Skip to main content

Articles

Page 216 of 337

  1. Paclitaxel (Taxol™) is an important anticancer drug with a unique mode of action. The biosynthesis of paclitaxel had been considered restricted to the Taxus species until it was discovered in Taxomyces andreanae,...

    Authors: Yanfang Yang, Hainan Zhao, Roberto A Barrero, Baohong Zhang, Guiling Sun, Iain W Wilson, Fuliang Xie, Kevin D Walker, Joshua W Parks, Robert Bruce, Guangwu Guo, Li Chen, Yong Zhang, Xin Huang, Qi Tang, Hongwei Liu…
    Citation: BMC Genomics 2014 15:69
    Content type: Research article Published on:

  2. Next-generation DNA sequencing (NGS) technologies have made huge impacts in many fields of biological research, but especially in evolutionary biology. One area where NGS has shown potential is for high-throug...

    Authors: Andrew C Clarke, Stefan Prost, Jo-Ann L Stanton, W Timothy J White, Matthew E Kaplan and Elizabeth A Matisoo-Smith
    Citation: BMC Genomics 2014 15:68
    Content type: Methodology article Published on:

  3. Wheat is an excellent plant species for nuclear mitochondrial interaction studies due to availability of large collection of alloplasmic lines. These lines exhibit different vegetative and physiological proper...

    Authors: Andrzej K Noyszewski, Farhad Ghavami, Loai M Alnemer, Ali Soltani, Yong Q Gu, Naxin Huo, Steven Meinhardt, Penny MA Kianian and Shahryar F Kianian
    Citation: BMC Genomics 2014 15:67
    Content type: Research article Published on:

  4. A successful development of herbivorous insects into plant tissues depends on coordination of metabolic processes. Plants have evolved complex mechanisms to recognize such attacks, and to trigger a defense res...

    Authors: Danielle C Cardoso, Juliana C Martinati, Poliana F Giachetto, Ramon O Vidal, Marcelo F Carazzolle, Lilian Padilha, Oliveiro Guerreiro-Filho and Mirian P Maluf
    Citation: BMC Genomics 2014 15:66
    Content type: Research article Published on:

  5. The relationships between bacterial genomes are complicated by rampant horizontal gene transfer, varied selection pressures, acquisition of new genes, loss of genes, and divergence of genes, even in closely re...

    Authors: Joe Rokicki, David Knox, Robin D Dowell and Shelley D Copley
    Citation: BMC Genomics 2014 15:65
    Content type: Software Published on:

  6. The copy number variation (CNV) in beta-defensin genes (DEFB) on human chromosome 8p23 has been proposed to contribute to the phenotypic differences in inflammatory diseases. However, determination of exact DE...

    Authors: Xianghong Zhang, Sebastian Müller, Michael Möller, Klaus Huse, Stefan Taudien, Malte Book, Frank Stuber, Matthias Platzer and Marco Groth
    Citation: BMC Genomics 2014 15:64
    Content type: Methodology article Published on:

  7. A close match of the HLA alleles between donor and recipient is an important prerequisite for successful unrelated hematopoietic stem cell transplantation. To increase the chances of finding an unrelated donor...

    Authors: Vinzenz Lange, Irina Böhme, Jan Hofmann, Kathrin Lang, Jürgen Sauter, Bianca Schöne, Patrick Paul, Viviane Albrecht, Johanna M Andreas, Daniel M Baier, Jochen Nething, Ulf Ehninger, Carmen Schwarzelt, Julia Pingel, Gerhard Ehninger and Alexander H Schmidt
    Citation: BMC Genomics 2014 15:63
    Content type: Methodology article Published on:

  8. Genome wide association studies (GWAS) in most cattle breeds result in large genomic intervals of significant associations making it difficult to identify causal mutations. This is due to the extensive, low-le...

    Authors: Lesley-Ann Raven, Benjamin G Cocks and Ben J Hayes
    Citation: BMC Genomics 2014 15:62
    Content type: Research article Published on:

  9. Sequence alignment has become an indispensable tool in modern molecular biology research, and probabilistic sequence alignment models have been shown to provide an effective framework for building accurate seq...

    Authors: Byung-Jun Yoon
    Citation: BMC Genomics 2014 15(Suppl 1):S14
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 15 Supplement 1

  10. Hepatocellular carcinoma (HCC) is one of the most highly malignant and lethal cancers of the world. Its pathogenesis has been reported to be multi-factorial, and the molecular carcinogenesis of HCC can not be ...

    Authors: Lin Wei, Baofeng Lian, Yuannv Zhang, Wei Li, Jianren Gu, Xianghuo He and Lu Xie
    Citation: BMC Genomics 2014 15(Suppl 1):S13
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 15 Supplement 1

  11. Taxonomic annotation of reads is an important problem in metagenomic analysis. Existing annotation tools, which rely on the approach of aligning each read to the taxonomic structure, are unable to annotate man...

    Authors: Yi Wang, Henry Chi Ming Leung, Siu Ming Yiu and Francis Yuk Lun Chin
    Citation: BMC Genomics 2014 15(Suppl 1):S12
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 15 Supplement 1

  12. Due to the importance of Penicillium chrysogenum holding in medicine, the genome of low-penicillin producing laboratorial strain Wisconsin54-1255 had been sequenced and fully annotated. Through classical mutagene...

    Authors: Fu-Qiang Wang, Jun Zhong, Ying Zhao, Jingfa Xiao, Jing Liu, Meng Dai, Guizhen Zheng, Li Zhang, Jun Yu, Jiayan Wu and Baoling Duan
    Citation: BMC Genomics 2014 15(Suppl 1):S11
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 15 Supplement 1

  13. In order to have a better understanding of unexplained heritability for complex diseases in conventional Genome-Wide Association Studies (GWAS), aggregated association analyses based on predefined functional r...

    Authors: Meng Lu, Hye-Seung Lee, David Hadley, Jianhua Z Huang and Xiaoning Qian
    Citation: BMC Genomics 2014 15(Suppl 1):S10
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 15 Supplement 1

  14. In mass spectrometry-based proteomics, the statistical significance of a peptide-spectrum or protein-spectrum match is an important indicator of the correctness of the peptide or protein identification. In bot...

    Authors: Xiaowen Liu, Matthew W Segar, Shuai Cheng Li and Sangtae Kim
    Citation: BMC Genomics 2014 15(Suppl 1):S9
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 15 Supplement 1

  15. During eukaryotic genome evolution, tandem gene duplication is the most frequent event giving rise to clustered gene families. However, how expression divergence between tandemly duplicated genes has emerged a...

    Authors: Ben-Yang Liao and Andrew Ying-Fei Chang
    Citation: BMC Genomics 2014 15(Suppl 1):S8
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 15 Supplement 1

  16. Histone proteins are subject to various posttranslational modifications (PTMs). Elucidating their functional relationships is crucial toward understanding many biological processes. Bayesian network (BN)-based...

    Authors: Ngoc Tu Le, Tu Bao Ho, Bich Hai Ho and Dang Hung Tran
    Citation: BMC Genomics 2014 15(Suppl 1):S7
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 15 Supplement 1

  17. Gene set enrichment analysis (GSEA) is an important approach to the analysis of coordinate expression changes at a pathway level. Although many statistical and computational methods have been proposed for GSEA...

    Authors: Yinglei Lai, Fanni Zhang, Tapan K Nayak, Reza Modarres, Norman H Lee and Timothy A McCaffrey
    Citation: BMC Genomics 2014 15(Suppl 1):S6
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 15 Supplement 1

  19. Reliable prediction of stability changes induced by a single amino acid substitution is an important aspect of computational protein design. Several machine learning methods capable of predicting stability cha...

    Authors: Lukas Folkman, Bela Stantic and Abdul Sattar
    Citation: BMC Genomics 2014 15(Suppl 1):S4
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 15 Supplement 1

  20. Tuberculosis has become a major health problem being the second leading cause of death worldwide. Mycobacterium tuberculosis secretes a virulence factor, protein tyrosine phosphatase B (mPTPB) in the cytoplasm of...

    Authors: Jaspreet Kaur Dhanjal, Sonam Grover, Sudhanshu Sharma, Ajeet Kumar Singh and Abhinav Grover
    Citation: BMC Genomics 2014 15(Suppl 1):S3
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 15 Supplement 1

  21. Prediction of the structural classes of proteins can provide important information about their functionalities as well as their major tertiary structures. It is also considered as an important step towards pro...

    Authors: Abdollah Dehzangi, Kuldip Paliwal, James Lyons, Alok Sharma and Abdul Sattar
    Citation: BMC Genomics 2014 15(Suppl 1):S2
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 15 Supplement 1

  22. Post-translational modification (PTM) of transcriptional factors and chromatin remodelling proteins is recognized as a major mechanism by which transcriptional regulation occurs. Chromatin immunoprecipitation ...

    Authors: Chia-Yang Cheng, Chia-Han Chu, Hung-Wei Hsu, Fang-Rong Hsu, Chung Yi Tang, Wen-Ching Wang, Hsing-Jien Kung and Pei-Ching Chang
    Citation: BMC Genomics 2014 15(Suppl 1):S1
    Content type: Proceedings Published on:

    This article is part of a Supplement: Volume 15 Supplement 1

  23. The gynoecium is one of the most complex organs of angiosperms specialized for seed production and dispersal, but only several genes important for ovule or embryo sac development were identified by using femal...

    Authors: Wen-qin Fu, Zhi-gang Zhao, Xian-hong Ge, Li Ding and Zai-yun Li
    Citation: BMC Genomics 2014 15:61
    Content type: Research article Published on:

  25. Prion diseases are characterized by the accumulation of the pathogenic PrPSc protein, mainly in the brain and the lymphoreticular system. Although prions multiply/accumulate in the lymph nodes without any detecta...

    Authors: Hicham Filali, Inmaculada Martín-Burriel, Frank Harders, Luis Varona, Carlos Hedman, Diego R Mediano, Marta Monzón, Alex Bossers, Juan J Badiola and Rosa Bolea
    Citation: BMC Genomics 2014 15:59
    Content type: Research article Published on:

  26. Mycobacterium avium subsp. avium (Maa) and M. avium subsp. hominissuis (Mah) are environmental mycobacteria and significant opportunistic pathogens. Mycobacterium avium infections in humans and pigs are mainly du...

    Authors: Angelika Agdestein, Anya Jones, Arnar Flatberg, Tone B Johansen, Inger Austrheim Heffernan, Berit Djønne, Anthony Bosco and Ingrid Olsen
    Citation: BMC Genomics 2014 15:58
    Content type: Research article Published on:

  27. Growth in fishes is regulated via many environmental and physiological factors and is shaped by the genetic background of each individual. Previous microarray studies of salmonid growth have examined fish expe...

    Authors: Andrea L Kocmarek, Moira M Ferguson and Roy G Danzmann
    Citation: BMC Genomics 2014 15:57
    Content type: Research article Published on:

  28. Our interest in Candida albicans mitochondria began with the identification of GOA1. We demonstrated its role in cell energy production, cross-talk among mitochondria and peroxisomes, non-glucose energy metabolis...

    Authors: Kasra Khamooshi, Patricia Sikorski, Nuo Sun, Richard Calderone and Dongmei Li
    Citation: BMC Genomics 2014 15:56
    Content type: Research article Published on:

  29. Clonostachys rosea strain IK726 is a mycoparasitic fungus capable of controlling mycotoxin-producing Fusarium species, including F. graminearum and F. culmorum, known to produce Zearalenone (ZEA) and Deoxynivalen...

    Authors: Chatchai Kosawang, Magnus Karlsson, Dan Funck Jensen, Adiphol Dilokpimol and David B Collinge
    Citation: BMC Genomics 2014 15:55
    Content type: Research article Published on:

  30. Klebsiella pneumoniae is an important opportunistic pathogen associated with nosocomial and community-acquired infections. A wide repertoire of virulence and antimicrobial resistance genes is present in K. pneumo...

    Authors: Pablo Ivan Pereira Ramos, Renata Christina Picão, Luiz Gonzaga Paula de Almeida, Nicholas Costa B Lima, Raquel Girardello, Ana Carolina P Vivan, Danilo E Xavier, Fernando G Barcellos, Marsileni Pelisson, Eliana C Vespero, Claudine Médigue, Ana Tereza Ribeiro de Vasconcelos, Ana Cristina Gales and Marisa Fabiana Nicolás
    Citation: BMC Genomics 2014 15:54
    Content type: Research article Published on:

  33. The Illumina HumanMethylation450 BeadChip (HM450K) measures the DNA methylation of 485,512 CpGs in the human genome. The technology relies on hybridization of genomic fragments to probes on the chip. However, ...

    Authors: Haroon Naeem, Nicholas C Wong, Zac Chatterton, Matthew K H Hong, John S Pedersen, Niall M Corcoran, Christopher M Hovens and Geoff Macintyre
    Citation: BMC Genomics 2014 15:51
    Content type: Methodology article Published on:

  35. Maternal undernutrition leads to an increased risk of metabolic disorders in offspring including obesity and insulin resistance, thought to be due to a programmed thrifty phenotype which is inappropriate for a...

    Authors: Peter JI Ellis, Tiffany J Morris, Benjamin M Skinner, Carole A Sargent, Mark H Vickers, Peter D Gluckman, Stewart Gilmour and Nabeel A Affara
    Citation: BMC Genomics 2014 15:49
    Content type: Research article Published on:

  36. Mechanical stimulation is necessary for regulating correct formation of the skeleton. Here we test the hypothesis that mechanical stimulation of the embryonic skeletal system impacts expression levels of genes...

    Authors: Rebecca A Rolfe, Niamh C Nowlan, Elaine M Kenny, Paul Cormican, Derek W Morris, Patrick J Prendergast, Daniel Kelly and Paula Murphy
    Citation: BMC Genomics 2014 15:48
    Content type: Research article Published on:

  37. It is widely known that castration has a significant effect on the accumulation of adipose tissue. microRNAs (miRNAs) are known to be involved in fat deposition and to be regulated by the androgen-induced andr...

    Authors: Ying Bai, Jin-Ming Huang, Gang Liu, Ji-Bin Zhang, Jian-Ying Wang, Cheng-Kun Liu and Mei-Ying Fang
    Citation: BMC Genomics 2014 15:47
    Content type: Research article Published on:

  38. Protein subcellular localization is a central problem in understanding cell biology and has been the focus of intense research. In order to predict localization from amino acid sequence a myriad of features ha...

    Authors: Yoshinori Fukasawa, Ross KK Leung, Stephen KW Tsui and Paul Horton
    Citation: BMC Genomics 2014 15:46
    Content type: Research article Published on:

  40. Blood-sucking lice (suborder Anoplura) parasitize eutherian mammals with 67% of the 540 described species found on rodents. The five species of blood-sucking lice that infest humans and pigs have fragmented mi...

    Authors: Wen-Ge Dong, Simon Song, Dao-Chao Jin, Xian-Guo Guo and Renfu Shao
    Citation: BMC Genomics 2014 15:44
    Content type: Research article Published on:

  41. Low efficiency of Somatic Cell Nuclear Transfer (NT) has been widely addressed with high incidence of placental abnormalities due to genetic and epigenetic modifications. MiRNAs are shown to be major regulator...

    Authors: Md Munir Hossain, Dawit Tesfaye, Dessie Salilew-Wondim, Eva Held, Maren J Pröll, Franca Rings, Gregor Kirfel, Christian Looft, Ernst Tholen, Jasim Uddin, Karl Schellander and Michael Hoelker
    Citation: BMC Genomics 2014 15:43
    Content type: Research article Published on:

  42. Anopheles sinensis is an important mosquito vector of Plasmodium vivax, which is the most frequent and widely distributed cause of recurring malaria throughout Asia, and particularly in China, Korea, and Japan.

    Authors: Dan Zhou, Donghui Zhang, Guohui Ding, Linna Shi, Qing Hou, Yuting Ye, Yang Xu, Huayun Zhou, Chunrong Xiong, Shengdi Li, Jing Yu, Shanchao Hong, Xinyou Yu, Ping Zou, Chen Chen, Xuelian Chang…
    Citation: BMC Genomics 2014 15:42
    Content type: Research article Published on:

  43. Genomic structure variation (GSV) is widely distributed in various organisms and is an important contributor to human diversity and disease susceptibility. Efficient approaches to induce targeted genomic struc...

    Authors: Sanyuan Ma, Xiaogang Wang, Yuanyuan Liu, Jie Gao, Shengling Zhang, Run Shi, Jiasong Chang, Ping Zhao and Qingyou Xia
    Citation: BMC Genomics 2014 15:41
    Content type: Research article Published on:

  44. The major function of the ovary is to produce oocytes for fertilisation. Oocytes mature in follicles surrounded by nurturing granulosa cells and all are enclosed by a basal lamina. During growth, granulosa cel...

    Authors: Nicholas Hatzirodos, Katja Hummitzsch, Helen F Irving-Rodgers, Margaret L Harland, Stephanie E Morris and Raymond J Rodgers
    Citation: BMC Genomics 2014 15:40
    Content type: Research article Published on:

  45. Differentiation of primordial germ cells into mature spermatozoa proceeds through multiple stages, one of the most important of which is meiosis. Meiotic recombination is in turn a key part of meiosis. To achi...

    Authors: Gennady Margolin, Pavel P Khil, Joongbaek Kim, Marina A Bellani and R Daniel Camerini-Otero
    Citation: BMC Genomics 2014 15:39
    Content type: Research article Published on:

  46. The incidence of invasive disease caused by encapsulated Haemophilus influenzae type f (Hif) has increased in the post-H. influenzae type b (Hib) vaccine era. We previously annotated the first complete Hif genome...

    Authors: Yu-Ching Su, Fredrik Resman, Franziska Hörhold and Kristian Riesbeck
    Citation: BMC Genomics 2014 15:38
    Content type: Research article Published on:

  47. The main limitations in the analysis of viral metagenomes are perhaps the high genetic variability and the lack of information in extant databases. To address these issues, several bioinformatic tools have bee...

    Authors: Jorge F Vázquez-Castellanos, Rodrigo García-López, Vicente Pérez-Brocal, Miguel Pignatelli and Andrés Moya
    Citation: BMC Genomics 2014 15:37
    Content type: Research article Published on:

  48. Development of novel antibacterial drugs is both an urgent healthcare necessity and a partially neglected field. The last decades have seen a substantial decrease in the discovery of novel antibiotics, which c...

    Authors: Alejandro Panjkovich, Isidre Gibert and Xavier Daura
    Citation: BMC Genomics 2014 15:36
    Content type: Methodology article Published on:

  49. Genomes of men and women differ in only a limited number of genes located on the sex chromosomes, whereas the transcriptome is far more sex-specific. Identification of sex-biased gene expression will contribut...

    Authors: Rick Jansen, Sandra Batista, Andrew I Brooks, Jay A Tischfield, Gonneke Willemsen, Gerard van Grootheest, Jouke-Jan Hottenga, Yuri Milaneschi, Hamdi Mbarek, Vered Madar, Wouter Peyrot, Jacqueline M Vink, Cor L Verweij, Eco JC de Geus, Johannes H Smit, Fred A Wright…
    Citation: BMC Genomics 2014 15:33
    Content type: Research article Published on:

  50. The purpose of this study was to sequence and assemble the tobacco mitochondrial transcriptome and obtain a genomic-level view of steady-state RNA abundance. Plant mitochondrial genomes have a small number of ...

    Authors: Benjamin T Grimes, Awa K Sisay, Hyrum D Carroll and A Bruce Cahoon
    Citation: BMC Genomics 2014 15:31
    Content type: Research article Published on:

Featured videos

View featured videos from across the BMC-series journals

Submit manuscript

Annual Journal Metrics

  • 2022 Citation Impact
    4.4 - 2-year Impact Factor
    4.7 - 5-year Impact Factor
    1.189 - SNIP (Source Normalized Impact per Paper)
    1.107 - SJR (SCImago Journal Rank)

    2023 Speed
    23 days submission to first editorial decision for all manuscripts (Median)
    137 days submission to accept (Median)

    2023 Usage
    7,167,242 downloads
    4,454 Altmetric mentions

Follow

Sign up for article alerts and news from this journal

BMC Genomics

ISSN: 1471-2164

Contact us