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  1. Splicing processes might play a major role in carcinogenesis and tumour progression. The Wnt pathway is of crucial relevance for cancer progression. Therefore we focussed on the Wnt/β-catenin signalling pathwa...

    Authors: Heike Pospisil, Alexander Herrmann, Kristine Butherus, Stefan Pirson, Jens G Reich and Wolfgang Kemmner
    Citation: BMC Genomics 2006 7:148
  2. Bacillus subtilis is one of the best-characterized organisms in Gram-positive bacteria. It represents a paradigm of gene regulation in bacteria due its complex life style (which could involve a transition between...

    Authors: Samadhi Moreno-Campuzano, Sarath Chandra Janga and Ernesto Pérez-Rueda
    Citation: BMC Genomics 2006 7:147
  3. Mouse strains with a contrasting response to morphine provide a unique model for studying the genetically determined diversity of sensitivity to opioid reward, tolerance and dependence. Four inbred strains sel...

    Authors: Michal Korostynski, Dorota Kaminska-Chowaniec, Marcin Piechota and Ryszard Przewlocki
    Citation: BMC Genomics 2006 7:146
  4. Cell-based microarrays were first described by Ziauddin and Sabatini in 2001 as a powerful new approach for performing high throughput screens of gene function. An important application of cell-based microarra...

    Authors: Ella L Palmer, Andrew D Miller and Tom C Freeman
    Citation: BMC Genomics 2006 7:145
  5. Recent developments in DNA microarray technology led to a variety of open and closed devices and systems including high and low density microarrays for high-throughput screening applications as well as microar...

    Authors: Susann Schüler, Ingrid Wenz, B Wiederanders, P Slickers and R Ehricht
    Citation: BMC Genomics 2006 7:144
  6. Extracting relevant biological information from large data sets is a major challenge in functional genomics research. Different aspects of the data hamper their biological interpretation. For instance, 5000-fo...

    Authors: Robert A van den Berg, Huub CJ Hoefsloot, Johan A Westerhuis, Age K Smilde and Mariët J van der Werf
    Citation: BMC Genomics 2006 7:142
  7. The structural and functional features associated with Simple Sequence Proteins (SSPs) are non-globularity, disease states, signaling and post-translational modification. SSPs are also an important source of g...

    Authors: Mekapati Bala Subramanyam, Muthiah Gnanamani and Srinivasan Ramachandran
    Citation: BMC Genomics 2006 7:141
  8. Approximately 11 Mb of finished high quality genomic sequences were sampled from cattle, dog and human to estimate genomic divergences and their regional variation among these lineages.

    Authors: George E Liu, Lakshmi K Matukumalli, Tad S Sonstegard, Larry L Shade and Curtis P Van Tassell
    Citation: BMC Genomics 2006 7:140
  9. Long Interspersed Nuclear Elements (LINEs) are the most abundant retrotransposons in humans. About 79% of human genes are estimated to contain at least one segment of LINE per transcription unit. Recent studie...

    Authors: Dae-Soo Kim, Tae-Hyung Kim, Jae-Won Huh, Il-Chul Kim, Seok-Won Kim, Hong-Seog Park and Heui-Soo Kim
    Citation: BMC Genomics 2006 7:139
  10. Advances made in the area of microarray comparative genomic hybridization (aCGH) have enabled the interrogation of the entire genome at a previously unattainable resolution. This has lead to the discovery of a...

    Authors: Ilan Braude, Bisera Vukovic, Mona Prasad, Paula Marrano, Stefanie Turley, Dwayne Barber, Maria Zielenska and Jeremy A Squire
    Citation: BMC Genomics 2006 7:138
  11. There is no effective method to obtain genome information from single-celled unculturable organisms such as radiolarians. Even worse, such organisms are often very difficult to collect. Sequence analysis of 18...

    Authors: Mariko Kouduka, Atsushi Matsuoka and Koichi Nishigaki
    Citation: BMC Genomics 2006 7:135
  12. The Cotton Microsatellite Database (CMD) http://​www.​cottonssr.​org is a curated and integrated web-based relational database providing centralized access to p...

    Authors: Anna Blenda, Jodi Scheffler, Brian Scheffler, Michael Palmer, Jean-Marc Lacape, John Z Yu, Christopher Jesudurai, Sook Jung, Sriram Muthukumar, Preetham Yellambalase, Stephen Ficklin, Margaret Staton, Robert Eshelman, Mauricio Ulloa, Sukumar Saha, Ben Burr…
    Citation: BMC Genomics 2006 7:132
  13. The main limitation in performing genome-wide gene-expression profiling is the assay of low-expression genes. Approaches with high throughput and high sensitivity for assaying low-expression transcripts are ur...

    Authors: Yi-Shin Pan, Yun-Shien Lee, Yung-Lin Lee, Wei-Chen Lee and Sen-Yung Hsieh
    Citation: BMC Genomics 2006 7:131
  14. A response to Snyder LA, Saunders NJ: The majority of genes in the pathogenic Neisseria species are present in non-pathogenic Neisseria lactamica , including those designated as virulence genes. BMC Genomics 2006...

    Authors: Richard Stabler and Jason Hinds
    Citation: BMC Genomics 2006 7:129
  15. Neisseria meningitidis causes the life-threatening diseases meningococcal meningitis and meningococcal septicemia. Neisseria gonorrhoeae is closely related to the meningococcus, but is the cause of the very diffe...

    Authors: Lori AS Snyder and Nigel J Saunders
    Citation: BMC Genomics 2006 7:128
  16. Gene expression profiling has been used to define molecular phenotypes of complex diseases such as breast cancer. The luminal A and basal-like subtypes have been repeatedly identified and validated as the two ...

    Authors: Therese Sørlie, Yulei Wang, Chunlin Xiao, Hilde Johnsen, Bjørn Naume, Raymond R Samaha and Anne-Lise Børresen-Dale
    Citation: BMC Genomics 2006 7:127
  17. Genomes of gram-positive bacteria encode many putative cell-surface proteins, of which the majority has no known function. From the rapidly increasing number of available genome sequences it has become apparen...

    Authors: Roland Siezen, Jos Boekhorst, Lidia Muscariello, Douwe Molenaar, Bernadet Renckens and Michiel Kleerebezem
    Citation: BMC Genomics 2006 7:126
  18. The Fragile Histidine Triad gene (FHIT) is an oncosuppressor implicated in many human cancers, including vesical tumors. FHIT is frequently hit by deletions caused by fragility at FRA3B, the most active of human ...

    Authors: Cristina Uboldi, Elena Guidi, Sante Roperto, Valeria Russo, Franco Roperto, Giulia Pia Di Meo, Leopoldo Iannuzzi, Sandrine Floriot, Mekki Boussaha, André Eggen and Luca Ferretti
    Citation: BMC Genomics 2006 7:123
  19. Olfactory receptors (ORs) are the largest gene family in the human genome. Although they are expected to be expressed specifically in olfactory tissues, some ectopic expression has been reported, with special ...

    Authors: Ester Feldmesser, Tsviya Olender, Miriam Khen, Itai Yanai, Ron Ophir and Doron Lancet
    Citation: BMC Genomics 2006 7:121
  20. The majority of introns in gene transcripts are found within the coding sequences (CDSs). A small but significant fraction of introns are also found to reside within the untranslated regions (5'UTRs and 3'UTRs...

    Authors: Betty YW Chung, Cas Simons, Andrew E Firth, Chris M Brown and Roger P Hellens
    Citation: BMC Genomics 2006 7:120
  21. Large scale sequencing of cDNA libraries can provide profiles of genes expressed in an organism under defined biological and environmental circumstances. We have analyzed sequences of 4541 Expressed Sequence T...

    Authors: Ali N Dana, Maureen E Hillenmeyer, Neil F Lobo, Marcia K Kern, Patricia A Romans and Frank H Collins
    Citation: BMC Genomics 2006 7:119
  22. The autism spectrum encompasses a set of complex multigenic developmental disorders that severely impact the development of language, non-verbal communication, and social skills, and are associated with odd, s...

    Authors: Valerie W Hu, Bryan C Frank, Shannon Heine, Norman H Lee and John Quackenbush
    Citation: BMC Genomics 2006 7:118
  23. The evolution of viral quasispecies can influence viral pathogenesis and the response to antiviral treatments. Mutant clouds in infected organisms represent the first stage in the genetic and antigenic diversi...

    Authors: Verónica Martín, Celia Perales, David Abia, Angel R Ortíz, Esteban Domingo and Carlos Briones
    Citation: BMC Genomics 2006 7:117
  24. The completed sequence of the Anopheles gambiae genome has enabled genome-wide analyses of gene expression and regulation in this principal vector of human malaria. These investigations have created a demand for ...

    Authors: Sumudu N Dissanayake, Osvaldo Marinotti, Jose Marcos C Ribeiro and Anthony A James
    Citation: BMC Genomics 2006 7:116
  25. Transmissible spongiform encephalopathies (TSEs) or prion diseases are fatal neurodegenerative disorders which occur in humans and various animal species. Examples include Creutzfeldt-Jakob disease (CJD) in hu...

    Authors: Pamela J Skinner, Hayet Abbassi, Bruce Chesebro, Richard E Race, Cavan Reilly and Ashley T Haase
    Citation: BMC Genomics 2006 7:114
  26. Comparative genomic analysis using cDNA microarray is a new approach and a useful tool to identify important genetic sequences or genes that are conserved throughout evolution. Identification of these conserve...

    Authors: Maud Vallée, Claude Robert, Steve Méthot, Marie-France Palin and Marc-André Sirard
    Citation: BMC Genomics 2006 7:113
  27. Staphylococcus epidermidis, long regarded as an innocuous commensal bacterium of the human skin, is the most frequent cause of nosocomial infections associated with implanted medical devices. This conditional pat...

    Authors: Wu Wei, ZhiWei Cao, Yu-Li Zhu, XiaoJing Wang, GuoHui Ding, Hao Xu, PeiLin Jia, Di Qu, Antoine Danchin and YiXue Li
    Citation: BMC Genomics 2006 7:112
  28. The MRP 1 gene encodes the 190 kDa multidrug resistance-associated protein 1 (MRP1/ABCC1) and effluxes diverse drugs and xenobiotics. Sequence variations within this gene might account for differences in drug res...

    Authors: Zihua Wang, Pui-Hoon Sew, Helen Ambrose, Stephen Ryan, Samuel S Chong, Edmund JD Lee and Caroline GL Lee
    Citation: BMC Genomics 2006 7:111
  29. One of the approaches for conducting genomics research in organisms without extant microarray platforms is to profile their expression patterns by using Cross-Species Hybridization (CSH). Several different stu...

    Authors: Carmiya Bar-Or, Meira Bar-Eyal, Tali Z Gal, Yoram Kapulnik, Henryk Czosnek and Hinanit Koltai
    Citation: BMC Genomics 2006 7:110
  30. Using microarrays by co-hybridizing two samples labeled with different dyes enables differential gene expression measurements and comparisons across slides while controlling for within-slide variability. Typic...

    Authors: Rishi L Khan, Gregory E Gonye, Guang Gao and James S Schwaber
    Citation: BMC Genomics 2006 7:109
  31. A number of publications have recently examined the occurrence and properties of the feed-forward motif in a variety of networks, including those that are of interest in genome biology, such as gene networks. ...

    Authors: Piers J Ingram, Michael PH Stumpf and Jaroslav Stark
    Citation: BMC Genomics 2006 7:108
  32. bZIPs are transcription factors that are found throughout the eukarya from fungi to flowering plants and mammals. They contain highly conserved basic region (BR) and leucine zipper (LZ) domains and often funct...

    Authors: Gregory D Amoutzias, Erich Bornberg-Bauer, Stephen G Oliver and David L Robertson
    Citation: BMC Genomics 2006 7:107
  33. Sharks are members of the taxonomic class Chondrichthyes, the oldest living jawed vertebrates. Genomic studies of this group, in comparison to representative species in other vertebrate taxa, will allow us to ...

    Authors: Meizhong Luo, HyeRan Kim, Dave Kudrna, Nicholas B Sisneros, So-Jeong Lee, Christopher Mueller, Kristi Collura, Andrea Zuccolo, E Bryan Buckingham, Suzanne M Grim, Kazuyo Yanagiya, Hidetoshi Inoko, Takashi Shiina, Martin F Flajnik, Rod A Wing and Yuko Ohta
    Citation: BMC Genomics 2006 7:106
  34. Fibroblast growth factors (FGFs) are multifunctional proteins that play important roles in cell communication, proliferation and differentiation. However, many aspects of their activities are not well defined....

    Authors: Cornel Popovici, Yael Berda, Fabien Conchonaud, Aurélie Harbis, Daniel Birnbaum and Régine Roubin
    Citation: BMC Genomics 2006 7:105
  35. Human embryonic stem (ES) cells hold great promise for medicine and science. The transcriptome of human ES cells has been studied in detail in recent years. However, no systematic analysis has yet addressed wh...

    Authors: Huai Li, Ying Liu, Soojung Shin, Yu Sun, Jeanne F Loring, Mark P Mattson, Mahendra S Rao and Ming Zhan 1
    Citation: BMC Genomics 2006 7:103
  36. By comparing the quail genome with that of chicken, chromosome rearrangements that have occurred in these two galliform species over 35 million years of evolution can be detected. From a more practical point o...

    Authors: Boniface B Kayang, Valérie Fillon, Miho Inoue-Murayama, Mitsuru Miwa, Sophie Leroux, Katia Fève, Jean-Louis Monvoisin, Frédérique Pitel, Matthieu Vignoles, Céline Mouilhayrat, Catherine Beaumont, Shin'ichi Ito, Francis Minvielle and Alain Vignal
    Citation: BMC Genomics 2006 7:101
  37. Chloroplasts descended from cyanobacteria and have a drastically reduced genome following an endosymbiotic event. Many genes of the ancestral cyanobacterial genome have been transferred to the plant nuclear ge...

    Authors: Zhuo Wang, Xin-Guang Zhu, Yazhu Chen, Yuanyuan Li, Jing Hou, Yixue Li and Lei Liu
    Citation: BMC Genomics 2006 7:100
  38. Nucleoplasmin is a nuclear chaperone protein that has been shown to participate in the remodeling of sperm chromatin immediately after fertilization by displacing highly specialized sperm nuclear basic protein...

    Authors: Lindsay J Frehlick, José María Eirín-López, Erin D Jeffery, Donald F Hunt and Juan Ausió
    Citation: BMC Genomics 2006 7:99

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