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  1. Cellular membranes are crucial host components utilized by positive-strand RNA viruses for replication of their genomes. Published studies have suggested that the synthesis and distribution of membrane lipids ...

    Authors: Kathryn M Castorena, Kenneth A Stapleford and David J Miller
    Citation: BMC Genomics 2010 11:183
    Content type: Research article Published on:

  2. Over the past decades, extensive comparative mapping research has been performed in the plant family Solanaceae. The recent identification of a large set of single-copy conserved orthologous (COSII) markers ha...

    Authors: Feinan Wu and Steven D Tanksley
    Citation: BMC Genomics 2010 11:182
    Content type: Research article Published on:

  3. Legionella pneumophila subsp. pneumophila is a gram-negative γ-Proteobacterium and the causative agent of Legionnaires' disease, a form of epidemic pneumonia. It has a water-related life cycle. In industrialized ...

    Authors: Giuseppe D'Auria, Nuria Jiménez-Hernández, Francesc Peris-Bondia, Andrés Moya and Amparo Latorre
    Citation: BMC Genomics 2010 11:181
    Content type: Research article Published on:

  4. Massively parallel sequencing of cDNA is now an efficient route for generating enormous sequence collections that represent expressed genes. This approach provides a valuable starting point for characterizing ...

    Authors: Thomas L Parchman, Katherine S Geist, Johan A Grahnen, Craig W Benkman and C Alex Buerkle
    Citation: BMC Genomics 2010 11:180
    Content type: Research article Published on:

  5. The ribosomal protein SA (RPSA), previously named 37-kDa laminin receptor precursor/67-kDa laminin receptor (LRP/LR) is a multifunctional protein that plays a role in a number of pathological processes, such a...

    Authors: Alice Van den Broeke, Mario Van Poucke, Ane Marcos-Carcavilla, Karine Hugot, Hélène Hayes, Maud Bertaud, Alex Van Zeveren and Luc J Peelman
    Citation: BMC Genomics 2010 11:179
    Content type: Research article Published on:

  7. The superfamily of ABC proteins is among the largest known in nature. Its members are mainly, but not exclusively, involved in the transport of a broad range of substrates across biological membranes. Many con...

    Authors: Andriy Kovalchuk and Arnold JM Driessen
    Citation: BMC Genomics 2010 11:177
    Content type: Research article Published on:

  8. The mouse skeletal muscle is composed of four distinct fiber types that differ in contractile function, number of mitochondria and metabolism. Every muscle type has a specific composition and distribution of t...

    Authors: Janneke de Wilde, Martijn FM Hulshof, Mark V Boekschoten, Philip de Groot, Egbert Smit and Edwin CM Mariman
    Citation: BMC Genomics 2010 11:176
    Content type: Research article Published on:

  9. RNA inhibition by siRNAs is a frequently used approach to identify genes required for specific biological processes. However RNAi screening using siRNAs is hampered by non-specific or off target effects of the...

    Authors: Ian Sudbery, Anton J Enright, Andrew G Fraser and Ian Dunham
    Citation: BMC Genomics 2010 11:175
    Content type: Research article Published on:

  10. Ostrinia nubilalis (ECB) and Sesamia nonagrioides (MCB) are two maize stem borers which cause important losses in temperate maize production, but QTL analyses for corn borer resistance were mostly restricted to E...

    Authors: Bernardo Ordas, Rosa A Malvar, Rogelio Santiago and Ana Butron
    Citation: BMC Genomics 2010 11:174
    Content type: Research article Published on:

  11. Insect cuticle plays essential roles in many physiological functions. During molting and metamorphosis tremendous changes occur in silkworm cuticle where multiple proteins exist and genes encoding them constit...

    Authors: Jiubo Liang, Liang Zhang, Zhonghuai Xiang and Ningjia He
    Citation: BMC Genomics 2010 11:173
    Content type: Research article Published on:

  14. The SROs (SIMILAR TO RCD-ONE) are a group of plant-specific proteins which have important functions in stress adaptation and development. They contain the catalytic core of the poly(ADP-ribose) polymerase (PAR...

    Authors: Pinja Jaspers, Kirk Overmyer, Michael Wrzaczek, Julia P Vainonen, Tiina Blomster, Jarkko Salojärvi, Ramesha A Reddy and Jaakko Kangasjärvi
    Citation: BMC Genomics 2010 11:170
    Content type: Research article Published on:

  16. The phenomenon of desiccation tolerance, also called anhydrobiosis, involves the ability of an organism to survive the loss of almost all cellular water without sustaining irreversible damage. Although there a...

    Authors: Brahim Mali, Markus A Grohme, Frank Förster, Thomas Dandekar, Martina Schnölzer, Dirk Reuter, Weronika Wełnicz, Ralph O Schill and Marcus Frohme
    Citation: BMC Genomics 2010 11:168
    Content type: Research article Published on:

  18. The TATA-box and TATA-variants are regulatory elements involved in the formation of a transcription initiation complex. Both have been conserved throughout evolution in a restricted region close to the Transcr...

    Authors: Virginie Bernard, Véronique Brunaud and Alain Lecharny
    Citation: BMC Genomics 2010 11:166
    Content type: Research article Published on:

  19. 6S RNA from E. coli is known to bind to RNA polymerase interfering with transcription initiation. Because 6S RNA concentrations are maximal at stationary phase and binding occurs preferentially to the holoenzyme ...

    Authors: Thomas Neusser, Tino Polen, René Geissen and Rolf Wagner
    Citation: BMC Genomics 2010 11:165
    Content type: Research article Published on:

  20. Helicobacter mustelae causes gastritis, ulcers and gastric cancer in ferrets and other mustelids. H. mustelae remains the only helicobacter other than H. pylori that causes gastric ulceration and cancer in its na...

    Authors: Paul W O'Toole, William J Snelling, Carlos Canchaya, Brian M Forde, Kim R Hardie, Christine Josenhans, Robert LJ Graham, Geoff McMullan, Julian Parkhill, Eugenio Belda and Stephen D Bentley
    Citation: BMC Genomics 2010 11:164
    Content type: Research article Published on:

  21. Laser capture microdissection (LCM) has successfully isolated pure cell populations from tissue sections and the combination of LCM with standard genomic and proteomic methods has revolutionized molecular anal...

    Authors: Shuyang Wang, Lei Wang, Tengfang Zhu, Xue Gao, Jian Li, Ying Wu and Hongguang Zhu
    Citation: BMC Genomics 2010 11:163
    Content type: Methodology article Published on:

  22. The hypothalamus plays a central role in regulating appetite and metabolism. However, the gene networks within the hypothalamus that regulate feed intake and metabolism, and the effects of fasting on those pat...

    Authors: Stacy E Higgins, Laura E Ellestad, Nares Trakooljul, Fiona McCarthy, Jason Saliba, Larry A Cogburn and Tom E Porter
    Citation: BMC Genomics 2010 11:162
    Content type: Research article Published on:

  24. Tsetse flies, vectors of African trypanosomes, undergo viviparous reproduction (the deposition of live offspring). This reproductive strategy results in a large maternal investment and the deposition of a smal...

    Authors: Geoffrey M Attardo, José MC Ribeiro, Yineng Wu, Matthew Berriman and Serap Aksoy
    Citation: BMC Genomics 2010 11:160
    Content type: Research article Published on:

  25. Variations in recombination fraction (θ) among chromosomal regions, individuals and families have been observed and have an important impact on quantitative trait loci (QTL) mapping studies. Such variations on...

    Authors: Junwu Ma, Nathalie Iannuccelli, Yanyu Duan, Weibing Huang, Beili Guo, Juliette Riquet, Lusheng Huang and Denis Milan
    Citation: BMC Genomics 2010 11:159
    Content type: Research article Published on:

  26. Utilization of the natural genetic variation in traditional breeding programs remains a major challenge in crop plants. The identification of candidate genes underlying, or associated with, phenotypic trait QT...

    Authors: Bjorn Kloosterman, Marian Oortwijn, Jan uitdeWilligen, Twan America, Ric de Vos, Richard GF Visser and Christian WB Bachem
    Citation: BMC Genomics 2010 11:158
    Content type: Research article Published on:

  27. Swarming is a multicellular phenomenom characterized by the coordinated and rapid movement of bacteria across semisolid surfaces. In Sinorhizobium meliloti this type of motility has been described in a fadD mutan...

    Authors: Joaquina Nogales, Ana Domínguez-Ferreras, Carol V Amaya-Gómez, Pieter van Dillewijn, Virginia Cuéllar, Juan Sanjuán, José Olivares and María J Soto
    Citation: BMC Genomics 2010 11:157
    Content type: Research article Published on:

  28. For decades, linkage mapping has been one of the most powerful and widely used approaches for elucidating the genetic architecture of phenotypic traits of medical, agricultural and evolutionary importance. How...

    Authors: Anti Vasemägi, Riho Gross, Daniel Palm, Tiit Paaver and Craig R Primmer
    Citation: BMC Genomics 2010 11:156
    Content type: Methodology article Published on:

  30. We have previously sequenced more than 500 kb of the duplicated MHC class I regions in Atlantic salmon. In the IA region we identified the loci for the MHC class I gene Sasa-UBA in addition to a soluble MHC class...

    Authors: Morten F Lukacs, Håvard Harstad, Hege G Bakke, Marianne Beetz-Sargent, Linda McKinnel, Krzysztof P Lubieniecki, Ben F Koop and Unni Grimholt
    Citation: BMC Genomics 2010 11:154
    Content type: Research article Published on:

  31. CTBT (7-chlorotetrazolo [5,1-c]benzo[1,2,4]triazine) increases efficacy of commonly used antifungal agents by an unknown mechanism. It increases the susceptibility of Saccharomyces cerevisiae, Candida albicans an...

    Authors: Monika Batova, Vlasta Klobucnikova, Zuzana Oblasova, Juraj Gregan, Pavol Zahradnik, Ivan Hapala, Julius Subik and Christoph Schüller
    Citation: BMC Genomics 2010 11:153
    Content type: Research article Published on:

  32. Rodents represent a high-risk reservoir for the emergence of new human pathogens. The recent completion of the 2.3 Mb genome of Bartonella grahamii, one of the most prevalent blood-borne bacteria in wild rodents,...

    Authors: Eva C Berglund, Christian Ehrenborg, Olga Vinnere Pettersson, Fredrik Granberg, Kristina Näslund, Martin Holmberg and Siv GE Andersson
    Citation: BMC Genomics 2010 11:152
    Content type: Research article Published on:

  33. Ultraconserved elements (UCEs) are highly constrained elements of mammalian genomes, whose functional role has not been completely elucidated yet. Previous studies have shown that some of them act as enhancers...

    Authors: Danilo Licastro, Vincenzo A Gennarino, Francesca Petrera, Remo Sanges, Sandro Banfi and Elia Stupka
    Citation: BMC Genomics 2010 11:151
    Content type: Research article Published on:

  34. With its genome sequence and other experimental attributes, Populus trichocarpa has become the model species for genomic studies of wood development. Wood is derived from secondary growth of tree stems, and begin...

    Authors: Palitha Dharmawardhana, Amy M Brunner and Steven H Strauss
    Citation: BMC Genomics 2010 11:150
    Content type: Research article Published on:

  35. Ultra Conserved Regions (UCRs) are a class of 481 noncoding sequences located in both intra- and inter-genic regions of the genome. The recent findings that they are significantly altered in adult chronic lymp...

    Authors: Paola Scaruffi, Sara Stigliani, Simona Coco, Franscesca Valdora, Carla De Vecchi, Stefano Bonassi and Gian Paolo Tonini
    Citation: BMC Genomics 2010 11:149
    Content type: Methodology article Published on:

  36. MicroRNA (miRNA) and other small regulatory RNAs contribute to the modulation of a large number of cellular processes. We sequenced three small RNA libraries prepared from the whole body, and the anterior-midd...

    Authors: Shiping Liu, Dong Li, Qibin Li, Ping Zhao, Zhonghuai Xiang and Qingyou Xia
    Citation: BMC Genomics 2010 11:148
    Content type: Research article Published on:

  39. The use of global gene expression profiling is a well established approach to understand biological processes. One of the major goals of these investigations is to identify sets of genes with similar expressio...

    Authors: Srinivas Veerla, Markus Ringnér and Mattias Höglund
    Citation: BMC Genomics 2010 11:145
    Content type: Methodology article Published on:

  40. Cells have the ability to respond and adapt to environmental changes through activation of stress-activated protein kinases (SAPKs). Although p38 SAPK signalling is known to participate in the regulation of ge...

    Authors: Isabel Ferreiro, Manel Joaquin, Abul Islam, Gonzalo Gomez-Lopez, Montserrat Barragan, Luís Lombardía, Orlando Domínguez, David G Pisano, Nuria Lopez-Bigas, Angel R Nebreda and Francesc Posas
    Citation: BMC Genomics 2010 11:144
    Content type: Research article Published on:

  41. Tortula ruralis, a widely distributed species in the moss family Pottiaceae, is increasingly used as a model organism for the study of desiccation tolerance and mechanisms of cellular repair. In this paper, we pr...

    Authors: Melvin J Oliver, Andrew G Murdock, Brent D Mishler, Jennifer V Kuehl, Jeffrey L Boore, Dina F Mandoli, Karin DE Everett, Paul G Wolf, Aaron M Duffy and Kenneth G Karol
    Citation: BMC Genomics 2010 11:143
    Content type: Research article Published on:

  42. Transcriptomics has resulted in the development of large data sets and tools for the progression of functional genomics and systems biology in many model organisms. Currently there is no commercially available...

    Authors: Kieron D Edwards, Aureliano Bombarely, Geraint W Story, Fraser Allen, Lukas A Mueller, Steve A Coates and Louise Jones
    Citation: BMC Genomics 2010 11:142
    Content type: Research article Published on:

  43. Higher crustaceans (class Malacostraca) represent the most species-rich and morphologically diverse group of non-insect arthropods and many of its members are commercially important. Although the crustacean DN...

    Authors: Takashi Koyama, Shuichi Asakawa, Takayuki Katagiri, Atsushi Shimizu, Fernand F Fagutao, Rapeepat Mavichak, Mudjekeewis D Santos, Kanako Fuji, Takashi Sakamoto, Toshihide Kitakado, Hidehiro Kondo, Nobuyoshi Shimizu, Takashi Aoki and Ikuo Hirono
    Citation: BMC Genomics 2010 11:141
    Content type: Research article Published on:

  44. In addition to shotgun sequencing, next generation sequencing has been shown to be suitable for deep sequencing of many specific PCR-amplified target genes in parallel. However, unspecific product formation is...

    Authors: Julia Sandberg, Marten Neiman, Afshin Ahmadian and Joakim Lundeberg
    Citation: BMC Genomics 2010 11:140
    Content type: Methodology article Published on:

  45. Genome-wide homozygosity estimation from genomic data is becoming an increasingly interesting research topic. The aim of this study was to compare different methods for estimating individual homozygosity-by-de...

    Authors: Ozren Polašek, Caroline Hayward, Celine Bellenguez, Veronique Vitart, Ivana Kolčić, Ruth McQuillan, Vanja Saftić, Ulf Gyllensten, James F Wilson, Igor Rudan, Alan F Wright, Harry Campbell and Anne-Louise Leutenegger
    Citation: BMC Genomics 2010 11:139
    Content type: Research article Published on:

  46. Coliform bacteria are the most common etiologic agents in severe mastitis of cows. Escherichia coli infections are mostly restricted to a single udder quarter whereas neighboring quarters stay clinically inappare...

    Authors: Simone Mitterhuemer, Wolfram Petzl, Stefan Krebs, Daniel Mehne, Andrea Klanner, Eckhard Wolf, Holm Zerbe and Helmut Blum
    Citation: BMC Genomics 2010 11:138
    Content type: Research article Published on:

  47. Cancer cells undergo massive alterations to their DNA methylation patterns that result in aberrant gene expression and malignant phenotypes. However, the mechanisms that underlie methylome changes are not well...

    Authors: Yoshinao Ruike, Yukako Imanaka, Fumiaki Sato, Kazuharu Shimizu and Gozoh Tsujimoto
    Citation: BMC Genomics 2010 11:137
    Content type: Research article Published on:

  48. Grass carp (Ctenopharyngodon idella) belongs to the family Cyprinidae which includes more than 2000 fish species. It is one of the most important freshwater food fish species in world aquaculture. A linkage map i...

    Authors: Jun Hong Xia, Feng Liu, Ze Yuan Zhu, Jianjun Fu, Jianbin Feng, Jiale Li and Gen Hua Yue
    Citation: BMC Genomics 2010 11:135
    Content type: Research article Published on:

  49. Protein phosphorylation is responsible for a large portion of the regulatory functions of eukaryotic cells. Although the list of sequenced genomes of filamentous fungi has grown rapidly, the kinomes of recentl...

    Authors: Idit Kosti, Yael Mandel-Gutfreund, Fabian Glaser and Benjamin A Horwitz
    Citation: BMC Genomics 2010 11:133
    Content type: Research article Published on:

  50. Intracranial pediatric germ cell tumors (GCTs) are rare and heterogeneous neoplasms and vary in histological differentiation, prognosis and clinical behavior. Germinoma and mature teratoma are GCTs that have a...

    Authors: Hsei-Wei Wang, Yu-Hsuan Wu, Jui-Yu Hsieh, Muh-Lii Liang, Meng-En Chao, Da-Jung Liu, Ming-Ta Hsu and Tai-Tong Wong
    Citation: BMC Genomics 2010 11:132
    Content type: Research article Published on:

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