Heim C, Nemeroff CB: The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies. Biol Psychiatry. 2001, 49: 1023-1039. 10.1016/S0006-3223(01)01157-X.
CAS
PubMed
Google Scholar
Charney D, Manji H: Life Stress, Genes, and Depression: Multiple Pathways Lead to Increased Risk and New Opportunities for Intervention. Science STKE. 2004, re5-10.1126/stke.2252004re5.
Google Scholar
de Kloet ER, Joels M, Holsboer F: Stress and the brain: from adaptation to disease. Nat Rev Neurosci. 2005, 6: 463-475. 10.1038/nrn1683.
CAS
PubMed
Google Scholar
Holsboer F: The corticosteroid receptor hypothesis of depression 1204. Neuropsychopharmacology. 2000, 23: 477-501. 10.1016/S0893-133X(00)00159-7.
CAS
PubMed
Google Scholar
Matthews SG: Early programming of the hypothalamo-pituitary-adrenal axise. Trends in Endocrinology and Metabolism. 2002, 13: 373-380. 10.1016/S1043-2760(02)00690-2.
CAS
PubMed
Google Scholar
Darnaudery M, Maccari S: Epigenetic programming of the stress response in male and female rats by prenatal restraint stress. Brain Research Reviews. 2008, 57: 571-585. 10.1016/j.brainresrev.2007.11.004.
CAS
PubMed
Google Scholar
Vieau D, Sebaai N, Leeonhardt M, Dutriez-Casteloot I, Molendi-Coste O, Laborie C, Breton C, Deloof S, Lesage J: HPA axis programming by maternal undernutrition in the male rat offspring. Psychoneuroendocrinology. 2007, 32: S16-S20. 10.1016/j.psyneuen.2007.03.014.
CAS
PubMed
Google Scholar
Murgatroyd C, Patchev AV, Wu Y, Micale V, Bockmuhl Y, Fischer D, Holsboer F, Wotjak CT, Almeida OF, Spengler D: Dynamic DNA methylation programs persistent adverse effects of early-life stress. Nat Neurosci. 2009, 12: 1559-1566. 10.1038/nn.2436.
CAS
PubMed
Google Scholar
De Bellis MD, Baum AS, Birmaher B, Keshavan MS, Eccard CH, Boring AM, Jenkins FJ, Ryan ND: Developmental traumatology Part I: Biological stress systems. Biological Psychiatry. 1999, 45: 1259-1270. 10.1016/S0006-3223(99)00044-X.
CAS
PubMed
Google Scholar
Heuser I, Lammers CH: Stress and the brain. Neurobiology of Aging. 2003, 24: S69-S76. 10.1016/S0197-4580(03)00048-4.
CAS
PubMed
Google Scholar
Armario A: The Hypothalamic-Pituitary-Adrenal Axis: What can it Tell us About Stressors. CNS Neurol Disord Drug Targets. 2006, 5: 485-501. 10.2174/187152706778559336.
PubMed
Google Scholar
Raadsheer FC, Sluiter AA, Ravid R, Tilders FJH, Swaab DF: Localization of Corticotropin-Releasing Hormone (Crh) Neurons in the Paraventricular Nucleus of the Human Hypothalamus - Age-Dependent Colocalization with Vasopressin. Brain Research. 1993, 615: 50-62. 10.1016/0006-8993(93)91113-7.
CAS
PubMed
Google Scholar
Gillies G, Lowry PJ: Corticotropin-Releasing Hormone and Its Vasopressin Component. Frontiers in Neuroendocrinology. 1982, 7: 45-75.
CAS
Google Scholar
Rivier C, Vale W: Interaction of Corticotropin-Releasing Factor and Arginine Vasopressin on Adrenocorticotropin Secretion Invivo. Endocrinology. 1983, 113: 939-942. 10.1210/endo-113-3-939.
CAS
PubMed
Google Scholar
Landgraf R: The involvement of vasopressin system in stress-related disorders. CNS Neurol Disord Drug Targets. 2006, 5: 167-179. 10.2174/187152706776359664.
CAS
PubMed
Google Scholar
Engelmann M, Landgraf R, Wotjak CT: The hypothalamic-neurohypophysial system regulates the hypothalamic-pituitary-adrenal axis under stress: An old concept revisited. Frontiers in Neuroendocrinology. 2004, 25: 132-149. 10.1016/j.yfrne.2004.09.001.
CAS
PubMed
Google Scholar
Swaab DF, Bao AM, Lucassen PJ: The stress system in the human brain in depression and neurodegeneration. Ageing Research Reviews. 2005, 4: 141-194. 10.1016/j.arr.2005.03.003.
CAS
PubMed
Google Scholar
Raadsheer FC, Hoogendijk WJG, Stam FC, Tilders FJH, Swaab DF: Increased Numbers of Corticotropin-Releasing Hormone Expressing Neurons in the Hypothalamic Paraventricular Nucleus of Depressed-Patients. Neuroendocrinology. 1994, 60: 436-444. 10.1159/000126778.
CAS
PubMed
Google Scholar
Raadsheer FC, Vanheerikhuize JJ, Lucassen PJ, Hoogendijk WJG, Tilders FJH, Swaab DF: Corticotropin-Releasing Hormone Messenger-RNA Levels in the Paraventricular Nucleus of Patients with Alzheimers-Disease and Depression. American Journal of Psychiatry. 1995, 152: 1372-1376.
CAS
Google Scholar
Ising M, Holsboer F: Genetics of stress response and stress-related disorders. Dialogues Clin Neurosci. 2006, 8 (4): 433-444. Ref Type: Generic
PubMed
PubMed Central
Google Scholar
Tsolakidou A, Trumbach D, Panhuysen M, Putz B, Deussing J, Wurst W, Sillaber I, Holsboer F, Rein T: Acute stress regulation of neuroplasticity genes in mouse hippocampus CA3 area--possible novel signalling pathways. Mol Cell Neurosci. 2008, 38: 444-452. 10.1016/j.mcn.2008.04.005.
CAS
PubMed
Google Scholar
Zacharko RM, Lalonde GT, Kasian M, Anisman H: Strain-Specific Effects of Inescapable Shock on Intracranial Self-Stimulation from the Nucleus-Accumbens. Brain Research. 1987, 426: 164-168. 10.1016/0006-8993(87)90436-7.
CAS
PubMed
Google Scholar
Zacharko RM, Gilmore W, Macneil G, Kasian M, Anisman H: Stressor Induced Variations of Intracranial Self-Stimulation from the Mesocortex in Several Strains of Mice. Brain Research. 1990, 533: 353-357. 10.1016/0006-8993(90)91363-L.
CAS
PubMed
Google Scholar
Ohl F, Roedel A, Binder E, Holsboer F: Impact of high and low anxiety on cognitive performance in a modified hole board test in C57BL/6 and DBA/2 mice. European Journal of Neuroscience. 2003, 17: 128-136. 10.1046/j.1460-9568.2003.02436.x.
Google Scholar
Rossi-Arnaud C, Ammassari-Teule M: What do comparative studies of inbred mice add to current investigations on the neural basis of spatial behaviors?. Experimental Brain Research. 1998, 123: 36-44. 10.1007/s002210050542.
CAS
PubMed
Google Scholar
Crowley JJ, Lucki I: Opportunities to discover genes regulating depression and antidepressant response from rodent behavioral genetics. Current Pharmaceutical Design. 2005, 11: 157-169. 10.2174/1381612053382278.
CAS
PubMed
Google Scholar
Sillaber I, Panhuysen M, Henniger MSH, Ohl F, Kuhne C, Pütz B, Pohl T, Deussing JM, Paez-Pereda M, Holsboer F: Profiling of behavioral changes and hippocampal gene expression in mice chronically treated with the SSRI paroxetine. Psychopharmacology. 2008, 200: 557-572. 10.1007/s00213-008-1232-6.
CAS
PubMed
Google Scholar
Porsolt RD, Lepichon M, Jalfre M: Depression - New Animal-Model Sensitive to Antidepressant Treatments. Nature. 1977, 266: 730-732. 10.1038/266730a0.
CAS
PubMed
Google Scholar
Giardino L, Puglisi-Allegra S, Ceccatelli S: CRH-R1 mRNA expression in two strains of inbred mice and its regulation after repeated restraint stress. Brain Res Mol Brain Res. 1996, 40: 310-314. 10.1016/0169-328X(96)00092-7.
CAS
PubMed
Google Scholar
Lee HC, Chang DE, Yeom M, Kim GH, Choi KD, Shim I, Lee HJ, Hahm DH: Gene expression profiling in hypothalamus of immobilization-stressed mouse using cDNA microarray. Brain Res Mol Brain Res. 2005, 135: 293-300. 10.1016/j.molbrainres.2004.11.016.
CAS
PubMed
Google Scholar
Reyes TM, Walker JR, DeCino C, Hogenesch JB, Sawchenko PE: Categorically distinct acute stressors elicit dissimilar transcriptional profiles in the paraventricular nucleus of the hypothalamus. Journal of Neuroscience. 2003, 23: 5607-5616.
CAS
PubMed
Google Scholar
Thoeringer CK, Sillaber I, Roedel A, Erhardt A, Mueller MB, Ohl F, Holsboer F, Keck ME: The temporal dynamics of intrahippocampal corticosterone in response to stress-related stimuli with different emotional and physical load: an in vivo microdialysis study in C57BL/6 and DBA/2 inbred mice. Psychoneuroendocrinology. 2007, 32: 746-757. 10.1016/j.psyneuen.2007.05.005.
CAS
PubMed
Google Scholar
Belzung C, Philippot P: Anxiety from a phylogenetic perspective: is there a qualitative difference between human and animal anxiety?. Neural Plast. 2007, 59676-
Google Scholar
Lucki I, Dalvi A, Mayorga AJ: Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice. Psychopharmacology. 2001, 155: 315-322. 10.1007/s002130100694.
CAS
PubMed
Google Scholar
Binder EB, Salyakina D, Lichtner P, Wochnik GM, Ising M, Putz B, Papiol S, Seaman S, Lucae S, Kohli MA, Nickel T, Kunzel HE, Fuchs B, Majer M, Pfennig A, Kern N, Brunner J, Modell S, Baghai T, Deiml T, Zill P, Bondy B, Rupprecht R, Messer T, Kohnlein O, Dabitz H, Bruckl T, Muller N, Pfister H, Lieb R, Mueller JC, Lohmussaar E, Strom TM, Bettecken T, Meitinger T, Uhr M, Rein T, Holsboer F, Muller-Myhsok B: Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment. Nat Genet. 2004, 36: 1319-1325. 10.1038/ng1479.
CAS
PubMed
Google Scholar
Wochnik GM, Ruegg J, Abel GA, Schmidt U, Holsboer F, Rein T: FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells. J Biol Chem. 2005, 280: 4609-4616. 10.1074/jbc.M407498200.
CAS
PubMed
Google Scholar
Uhr M, Tontsch A, Namendorf C, Ripke S, Lucae S, Ising M, Dose T, Ebinger M, Rosenhagen M, Kohli M, Kloiber S, Salyakina D, Bettecken T, Specht M, Putz B, Binder EB, Muller-Myhsok B, Holsboer F: Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression. Neuron. 2008, 57: 203-209. 10.1016/j.neuron.2007.11.017.
CAS
PubMed
Google Scholar
Ising M, Lucae S, Binder EB, Bettecken T, Uhr M, Ripke S, Kohli MA, Hennings JM, Horstmann S, Kloiber S, Menke A, Bondy B, Rupprecht R, Domschke K, Baune BT, Arolt V, Rush AJ, Holsboer F, Müller-Myhsok B: A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depression. Arch Gen Psychiatry. 2009, 66: 966-975. 10.1001/archgenpsychiatry.2009.95.
CAS
PubMed
PubMed Central
Google Scholar
Herr AS, Tsolakidou AF, Yassouridis A, Holsboer F, Rein T: Antidepressants differentially influence the transcriptional activity of the glucocorticoid receptor in vitro. Neuroendocrinology. 2003, 78: 12-22. 10.1159/000071701.
CAS
PubMed
Google Scholar
Montkowski A, Barden N, Wotjak C, Stec I, Ganster J, Meaney M, Engelmann M, Reul JM, Landgraf R, Holsboer F: Long-term antidepressant treatment reduces behavioural deficits in transgenic mice with impaired glucocorticoid receptor function. J Neuroendocrinol. 1995, 7: 841-845. 10.1111/j.1365-2826.1995.tb00724.x.
CAS
PubMed
Google Scholar
Neves SR, Ram PT, Iyengar R: G protein pathways. Science. 2002, 296: 1636-1639. 10.1126/science.1071550.
CAS
PubMed
Google Scholar
Khan ZU, Gutierrez A: Distribution of C-terminal splice variant of G alpha(i2) in rat and monkey brain. Neuroscience. 2004, 127: 833-843. 10.1016/j.neuroscience.2004.05.017.
CAS
PubMed
Google Scholar
Neves SR, Ram PT, Iyengar R: G protein pathways. Science. 2002, 296: 1636-1639. 10.1126/science.1071550.
CAS
PubMed
Google Scholar
Arinze IJ, Kawai Y: Transcriptional activation of the human G alpha(i2) gene promoter through nuclear factor-kappa B and antioxidant response elements. Journal of Biological Chemistry. 2005, 280: 9786-9795. 10.1074/jbc.M414006200.
CAS
Google Scholar
Turner PR, O'Connor K, Tate WP, Abraham WC: Roles of amyloid precursor protein and its fragments in regulating neural activity, plasticity and memory. Prog Neurobiol. 2003, 70: 1-32. 10.1016/S0301-0082(03)00089-3.
CAS
PubMed
Google Scholar
Panegyres PK: The functions of the amyloid precursor protein gene. Reviews in the Neurosciences. 2001, 12: 1-39.
CAS
PubMed
Google Scholar
Roch JM, Masliah E, Rochlevecq AC, Sundsmo MP, Otero DAC, Veinbergs I, Saitoh T: Increase of Synaptic Density and Memory Retention by A Peptide Representing the Trophic Domain of the Amyloid Beta/A4 Protein-Precursor. Proceedings of the National Academy of Sciences of the United States of America. 1994, 91: 7450-7454. 10.1073/pnas.91.16.7450.
CAS
PubMed
PubMed Central
Google Scholar
Mucke L, Abraham CR, Masliah E: Neurotrophic and neuroprotective effects of hAPP in transgenic mice. Neurobiology of Alzheimer'S Disease. 1996, 777: 82-88.
CAS
Google Scholar
Palacios G, Mengod G, Frey P, Palacios JM: Rapid Increase in Amyloid Precursor Protein Immunoreactivity in the Supraoptic and Paraventricular Nuclei of the Rat Hypothalamus After Osmotic-Stress. Neuroreport. 1995, 6: 265-268. 10.1097/00001756-199501000-00010.
CAS
PubMed
Google Scholar
Huber G, Bailly Y, Martin JR, Mariani J, Brugg B: Synaptic beta-amyloid precursor proteins increase with learning capacity in rats. Neuroscience. 1997, 80: 313-320. 10.1016/S0306-4522(97)00120-6.
CAS
PubMed
Google Scholar
Gralle M, Ferreira ST: Structure and functions of the human amyloid precursor protein: The whole is more than the sum of its parts. Progress in Neurobiology. 2007, 82: 11-32. 10.1016/j.pneurobio.2007.02.001.
CAS
PubMed
Google Scholar
Mattson MP, Duan WZ, Chan SL, Cheng AW, Haughey N, Gary DS, Guo ZH, Lee JW, Furukawa K: Neuroprotective and neurorestorative signal transduction mechanisms in brain aging: modification by genes, diet and behavior. Neurobiology of Aging. 2002, 23: 695-705. 10.1016/S0197-4580(02)00025-8.
CAS
PubMed
Google Scholar
Siman R, Card JP, Nelson RB, Davis LG: Expression of Beta-Amyloid Precursor Protein in Reactive Astrocytes Following Neuronal Damage. Neuron. 1989, 3: 275-285. 10.1016/0896-6273(89)90252-3.
CAS
PubMed
Google Scholar
Postina R, Schroeder A, Dewachter I, Bohl J, Schmitt U, Kojro E, Prinzen C, Endres K, Hiemke C, Blessing M, Flamez P, Dequenne A, Godaux E, van Leuven F, Fahrenholz F: A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model. Journal of Clinical Investigation. 2004, 113: 1456-1464.
CAS
PubMed Central
Google Scholar
Kirazov L, Loffler T, Schliebs R, Bigl V: Glutamate-stimulated secretion of amyloid precursor protein from cortical rat brain slices. Neurochemistry International. 1997, 30: 557-563. 10.1016/S0197-0186(96)00119-2.
CAS
PubMed
Google Scholar
Nitsch RM, Deng A, Wurtman RJ, Growdon JH: Metabotropic glutamate receptor subtype mGluR1 alpha stimulates the secretion of the amyloid beta-protein precursor ectodomain. Journal of Neurochemistry. 1997, 69: 704-712. 10.1046/j.1471-4159.1997.69020704.x.
CAS
PubMed
Google Scholar
Churchill GA: Fundamentals of experimental design for cDNA microarrays. Nature Genetics. 2002, 32: 490-495. 10.1038/ng1031.
CAS
PubMed
Google Scholar
Deussing JM, Kuehne C, Puetz B, Panhuysen M, Breu J, Stenzel-Poore M, Holsboer F, Wurst W: Expression profiling identifies the CRH/CRH-R1 system as a modulator of neurovascular gene activity. J Cereb Blood Flow Metab. 2007, 27: 1476-1495. 10.1038/sj.jcbfm.9600451.
CAS
PubMed
Google Scholar
Hackl H, Cabo FS, Sturn A, Wolkenhauer O, Trajanoski Z: Analysis of DNA microarray data. Current Topics in Medicinal Chemistry. 2004, 4: 1357-1370. 10.2174/1568026043387773.
CAS
PubMed
Google Scholar
Yang YH, Dudoit S, Luu P, Lin DM, Peng V, Ngai J, Speed TP: Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res. 2002, 30: e15-10.1093/nar/30.4.e15.
PubMed
PubMed Central
Google Scholar
Schmidt MV, Deussing JM, Oitzl MS, Ohl F, Levine S, Wurst W, Holsboer F, Müller MB, de Kloet ER: Differential disinhibition of the neonatal hypothalamic-pituitary-adrenal axis in brain-specific CRH receptor 1-knockout mice. European Journal of Neuroscience. 2006, 24: 2291-2298. 10.1111/j.1460-9568.2006.05121.x.
CAS
Google Scholar
Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(T)(-Delta Delta C) method. Methods. 2001, 25: 402-408. 10.1006/meth.2001.1262.
CAS
PubMed
Google Scholar