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  1. The underlying strategies used by influenza A viruses (IAVs) to adapt to new hosts while crossing the species barrier are complex and yet to be understood completely. Several studies have been published identi...

    Authors: Zeeshan Khaliq, Mikael Leijon, Sándor Belák and Jan Komorowski
    Citation: BMC Genomics 2016 17:529
    Content type: Research Article Published on:

  2. The rise of the primate lineage is accompanied by an outstanding emergence of microRNAs, small non-coding RNAs with a prominent role in gene regulation. In spite of their biological importance little is known ...

    Authors: Gabriel Santpere, Maria Lopez-Valenzuela, Natalia Petit-Marty, Arcadi Navarro and Yolanda Espinosa-Parrilla
    Citation: BMC Genomics 2016 17:528
    Content type: Research article Published on:

  4. Recently, a physical model of nucleosome formation based on sequence-dependent bending properties of the DNA double-helix has been used to reveal some enrichment of nucleosome-inhibiting energy barriers (NIEBs...

    Authors: Guénola Drillon, Benjamin Audit, Françoise Argoul and Alain Arneodo
    Citation: BMC Genomics 2016 17:526
    Content type: Research Article Published on:

  6. Teleosts are exposed to a broad range of external stimuli, which may be either of acute or chronic nature. The larval phase of certain fish species offer a unique opportunity to study the interactions between ...

    Authors: E. Sarropoulou, A. Tsalafouta, A. Y. M. Sundaram, G. D. Gilfillan, G. Kotoulas, N. Papandroulakis and M. Pavlidis
    Citation: BMC Genomics 2016 17:506
    Content type: Research article Published on:

  7. The allotetraploid durum wheat [Triticum turgidum subsp. durum (Desf.) Husn.] is a highly economically important species especially in the Mediterranean basin. However, its genomics, transcriptomics and in partic...

    Authors: Domenico De Paola, Diana L. Zuluaga and Gabriella Sonnante
    Citation: BMC Genomics 2016 17:505
    Content type: Research article Published on:

  8. The study of local adaptation processes is a very important research topic in the field of population genomics. There is a particular interest in the study of human populations because they underwent a process...

    Authors: Alexandra I. Vatsiou, Eric Bazin and Oscar E. Gaggiotti
    Citation: BMC Genomics 2016 17:504
    Content type: Research article Published on:

  10. O1 Regulation of genes by telomere length over long distances

    Authors: Jerry W. Shay, Noriko Homma, Ruyun Zhou, Muhammad Imran Naseer, Adeel G. Chaudhary, Mohammed Al-Qahtani, Nobutaka Hirokawa, Maryam Goudarzi, Albert J. Fornace Jr., Saleh Baeesa, Deema Hussain, Mohammed Bangash, Fahad Alghamdi, Hans-Juergen Schulten, Angel Carracedo, Ishaq Khan…
    Citation: BMC Genomics 2016 17(Suppl 6):487
    Content type: Meeting abstracts Published on:

    This article is part of a Supplement: Volume 17 Supplement 6

  12. The current approach to reducing the tendency for wheat grown under high fertilizer conditions to collapse (lodge) under the weight of its grain is based on reducing stem height via the introduction of Rht genes....

    Authors: Charlotte N. Miller, Andrea L. Harper, Martin Trick, Peter Werner, Keith Waldron and Ian Bancroft
    Citation: BMC Genomics 2016 17:500
    Content type: Research article Published on:

  13. Authors: Maurício A. Mudadu, Laercio R. Porto-Neto, Fabiana B. Mokry, Polyana C. Tizioto, Priscila S. N. Oliveira, Rymer R. Tullio, Renata T. Nassu, Simone C. M. Niciura, Patrícia Tholon, Maurício M. Alencar, Roberto H. Higa, Antônio N. Rosa, Gélson L. D. Feijó, André L. J. Ferraz, Luiz O. C. Silva, Sérgio R. Medeiros…
    Citation: BMC Genomics 2016 17:492
    Content type: Erratum Published on:

    The original article was published in BMC Genomics 2016 17:235

  14. Biocides and antibiotics are used to eradicate or prevent the growth of microbial species on surfaces (occasionally on catheters), or infected sites, either in combination or sequentially, raising concerns abo...

    Authors: Tânia Curiao, Emmanuela Marchi, Denis Grandgirard, Ricardo León-Sampedro, Carlo Viti, Stephen L. Leib, Fernando Baquero, Marco R. Oggioni, José Luis Martinez and Teresa M. Coque
    Citation: BMC Genomics 2016 17:491
    Content type: Research article Published on:

  15. Meiosis is a form of specialized cell division that marks the transition from diploid meiocyte to haploid gamete, and provides an opportunity for genetic reassortment through recombination. Experimental data i...

    Authors: Nathalia M. V. Flórez-Zapata, M. Humberto Reyes-Valdés and Octavio Martínez
    Citation: BMC Genomics 2016 17:490
    Content type: Research article Published on:

  17. In clinical practice, it is difficult to monitor the repeating relapse in patients who have been suffering from systemic lupus erythematosus (SLE). The underlying etiology remains largely unknown.

    Authors: Donge Tang, Yuyu Chen, Huiyan He, Jianrong Huang, Wenbiao Chen, Wujian Peng, Qianjin Lu and Yong Dai
    Citation: BMC Genomics 2016 17:488
    Content type: Research article Published on:

  18. The ability to capture and sequence large contiguous DNA fragments represents a significant advancement towards the comprehensive characterization of complex genomic regions. While emerging sequencing platform...

    Authors: Johannes Dapprich, Deborah Ferriola, Kate Mackiewicz, Peter M. Clark, Eric Rappaport, Monica D’Arcy, Ariella Sasson, Xiaowu Gai, Jonathan Schug, Klaus H. Kaestner and Dimitri Monos
    Citation: BMC Genomics 2016 17:486
    Content type: Methodology article Published on:

  19. Citrus blight is a citrus tree overall decline disease and causes serious losses in the citrus industry worldwide. Although it was described more than one hundred years ago, its causal agent remains unknown an...

    Authors: Yunzeng Zhang, Gary Barthe, Jude W. Grosser and Nian Wang
    Citation: BMC Genomics 2016 17:485
    Content type: Research article Published on:

  20. Salmon lice, Lepeophtheirus salmonis (Copepoda: Caligidae), are highly important ectoparasites of farmed and wild salmonids, and cause multi-million dollar losses to the salmon aquaculture industry annually. Salm...

    Authors: Jordan D. Poley, Ben J. G. Sutherland, Simon R. M. Jones, Ben F. Koop and Mark D. Fast
    Citation: BMC Genomics 2016 17:483
    Content type: Research article Published on:

  21. The cell wall is essential for the yeast to hypha (Y-H) transition that enables Candida albicans to invade human tissues and evade the immune system. The main constituent, β(1,3)-glucan, is remodeled by glucanosy...

    Authors: Genny Degani, Enrico Ragni, Pedro Botias, Davide Ravasio, Julia Calderon, Elena Pianezzola, Jose Manuel Rodriguez-Peña, Maria Antonietta Vanoni, Javier Arroyo, William A. Fonzi and Laura Popolo
    Citation: BMC Genomics 2016 17:482
    Content type: Research article Published on:

  23. Immunocompromised individuals with chronic norovirus (NoV) infection and elderly patients are hypothesized to be reservoirs where NoV might accumulate mutations and evolve into pandemic strains. Next generatio...

    Authors: Maria E. Hasing, Bart Hazes, Bonita E. Lee, Jutta K. Preiksaitis and Xiaoli L. Pang
    Citation: BMC Genomics 2016 17:480
    Content type: Research article Published on:

  24. Bovine arthrogryposis multiplex congenita (AMC) is a syndromic term for a congenital condition characterized by multiple joint contractures. Rare inherited forms of bovine AMC have been reported in different b...

    Authors: Jørgen S. Agerholm, Fintan J. McEvoy, Fiona Menzi, Vidhya Jagannathan and Cord Drögemüller
    Citation: BMC Genomics 2016 17:479
    Content type: Research article Published on:

  25. Grapes are one of the world’s most valuable crops and most are made into wine. Grapes belong to the genus Vitis, which includes over 60 inter-fertile species. The most common grape cultivars derive their entire a...

    Authors: Zoë Migicovsky, Jason Sawler, Daniel Money, Rudolph Eibach, Allison J. Miller, James J. Luby, Andrew R. Jamieson, Dianne Velasco, Sven von Kintzel, John Warner, Walter Wührer, Patrick J. Brown and Sean Myles
    Citation: BMC Genomics 2016 17:478
    Content type: Research article Published on:

  26. Prostatic Acid Phosphatase (PAP) is an enzyme that is produced primarily in the prostate and functions as a cell growth regulator and potential tumor suppressor. Understanding the genetic regulation of this en...

    Authors: Lyndsay A. Staley, Mark T. W. Ebbert, Daniel Bunker, Matthew Bailey, Perry G. Ridge, Alison M. Goate and John S. K. Kauwe
    Citation: BMC Genomics 2016 17(Suppl 3):439
    Content type: Research Published on:

    This article is part of a Supplement: Volume 17 Supplement 3

  27. Alzheimer's disease is the leading cause of dementia in the elderly and the third most common cause of death in the United States. A vast number of genes regulate Alzheimer’s disease, including Presenilin 1 (PSEN...

    Authors: Ariel A. Hippen, Mark T. W. Ebbert, Maria C. Norton, JoAnn T. Tschanz, Ronald G. Munger, Christopher D. Corcoran and John S. K. Kauwe
    Citation: BMC Genomics 2016 17(Suppl 3):438
    Content type: Research Published on:

    This article is part of a Supplement: Volume 17 Supplement 3

  28. CCL16 is a chemokine predominantly expressed in the liver, but is also found in the blood and brain, and is known to play important roles in immune response and angiogenesis. Little is...

    Authors: Mark T. W. Ebbert, Lyndsay A. Staley, Joshua Parker, Sheradyn Parker, Matthew Bailey, Perry G. Ridge, Alison M. Goate and John S. K. Kauwe
    Citation: BMC Genomics 2016 17(Suppl 3):437
    Content type: Research Published on:

    This article is part of a Supplement: Volume 17 Supplement 3

  29. Prolactin is a polypeptide hormone secreted by the anterior pituitary gland that plays an essential role in lactation, tissue growth, and suppressing apoptosis to increase cell survival. Prolactin serves as a ...

    Authors: Lyndsay A. Staley, Mark T. W. Ebbert, Sheradyn Parker, Matthew Bailey, Perry G. Ridge, Alison M. Goate and John S. K. Kauwe
    Citation: BMC Genomics 2016 17(Suppl 3):436
    Content type: Research Published on:

    This article is part of a Supplement: Volume 17 Supplement 3

  30. A number of researchers have speculated that neurological disorders are mostly due to the interaction of common susceptibility genes with environmental, epigenetic and stochastic factors. Genetic factors such ...

    Authors: Gaurav Kaushik, Yu Xia, Luobin Yang and Michael A. Thomas
    Citation: BMC Genomics 2016 17(Suppl 3):435
    Content type: Research Published on:

    This article is part of a Supplement: Volume 17 Supplement 3

  31. Gibberella stalk rot caused by Fusarium graminearum is one of the most destructive soil-borne diseases of maize (Zea mays L.). Chemical means of controlling Gibberella stalk rot are no...

    Authors: Yongjie Liu, Yanling Guo, Chuanyu Ma, Dongfeng Zhang, Chao Wang and Qin Yang
    Citation: BMC Genomics 2016 17:477
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Genomics 2016 17:830

  32. Signalling pathways underlie development, behaviour and pathology. To understand patterns in the evolution of signalling pathways, we undertook a comprehensive investigation of the pathways that control the sw...

    Authors: Aude Gilabert, David M. Curran, Simon C. Harvey and James D. Wasmuth
    Citation: BMC Genomics 2016 17:476
    Content type: Research article Published on:

  33. The recent Xylella fastidiosa subsp. pauca (Xfp) outbreak in olive (Olea europaea) groves in southern Italy is causing a destructive disease denoted Olive Quick Decline Syndrome (OQDS). Field observations disclos...

    Authors: Annalisa Giampetruzzi, Massimiliano Morelli, Maria Saponari, Giuliana Loconsole, Michela Chiumenti, Donato Boscia, Vito N. Savino, Giovanni P. Martelli and Pasquale Saldarelli
    Citation: BMC Genomics 2016 17:475
    Content type: Research article Published on:

  34. Perilla (Perilla frutescens (L.) var frutescens) produces high levels of α-linolenic acid (ALA), a ω-3 fatty acid important to health and development. To uncover key genes involved in fatty acid (FA) and triacylg...

    Authors: Hyun Uk Kim, Kyeong-Ryeol Lee, Donghwan Shim, Jeong Hee Lee, Grace Q. Chen and Seongbin Hwang
    Citation: BMC Genomics 2016 17:474
    Content type: Research article Published on:

  35. Gene fusions are the most powerful type of in silico-derived functional associations. However, many fusion compilations were made when <100 genomes were available, and algorithms for identifying fusions need upda...

    Authors: Christopher S. Henry, Claudia Lerma-Ortiz, Svetlana Y. Gerdes, Jeffrey D. Mullen, Ric Colasanti, Aleksey Zhukov, Océane Frelin, Jennifer J. Thiaville, Rémi Zallot, Thomas D. Niehaus, Ghulam Hasnain, Neal Conrad, Andrew D. Hanson and Valérie de Crécy-Lagard
    Citation: BMC Genomics 2016 17:473
    Content type: Research article Published on:

  36. Appropriate protein subcellular localization is essential for proper cellular function. Central to the regulation of protein localization are protein targeting motifs, stretches of amino acids serving as guide...

    Authors: Mikael-Jonathan Luce, Anna Akuvi Akpawu, Daniel C. Tucunduva, Spencer Mason and Michelle S. Scott
    Citation: BMC Genomics 2016 17:472
    Content type: Research article Published on:

  37. Infectious disease involving multiple genetically distinct populations of pathogens is frequently concurrent, but difficult to detect or describe with current routine methodology. Cryptosporidium sp. is a widespr...

    Authors: Karin Troell, Björn Hallström, Anna-Maria Divne, Cecilia Alsmark, Romanico Arrighi, Mikael Huss, Jessica Beser and Stefan Bertilsson
    Citation: BMC Genomics 2016 17:471
    Content type: Research article Published on:

  38. Alzheimer’s disease (AD) represents the most common form of dementia in elder populations with approximately 30 million cases worldwide. Genome wide genotyping and sequencing studies have identified many genet...

    Authors: Kristin L. Ayers, Uyenlinh L. Mirshahi, Amr H. Wardeh, Michael F. Murray, Ke Hao, Benjamin S. Glicksberg, Shuyu Li, David J. Carey and Rong Chen
    Citation: BMC Genomics 2016 17(Suppl 2):445
    Content type: Research article Published on:

    This article is part of a Supplement: Volume 17 Supplement 2

  39. Next generation sequencing (NGS) provides a key technology for deciphering the genetic underpinnings of human diseases. Typical NGS analyses of a patient depict tens of thousands non-reference coding variants,...

    Authors: Gil Stelzer, Inbar Plaschkes, Danit Oz-Levi, Anna Alkelai, Tsviya Olender, Shahar Zimmerman, Michal Twik, Frida Belinky, Simon Fishilevich, Ron Nudel, Yaron Guan-Golan, David Warshawsky, Dvir Dahary, Asher Kohn, Yaron Mazor, Sergey Kaplan…
    Citation: BMC Genomics 2016 17(Suppl 2):444
    Content type: Methodology article Published on:

    This article is part of a Supplement: Volume 17 Supplement 2

  41. Modern genomic techniques allow to associate several Mendelian human diseases to single residue variations in different proteins. Molecular mechanisms explaining the relationship among genotype and phenotype a...

    Authors: Pier Luigi Martelli, Piero Fariselli, Castrense Savojardo, Giulia Babbi, Francesco Aggazio and Rita Casadio
    Citation: BMC Genomics 2016 17(Suppl 2):397
    Content type: Research article Published on:

    This article is part of a Supplement: Volume 17 Supplement 2

  42. The association between aberrant signal processing by protein kinases and human diseases such as cancer was established long time ago. However, understanding the link between sequence variants in the protein k...

    Authors: Tirso Pons, Miguel Vazquez, María Luisa Matey-Hernandez, Søren Brunak, Alfonso Valencia and Jose MG Izarzugaza
    Citation: BMC Genomics 2016 17(Suppl 2):396
    Content type: Methodology article Published on:

    This article is part of a Supplement: Volume 17 Supplement 2

  43. Somatic mutations in cancer cells affect various genomic elements disrupting important cell functions. In particular, mutations in DNA binding sites recognized by transcription factors can alter regulator bind...

    Authors: Ilya E. Vorontsov, Grigory Khimulya, Elena N. Lukianova, Daria D. Nikolaeva, Irina A. Eliseeva, Ivan V. Kulakovskiy and Vsevolod J. Makeev
    Citation: BMC Genomics 2016 17(Suppl 2):395
    Content type: Research article Published on:

    This article is part of a Supplement: Volume 17 Supplement 2

  44. An important step towards personalizing cancer treatment is to integrate heterogeneous evidences to catalog mutational hotspots that are biologically and therapeutically relevant and thus represent where targe...

    Authors: Tenghui Chen, Zixing Wang, Wanding Zhou, Zechen Chong, Funda Meric-Bernstam, Gordon B. Mills and Ken Chen
    Citation: BMC Genomics 2016 17(Suppl 2):394
    Content type: Research article Published on:

    This article is part of a Supplement: Volume 17 Supplement 2

  45. The regulatory effect of inherited or de novo genetic variants occurring in promoters as well as in transcribed or even coding gene regions is gaining greater recognition as a contributing factor to disease proce...

    Authors: Alexander Kaplun, Mathias Krull, Karthick Lakshman, Volker Matys, Birgit Lewicki and Jennifer D. Hogan
    Citation: BMC Genomics 2016 17(Suppl 2):393
    Content type: Methodology article Published on:

    This article is part of a Supplement: Volume 17 Supplement 2

  46. The capsular polysaccharide is the principal virulence factor of Streptococcus pneumoniae and a target for current pneumococcal vaccines. However, some pathogenic pneumococci are serologically nontypeable [nontyp...

    Authors: Thabo Mohale, Nicole Wolter, Mushal Allam, Kedibone Ndlangisa, Penny Crowther-Gibson, Mignon du Plessis and Anne von Gottberg
    Citation: BMC Genomics 2016 17:470
    Content type: Research article Published on:

  48. Litter size and piglet mortality are important traits in pig production. The study aimed to identify quantitative trait loci (QTL) for litter size and mortality traits, including total number of piglets born (...

    Authors: Xiangyu Guo, Guosheng Su, Ole Fredslund Christensen, Luc Janss and Mogens Sandø Lund
    Citation: BMC Genomics 2016 17:468
    Content type: Research article Published on:

  49. Alternative splicing (AS) is a major source of variability in the transcriptome of eukaryotes. There is an increasing interest in its role in different pathologies. Before sequencing technology appeared, AS wa...

    Authors: Juan P. Romero, Ander Muniategui, Fernando J. De Miguel, Ander Aramburu, Luis Montuenga, Ruben Pio and Angel Rubio
    Citation: BMC Genomics 2016 17:467
    Content type: Methodology article Published on:

  50. The sacred lotus (Nelumbo nucifera) is widely cultivated in China for its edible rhizomes and seeds. Traditional plant breeding methods have been used to breed cultivars with increased yields and quality of rhizo...

    Authors: Zhengwei Liu, Honglian Zhu, Yuping Liu, Jing Kuang, Kai Zhou, Fan Liang, Zhenhua Liu, Depeng Wang and Weidong Ke
    Citation: BMC Genomics 2016 17:466
    Content type: Research article Published on:

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