FAO. The state of world fisheries and aquaculture 2014; 2014. p. 223.
Google Scholar
Balcázar JL, De Blas I, Ruiz-Zarzuela I, Cunningham D, Vendrell D, Múzquiz JL. The role of probiotics in aquaculture. Vet Microbiol. 2006;114:173–86.
Article
PubMed
Google Scholar
Esteban MA. An overview of the immunological defenses in fish skin. ISRN Immunol. 2012;2012:1–29.
Article
Google Scholar
Sarasquete C, González de Canales ML, Arellano J, Pérez-Prieto S, García-Rosado E, Borrego JJ. Histochemical study of lymphocystis disease in skin of gilthead seabream, Sparus aurata L. Histol Histopathol. 1998;13:37–45.
CAS
PubMed
Google Scholar
Borrego JJ, Valverde EJ, Labella AM, Castro D. Lymphocystis disease virus: its importance in aquaculture. Rev Aquacult. 2015;1:1–15.
Google Scholar
Cordero H, Cuesta A, Meseguer J, Esteban MA. Characterization of the gilthead seabream (Sparus aurata L.) immune response under a natural lymphocystis disease virus outbreak. J Fish Dis. 2016;39:1467–76.
Article
CAS
PubMed
Google Scholar
Balebona MC, Andreu MJ, Bordas MA, Zorrilla I, Moriñigo MA, Borrego JJ. Pathogenicity of Vibrio alginolyticus for cultured gilt-head sea bream (Sparus aurata L.). Appl Environ Microbiol. 1998;64:4269–75.
CAS
PubMed
PubMed Central
Google Scholar
Shephard K. Functions for fish mucus. Rev Fish Biol Fisheries. 1994;4:401–29.
Article
Google Scholar
Brinchmann MF. Immune relevant molecules identified in the skin mucus of fish using -omics technologies. Mol BioSyst. 2016;12:2056–63.
Article
CAS
PubMed
Google Scholar
Ross NW, Firth KJ, Anping W, Burka J, Johnson SC. Changes in hydrolytic enzyme activities of naïve Atlantic salmon Salmo salar skin mucus due to infection with the salmon louse Lepeophtheirus salmonis and cortisol implantation. Dis Aquat Org. 2000;41:43–51.
Article
CAS
PubMed
Google Scholar
Guardiola FA, Cuesta A, Abellán E, Meseguer J, Esteban MA. Comparative analysis of the humoral immunity of skin mucus from several marine teleost fish. Fish Shellfish Immunol. 2014;40:24–31.
Article
CAS
PubMed
Google Scholar
Cordero H, Cuesta A, Meseguer J, Esteban MA. Changes in the levels of humoral immune activities after storage of gilthead seabream (Sparus aurata) skin mucus. Fish Shellfish Immunol. 2016;58:500–7.
Article
CAS
PubMed
Google Scholar
Rakers S, Niklasson L, Steinhagen D, Kruse C, Sundell K, Paus R. Antimicrobial peptides (AMPs) from fish epidermis: perspectives for investigative dermatology. J Invest Dermatol. 2013;133:1140–9.
Article
CAS
PubMed
Google Scholar
Xu Z, Parra D, Gómez D, Salinas I, Zhang Y-A, Von Gersdorff JL, et al. Teleost skin, an ancient mucosal surface that elicits gut-like immune responses. Proc Natl Acad Sci U S A. 2013;110:13097–102.
Article
CAS
PubMed
PubMed Central
Google Scholar
Ng TB, Chi R, Cheung F, Cheuk C, Ng W, Fang EF, et al. A review of fish lectins. Curr Protein Pept Sci. 2015;16:337–51.
Article
CAS
PubMed
Google Scholar
Gstaiger M, Aebersold R. Applying mass spectrometry-based proteomics to genetics, genomics and network biology. Nat Rev Genet. 2009;10:617–27.
Article
CAS
PubMed
Google Scholar
Junqueira M, Spirin V, Balbuena TS, Thomas H, Adzhubei I, Sunyaev S, et al. Protein identification pipeline for the homology-driven proteomics. J Proteome. 2008;71:346–56.
Article
CAS
Google Scholar
Liska AJ, Shevchenko A. Expanding the organismal scope of proteomics: cross-species protein identification by mass spectrometry and its implications. Proteomics. 2003;3:19–28.
Article
CAS
PubMed
Google Scholar
Rajan B, Fernandes JMO, Caipang CMA, Kiron V, Rombout JHWM, Brinchmann MF. Proteome reference map of the skin mucus of Atlantic cod (Gadus morhua) revealing immune competent molecules. Fish Shellfish Immunol. 2011;31:224–31.
Article
CAS
PubMed
Google Scholar
Patel DM, Brinchmann MF. Skin mucus proteins of lumpsucker (Cyclopterus lumpus). Biochem Biophys Rep. 2017;9:217–25.
PubMed
PubMed Central
Google Scholar
Cordero H, Brinchmann MF, Cuesta A, Meseguer J, Esteban MA. Skin mucus proteome map of European sea bass (Dicentrarchus labrax). Proteomics. 2015;15:4007–20.
Article
CAS
PubMed
Google Scholar
Sanahuja I, Ibarz A. Skin mucus proteome of gilthead sea bream: a non-invasive method to screen for welfare indicators. Fish Shellfish Immunol. 2015;46:426–35.
Article
CAS
PubMed
Google Scholar
Jurado J, Fuentes-Almagro CA, Guardiola FA, Cuesta A, Esteban MA, Prieto-Álamo MJ. Proteomic profile of the skin mucus of farmed gilthead seabream (Sparus aurata). J Proteome. 2015;120:21–34.
Article
CAS
Google Scholar
Provan F, Jensen LB, Uleberg KE, Larssen E, Rajalahti T, Mullins J, et al. Proteomic analysis of epidermal mucus from sea lice-infected Atlantic salmon, Salmo salar L. J Fish Dis. 2013;36:311–21.
Article
CAS
PubMed
Google Scholar
Valdenegro-Vega V, Crosbie P, Bridle A, Leef M, Wilson R, Nowak BF. Differentially expressed proteins in gill and skin mucus of Atlantic salmon (Salmo salar) affected by amoebic gill disease. Fish Shellfish Immunol. 2014;40:69–77.
Article
CAS
PubMed
Google Scholar
Rajan B, Lokesh J, Kiron V, Brinchmann MF. Differentially expressed proteins in the skin mucus of Atlantic cod (Gadus morhua) upon natural infection with Vibrio anguillarum. BMC Vet Res. 2013;9:103.
Article
PubMed
PubMed Central
Google Scholar
Easy RH, Ross NW. Changes in Atlantic salmon (Salmo salar) epidermal mucus protein composition profiles following infection with sea lice (Lepeophtheirus salmonis). Comp Biochem Physiol - Part D. 2009;4:159–67.
Easy RH, Ross NW. Changes in Atlantic salmon Salmo salar mucus components following short- and long-term handling stress. J Fish Biol. 2010;77:1616–31.
Article
CAS
PubMed
Google Scholar
Cordero H, Morcillo P, Cuesta A, Brinchmann MF, Esteban MA. Differential proteome profile of skin mucus of gilthead seabream (Sparus aurata) after probiotic intake and/or overcrowding stress. J Proteome. 2016;132:41–50.
Article
CAS
Google Scholar
Chong K, Joshi S, Jin LT, Shu-Chien AC. Proteomics profiling of epidermal mucus secretion of a cichlid (Symphysodon aequifasciata) demonstrating parental care behavior. Proteomics. 2005;5:2251–8.
Google Scholar
Micallef G, Cash P, Fernandes JMO, Rajan B, Tinsley JW, Bickerdike R, et al. Dietary yeast cell wall extract alters the proteome of the skin mucous barrier in Atlantic Salmon (Salmo salar): increased abundance and expression of a calreticulin-like protein. PLoS One. 2017;12:e0169075.
Article
PubMed
PubMed Central
Google Scholar
Valero Y, Chaves-Pozo E, Meseguer J, Esteban MA, Cuesta A. Biological role of fish antimicrobial peptides. Antimicrobial Peptides. Nova Science Publishers; 2013. p. 31–60.
Valero Y, Martínez-Morcillo FJ, Esteban MA, Chaves-Pozo E, Cuesta A. Fish peroxiredoxins and their role in immunity. Biology. 2015;4:860–80.
Article
PubMed
PubMed Central
Google Scholar
Wahli T, Verlhac V, Girling P, Gabaudan J, Aebischer C. Influence of dietary vitamin C on the wound healing process in rainbow trout (Oncorhynchus mykiss). Aquaculture. 2003;225:371–86.
Article
CAS
Google Scholar
Vetvicka V, Vetvickova J. β(1-3)-D-glucan affects adipogenesis, wound healing and inflammation. Orient Pharma Exp Med. 2011;11:169–75.
Article
Google Scholar
Przybylska-Diaz D, Schmidt J, Vera-Jiménez N, Steinhagen D, Nielsen M. β-glucan enriched bath directly stimulates the wound healing process in common carp (Cyprinus carpio L.). Fish Shellfish Immunol. 2013;35:998–1006.
Article
CAS
PubMed
Google Scholar
Jensen LB, Wahli T, McGurk C, Eriksen TB, Obach A, Waagbø R, et al. Effect of temperature and diet on wound healing in Atlantic salmon (Salmo salar L.). Fish Physiol Biochem. 2015;41:1524–43.
Article
Google Scholar
Vieira FA, Gregório SF, Ferraresso S, Thorne MAS, Costa R, Milan M, et al. Skin healing and scale regeneration in fed and unfed sea bream, Sparus auratus. BMC Genomics. 2011;12:490.
Article
PubMed
PubMed Central
Google Scholar
Guardiola FA, Cuesta A, Arizcun M, Meseguer J, Esteban MA. Comparative skin mucus and serum humoral defence mechanisms in the teleost gilthead seabream (Sparus aurata). Fish Shellfish Immunol. 2014;36:545–51.
Article
CAS
PubMed
Google Scholar
Pérez-Sánchez J, Terova G, Simó-Mirabet P, Rimoldi S, Folkedal O, Calduch-Giner JA, et al. Skin mucus of gilthead sea bream (Sparus aurata L.). Protein mapping and regulation in chronically stressed fish. Front Physiol. 2017;8:34.
Article
PubMed
PubMed Central
Google Scholar
Breslow J, Ross D, McPherson J, Williams H, Kurnit D, Karathanasis SK, et al. Isolation and characterization of cDNA clones for human apolipoprotein A-I. Proc Natl Acad Sci U S A. 1982;79:6861–5.
Article
CAS
PubMed
PubMed Central
Google Scholar
Villarroel F, Bastías A, Casado A, Amthauer R, Concha MI, Apolipoprotein A-I. An antimicrobial protein in Oncorhynchus mykiss: evaluation of its expression in primary defence barriers and plasma levels in sick and healthy fish. Fish Shellfish Immunol. 2007;23:197–209.
Article
CAS
PubMed
Google Scholar
Concha MI, Smith VJ, Castro K, Bastías A, Romero A, Amthauer RJ. Apolipoproteins A-I and A-II are potentially important effectors of innate immunity in the teleost fish Cyprinus carpio. Eur J Biochem. 2004;271:2984–90.
Article
CAS
PubMed
Google Scholar
Valero Y, Arizcun M, Esteban MA, Cuesta A, Chaves-Pozo E. Transcription of histones H1 and H2B is regulated by several immune stimuli in gilthead seabream and European sea bass. Fish Shellfish Immunol. 2016;57:107–15.
Article
CAS
PubMed
Google Scholar
Bergsson G, Agerberth B, Jörnvall H, Gudmundsson GH. Isolation and identification of antimicrobial components from the epidermal mucus of Atlantic cod (Gadus morhua). FEBS J. 2005;272:4960–9.
Article
CAS
PubMed
Google Scholar
Fernandes JMO, Molle G, Kemp G, Smith VJ. Isolation and characterisation of oncorhyncin II, a histone H1-derived antimicrobial peptide from skin secretions of rainbow trout, Oncorhynchus mykiss. Dev Comp Immunol. 2004;28:127–38.
Article
CAS
PubMed
Google Scholar
Tort L. Stress and immune modulation in fish. Dev Comp Immunol. 2011;35:1366–75.
Article
CAS
PubMed
Google Scholar
Ishii T, Warabi E, Yanagawa T. Novel roles of peroxiredoxins in inflammation, cancer and innate immunity. J Clin Biochem Nutr. 2012;50:91–105.
Article
CAS
PubMed
PubMed Central
Google Scholar
Break TJ, Jun S, Indramohan M, Carr KD, Sieve AN, Dory L, et al. Extracellular superoxide dismutase inhibits innate immune responses and clearance of an intracellular bacterial infection. J Immunol. 2012;188:3342–50.
Article
CAS
PubMed
PubMed Central
Google Scholar
Terrazzano G, Rubino V, Damiano S, Sasso A, Petrozziello T, Ucci V, et al. T cell activation induces CuZn superoxide dismutase (SOD)-1 intracellular re-localization, production and secretion. Biochim Biophys Acta. 2014;1843:265–74.
Article
CAS
PubMed
Google Scholar
Morcillo P, Romero D, Meseguer J, Esteban MÁ, Cuesta A. Cytotoxicity and alterations at transcriptional level caused by metals on fish erythrocytes in vitro. Environ Sci Pollut Res. 2016;23:12312–22.
Article
Google Scholar
Morcillo P, Esteban MÁ, Cuesta A. Heavy metals produce toxicity, oxidative stress and apoptosis in the marine teleost fish SAF-1 cell line. Chemosphere. 2016;144:225–33.
Article
CAS
PubMed
Google Scholar
Teles M, Fierro-Castro C, Na-Phatthalung P, Tvarijonaviciute A, Trindade T, Soares AMVM, et al. Assessment of gold nanoparticle effects in a marine teleost (Sparus aurata) using molecular and biochemical biomarkers. Aquat Toxicol. 2016;177:125–35.
Article
CAS
PubMed
Google Scholar
Jesus TF, Inácio Â, Coelho MM. Different levels of hsp70 and hsc70 mRNA expression in Iberian fish exposed to distinct river conditions. Genet Mol Biol. 2013;36:61–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Das S, Mohapatra A, Sahoo PK. Expression analysis of heat shock protein genes during Aeromonas hydrophila infection in rohu, Labeo rohita, with special reference to molecular characterization of Grp78. Cell Stress Chaperon. 2015;20:73–84.
Article
CAS
Google Scholar
Morcillo P, Cordero H, Meseguer J, Esteban MA, Cuesta A. vitro immunotoxicological effects of heavy metals on European sea bass (Dicentrarchus labrax L.) head-kidney leucocytes. Fish Shellfish Immunol. 2015;47:245–54.
Article
CAS
PubMed
Google Scholar
Jia S, Nakaya N, Piatigorsky J. Differential expression patterns and developmental roles of duplicated scinderin-like genes in zebrafish. Dev Dynam. 2009;238:2633–40.
Article
CAS
Google Scholar
Kanungo J, Kozmik Z, Swamynathan SK, Piatigorsky J. Gelsolin is a dorsalizing factor in zebrafish. Proc Natl Acad Sci U S A. 2003;100:3287–92.
Article
CAS
PubMed
PubMed Central
Google Scholar
Marceau N, Loranger A, Gilbert S, Daigle N, Champetier S. Keratin-mediated resistance to stress and apoptosis in simple epithelial cells in relation to health and disease. Biochem Cell Biol. 2001;79:543–55.
Article
CAS
PubMed
Google Scholar
Molle V, Campagna S, Bessin Y, Ebran N, Saint N, Molle G. First evidence of the pore-forming properties of a keratin from skin mucus of rainbow trout (Oncorhynchus mykiss, formerly Salmo gairdneri). Biochem J. 2008;411:33–40.
Article
CAS
PubMed
Google Scholar
Schaffeld M, Höffling S, Haberkamp M, Conrad M, Markl J. Type I keratin cDNAs from the rainbow trout: independent radiation of keratins in fish. Differentiation. 2002;70:282–91.
Article
CAS
PubMed
Google Scholar
Palaksha KJ, Shin GW, Kim YR, Jung TS. Evaluation of non-specific immune components from the skin mucus of olive flounder (Paralichthys olivaceus). Fish Shellfish Immunol. 2008;24:479–88.
Article
CAS
PubMed
Google Scholar
Cordero H, Ceballos-Francisco D, Cuesta A, Esteban MA. Dorso-ventral skin characterization of the farmed fish gilthead seabream (Sparus aurata). PLoS One. 2017;12:e0180438.
Article
PubMed
PubMed Central
Google Scholar
Reddy VM, Suleman FG, Hayworth DA. Mycobacterium avium binds to mouse intestinal mucus aldolase. Tuberculosis. 2004;84:303–10.
Article
CAS
PubMed
Google Scholar
Laemmli UK. Cleavage of structural proteins during the assembly of the head bacteriophage T4. Nature. 1970;227:680–5.
Article
CAS
PubMed
Google Scholar
Shevchenko A, Wilm M, Vorm O, Mann M. Mass spectrometric sequencing of proteins from silver-stained polyacrylamide gels. Anal Chem. 1996;68:850–8.
Article
CAS
PubMed
Google Scholar
Lokesh J, Fernandes JMO, Korsnes K, Bergh O, Brinchmann MF, Kiron V. Transcriptional regulation of cytokines in the intestine of Atlantic cod fed yeast derived mannan oligosaccharide or β-glucan and challenged with Vibrio anguillarum. Fish Shellfish Immunol. 2012;33:626–31.
Article
CAS
PubMed
Google Scholar
Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 2001;25:402–8.
Article
CAS
PubMed
Google Scholar
Pfaffl MW, Tichopad A, Prgomet C, Neuvians TP. Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper – excel-based tool using pair-wise correlations. Biotechnol Lett. 2004;26:509–15.
Article
CAS
PubMed
Google Scholar
Cuesta A, Meseguer J, Esteban MA. Total serum immunoglobulin M levels are affected by immunomodulators in seabream (Sparus aurata L.). Vet Immunol Immunopathol. 2004;101:203–10.
Article
CAS
PubMed
Google Scholar