...

    Authors: Richard D Waite, Alberto Paccanaro, Anastasia Papakonstantinopoulou, Jacob M Hurst, Mansoor Saqi, Eddie Littler and Michael A Curtis
    Citation: BMC Genomics 2006 7:162
    Content type: Research article Published on:

  18. Genomic approaches provide unique opportunities to study interactions of insects with their pathogens. We developed a cDNA microarray to analyze the gene transcription profile of the lepidopteran pest Spodoptera ...

    Authors: M Barat-Houari, F Hilliou, F-X Jousset, L Sofer, E Deleury, J Rocher, M Ravallec, L Galibert, P Delobel, R Feyereisen, P Fournier and A-N Volkoff
    Citation: BMC Genomics 2006 7:160
    Content type: Research article Published on:

  19. The purpose of this work was to study the gene expression of transient receptor potential (TRP) channels in the mouse. The application of a standardized and quantitative technique, TaqMan RT-PCR, should give i...

    Authors: Christiane Kunert-Keil, Frederike Bisping, Jana Krüger and Heinrich Brinkmeier
    Citation: BMC Genomics 2006 7:159
    Content type: Research article Published on:

  20. The maize INDETERMINATE1 gene, ID1, is a key regulator of the transition to flowering and the founding member of a transcription factor gene family that encodes a protein with a distinct arrangement of zinc finge...

    Authors: Joseph Colasanti, Reynald Tremblay, Ada YM Wong, Viktoriya Coneva, Akiko Kozaki and Barbara K Mable
    Citation: BMC Genomics 2006 7:158
    Content type: Research article Published on:

  21. The nematode Strongyloides ratti has two adult phases in its lifecycle: one obligate, female and parasitic and one facultative, dioecious and free-living. The molecular control of the development of this free-liv...

    Authors: Fiona J Thompson, Gary LA Barker, Louise Hughes, Clare P Wilkes, Jane Coghill and Mark E Viney
    Citation: BMC Genomics 2006 7:157
    Content type: Research article Published on:

  23. Trisomy of human chromosome 21 (Chr21) results in Down's syndrome, a complex developmental and neurodegenerative disease. Molecular analysis of Down's syndrome, however, poses a particular challenge, because t...

    Authors: Yu-Hui Hu, Hans-Jörg Warnatz, Dominique Vanhecke, Florian Wagner, Andrea Fiebitz, Sabine Thamm, Pascal Kahlem, Hans Lehrach, Marie-Laure Yaspo and Michal Janitz
    Citation: BMC Genomics 2006 7:155
    Content type: Research article Published on:

  24. Biologists are becoming increasingly aware that the interaction of animals, including humans, with their coevolved bacterial partners is essential for health. This growing awareness has been a driving force fo...

    Authors: Carlene K Chun, Todd E Scheetz, Maria de Fatima Bonaldo, Bartley Brown, Anik Clemens, Wendy J Crookes-Goodson, Keith Crouch, Tad DeMartini, Mari Eyestone, Michael S Goodson, Bernadette Janssens, Jennifer L Kimbell, Tanya A Koropatnick, Tamara Kucaba, Christina Smith, Jennifer J Stewart…
    Citation: BMC Genomics 2006 7:154
    Content type: Research article Published on:

  25. There are many potential sources of variability in a microarray experiment. Variation can arise from many aspects of the collection and processing of samples for gene expression analysis. Oligonucleotide-based...

    Authors: LanMin Zhang, Sean J Yoder and Steven A Enkemann
    Citation: BMC Genomics 2006 7:153
    Content type: Research article Published on:

  26. The snake venom gland is a specialized organ, which synthesizes and secretes the complex and abundant toxin proteins. Though gene expression in the snake venom gland has been extensively studied, the focus has...

    Authors: Bing Zhang, Qinghua Liu, Wei Yin, Xiaowei Zhang, Yijun Huang, Yingfeng Luo, Pengxin Qiu, Xingwen Su, Jun Yu, Songnian Hu and Guangmei Yan
    Citation: BMC Genomics 2006 7:152
    Content type: Research article Published on:

  27. Macrohaplogroups 'M' and 'N' have evolved almost in parallel from a founder haplogroup L3. Macrohaplogroup N in India has already been defined in previous studies and recently the macrohaplogroup M among the I...

    Authors: Kumarasamy Thangaraj, Gyaneshwer Chaubey, Vijay Kumar Singh, Ayyasamy Vanniarajan, Ismail Thanseem, Alla G Reddy and Lalji Singh
    Citation: BMC Genomics 2006 7:151
    Content type: Research article Published on:

  28. Since DNA sequencing has become easier and cheaper, an increasing number of closely related viral genomes have been sequenced. However, many of these have been deposited in GenBank without annotations, severel...

    Authors: Vasily Tcherepanov, Angelika Ehlers and Chris Upton
    Citation: BMC Genomics 2006 7:150
    Content type: Software Published on:

  29. Wheat is an excellent species to study freezing tolerance and other abiotic stresses. However, the sequence of the wheat genome has not been completely characterized due to its complexity and large size. To ci...

    Authors: Mario Houde, Mahdi Belcaid, François Ouellet, Jean Danyluk, Antonio F Monroy, Ani Dryanova, Patrick Gulick, Anne Bergeron, André Laroche, Matthew G Links, Luke MacCarthy, William L Crosby and Fathey Sarhan
    Citation: BMC Genomics 2006 7:149
    Content type: Research article Published on:

  30. Splicing processes might play a major role in carcinogenesis and tumour progression. The Wnt pathway is of crucial relevance for cancer progression. Therefore we focussed on the Wnt/β-catenin signalling pathwa...

    Authors: Heike Pospisil, Alexander Herrmann, Kristine Butherus, Stefan Pirson, Jens G Reich and Wolfgang Kemmner
    Citation: BMC Genomics 2006 7:148
    Content type: Research article Published on:

  31. Bacillus subtilis is one of the best-characterized organisms in Gram-positive bacteria. It represents a paradigm of gene regulation in bacteria due its complex life style (which could involve a transition between...

    Authors: Samadhi Moreno-Campuzano, Sarath Chandra Janga and Ernesto Pérez-Rueda
    Citation: BMC Genomics 2006 7:147
    Content type: Research article Published on:

  32. Mouse strains with a contrasting response to morphine provide a unique model for studying the genetically determined diversity of sensitivity to opioid reward, tolerance and dependence. Four inbred strains sel...

    Authors: Michal Korostynski, Dorota Kaminska-Chowaniec, Marcin Piechota and Ryszard Przewlocki
    Citation: BMC Genomics 2006 7:146
    Content type: Research article Published on:

  33. Cell-based microarrays were first described by Ziauddin and Sabatini in 2001 as a powerful new approach for performing high throughput screens of gene function. An important application of cell-based microarra...

    Authors: Ella L Palmer, Andrew D Miller and Tom C Freeman
    Citation: BMC Genomics 2006 7:145
    Content type: Research article Published on:

  34. Recent developments in DNA microarray technology led to a variety of open and closed devices and systems including high and low density microarrays for high-throughput screening applications as well as microar...

    Authors: Susann Schüler, Ingrid Wenz, B Wiederanders, P Slickers and R Ehricht
    Citation: BMC Genomics 2006 7:144
    Content type: Methodology article Published on:

  36. Extracting relevant biological information from large data sets is a major challenge in functional genomics research. Different aspects of the data hamper their biological interpretation. For instance, 5000-fo...

    Authors: Robert A van den Berg, Huub CJ Hoefsloot, Johan A Westerhuis, Age K Smilde and Mariët J van der Werf
    Citation: BMC Genomics 2006 7:142
    Content type: Research article Published on:

  37. The structural and functional features associated with Simple Sequence Proteins (SSPs) are non-globularity, disease states, signaling and post-translational modification. SSPs are also an important source of g...

    Authors: Mekapati Bala Subramanyam, Muthiah Gnanamani and Srinivasan Ramachandran
    Citation: BMC Genomics 2006 7:141
    Content type: Research article Published on:

  38. Approximately 11 Mb of finished high quality genomic sequences were sampled from cattle, dog and human to estimate genomic divergences and their regional variation among these lineages.

    Authors: George E Liu, Lakshmi K Matukumalli, Tad S Sonstegard, Larry L Shade and Curtis P Van Tassell
    Citation: BMC Genomics 2006 7:140
    Content type: Research article Published on:

  39. Long Interspersed Nuclear Elements (LINEs) are the most abundant retrotransposons in humans. About 79% of human genes are estimated to contain at least one segment of LINE per transcription unit. Recent studie...

    Authors: Dae-Soo Kim, Tae-Hyung Kim, Jae-Won Huh, Il-Chul Kim, Seok-Won Kim, Hong-Seog Park and Heui-Soo Kim
    Citation: BMC Genomics 2006 7:139
    Content type: Database Published on:

  40. Advances made in the area of microarray comparative genomic hybridization (aCGH) have enabled the interrogation of the entire genome at a previously unattainable resolution. This has lead to the discovery of a...

    Authors: Ilan Braude, Bisera Vukovic, Mona Prasad, Paula Marrano, Stefanie Turley, Dwayne Barber, Maria Zielenska and Jeremy A Squire
    Citation: BMC Genomics 2006 7:138
    Content type: Research article Published on:

  43. There is no effective method to obtain genome information from single-celled unculturable organisms such as radiolarians. Even worse, such organisms are often very difficult to collect. Sequence analysis of 18...

    Authors: Mariko Kouduka, Atsushi Matsuoka and Koichi Nishigaki
    Citation: BMC Genomics 2006 7:135
    Content type: Methodology article Published on:

  46. The Cotton Microsatellite Database (CMD) http://​www.​cottonssr.​org is a curated and integrated web-based relational database providing centralized access to p...

    Authors: Anna Blenda, Jodi Scheffler, Brian Scheffler, Michael Palmer, Jean-Marc Lacape, John Z Yu, Christopher Jesudurai, Sook Jung, Sriram Muthukumar, Preetham Yellambalase, Stephen Ficklin, Margaret Staton, Robert Eshelman, Mauricio Ulloa, Sukumar Saha, Ben Burr…
    Citation: BMC Genomics 2006 7:132
    Content type: Database Published on:

  47. The main limitation in performing genome-wide gene-expression profiling is the assay of low-expression genes. Approaches with high throughput and high sensitivity for assaying low-expression transcripts are ur...

    Authors: Yi-Shin Pan, Yun-Shien Lee, Yung-Lin Lee, Wei-Chen Lee and Sen-Yung Hsieh
    Citation: BMC Genomics 2006 7:131
    Content type: Methodology article Published on:

  48. Butterfly wing color patterns are a key model for integrating evolutionary developmental biology and the study of adaptive morphological evolution. Yet, despite the biological, economical and educational value...

    Authors: Patrícia Beldade, Stephen Rudd, Jonathan D Gruber and Anthony D Long
    Citation: BMC Genomics 2006 7:130
    Content type: Research article Published on:

  49. A response to Snyder LA, Saunders NJ: The majority of genes in the pathogenic Neisseria species are present in non-pathogenic Neisseria lactamica , including those designated as virulence genes. BMC Genomics 2006...

    Authors: Richard Stabler and Jason Hinds
    Citation: BMC Genomics 2006 7:129
    Content type: Correspondence Published on:

  50. Neisseria meningitidis causes the life-threatening diseases meningococcal meningitis and meningococcal septicemia. Neisseria gonorrhoeae is closely related to the meningococcus, but is the cause of the very diffe...

    Authors: Lori AS Snyder and Nigel J Saunders
    Citation: BMC Genomics 2006 7:128
    Content type: Research article Published on:

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BMC Genomics

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