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  1. The mesencephalic dopaminergic (mDA) cell system is composed of two major groups of projecting cells in the Substantia Nigra (SN) (A9 neurons) and the Ventral Tegmental Area (VTA) (A10 cells). Selective degene...

    Authors: Alice Grison, Silvia Zucchelli, Alice Urzì, Ilaria Zamparo, Dejan Lazarevic, Giovanni Pascarella, Paola Roncaglia, Alejandro Giorgetti, Paula Garcia-Esparcia, Christina Vlachouli, Roberto Simone, Francesca Persichetti, Alistair RR Forrest, Yoshihide Hayashizaki, Paolo Carloni, Isidro Ferrer…
    Citation: BMC Genomics 2014 15:729
    Content type: Research article Published on:

  2. Aberrational epigenetic marks are believed to play a major role in establishing the abnormal features of cancer cells. Rational use and development of drugs aimed at epigenetic processes requires an understand...

    Authors: Sally Yoo and Mark C Bieda
    Citation: BMC Genomics 2014 15:724
    Content type: Research article Published on:

  3. Since the first fungal genome sequences became available, investigators have been employing comparative genomics to understand how fungi have evolved to occupy diverse ecological niches. The secretome, i.e. th...

    Authors: Jorrit-Jan Krijger, Michael R Thon, Holger B Deising and Stefan GR Wirsel
    Citation: BMC Genomics 2014 15:722
    Content type: Research article Published on:

  4. Molecular characterization of highly diverse gene families can be time consuming, expensive, and difficult, especially when considering the potential for relatively large numbers of paralogs and/or pseudogenes...

    Authors: Peter A Larsen, Amy M Heilman and Anne D Yoder
    Citation: BMC Genomics 2014 15:720
    Content type: Research article Published on:

  5. Analysis of single nucleotide polymorphisms (SNPs) derived from whole-genome studies allows for rapid evaluation of genome-wide diversity, and genomic epidemiology studies of Plasmodium falciparum provide insight...

    Authors: Christopher G Jacob, John C Tan, Becky A Miller, Asako Tan, Shannon Takala-Harrison, Michael T Ferdig and Christopher V Plowe
    Citation: BMC Genomics 2014 15:719
    Content type: Methodology article Published on:

  6. The complex societies of ants and other social insects rely on sophisticated chemical communication. Two families of small soluble proteins, the odorant binding and chemosensory proteins (OBPs and CSPs), are b...

    Authors: Sean K McKenzie, Peter R Oxley and Daniel JC Kronauer
    Citation: BMC Genomics 2014 15:718
    Content type: Research article Published on:

  8. The serious feeding- and microbiota-associated intestinal disease, necrotizing enterocolitis (NEC), occurs mainly in infants born prematurely (5-10% of all newborns) and most frequently after formula-feeding. ...

    Authors: Fei Gao, Juyong Zhang, Pingping Jiang, Desheng Gong, Jun-Wen Wang, Yudong Xia, Mette Viberg Østergaard, Jun Wang and Per Torp Sangild
    Citation: BMC Genomics 2014 15:716
    Content type: Research article Published on:

  9. Schistosoma japonicum is a pathogen of the phylum Platyhelminthes that causes zoonotic schistosomiasis in China and Southeast Asian countries where a lack of efficient measures has hampered disease control. The d...

    Authors: Xianyu Piao, Nan Hou, Pengfei Cai, Shuai Liu, Chuang Wu and Qijun Chen
    Citation: BMC Genomics 2014 15:715
    Content type: Research article Published on:

  10. The olive fly, Bactrocera oleae, is the most devastating pest of cultivated olives. Its control has been traditionally based on insecticides, mainly organophosphates and pyrethroids. In recent years, the naturaly...

    Authors: Efthimia Sagri, Martin Reczko, Maria-Eleni Gregoriou, Konstantina T Tsoumani, Nikolaos E Zygouridis, Klelia D Salpea, Frank G Zalom, Jiannis Ragoussis and Kostas D Mathiopoulos
    Citation: BMC Genomics 2014 15:714
    Content type: Research article Published on:

  11. There is a need to characterize genomes of the foodborne pathogen, Salmonella enterica serovar Enteritidis (SE) and identify genetic information that could be ultimately deployed for differentiating strains of th...

    Authors: Dele Ogunremi, John Devenish, Kingsley Amoako, Hilary Kelly, Andrée Ann Dupras, Sebastien Belanger and Lin Ru Wang
    Citation: BMC Genomics 2014 15:713
    Content type: Research article Published on:

  12. Legumes form root nodules to house nitrogen fixing bacteria of the rhizobium family. The rhizobia are located intracellularly in the symbiotic nodule cells. In the legume Medicago truncatula these cells produce h...

    Authors: Ibtissem Guefrachi, Marianna Nagymihaly, Catalina I Pislariu, Willem Van de Velde, Pascal Ratet, Mohamed Mars, Michael K Udvardi, Eva Kondorosi, Peter Mergaert and Benoît Alunni
    Citation: BMC Genomics 2014 15:712
    Content type: Research article Published on:

  13. SOX2 is a core component of the transcriptional network responsible for maintaining embryonal carcinoma cells (ECCs) in a pluripotent, undifferentiated state of self-renewal. As such, SOX2 is an oncogenic tran...

    Authors: Sebastian F Vencken, Praveen Sethupathy, Gordon Blackshields, Cathy Spillane, Salah Elbaruni, Orla Sheils, Michael F Gallagher and John J O’Leary
    Citation: BMC Genomics 2014 15:711
    Content type: Research article Published on:

  14. Fusarium verticillioides causes ear rot in maize (Zea mays L.) and accumulation of mycotoxins, that affect human and animal health. Currently, chemical and agronomic measures to control Fusarium ear rot are not v...

    Authors: Alessandra Lanubile, Alberto Ferrarini, Valentina Maschietto, Massimo Delledonne, Adriano Marocco and Diana Bellin
    Citation: BMC Genomics 2014 15:710
    Content type: Research article Published on:

  15. The laying hen model of spontaneous epithelial ovarian cancer (EOC) is unique in that it is the only model that enables observations of early events in disease progression and is therefore also uniquely suited...

    Authors: Karen H Hales, Sheree C Speckman, Nawneet K Kurrey and Dale B Hales
    Citation: BMC Genomics 2014 15:709
    Content type: Research article Published on:

  16. In the whole genome sequencing, genetic map provides an essential framework for accurate and efficient genome assembly and validation. The main objectives of this study were to develop a high-density genetic m...

    Authors: Amit A Deokar, Larissa Ramsay, Andrew G Sharpe, Marwan Diapari, Anoop Sindhu, Kirstin Bett, Thomas D Warkentin and Bunyamin Tar’an
    Citation: BMC Genomics 2014 15:708
    Content type: Research article Published on:

  17. The Smyth line (SL) chicken is the only animal model for autoimmune vitiligo that spontaneously displays all clinical and biological manifestations of the human disorder. To understand the genetic components u...

    Authors: Hyeon-Min Jang, Gisela F Erf, Kaylee C Rowland and Byung-Whi Kong
    Citation: BMC Genomics 2014 15:707
    Content type: Research article Published on:

  18. Magnolia sprengeri Pamp is one of the most highly valuable medicinal and ornamental plants of the Magnolia Family. The natural color of M. sprengeri is variable. The complete genome sequence of M. sprengeri is no...

    Authors: Shou-Guo Shi, Mei Yang, Min Zhang, Ping Wang, Yong-Xiang Kang and Jian-Jun Liu
    Citation: BMC Genomics 2014 15:706
    Content type: Research article Published on:

  20. Spodoptera frugiperda (Noctuidae) is a major agricultural pest throughout the American continent. The highly polyphagous larvae are frequently devastating crops of importance such as corn, sorghum, cotton and gra...

    Authors: Fabrice Legeai, Sylvie Gimenez, Bernard Duvic, Jean-Michel Escoubas, Anne-Sophie Gosselin Grenet, Florence Blanc, François Cousserans, Imène Séninet, Anthony Bretaudeau, Doriane Mutuel, Pierre-Alain Girard, Christelle Monsempes, Ghislaine Magdelenat, Frédérique Hilliou, René Feyereisen, Mylène Ogliastro…
    Citation: BMC Genomics 2014 15:704
    Content type: Research article Published on:

  21. Current practice in mass spectrometry (MS)-based proteomics is to identify peptides by comparison of experimental mass spectra with theoretical mass spectra derived from a reference protein database; however, ...

    Authors: Gloria M Sheynkman, James E Johnson, Pratik D Jagtap, Michael R Shortreed, Getiria Onsongo, Brian L Frey, Timothy J Griffin and Lloyd M Smith
    Citation: BMC Genomics 2014 15:703
    Content type: Methodology article Published on:

  22. Iron is an essential micronutrient for all living things, required in plants for photosynthesis, respiration and metabolism. A lack of bioavailable iron in soil leads to iron deficiency chlorosis (IDC), causin...

    Authors: Adrienne N Moran Lauter, Gregory A Peiffer, Tengfei Yin, Steven A Whitham, Dianne Cook, Randy C Shoemaker and Michelle A Graham
    Citation: BMC Genomics 2014 15:702
    Content type: Research article Published on:

  23. Hybridization coupled with whole-genome duplication (allopolyploidy) leads to a variety of genetic and epigenetic modifications in the resultant merged genomes. In particular, gene loss and gene silencing are ...

    Authors: Tina Sehrish, V Vaughan Symonds, Douglas E Soltis, Pamela S Soltis and Jennifer A Tate
    Citation: BMC Genomics 2014 15:701
    Content type: Research article Published on:

  24. Engineered nanomaterials may release nanosized residues, by degradation, throughout their life cycle. These residues may be a threat for living organisms. They may be ingested by humans through food and water....

    Authors: Matthieu Fisichella, Frederic Berenguer, Gerard Steinmetz, Melanie Auffan, Jerome Rose and Odette Prat
    Citation: BMC Genomics 2014 15:700
    Content type: Research article Published on:

  25. The availability of diverse second- and third-generation sequencing technologies enables the rapid determination of the sequences of bacterial genomes. However, identifying the sequencing technology most suita...

    Authors: Mari Miyamoto, Daisuke Motooka, Kazuyoshi Gotoh, Takamasa Imai, Kazutoshi Yoshitake, Naohisa Goto, Tetsuya Iida, Teruo Yasunaga, Toshihiro Horii, Kazuharu Arakawa, Masahiro Kasahara and Shota Nakamura
    Citation: BMC Genomics 2014 15:699
    Content type: Research article Published on:

  26. Marine diatoms constitute a major component of eukaryotic phytoplankton and stand at the crossroads of several evolutionary lineages. These microalgae possess peculiar genomic features and novel combinations o...

    Authors: Alessandra Rogato, Hugues Richard, Alexis Sarazin, Björn Voss, Soizic Cheminant Navarro, Raphaël Champeimont, Lionel Navarro, Alessandra Carbone, Wolfgang R Hess and Angela Falciatore
    Citation: BMC Genomics 2014 15:698
    Content type: Research article Published on:

  27. Marine phytoplankton are responsible for 50% of the CO2 that is fixed annually worldwide and contribute massively to other biogeochemical cycles in the oceans. Diatoms and coccolithophores play a significant role...

    Authors: Sara Lopez-Gomollon, Matthew Beckers, Tina Rathjen, Simon Moxon, Florian Maumus, Irina Mohorianu, Vincent Moulton, Tamas Dalmay and Thomas Mock
    Citation: BMC Genomics 2014 15:697
    Content type: Research article Published on:

  28. The phylum Apicomplexa comprises important unicellular human parasites such as Toxoplasma and Plasmodium. Eimeria is the largest and most diverse genus of apicomplexan parasites and some species of the genus are ...

    Authors: Emanuel Heitlinger, Simone Spork, Richard Lucius and Christoph Dieterich
    Citation: BMC Genomics 2014 15:696
    Content type: Research article Published on:

  29. In plants, microRNAs (miRNAs) regulate gene expression mainly at the post-transcriptional level. Previous studies have demonstrated that miRNA-mediated gene silencing pathways play vital roles in plant develop...

    Authors: Yuanlong Liu, Lun Wang, Dijun Chen, Xiaomeng Wu, Ding Huang, Lingling Chen, Li Li, Xiuxin Deng and Qiang Xu
    Citation: BMC Genomics 2014 15:695
    Content type: Research article Published on:

  30. Uranium (U) is a naturally occurring radionuclide that has been found in the aquatic environment due to anthropogenic activities. Exposure to U may pose risk to aquatic organisms due to its radiological and ch...

    Authors: You Song, Brit Salbu, Hans-Christian Teien, Lene Sørlie Heier, Bjørn Olav Rosseland, Tore Høgåsen and Knut Erik Tollefsen
    Citation: BMC Genomics 2014 15:694
    Content type: Research article Published on:

  31. Previous studies have shown that CpG dinucleotides are enriched in a subset of promoters and the CpG content of promoters is positively correlated with gene expression levels. But the relationship between dive...

    Authors: Huan Yang, Dawei Li and Chao Cheng
    Citation: BMC Genomics 2014 15:693
    Content type: Research article Published on:

  33. Although mitochondrial (mt) gene order is highly conserved among vertebrates, widespread gene rearrangements occur in anurans, especially in neobatrachians. Protein coding genes in the mitogenome experience ad...

    Authors: Yun Xia, Yuchi Zheng, Ikuo Miura, Pamela BY Wong, Robert W Murphy and Xiaomao Zeng
    Citation: BMC Genomics 2014 15:691
    Content type: Research article Published on:

  34. The yolk sac (YS) is an extra-embryonic tissue that surrounds the yolk and absorbs, digests and transports nutrients during incubation of the avian embryo as well as during early term mammalian embryonic devel...

    Authors: Liran Yadgary, Eric A Wong and Zehava Uni
    Citation: BMC Genomics 2014 15:690
    Content type: Research article Published on:

  35. Herbaceous peony (Paeonia lactiflora Pall.) is a traditional flower in China and a wedding attractive flower in worldwide. In its flower colour, yellow is the rarest which is ten times the price of the other colo...

    Authors: Daqiu Zhao, Yao Jiang, Chuanlong Ning, Jiasong Meng, Shasha Lin, Wen Ding and Jun Tao
    Citation: BMC Genomics 2014 15:689
    Content type: Research article Published on:

  36. Variability in protein levels is generated through intricate control of the different gene decoding phases. Presently little is known about the links between the various gene expression stages. Here we investi...

    Authors: Ana Tamarkin-Ben-Harush, Edna Schechtman and Rivka Dikstein
    Citation: BMC Genomics 2014 15:688
    Content type: Research article Published on:

  37. Array comparative genomic hybridization (aCGH) is commonly used to screen different types of genetic variation in humans and model species. Here, we performed aCGH using an oligonucleotide gene-expression arra...

    Authors: Marina Panova, Tomas Johansson, Björn Canbäck, Johan Bentzer, Magnus Alm Rosenblad, Kerstin Johannesson, Anders Tunlid and Carl André
    Citation: BMC Genomics 2014 15:687
    Content type: Research article Published on:

  38. Hypoxia is a critical aspect of the glioma microenvironment and has been associated with poor prognosis and resistance to various therapies. However, the mechanisms responsible for hypoxic survival of glioma c...

    Authors: Rahul Agrawal, Priyatama Pandey, Prerana Jha, Vivek Dwivedi, Chitra Sarkar and Ritu Kulshreshtha
    Citation: BMC Genomics 2014 15:686
    Content type: Research article Published on:

  39. Sequences up to several megabases in length have been found to be present in individual genomes but absent in the human reference genome. These sequences may be common in populations, and their absence in the ...

    Authors: Yu Liu, Mehmet Koyutürk, Sean Maxwell, Min Xiang, Martina Veigl, Richard S Cooper, Bamidele O Tayo, Li Li, Thomas LaFramboise, Zhenghe Wang, Xiaofeng Zhu and Mark R Chance
    Citation: BMC Genomics 2014 15:685
    Content type: Research article Published on:

  40. Prokaryotes have relatively small genomes, densely-packed with protein-encoding sequences. RNA sequencing has, however, revealed surprisingly complex transcriptomes and here we report the transcripts present i...

    Authors: Dominik Jäger, Konrad U Förstner, Cynthia M Sharma, Thomas J Santangelo and John N Reeve
    Citation: BMC Genomics 2014 15:684
    Content type: Research article Published on:

  41. Milk production is an economically important sector of global agriculture. Much attention has been paid to the identification of quantitative trait loci (QTL) associated with milk, fat, and protein yield and t...

    Authors: Lingyang Xu, John B Cole, Derek M Bickhart, Yali Hou, Jiuzhou Song, Paul M VanRaden, Tad S Sonstegard, Curtis P Van Tassell and George E Liu
    Citation: BMC Genomics 2014 15:683
    Content type: Research article Published on:

  42. Bats are a major source of new and emerging viral diseases. Despite the fact that bats carry and shed highly pathogenic viruses including Ebola, Nipah and SARS, they rarely display clinical symptoms of infecti...

    Authors: Christopher Cowled, Cameron R Stewart, Vladimir A Likic, Marc R Friedländer, Mary Tachedjian, Kristie A Jenkins, Mark L Tizard, Pauline Cottee, Glenn A Marsh, Peng Zhou, Michelle L Baker, Andrew G Bean and Lin-fa Wang
    Citation: BMC Genomics 2014 15:682
    Content type: Research article Published on:

  43. High density stress, also known as intraspecies competition, causes significant yield losses in a wide variety of crop plants. At the same time, increases in density tolerance through selective breeding and th...

    Authors: Maksym Misyura, David Guevara, Sanjeena Subedi, Darryl Hudson, Paul D McNicholas, Joseph Colasanti and Steven J Rothstein
    Citation: BMC Genomics 2014 15:681
    Content type: Research article Published on:

  44. Mapping expression quantitative trait loci (eQTL) of targeted genes represents a powerful and widely adopted approach to identify putative regulatory variants. Linking regulation differences to specific genes ...

    Authors: Yan Wang, Yingpeng Han, Weili Teng, Xue Zhao, Yongguang Li, Lin Wu, Dongmei Li and Wenbin Li
    Citation: BMC Genomics 2014 15:680
    Content type: Research article Published on:

  45. A seventh order of methanogens, the Methanomassiliicoccales, has been identified in diverse anaerobic environments including the gastrointestinal tracts (GIT) of humans and other animals and may contribute sig...

    Authors: Guillaume Borrel, Nicolas Parisot, Hugh MB Harris, Eric Peyretaillade, Nadia Gaci, William Tottey, Olivier Bardot, Kasie Raymann, Simonetta Gribaldo, Pierre Peyret, Paul W O’Toole and Jean-François Brugère
    Citation: BMC Genomics 2014 15:679
    Content type: Research article Published on:

  46. Babesia bovis is an apicomplexan parasite that causes babesiosis in infected cattle. Genomes of pathogens contain promising information that can facilitate the development of methods for controlling infections. A...

    Authors: Junya Yamagishi, Hiroyuki Wakaguri, Naoaki Yokoyama, Riu Yamashita, Yutaka Suzuki, Xuenan Xuan and Ikuo Igarashi
    Citation: BMC Genomics 2014 15:678
    Content type: Research article Published on:

  47. Mitochondrial DNA (mtDNA) deletions cause disease and accumulate during aging, yet our understanding of the molecular mechanisms underlying their formation remains rudimentary. Guanine-quadruplex (GQ) DNA stru...

    Authors: Dawei W Dong, Filipe Pereira, Steven P Barrett, Jill E Kolesar, Kajia Cao, Joana Damas, Liliya A Yatsunyk, F Brad Johnson and Brett A Kaufman
    Citation: BMC Genomics 2014 15:677
    Content type: Research article Published on:

  48. The major medicinal alkaloids isolated from Uncaria rhynchophylla (gouteng in chinese) capsules are rhynchophylline (RIN) and isorhynchophylline (IRN). Extracts containing these terpene indole alkaloids (TIAs) ca...

    Authors: Qianqian Guo, Xiaojun Ma, Shugen Wei, Deyou Qiu, Iain W Wilson, Peng Wu, Qi Tang, Lijun Liu, Shoukun Dong and Wei Zu
    Citation: BMC Genomics 2014 15:676
    Content type: Research article Published on:

  49. Gene expression analysis by RNA sequencing is now widely used in a number of applications surveying the whole transcriptomes of cells and tissues. The recent introduction of ribosomal RNA depletion protocols, ...

    Authors: Marc Sultan, Vyacheslav Amstislavskiy, Thomas Risch, Moritz Schuette, Simon Dökel, Meryem Ralser, Daniela Balzereit, Hans Lehrach and Marie-Laure Yaspo
    Citation: BMC Genomics 2014 15:675
    Content type: Research article Published on:

  50. Brown planthopper (BPH, Nilaparvata lugens Stål), is the most destructive phloem-feeding insect pest of rice (Oryza sativa). The BPH-resistance gene BPH15 has been proved to be effective in controlling the pest a...

    Authors: Wentang Lv, Ba Du, Xinxin Shangguan, Yan Zhao, Yufang Pan, Lili Zhu, Yuqing He and Guangcun He
    Citation: BMC Genomics 2014 15:674
    Content type: Research article Published on:

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BMC Genomics

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