Brass W. Hüftgelenkdysplasie und Ellbogenkrankkung im Visier der Fédération Cynologique Internationale. Kleintierpraxis. 1993;38:191–266.
Google Scholar
Skurková L, Hluchý M, Lacková M, Mihalová M, Ledecký V. Relation of the norberg angle and position of the femoral head Centre to the dorsal acetabular edge in evaluation of canine hip dysplasia. Vet Comp Orthop Traumatol. 2010;23:433–8.
Article
PubMed
Google Scholar
Allen MJ. What’s new in Orthopaedic basic science. J Bone Jt Surg. 2016;98:2025–9.
Article
Google Scholar
Wilson BJ, Nicholas FW, James JW, Wade CM, Raadsma HW, Thomson PC. Genetic correlations among canine hip dysplasia radiographic traits in a cohort of Australian German shepherd dogs, and implications for the design of a more effective genetic control program. PLoS One. 2013;8:e78929.
Article
CAS
PubMed
PubMed Central
Google Scholar
Zhou Z, Sheng X, Zhang Z, Zhao K, Zhu L, Guo G, et al. Differential genetic regulation of canine hip dysplasia and osteoarthritis. PLoS One. 2010;5:e13219.
Article
PubMed
PubMed Central
CAS
Google Scholar
Mateescu RG, Burton-Wurster NI, Tsai K, Phavaphutanon J, Zhang Z, Murphy KE, et al. Identification of quantitative trait loci for osteoarthritis of hip joints in dogs. Am J Vet Res. 2008;69:1294–300.
Article
PubMed
Google Scholar
Sánchez-Molano E, Woolliams JA, Pong-Wong R, Clements DN, Blott SC, Wiener P. Quantitative trait loci mapping for canine hip dysplasia and its related traits in UK Labrador retrievers. BMC Genomics. 2014;15:833.
Article
PubMed
PubMed Central
Google Scholar
Janutta V, Hamann H, Distl O. Complex segregation analysis of canine hip dysplasia in German shepherd dogs. J Hered. 2006;97:13–20.
Article
CAS
PubMed
Google Scholar
Pfahler S, Distl O. Identification of quantitative trait loci (QTL) for canine hip dysplasia and canine elbow dysplasia in Bernese mountain dogs. PLoS One. 2012;7:e49782.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lavrijsen ICM, Leegwater PAJ, Martin AJ, Harris SJ, Tryfonidou MA, Heuven HCM, et al. Genome wide analysis indicates genes for basement membrane and cartilage matrix proteins as candidates for hip dysplasia in Labrador retrievers. PLoS One. 2014;9:e87735.
Article
PubMed
PubMed Central
CAS
Google Scholar
Todhunter RJ, Bliss SP, Casella G, Wu R, Lust G, Burton-Wurster NI, et al. Genetic structure of susceptibility traits for hip dysplasia and microsatellite Informativeness of an outcrossed canine pedigree. J Hered. 2003;94:39–48.
Article
CAS
PubMed
Google Scholar
Mäki K, Janss LLG, Groen AF, Liinamo A-E, Ojala M. An indication of major genes affecting hip and elbow dysplasia in four Finnish dog populations. Hered (Edinb). 2004;92:402–8.
Article
CAS
Google Scholar
Hayward JJ, Castelhano MG, Oliveira KC, Corey E, Balkman C, Baxter TL, et al. Complex disease and phenotype mapping in the domestic dog. Nat Commun. 2016;7:10460.
Article
CAS
PubMed
PubMed Central
Google Scholar
Fels L, Distl O. Identification and validation of quantitative trait loci (QTL) for canine hip dysplasia (CHD) in German shepherd dogs. PLoS One. 2014;9:e96618.
Article
PubMed
PubMed Central
CAS
Google Scholar
Bartolomé N, Segarra S, Artieda M, Francino O, Sánchez E, Szczypiorska M, et al. A genetic predictive model for canine hip dysplasia: integration of genome wide association study (GWAS) and candidate gene approaches. PLoS One. 2015;10:e0122558.
Article
PubMed
PubMed Central
CAS
Google Scholar
Fels L, Marschall Y, Philipp U, Distl O. Multiple loci associated with canine hip dysplasia (CHD) in German shepherd dogs. Mamm Genome. 2014;25:262–9.
Article
CAS
PubMed
Google Scholar
Sánchez-Molano E, Woolliams JA, Blott SC, Wiener P. Assessing the impact of genomic selection against hip dysplasia in the Labrador retriever dog. J Anim Breed Genet. 2014;131:134–45.
Article
PubMed
Google Scholar
Smith GK, Mayhew PD, Kapatkin AS, McKelvie PJ, Shofer FS, Gregor TP. Evaluation of risk factors for degenerative joint disease associated with hip dysplasia in German shepherd dogs, Golden retrievers, Labrador retrievers, and Rottweilers. J Am Vet Med Assoc. 2001;219:1719–24.
Article
CAS
PubMed
Google Scholar
Hou Y, Wang Y, Lu X, Zhang X, Zhao Q, Todhunter RJ, et al. Monitoring hip and elbow dysplasia achieved modest genetic improvement of 74 dog breeds over 40 years in USA. PLoS One. 2013;8:e76390.
Article
CAS
PubMed
PubMed Central
Google Scholar
Lewis TW, Blott SC, Woolliams JA. Comparative analyses of genetic trends and prospects for selection against hip and elbow dysplasia in 15 UK dog breeds. BMC Genet. 2013;14:16.
Article
PubMed
PubMed Central
Google Scholar
Edwards SM, Woolliams JA, Hickey JM, Blott SC, Clements DN, Sánchez-Molano E, et al. Joint genomic prediction of canine hip dysplasia in UK and US Labrador retrievers. Front Genet. 2018;9:101.
Article
PubMed
PubMed Central
Google Scholar
Oberbauer AM, Keller GG, Famula TR. Long-term genetic selection reduced prevalence of hip and elbow dysplasia in 60 dog breeds. PLoS One. 2017;12:e0172918.
Article
CAS
PubMed
PubMed Central
Google Scholar
Sánchez-Molano E, Pong-Wong R, Clements DN, Blott SC, Wiener P, Woolliams JA. Genomic prediction of traits related to canine hip dysplasia. Front Genet. 2015;6:97.
Article
PubMed
PubMed Central
CAS
Google Scholar
Guo G, Zhou Z, Wang Y, Zhao K, Zhu L, Lust G, et al. Canine hip dysplasia is predictable by genotyping. Osteoarthr Cartil. 2011;19:420–9.
Article
CAS
Google Scholar
Broeckx BJG, Vezzoni A, Bogaerts E, Bertal M, Deforce D, Peelman L, et al. Comparison of three methods to quantify laxity in the canine hip joint. Vet Comp Orthop Traumatol. 2018;31:23–9.
Article
PubMed
Google Scholar
Verhoeven GE, Coopman F, Duchateau L, Bosmans T, Van Ryssen B, Van Bree H. Interobserver agreement of the assessability of standard ventrodorsal hip-extended radiographs and its effect on agreement in the diagnosis of canine hip dysplasia and routine FCI scoring. Vet Radiol Ultrasound. 2009;50:259–63.
Article
PubMed
Google Scholar
Loeser RF, Goldring SR, Scanzello CR, Goldring MB. Osteoarthritis: a disease of the joint as an organ. Arthritis Rheum. 2012;64:1697–707.
Article
PubMed
PubMed Central
Google Scholar
Mikkola LI, Holopainen S, Lappalainen AK, Pessa-Morikawa T, Augustine TJP, Arumilli M, et al. Novel protective and risk loci in hip dysplasia in German shepherds. PLoS Genet. 2019;15:e1008197.
Article
PubMed
PubMed Central
CAS
Google Scholar
Daumer KM, Khan AU, Steinbeck MJ. Chlorination of pyridinium compounds. Possible role of hypochlorite, N-chloramines, and chlorine in the oxidation of pyridinoline cross-links of articular cartilage collagen type II during acute inflammation. J Biol Chem. 2000;275:34681–92.
Article
CAS
PubMed
Google Scholar
Steinbeck MJ, Nesti LJ, Sharkey PF, Parvizi J. Myeloperoxidase and chlorinated peptides in osteoarthritis: potential biomarkers of the disease. J Orthop Res. 2007;25:1128–35.
Article
CAS
PubMed
PubMed Central
Google Scholar
Breitenbach M, Rinnerthaler M, Weber M, Breitenbach-Koller H, Karl T, Cullen P, et al. The defense and signaling role of NADPH oxidases in eukaryotic cells. Wien Med Wochenschr. 2018;168:286–99.
Article
PubMed
PubMed Central
Google Scholar
Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, et al. STRING v10: protein–protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 2015;43:D447–52.
Article
CAS
PubMed
Google Scholar
Volk SW, Kapatkin AS, Haskins ME, Walton RM, D’Angelo M. Gelatinase activity in synovial fluid and synovium obtained from healthy and osteoarthritic joints of dogs. Am J Vet Res. 2003;64:1225–33.
Article
CAS
PubMed
Google Scholar
Fujiki M, Shineha J, Yamanokuchi K, Misumi K, Sakamoto H. Effects of treatment with polysulfated glycosaminoglycan on serum cartilage oligomeric matrix protein and C-reactive protein concentrations, serum matrix metalloproteinase-2 and -9 activities, and lameness in dogs with osteoarthritis. Am J Vet Res. 2007;68:827–33.
Article
CAS
PubMed
Google Scholar
Zeng GQ, Chen AB, Li W, Song JH, Gao CY. High MMP-1, MMP-2, and MMP-9 protein levels in osteoarthritis. Genet Mol Res. 2015;14:14811–22.
Article
CAS
PubMed
Google Scholar
Chiu CY, Leng S, Martin KA, Kim E, Gorman S, Duhl DM. Cloning and characterization of T-cell lymphoma invasion and metastasis 2 (TIAM2), a novel guanine nucleotide exchange factor related to TIAM1. Genomics. 1999;61:66–73.
Article
CAS
PubMed
Google Scholar
ARID1B. Uniprot. https://www.uniprot.org/uniprot/Q8NFD5#function. Accessed 23 Nov 2018.
Schrier Vergano S, Santen G, Wieczorek D, Wollnik B, Matsumoto N, Deardorff MA. Coffin-Siris Syndrome. GeneReviews®. 1993. http://www.ncbi.nlm.nih.gov/pubmed/23556151. Accessed 27 Nov 2018.
Google Scholar
Santen GWE, Clayton-Smith J. The ARID1B phenotype: what we have learned so far. Am J Med Genet Part C Semin Med Genet. 2014;166:276–89.
Article
CAS
Google Scholar
Chase K, Lawler DF, Carrier DR, Lark KG. Genetic regulation of osteoarthritis: a QTL regulating cranial and caudal acetabular osteophyte formation in the hip joint of the dog (Canis familiaris). Am J Med Genet A. 2005;135:334–5.
Article
PubMed
PubMed Central
Google Scholar
Todhunter RJ, Zachos TA, Gilbert RO, Erb HN, Williams AJ, Burton-Wurster N, et al. Onset of epiphyseal mineralization and growth plate closure in radiographically normal and dysplastic Labrador retrievers. J Am Vet Med Assoc. 1997;210:1458–62.
CAS
PubMed
Google Scholar
Madsen JS, Reimann I, Svalastoga E. Delayed ossification of the femoral head in dogs with hip dysplasia. J Small Anim Pract. 1991;32:351–4.
Article
Google Scholar
McMahon JA, Takada S, Zimmerman LB, Fan CM, Harland RM, McMahon AP. Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite. Genes Dev. 1998;12:1438–52.
Article
CAS
PubMed
PubMed Central
Google Scholar
Brunet LJ, McMahon JA, McMahon AP, Harland RM. Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Sci. 1998;280:1455–7.
Article
CAS
Google Scholar
Potti TA, Petty EM, Lesperance MM. A comprehensive review of reported heritable noggin-associated syndromes and proposed clinical utility of one broadly inclusive diagnostic term: NOG-related-symphalangism spectrum disorder (NOG-SSD). Hum Mutat. 2011;32:877–86.
Article
CAS
PubMed
Google Scholar
Tylzanowski P, Mebis L, Luyte FP. The noggin null mouse phenotype is strain dependent and haploinsufficieny leads to skeletal defects. Dev Dyn. 2006;235:1599–607.
Article
CAS
PubMed
Google Scholar
Devlin RD, Du Z, Pereira RC, Kimble RB, Economides AN, Jorgetti V, et al. Skeletal overexpression of noggin results in osteopenia and reduced bone formation. Endocrinol. 2003;144:1972–8.
Article
CAS
Google Scholar
Ghadakzadeh S, Hamdy RC, Tabrizian M. Efficient in vitro delivery of noggin siRNA enhances osteoblastogenesis. Heliyon. 2017;3:e00450.
Article
CAS
PubMed
PubMed Central
Google Scholar
Kong Y, Nan K, Yin Y. Identification and characterization of CAC1 as a novel CDK2-associated cullin. Cell Cycle. 2009;8:3552–61.
Article
CAS
PubMed
Google Scholar
Bonnomet A, Polette M, Strumane K, Gilles C, Dalstein V, Kileztky C, et al. The E-cadherin-repressed hNanos1 gene induces tumor cell invasion by upregulating MT1-MMP expression. Oncogene. 2008;27:3692–9.
Article
CAS
PubMed
Google Scholar
Shi J, Son M-Y, Yamada S, Szabova L, Kahan S, Chrysovergis K, et al. Membrane-type MMPs enable extracellular matrix permissiveness and mesenchymal cell proliferation during embryogenesis. Dev Biol. 2008;313:196–209.
Article
CAS
PubMed
Google Scholar
Itoh Y, Ito N, Nagase H, Evans RD, Bird SA, Seiki M. Cell surface collagenolysis requires homodimerization of the membrane-bound collagenase MT1-MMP. Mol Biol Cell. 2006;17:5390–9.
Article
CAS
PubMed
PubMed Central
Google Scholar
Miller M-C, Manning HB, Jain A, Troeberg L, Dudhia J, Essex D, et al. Membrane type 1 matrix metalloproteinase is a crucial promoter of synovial invasion in human rheumatoid arthritis. Arthritis Rheum. 2009;60:686–97.
Article
CAS
PubMed
PubMed Central
Google Scholar
Huang M, Hayward JJ, Corey E, Garrison SJ, Wagner GR, Krotscheck U, et al. A novel iterative mixed model to remap three complex orthopedic traits in dogs. PLoS One. 2017;12:e0176932.
Article
PubMed
PubMed Central
CAS
Google Scholar
Delgado-Calle J, Fernández AF, Sainz J, Zarrabeitia MT, Sañudo C, García-Renedo R, et al. Genome-wide profiling of bone reveals differentially methylated regions in osteoporosis and osteoarthritis. Arthritis Rheum. 2013;65:197–205.
Article
CAS
PubMed
Google Scholar
Fei Q, Lin J, Meng H, Wang B, Yang Y, Wang Q, et al. Identification of upstream regulators for synovial expression signature genes in osteoarthritis. Jt Bone Spine. 2016;83:545–51.
Article
CAS
Google Scholar
Ahola-Olli AV, Würtz P, Havulinna AS, Aalto K, Pitkänen N, Lehtimäki T, et al. Genome-wide association study identifies 27 loci influencing concentrations of circulating cytokines and growth factors. Am J Hum Genet. 2017;100:40–50.
Article
CAS
PubMed
Google Scholar
GWAS Catalog. https://www.ebi.ac.uk/gwas/variants/rs1452928. Accessed 18 Jan 2019.
Koch AE, Kunkel SL, Shah MR, Fu R, Mazarakis DD, Haines GK, et al. Macrophage inflammatory protein-Iβ: a C-C chemokine in osteoarthritis. Clin Immunol Immunopathol. 1995;77:307–14.
Article
CAS
PubMed
Google Scholar
SLC7A1. https://www.uniprot.org/uniprot/P30825#function. Accessed 28 Jan 2019.
Pascale V, Pascale W, Lavanga V, Sansone V, Ferrario P, De Gennaro Colonna V. L-arginine, asymmetric dimethylarginine, and symmetric dimethylarginine in plasma and synovial fluid of patients with knee osteoarthritis. Med Sci Monit. 2013;19:1057–62.
Article
PubMed
PubMed Central
CAS
Google Scholar
Boyle EA, Li YI, Pritchard JK. An expanded view of complex traits: from polygenic to Omnigenic. Cell. 2017;169:1177–86.
Article
CAS
PubMed
PubMed Central
Google Scholar
Hip joint statistics - German shepherd. In: Breeding database of the Finnish Kennel Club; 2017. https://jalostus.kennelliitto.fi/frmTerveystilastot.aspx?R=166&Lang=en. Accessed 18 Sep 2017.
Flückiger M, Ecvdi D. Scoring radiographs for canine hip dysplasia-the big three organisations in the world. Eur J Companion Anim Pract. 2008;17:135–40.
Google Scholar
Lust G, Todhunter RJ, Erb HN, Dykes NL, Williams AJ, Burton-Wurster NI, et al. Repeatability of dorsolateral subluxation scores in dogs and correlation with macroscopic appearance of hip osteoarthritis. Am J Vet Res. 2001;62:1711–5.
Article
CAS
PubMed
Google Scholar
R Core Team. R: The R Project for Statistical Computing. R Foundation for statistical computing. 2017. https://www.r-project.org/.
Fraley C, Raftery AE, Murphy TB, Scrucca L. mclust Version 4 for R: Normal Mixture Modeling for Model-Based Clustering, Classification, and Density Estimation. In: Technical Report 597. Seattle: University of Washington; 2012. p. 1–50. http://www.stat.washington.edu/research/reports/2012/tr597.pdf.
Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MAR, Bender D, et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet. 2007;81:559–75.
Article
CAS
PubMed
PubMed Central
Google Scholar
Aulchenko YS, Ripke S, Isaacs A, van Duijn CM. GenABEL: an R library for genome-wide association analysis. Bioinformatics. 2007;23:1294–6.
Article
CAS
PubMed
Google Scholar
CanFam3.1 GCA_000002285.2. https://www.ncbi.nlm.nih.gov/assembly/GCF_000002285.3/. Accessed 26 Apr 2018.
Chen W-M, Abecasis GR. Family-based association tests for Genomewide association scans. Am J Hum Genet. 2007;81:913–26.
Article
CAS
PubMed
PubMed Central
Google Scholar
lm {stats} R Documentation. https://stat.ethz.ch/R-manual/R-devel/library/stats/html/lm.html. Accessed 3 May 2019.
glm {stats} R documentation. https://stat.ethz.ch/R-manual/R-devel/library/stats/html/glm.html. Accessed 3 May 2019.
r2fast. https://www.rdocumentation.org/packages/GenABEL/versions/1.8-0/topics/r2fast. Accessed 3 May 2019.
Johnson RC, Nelson GW, Troyer JL, Lautenberger JA, Kessing BD, Winkler CA, et al. Accounting for multiple comparisons in a genome-wide association study (GWAS). BMC Genomics. 2010;11:724.
Article
PubMed
PubMed Central
Google Scholar
Gao X, Becker LC, Becker DM, Starmer JD, Province MA. Avoiding the high Bonferroni penalty in genome-wide association studies. Genet Epidemiol. 2010;34:100–5.
PubMed
PubMed Central
Google Scholar