Stern JH, Rutkowski JM, Scherer PE. Adiponectin, leptin, and fatty acids in the maintenance of metabolic homeostasis through adipose tissue crosstalk. Cell Metab. 2016;23:770–84.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hong P, Yu M, Tian W. Diverse rnas in adipose-derived extracellular vesicles and their therapeutic potential. Mol Ther Nucleic Acids. 2021;26:665–77.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bartelt A, Heeren J. Adipose tissue browning and metabolic health. Nat Rev Endocrinol. 2014;10:24–36.
Article
CAS
PubMed
Google Scholar
Wu J, Bostrom P, Sparks LM, Ye L, Choi JH, Giang AH, Khandekar M, Virtanen KA, Nuutila P, Schaart G, et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell. 2012;150:366–76.
Article
CAS
PubMed
PubMed Central
Google Scholar
Villarroya F, Cereijo R, Villarroya J, Giralt M. Brown adipose tissue as a secretory organ. Nat Rev Endocrinol. 2016;13:26–35.
Article
PubMed
CAS
Google Scholar
Thomou T, Mori MA, Dreyfuss JM, Konishi M, Sakaguchi M, Wolfrum C, Rao TN, Winnay JN, Garcia-Martin R, Grinspoon SK, et al. Adipose-derived circulating mirnas regulate gene expression in other tissues. Nature. 2017;542:450–5.
Article
CAS
PubMed
PubMed Central
Google Scholar
Deshmukh AS, Peijs L, Beaudry JL, Jespersen NZ, Nielsen CH, Ma T, Brunner AD, Larsen TJ, Bayarri-Olmos R, Prabhakar BS, et al. Proteomics-based comparative mapping of the secretomes of human brown and white adipocytes reveals epdr1 as a novel batokine. Cell Metab. 2019;30(963–975):e967.
Google Scholar
Stanford KI, Middelbeek RJ, Townsend KL, An D, Nygaard EB, Hitchcox KM, Markan KR, Nakano K, Hirshman MF, Tseng YH, et al. Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. J Clin Invest. 2013;123:215–23.
Article
CAS
PubMed
Google Scholar
Thery C, Witwer KW, Aikawa E, Alcaraz MJ, Anderson JD, Andriantsitohaina R, Antoniou A, Arab T, Archer F, Atkin-Smith GK, et al. Minimal information for studies of extracellular vesicles 2018 (misev2018): A position statement of the international society for extracellular vesicles and update of the misev2014 guidelines. J Extracell Vesicles. 2018;7:1535750.
Article
PubMed
PubMed Central
Google Scholar
Kim KM, Abdelmohsen K, Mustapic M, Kapogiannis D, Gorospe M. Rna in extracellular vesicles. Wiley Interdiscip Rev RNA. 2017;8:10.
Article
PubMed Central
CAS
Google Scholar
Zhou X, Li Z, Qi M, Zhao P, Duan Y, Yang G, Yuan L. Brown adipose tissue-derived exosomes mitigate the metabolic syndrome in high fat diet mice. Theranostics. 2020;10:8197–210.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jung YJ, Kim HK, Cho Y, Choi JS, Woo CH, Lee KS, Sul JH, Lee CM, Han J, Park JH, et al. Cell reprogramming using extracellular vesicles from differentiating stem cells into white/beige adipocytes. Sci Adv. 2020;6:6721.
Article
CAS
Google Scholar
Li CJ, Fang QH, Liu ML, Lin JN. Current understanding of the role of adipose-derived extracellular vesicles in metabolic homeostasis and diseases: Communication from the distance between cells/tissues. Theranostics. 2020;10:7422–35.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ji C, Guo X. The clinical potential of circulating micrornas in obesity. Nat Rev Endocrinol. 2019;15:731–43.
Article
CAS
PubMed
Google Scholar
Ying W, Riopel M, Bandyopadhyay G, Dong Y, Birmingham A, Seo JB, Ofrecio JM, Wollam J, Hernandez-Carretero A, Fu W, et al. Adipose tissue macrophage-derived exosomal mirnas can modulate in vivo and in vitro insulin sensitivity. Cell. 2017;171(372–384): e312.
Article
CAS
Google Scholar
Wu H, Yang L, Chen LL. The diversity of long noncoding rnas and their generation. Trends Genet. 2017;33:540–52.
Article
CAS
PubMed
Google Scholar
Bai Z, Chai XR, Yoon MJ, Kim HJ, Lo KA, Zhang ZC, Xu D, Siang DTC, Walet ACE, Xu SH, et al. Dynamic transcriptome changes during adipose tissue energy expenditure reveal critical roles for long noncoding rna regulators. PLoS Biol. 2017;15: e2002176.
Article
PubMed
PubMed Central
CAS
Google Scholar
Li S, Mi L, Yu L, Yu Q, Liu T, Wang GX, Zhao XY, Wu J, Lin JD. Zbtb7b engages the long noncoding rna blnc1 to drive brown and beige fat development and thermogenesis. Proc Natl Acad Sci USA. 2017;114:E7111–20.
Tait S, Baldassarre A, Masotti A, Calura E, Martini P, Varì R, Scazzocchio B, Gessani S, Del Cornò M. Integrated transcriptome analysis of human visceral adipocytes unravels dysregulated microrna-long non-coding rna-mrna networks in obesity and colorectal cancer. Front Oncol. 2020;10:1089.
Article
PubMed
PubMed Central
Google Scholar
Schmidt E, Dhaouadi I, Gaziano I, Oliverio M, Klemm P, Awazawa M, Mitterer G, Fernandez-Rebollo E, Pradas-Juni M, Wagner W, et al. Lincrna h19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat. Nat Commun. 2018;9:3622.
Article
PubMed
PubMed Central
CAS
Google Scholar
Zhao XY, Li S, Wang GX, Yu Q, Lin JD. A long noncoding rna transcriptional regulatory circuit drives thermogenic adipocyte differentiation. Mol Cell. 2014;55:372–82.
Article
CAS
PubMed
PubMed Central
Google Scholar
Alvarez-Dominguez JR, Bai Z, Xu D, Yuan B, Lo KA, Yoon MJ, Lim YC, Knoll M, Slavov N, Chen S, et al. De novo reconstruction of adipose tissue transcriptomes reveals long non-coding rna regulators of brown adipocyte development. Cell Metab. 2015;21:764–76.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ding C, Lim YC, Chia SY, Walet ACE, Xu S, Lo KA, Zhao Y, Zhu D, Shan Z, Chen Q, et al. De novo reconstruction of human adipose transcriptome reveals conserved lncrnas as regulators of brown adipogenesis. Nat Commun. 2018;9:1329.
Article
PubMed
PubMed Central
CAS
Google Scholar
Guttman M, Amit I, Garber M, French C, Lin MF, Feldser D, Huarte M, Zuk O, Carey BW, Cassady JP, et al. Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals. Nature. 2009;2458:223–7.
Article
CAS
Google Scholar
Khalil AM, Guttman M, Huarte M, Garber M, Raj A, Rivea Morales D, Thomas K, Presser A, Bernstein BE, van Oudenaarden A, et al. Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc Natl Acad Sci USA. 2009;106:11667–72.
Hong P, Xu X, Hu X, Yang H, Wu Y, Chen J, Li K, Tang Z. Therapeutic potential of small extracellular vesicles derived from lipoma tissue in adipose tissue regeneration-an in vitro and in vivo study. Stem Cell Res Ther. 2021;12:222.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhang Y, Yu M, Dai M, Chen C, Tang Q, Jing W, Wang H, Tian W. Mir-450a-5p within rat adipose tissue exosome-like vesicles promotes adipogenic differentiation by targeting wisp2. J Cell Sci. 2017;130:1158–68.
CAS
PubMed
Google Scholar
Dai M, Yu M, Zhang Y, Tian W. Exosome-like vesicles derived from adipose tissue provide biochemical cues for adipose tissue regeneration. Tissue Eng Part A. 2017;23:1221–30.
Article
CAS
PubMed
Google Scholar
Wei M, Gao X, Liu L, Li Z, Wan Z, Dong Y, Chen X, Niu Y, Zhang J, Yang G. Visceral adipose tissue derived exosomes exacerbate colitis severity via pro-inflammatory mirnas in high fat diet fed mice. ACS Nano. 2020;14:5099–110.
Article
CAS
PubMed
Google Scholar
Fayyad AM, Khan AA, Abdallah SH, Alomran SS, Bajou K, Khattak MNK. Rosiglitazone enhances browning adipocytes in association with mapk and pi3-k pathways during the differentiation of telomerase-transformed mesenchymal stromal cells into adipocytes. Int J Mol Sci. 2019;20:1618.
Article
CAS
PubMed Central
Google Scholar
Ohno H, Shinoda K, Spiegelman BM, Kajimura S. Pparγ agonists induce a white-to-brown fat conversion through stabilization of prdm16 protein. Cell Metab. 2012;15:395–404.
Article
CAS
PubMed
PubMed Central
Google Scholar
Dong J, Wu Y, Zhang Y, Yu M, Tian W. Comparison of the therapeutic effect of allogeneic and xenogeneic small extracellular vesicles in soft tissue repair. Int J Nanomedicine. 2020;15:6975–91.
Article
CAS
PubMed
PubMed Central
Google Scholar
Farmer SR. Brown fat and skeletal muscle: Unlikely cousins? Cell. 2008;134:726–7.
Article
CAS
PubMed
Google Scholar
Patrick S, Bryan B, Wenli Y, Shingo K, Sherry C, Shihuan K, Anthony S, Srikripa D, Conroe HM, Hediye EB, et al. Prdm16 controls a brown fat/skeletal muscle switch. Nature. 2019;454:961–7.
Google Scholar
Born LJ, Harmon JW, Jay SM. Therapeutic potential of extracellular vesicle-associated long noncoding rna. Bioeng Transl Med. 2020;5: e10172.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhu J, Yu W, Wang Y, Xia K, Huang Y, Xu A, Chen Q, Liu B, Tao H, Li F, et al. Lncrnas: Function and mechanism in cartilage development, degeneration, and regeneration. Stem Cell Res Ther. 2019;10:344.
Article
PubMed
PubMed Central
Google Scholar
Wang Y, Hua S, Cui X, Cao Y, Wen J, Chi X, Ji C, Pang L, You L. The effect of foxc2-as1 on white adipocyte browning and the possible regulatory mechanism. Front Endocrinol (Lausanne). 2020;11: 565483.
Article
Google Scholar
Feng J, Xu H, Pan F, Hu J, Wu Y, Lin N, Zhang X, Ji C, Hu Y, Zhong H, et al. An integrated analysis of mrna and lncrna expression profiles indicates their potential contribution to brown fat dysfunction with aging. Front Endocrinol (Lausanne). 2020;11:46.
Article
Google Scholar
Yang X, Fu Y, Hu F, Luo X, Hu J, Wang G. Pik3r3 regulates pparα expression to stimulate fatty acid β-oxidation and decrease hepatosteatosis. Exp Mol Med. 2018;50:e431.
Jiao L, Zhang HL, Li DD, Yang KL, Tang J, Li X, Ji J, Yu Y, Wu RY, Ravichandran S, et al. Regulation of glycolytic metabolism by autophagy in liver cancer involves selective autophagic degradation of hk2 (hexokinase 2). Autophagy. 2018;14:671–84.
Article
CAS
PubMed
Google Scholar
Sun MW, Lee JY, de Bakker PI, Burtt NP, Almgren P, Råstam L, Tuomi T, Gaudet D, Daly MJ, Hirschhorn JN, et al. Haplotype structures and large-scale association testing of the 5’ amp-activated protein kinase genes prkaa2, prkab1, and prkab2 [corrected] with type 2 diabetes. Diabetes. 2006;55:849–55.
Willert K, Brown JD, Danenberg E, Duncan AW, Weissman IL, Reya T, Yates JR 3rd, Nusse R. Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature. 2003;423:448–52.
Article
CAS
PubMed
Google Scholar
Lo KA, Ng PY, Kabiri Z, Virshup D, Sun L. Wnt inhibition enhances browning of mouse primary white adipocytes. Adipocyte. 2016;5:224–31.
Article
CAS
PubMed
PubMed Central
Google Scholar
Chen N, Wang J. Wnt/β-catenin signaling and obesity Front Physiol. 2018;9:792.
PubMed
Google Scholar
Zhang Y, Li R, Meng Y, Li S, Donelan W, Zhao Y, Qi L, Zhang M, Wang X, Cui T, et al. Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 map kinase and erk map kinase signaling. Diabetes. 2014;63:514–25.
Article
CAS
PubMed
Google Scholar
Geller S, Arribat Y, Netzahualcoyotzi C, Lagarrigue S, Carneiro L, Zhang L, Amati F, Lopez-Mejia IC, Pellerin L. Tanycytes regulate lipid homeostasis by sensing free fatty acids and signaling to key hypothalamic neuronal populations via fgf21 secretion. Cell Metab. 2019;30:833-844.e7.
Article
CAS
PubMed
Google Scholar
Quinn JJ, Chang HY. Unique features of long non-coding rna biogenesis and function. Nat Rev Genet. 2016;17:47–62.
Article
CAS
PubMed
Google Scholar