Leone G, Voso MT, Sica S, Morosetti R, Pagano L: Therapy related leukemias: susceptibility, prevention and treatment. Leuk Lymphoma. 2001, 41 (3-4): 255-276. 10.3109/10428190109057981.
Article
CAS
PubMed
Google Scholar
Leone G, Pagano L, Ben-Yehuda D, Voso MT: Therapy-related leukemia and myelodysplasia: susceptibility and incidence. Haematologica. 2007, 92 (10): 1389-1398. 10.3324/haematol.11034.
Article
CAS
PubMed
Google Scholar
Larson RA, Le Beau MM: Therapy-related myeloid leukaemia: a model for leukemogenesis in humans. Chem Biol Interact. 2005, 153-154: 187-195. 10.1016/j.cbi.2005.03.023.
Article
CAS
PubMed
Google Scholar
Knoche E, Mc Leod HL, Graubert TA: Pharmacogenetics of alkylator-associated acute myeloid leukemia. Pharmacogenomics. 2006, 7 (5): 719-729. 10.2217/14622416.7.5.719.
Article
CAS
PubMed
Google Scholar
Side L, Taylor B, Cayouette M, Conner E, Thompson P, Luce M, Shannon K: Homozygous inactivation of the NF1 gene in bone marrow cells from children with neurofibromatosis type 1 and malignant myeloid disorders. N Engl J Med. 1997, 336 (24): 1713-1720. 10.1056/NEJM199706123362404.
Article
CAS
PubMed
Google Scholar
Jacks T, Shih TS, Schmitt EM, Bronson RT, Bernards A, Weinberg RA: Tumour predisposition in mice heterozygous for a targeted mutation in Nf1. Nat Genet. 1994, 7 (3): 353-361. 10.1038/ng0794-353.
Article
CAS
PubMed
Google Scholar
Meikrantz W, Bergom MA, Memisoglu A, Samson L: O6-alkylguanine DNA lesions trigger apoptosis. Carcinogenesis. 1998, 19 (2): 369-372. 10.1093/carcin/19.2.369.
Article
CAS
PubMed
Google Scholar
Seedhouse C, Bainton R, Lewis M, Harding A, Russell N, Das-Gupta E: The genotype distribution of the XRCC1 gene indicates a role for base excision repair in the development of therapy-related acute myeloblastic leukemia. Blood. 2002, 100 (10): 3761-3766. 10.1182/blood-2002-04-1152.
Article
CAS
PubMed
Google Scholar
Allan JM, Wild CP, Rollinson S, Willett EV, Moorman AV, Dovey GJ, Roddam PL, Roman E, Cartwright RA, Morgan GJ: Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia. Proc Natl Acad Sci USA. 2001, 98 (20): 11592-11597. 10.1073/pnas.191211198.
Article
CAS
PubMed
PubMed Central
Google Scholar
Larson RA, Wang Y, Banerjee M, Wiemels J, Hartford C, Le Beau MM, Smith MT: Prevalence of the inactivating 609C-->T polymorphism in the NAD(P)H:quinone oxidoreductase (NQO1) gene in patients with primary and therapy-related myeloid leukemia. Blood. 1999, 94 (2): 803-807.
Article
CAS
PubMed
Google Scholar
Fenske TS, Mc Mahon C, Edwin D, Jarvis JC, Cheverud JM, Minn M, Mathews V, Bogue MA, Province MA, McLeod HL, et al: Identification of candidate alkylator-induced cancer susceptibility genes by whole genome scanning in mice. Cancer Res. 2006, 66 (10): 5029-5038. 10.1158/0008-5472.CAN-05-3404.
Article
CAS
PubMed
Google Scholar
Noveroske JK, Weber JS, Justice MJ: The mutagenic action of N-ethyl-N-nitrosourea in the mouse. Mamm Genome. 2000, 11 (7): 478-483. 10.1007/s003350010093.
Article
CAS
PubMed
Google Scholar
Thirman MJ, Larson RA: Therapy-related myeloid leukemia. Hematol Oncol Clin North Am. 1996, 10 (2): 293-320. 10.1016/S0889-8588(05)70340-3.
Article
CAS
PubMed
Google Scholar
Birrell GW, Brown JA, Wu HI, Giaever G, Chu AM, Davis RW, Brown JM: Transcriptional response of Saccharomyces cerevisiae to DNA-damaging agents does not identify the genes that protect against these agents. Proc Natl Acad Sci USA. 2002, 99 (13): 8778-8783. 10.1073/pnas.132275199.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fry RC, Svensson JP, Valiathan C, Wang E, Hogan BJ, Bhattacharya S, Bugni JM, Whittaker CA, Samson LD: Genomic predictors of interindividual differences in response to DNA damaging agents. Genes Dev. 2008, 22 (19): 2621-2626. 10.1101/gad.1688508.
Article
CAS
PubMed
PubMed Central
Google Scholar
Schadt EE: Molecular networks as sensors and drivers of common human diseases. Nature. 2009, 461 (7261): 218-223. 10.1038/nature08454.
Article
CAS
PubMed
Google Scholar
Meng H, Vera I, Che N, Wang X, Wang SS, Ingram-Drake L, Schadt EE, Drake TA, Lusis AJ: Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics. Proc Natl Acad Sci USA. 2007, 104 (11): 4530-4535. 10.1073/pnas.0607620104.
Article
CAS
PubMed
PubMed Central
Google Scholar
Wang SS, Shi W, Wang X, Velky L, Greenlee S, Wang MT, Drake TA, Lusis AJ: Mapping, genetic isolation, and characterization of genetic loci that determine resistance to atherosclerosis in C3H mice. Arterioscler Thromb Vasc Biol. 2007, 27 (12): 2671-2676. 10.1161/ATVBAHA.107.148106.
Article
CAS
PubMed
Google Scholar
Schadt EE, Monks SA, Drake TA, Lusis AJ, Che N, Colinayo V, Ruff TG, Milligan SB, Lamb JR, Cavet G, et al: Genetics of gene expression surveyed in maize, mouse and man. Nature. 2003, 422 (6929): 297-302. 10.1038/nature01434.
Article
CAS
PubMed
Google Scholar
Schadt EE, Lamb J, Yang X, Zhu J, Edwards S, Guhathakurta D, Sieberts SK, Monks S, Reitman M, Zhang C, et al: An integrative genomics approach to infer causal associations between gene expression and disease. Nat Genet. 2005, 37 (7): 710-717. 10.1038/ng1589.
Article
CAS
PubMed
PubMed Central
Google Scholar
Yang X, Deignan JL, Qi H, Zhu J, Qian S, Zhong J, Torosyan G, Majid S, Falkard B, Kleinhanz RR, et al: Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nat Genet. 2009, 41 (4): 415-423. 10.1038/ng.325.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ghazalpour A, Doss S, Zhang B, Wang S, Plaisier C, Castellanos R, Brozell A, Schadt EE, Drake TA, Lusis AJ: Integrating genetic and network analysis to characterize genes related to mouse weight. PLoS Genet. 2006, 2 (8): e130. 10.1371/journal.pgen.0020130.
Plaisier CL, Horvath S, Huertas-Vazquez A, Cruz-Bautista I, Herrera MF, Tusie-Luna T, Aguilar-Salinas C, Pajukanta P: A systems genetics approach implicates USF1, FADS3, and other causal candidate genes for familial combined hyperlipidemia. PLoS Genet. 2009, 5 (9): e1000642. 10.1371/journal.pgen.1000642.
Cahan P, Li Y, Izumi M, Graubert TA: The impact of copy number variation on local gene expression in mouse hematopoietic stem and progenitor cells. Nat Genet. 2009, 41 (4): 430-437. 10.1038/ng.350.
Article
CAS
PubMed
PubMed Central
Google Scholar
Bogue MA, Grubb SC, Maddatu TP, Bult CJ: Mouse Phenome Database (MPD). Nucleic Acids Res. 2007, D643-649. 10.1093/nar/gkl1049. 35 Database
Cahan P, Godfrey LE, Eis PS, Richmond TA, Selzer RR, Brent M, Mc Leod HL, Ley TJ, Graubert TA: wuHMM: a robust algorithm to detect DNA copy number variation using long oligonucleotide microarray data. Nucleic Acids Res. 2008, 36 (7): e41. 10.1093/nar/gkn110.
Nadler JJ, Zou F, Huang H, Moy SS, Lauder J, Crawley JN, Threadgill DW, Wright FA, Magnuson TR: Large-scale gene expression differences across brain regions and inbred strains correlate with a behavioral phenotype. Genetics. 2006, 174 (3): 1229-1236. 10.1534/genetics.106.061481.
Article
CAS
PubMed
PubMed Central
Google Scholar
Breitling R, Li Y, Tesson BM, Fu J, Wu C, Wiltshire T, Gerrits A, Bystrykh LV, de Haan G, Su AI: Genetical genomics: spotlight on QTL hotspots. PLoS Genet. 2008, 4 (10): e1000232. 10.1371/journal.pgen.1000232.
Gerrits A, Li Y, Tesson BM, Bystrykh LV, Weersing E, Ausema A, Dontje B, Wang X, Breitling R, Jansen RC: Expression quantitative trait loci are highly sensitive to cellular differentiation state. PLoS Genet. 2009, 5 (10): e1000692. 10.1371/journal.pgen.1000692.
Zhang B, Horvath S: A general framework for weighted gene co-expression network analysis. Stat Appl Genet Mol Biol. 2005, 4: Article17
Google Scholar
Langfelder P, Horvath S: WGCNA: an R package for weighted correlation network analysis. BMC Bioinformatics. 2008, 9: 559. 10.1186/1471-2105-9-559.
Google Scholar
Stranger BE, Nica AC, Forrest MS, Dimas A, Bird CP, Beazley C, Ingle CE, Dunning M, Flicek P, Koller D, et al: Population genomics of human gene expression. Nat Genet. 2007, 39 (10): 1217-1224. 10.1038/ng2142.
Article
CAS
PubMed
PubMed Central
Google Scholar
Visel A, Zhu Y, May D, Afzal V, Gong E, Attanasio C, Blow MJ, Cohen JC, Rubin EM, Pennacchio LA: Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice. Nature. 464 (7287): 409-412. 10.1038/nature08801.
Mc Carroll SA, Kuruvilla FG, Korn JM, Cawley S, Nemesh J, Wysoker A, Shapero MH, de Bakker PI, Maller JB, Kirby A, et al: Integrated detection and population-genetic analysis of SNPs and copy number variation. Nat Genet. 2008, 40 (10): 1166-1174. 10.1038/ng.238.
Article
CAS
Google Scholar
Young LC, Peters AC, Maeda T, Edelmann W, Kucherlapati R, Andrew SE, Tron VA: DNA mismatch repair protein Msh6 is required for optimal levels of ultraviolet-B-induced apoptosis in primary mouse fibroblasts. J Invest Dermatol. 2003, 121 (4): 876-880. 10.1046/j.1523-1747.2003.12486.x.
Article
CAS
PubMed
Google Scholar
Roos WP, Christmann M, Fraser ST, Kaina B: Mouse embryonic stem cells are hypersensitive to apoptosis triggered by the DNA damage O(6)-methylguanine due to high E2F1 regulated mismatch repair. Cell Death Differ. 2007, 14 (8): 1422-1432. 10.1038/sj.cdd.4402136.
Article
CAS
PubMed
Google Scholar
Klapacz J, Meira LB, Luchetti DG, Calvo JA, Bronson RT, Edelmann W, Samson LD: O6-methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo. Proc Natl Acad Sci USA. 2009, 106 (2): 576-581. 10.1073/pnas.0811991106.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hakem R, Hakem A, Duncan GS, Henderson JT, Woo M, Soengas MS, Elia A, de la Pompa JL, Kagi D, Khoo W, et al: Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell. 1998, 94 (3): 339-352. 10.1016/S0092-8674(00)81477-4.
Article
CAS
PubMed
Google Scholar
Kuida K, Haydar TF, Kuan CY, Gu Y, Taya C, Karasuyama H, Su MS, Rakic P, Flavell RA: Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell. 1998, 94 (3): 325-337. 10.1016/S0092-8674(00)81476-2.
Article
CAS
PubMed
Google Scholar
Marsden VS, O'Connor L, O'Reilly LA, Silke J, Metcalf D, Ekert PG, Huang DC, Cecconi F, Kuida K, Tomaselli KJ, et al: Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome. Nature. 2002, 419 (6907): 634-637. 10.1038/nature01101.
Article
CAS
PubMed
Google Scholar
Wu C, Orozco C, Boyer J, Leglise M, Goodale J, Batalov S, Hodge CL, Haase J, Janes J, Huss JW, et al: BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources. Genome Biol. 2009, 10 (11): R130-10.1186/gb-2009-10-11-r130.
Article
PubMed
PubMed Central
CAS
Google Scholar
Seki A, Fang G: CKAP2 is a spindle-associated protein degraded by APC/C-Cdh1 during mitotic exit. J Biol Chem. 2007, 282 (20): 15103-15113. 10.1074/jbc.M701688200.
Article
CAS
PubMed
Google Scholar
Hong KU, Kim HJ, Kim HS, Seong YS, Hong KM, Bae CD, Park J: Cdk1-cyclin B1-mediated phosphorylation of tumor-associated microtubule-associated protein/cytoskeleton-associated protein 2 in mitosis. J Biol Chem. 2009, 284 (24): 16501-16512. 10.1074/jbc.M900257200.
Article
CAS
PubMed
PubMed Central
Google Scholar
Jeon SM, Choi B, Hong KU, Kim E, Seong YS, Bae CD, Park J: A cytoskeleton-associated protein, TMAP/CKAP2, is involved in the proliferation of human foreskin fibroblasts. Biochem Biophys Res Commun. 2006, 348 (1): 222-228. 10.1016/j.bbrc.2006.07.046.
Article
CAS
PubMed
Google Scholar
Schreiber V, Ame JC, Dolle P, Schultz I, Rinaldi B, Fraulob V, Menissier-de Murcia J, de Murcia G: Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1. J Biol Chem. 2002, 277 (25): 23028-23036. 10.1074/jbc.M202390200.
Article
CAS
PubMed
Google Scholar
Raffoul JJ, Cabelof DC, Nakamura J, Meira LB, Friedberg EC, Heydari AR: Apurinic/apyrimidinic endonuclease (APE/REF-1) haploinsufficient mice display tissue-specific differences in DNA polymerase beta-dependent base excision repair. J Biol Chem. 2004, 279 (18): 18425-18433. 10.1074/jbc.M313983200.
Article
CAS
PubMed
Google Scholar
Yang H, Ding Y, Hutchins LN, Szatkiewicz J, Bell TA, Paigen BJ, Graber JH, de Villena FP, Churchill GA: A customized and versatile high-density genotyping array for the mouse. Nat Methods. 2009, 6 (9): 663-666. 10.1038/nmeth.1359.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sudbery I, Stalker J, Simpson JT, Keane T, Rust AG, Hurles ME, Walter K, Lynch D, Teboul L, Brown SD, et al: Deep short-read sequencing of chromosome 17 from the mouse strains A/J and CAST/Ei identifies significant germline variation and candidate genes that regulate liver triglyceride levels. Genome Biol. 2009, 10 (10): R112-10.1186/gb-2009-10-10-r112.
Article
PubMed
PubMed Central
CAS
Google Scholar
Quinlan AR, Clark RA, Sokolova S, Leibowitz ML, Zhang Y, Hurles ME, Mell JC, Hall IM: Genome-wide mapping and assembly of structural variant breakpoints in the mouse genome. Genome Res.
Rousseeuw PJ, Kaufman L: Finding Groups in Data: An Introduction to Cluster Analysis. 1990, New York: Wiley
Google Scholar
Szatkiewicz JP, Beane GL, Ding Y, Hutchins L, Pardo-Manuel de Villena F, Churchill GA: An imputed genotype resource for the laboratory mouse. Mamm Genome. 2008, 19 (3): 199-208. 10.1007/s00335-008-9098-9.
Article
PubMed
PubMed Central
Google Scholar
Zhao H, Nettleton D, Dekkers JC: Evaluation of linkage disequilibrium measures between multi-allelic markers as predictors of linkage disequilibrium between single nucleotide polymorphisms. Genet Res. 2007, 89 (1): 1-6. 10.1017/S0016672307008634.
Article
CAS
PubMed
Google Scholar
Smyth GK: Limma: linear models for microarray data. Bioinformatics and Computational Biology Solutions using R and Bioconductor. Edited by: R Gentleman VC, Dudoit S, Irizarry R, Huber W. 2005, New York: Springer, 397-420. full_text.
Chapter
Google Scholar
Smyth GK: Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol. 2004, 3: Article3
Google Scholar
Storey JD, Tibshirani R: Statistical significance for genomewide studies. Proc Natl Acad Sci USA. 2003, 100 (16): 9440-9445. 10.1073/pnas.1530509100.
Article
CAS
PubMed
PubMed Central
Google Scholar
Huang da W, Sherman BT, Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009, 4 (1): 44-57. 10.1038/nprot.2008.211.
Article
PubMed
CAS
Google Scholar
Mc Clurg P, Janes J, Wu C, Delano DL, Walker JR, Batalov S, Takahashi JS, Shimomura K, Kohsaka A, Bass J, et al: Genomewide association analysis in diverse inbred mice: power and population structure. Genetics. 2007, 176 (1): 675-683. 10.1534/genetics.106.066241.
Article
CAS
Google Scholar
Pletcher MT, Mc Clurg P, Batalov S, Su AI, Barnes SW, Lagler E, Korstanje R, Wang X, Nusskern D, Bogue MA, et al: Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse. PLoS Biol. 2004, 2 (12): e393-10.1371/journal.pbio.0020393.
Article
PubMed
PubMed Central
CAS
Google Scholar
Mc Clurg P, Pletcher MT, Wiltshire T, Su AI: Comparative analysis of haplotype association mapping algorithms. BMC Bioinformatics. 2006, 7: 61-10.1186/1471-2105-7-61.
Article
CAS
Google Scholar
Holm S: A simple sequentially rejective multiple test procedure. Scandinavian Journal of Statistics. 1979, 6: 65-70.
Google Scholar
Benjamini Y, Hochberg Y: Controlling the false discovery rate: A practical and powerful approach to multiple testing. J R Stat Soc B. 1995, 57: 289-300.
Google Scholar