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  1. Content type: Research article

    Genomic approaches provide unique opportunities to study interactions of insects with their pathogens. We developed a cDNA microarray to analyze the gene transcription profile of the lepidopteran pest Spodoptera ...

    Authors: M Barat-Houari, F Hilliou, F-X Jousset, L Sofer, E Deleury, J Rocher, M Ravallec, L Galibert, P Delobel, R Feyereisen, P Fournier and A-N Volkoff

    Citation: BMC Genomics 2006 7:160

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  2. Content type: Research article

    The purpose of this work was to study the gene expression of transient receptor potential (TRP) channels in the mouse. The application of a standardized and quantitative technique, TaqMan RT-PCR, should give i...

    Authors: Christiane Kunert-Keil, Frederike Bisping, Jana Krüger and Heinrich Brinkmeier

    Citation: BMC Genomics 2006 7:159

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  3. Content type: Research article

    The maize INDETERMINATE1 gene, ID1, is a key regulator of the transition to flowering and the founding member of a transcription factor gene family that encodes a protein with a distinct arrangement of zinc finge...

    Authors: Joseph Colasanti, Reynald Tremblay, Ada YM Wong, Viktoriya Coneva, Akiko Kozaki and Barbara K Mable

    Citation: BMC Genomics 2006 7:158

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  4. Content type: Research article

    The nematode Strongyloides ratti has two adult phases in its lifecycle: one obligate, female and parasitic and one facultative, dioecious and free-living. The molecular control of the development of this free-liv...

    Authors: Fiona J Thompson, Gary LA Barker, Louise Hughes, Clare P Wilkes, Jane Coghill and Mark E Viney

    Citation: BMC Genomics 2006 7:157

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  5. Content type: Research article

    Trisomy of human chromosome 21 (Chr21) results in Down's syndrome, a complex developmental and neurodegenerative disease. Molecular analysis of Down's syndrome, however, poses a particular challenge, because t...

    Authors: Yu-Hui Hu, Hans-Jörg Warnatz, Dominique Vanhecke, Florian Wagner, Andrea Fiebitz, Sabine Thamm, Pascal Kahlem, Hans Lehrach, Marie-Laure Yaspo and Michal Janitz

    Citation: BMC Genomics 2006 7:155

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  6. Content type: Research article

    Biologists are becoming increasingly aware that the interaction of animals, including humans, with their coevolved bacterial partners is essential for health. This growing awareness has been a driving force fo...

    Authors: Carlene K Chun, Todd E Scheetz, Maria de Fatima Bonaldo, Bartley Brown, Anik Clemens, Wendy J Crookes-Goodson, Keith Crouch, Tad DeMartini, Mari Eyestone, Michael S Goodson, Bernadette Janssens, Jennifer L Kimbell, Tanya A Koropatnick, Tamara Kucaba, Christina Smith, Jennifer J Stewart…

    Citation: BMC Genomics 2006 7:154

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  7. Content type: Research article

    There are many potential sources of variability in a microarray experiment. Variation can arise from many aspects of the collection and processing of samples for gene expression analysis. Oligonucleotide-based...

    Authors: LanMin Zhang, Sean J Yoder and Steven A Enkemann

    Citation: BMC Genomics 2006 7:153

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  8. Content type: Research article

    The snake venom gland is a specialized organ, which synthesizes and secretes the complex and abundant toxin proteins. Though gene expression in the snake venom gland has been extensively studied, the focus has...

    Authors: Bing Zhang, Qinghua Liu, Wei Yin, Xiaowei Zhang, Yijun Huang, Yingfeng Luo, Pengxin Qiu, Xingwen Su, Jun Yu, Songnian Hu and Guangmei Yan

    Citation: BMC Genomics 2006 7:152

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  9. Content type: Research article

    Macrohaplogroups 'M' and 'N' have evolved almost in parallel from a founder haplogroup L3. Macrohaplogroup N in India has already been defined in previous studies and recently the macrohaplogroup M among the I...

    Authors: Kumarasamy Thangaraj, Gyaneshwer Chaubey, Vijay Kumar Singh, Ayyasamy Vanniarajan, Ismail Thanseem, Alla G Reddy and Lalji Singh

    Citation: BMC Genomics 2006 7:151

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  10. Content type: Software

    Since DNA sequencing has become easier and cheaper, an increasing number of closely related viral genomes have been sequenced. However, many of these have been deposited in GenBank without annotations, severel...

    Authors: Vasily Tcherepanov, Angelika Ehlers and Chris Upton

    Citation: BMC Genomics 2006 7:150

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  11. Content type: Research article

    Wheat is an excellent species to study freezing tolerance and other abiotic stresses. However, the sequence of the wheat genome has not been completely characterized due to its complexity and large size. To ci...

    Authors: Mario Houde, Mahdi Belcaid, François Ouellet, Jean Danyluk, Antonio F Monroy, Ani Dryanova, Patrick Gulick, Anne Bergeron, André Laroche, Matthew G Links, Luke MacCarthy, William L Crosby and Fathey Sarhan

    Citation: BMC Genomics 2006 7:149

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  12. Content type: Research article

    Splicing processes might play a major role in carcinogenesis and tumour progression. The Wnt pathway is of crucial relevance for cancer progression. Therefore we focussed on the Wnt/β-catenin signalling pathwa...

    Authors: Heike Pospisil, Alexander Herrmann, Kristine Butherus, Stefan Pirson, Jens G Reich and Wolfgang Kemmner

    Citation: BMC Genomics 2006 7:148

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  13. Content type: Research article

    Bacillus subtilis is one of the best-characterized organisms in Gram-positive bacteria. It represents a paradigm of gene regulation in bacteria due its complex life style (which could involve a transition between...

    Authors: Samadhi Moreno-Campuzano, Sarath Chandra Janga and Ernesto Pérez-Rueda

    Citation: BMC Genomics 2006 7:147

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  14. Content type: Research article

    Mouse strains with a contrasting response to morphine provide a unique model for studying the genetically determined diversity of sensitivity to opioid reward, tolerance and dependence. Four inbred strains sel...

    Authors: Michal Korostynski, Dorota Kaminska-Chowaniec, Marcin Piechota and Ryszard Przewlocki

    Citation: BMC Genomics 2006 7:146

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  15. Content type: Research article

    Cell-based microarrays were first described by Ziauddin and Sabatini in 2001 as a powerful new approach for performing high throughput screens of gene function. An important application of cell-based microarra...

    Authors: Ella L Palmer, Andrew D Miller and Tom C Freeman

    Citation: BMC Genomics 2006 7:145

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  16. Content type: Methodology article

    Recent developments in DNA microarray technology led to a variety of open and closed devices and systems including high and low density microarrays for high-throughput screening applications as well as microar...

    Authors: Susann Schüler, Ingrid Wenz, B Wiederanders, P Slickers and R Ehricht

    Citation: BMC Genomics 2006 7:144

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  17. Content type: Research article

    Extracting relevant biological information from large data sets is a major challenge in functional genomics research. Different aspects of the data hamper their biological interpretation. For instance, 5000-fo...

    Authors: Robert A van den Berg, Huub CJ Hoefsloot, Johan A Westerhuis, Age K Smilde and Mariët J van der Werf

    Citation: BMC Genomics 2006 7:142

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  18. Content type: Research article

    The structural and functional features associated with Simple Sequence Proteins (SSPs) are non-globularity, disease states, signaling and post-translational modification. SSPs are also an important source of g...

    Authors: Mekapati Bala Subramanyam, Muthiah Gnanamani and Srinivasan Ramachandran

    Citation: BMC Genomics 2006 7:141

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  19. Content type: Research article

    Approximately 11 Mb of finished high quality genomic sequences were sampled from cattle, dog and human to estimate genomic divergences and their regional variation among these lineages.

    Authors: George E Liu, Lakshmi K Matukumalli, Tad S Sonstegard, Larry L Shade and Curtis P Van Tassell

    Citation: BMC Genomics 2006 7:140

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  20. Content type: Database

    Long Interspersed Nuclear Elements (LINEs) are the most abundant retrotransposons in humans. About 79% of human genes are estimated to contain at least one segment of LINE per transcription unit. Recent studie...

    Authors: Dae-Soo Kim, Tae-Hyung Kim, Jae-Won Huh, Il-Chul Kim, Seok-Won Kim, Hong-Seog Park and Heui-Soo Kim

    Citation: BMC Genomics 2006 7:139

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  21. Content type: Research article

    Advances made in the area of microarray comparative genomic hybridization (aCGH) have enabled the interrogation of the entire genome at a previously unattainable resolution. This has lead to the discovery of a...

    Authors: Ilan Braude, Bisera Vukovic, Mona Prasad, Paula Marrano, Stefanie Turley, Dwayne Barber, Maria Zielenska and Jeremy A Squire

    Citation: BMC Genomics 2006 7:138

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  22. Content type: Methodology article

    There is no effective method to obtain genome information from single-celled unculturable organisms such as radiolarians. Even worse, such organisms are often very difficult to collect. Sequence analysis of 18...

    Authors: Mariko Kouduka, Atsushi Matsuoka and Koichi Nishigaki

    Citation: BMC Genomics 2006 7:135

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  23. Content type: Database

    The Cotton Microsatellite Database (CMD) http://​www.​cottonssr.​org is a curated and integrated web-based relational database providing centralized acces...

    Authors: Anna Blenda, Jodi Scheffler, Brian Scheffler, Michael Palmer, Jean-Marc Lacape, John Z Yu, Christopher Jesudurai, Sook Jung, Sriram Muthukumar, Preetham Yellambalase, Stephen Ficklin, Margaret Staton, Robert Eshelman, Mauricio Ulloa, Sukumar Saha, Ben Burr…

    Citation: BMC Genomics 2006 7:132

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  24. Content type: Methodology article

    The main limitation in performing genome-wide gene-expression profiling is the assay of low-expression genes. Approaches with high throughput and high sensitivity for assaying low-expression transcripts are ur...

    Authors: Yi-Shin Pan, Yun-Shien Lee, Yung-Lin Lee, Wei-Chen Lee and Sen-Yung Hsieh

    Citation: BMC Genomics 2006 7:131

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  25. Content type: Correspondence

    A response to Snyder LA, Saunders NJ: The majority of genes in the pathogenic Neisseria species are present in non-pathogenic Neisseria lactamica , including those designated as virulence genes. BMC Genomics 2006...

    Authors: Richard Stabler and Jason Hinds

    Citation: BMC Genomics 2006 7:129

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  26. Content type: Research article

    Neisseria meningitidis causes the life-threatening diseases meningococcal meningitis and meningococcal septicemia. Neisseria gonorrhoeae is closely related to the meningococcus, but is the cause of the very diffe...

    Authors: Lori AS Snyder and Nigel J Saunders

    Citation: BMC Genomics 2006 7:128

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  27. Content type: Research article

    Gene expression profiling has been used to define molecular phenotypes of complex diseases such as breast cancer. The luminal A and basal-like subtypes have been repeatedly identified and validated as the two ...

    Authors: Therese Sørlie, Yulei Wang, Chunlin Xiao, Hilde Johnsen, Bjørn Naume, Raymond R Samaha and Anne-Lise Børresen-Dale

    Citation: BMC Genomics 2006 7:127

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  28. Content type: Research article

    Genomes of gram-positive bacteria encode many putative cell-surface proteins, of which the majority has no known function. From the rapidly increasing number of available genome sequences it has become apparen...

    Authors: Roland Siezen, Jos Boekhorst, Lidia Muscariello, Douwe Molenaar, Bernadet Renckens and Michiel Kleerebezem

    Citation: BMC Genomics 2006 7:126

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  29. Content type: Research article

    The Fragile Histidine Triad gene (FHIT) is an oncosuppressor implicated in many human cancers, including vesical tumors. FHIT is frequently hit by deletions caused by fragility at FRA3B, the most active of human ...

    Authors: Cristina Uboldi, Elena Guidi, Sante Roperto, Valeria Russo, Franco Roperto, Giulia Pia Di Meo, Leopoldo Iannuzzi, Sandrine Floriot, Mekki Boussaha, André Eggen and Luca Ferretti

    Citation: BMC Genomics 2006 7:123

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  30. Content type: Research article

    Olfactory receptors (ORs) are the largest gene family in the human genome. Although they are expected to be expressed specifically in olfactory tissues, some ectopic expression has been reported, with special ...

    Authors: Ester Feldmesser, Tsviya Olender, Miriam Khen, Itai Yanai, Ron Ophir and Doron Lancet

    Citation: BMC Genomics 2006 7:121

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  31. Content type: Research article

    The majority of introns in gene transcripts are found within the coding sequences (CDSs). A small but significant fraction of introns are also found to reside within the untranslated regions (5'UTRs and 3'UTRs...

    Authors: Betty YW Chung, Cas Simons, Andrew E Firth, Chris M Brown and Roger P Hellens

    Citation: BMC Genomics 2006 7:120

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  32. Content type: Research article

    Large scale sequencing of cDNA libraries can provide profiles of genes expressed in an organism under defined biological and environmental circumstances. We have analyzed sequences of 4541 Expressed Sequence T...

    Authors: Ali N Dana, Maureen E Hillenmeyer, Neil F Lobo, Marcia K Kern, Patricia A Romans and Frank H Collins

    Citation: BMC Genomics 2006 7:119

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  33. Content type: Research article

    The autism spectrum encompasses a set of complex multigenic developmental disorders that severely impact the development of language, non-verbal communication, and social skills, and are associated with odd, s...

    Authors: Valerie W Hu, Bryan C Frank, Shannon Heine, Norman H Lee and John Quackenbush

    Citation: BMC Genomics 2006 7:118

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  34. Content type: Methodology article

    The evolution of viral quasispecies can influence viral pathogenesis and the response to antiviral treatments. Mutant clouds in infected organisms represent the first stage in the genetic and antigenic diversi...

    Authors: Verónica Martín, Celia Perales, David Abia, Angel R Ortíz, Esteban Domingo and Carlos Briones

    Citation: BMC Genomics 2006 7:117

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  35. Content type: Database

    The completed sequence of the Anopheles gambiae genome has enabled genome-wide analyses of gene expression and regulation in this principal vector of human malaria. These investigations have created a demand for ...

    Authors: Sumudu N Dissanayake, Osvaldo Marinotti, Jose Marcos C Ribeiro and Anthony A James

    Citation: BMC Genomics 2006 7:116

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  36. Content type: Research article

    Transmissible spongiform encephalopathies (TSEs) or prion diseases are fatal neurodegenerative disorders which occur in humans and various animal species. Examples include Creutzfeldt-Jakob disease (CJD) in hu...

    Authors: Pamela J Skinner, Hayet Abbassi, Bruce Chesebro, Richard E Race, Cavan Reilly and Ashley T Haase

    Citation: BMC Genomics 2006 7:114

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  37. Content type: Research article

    Comparative genomic analysis using cDNA microarray is a new approach and a useful tool to identify important genetic sequences or genes that are conserved throughout evolution. Identification of these conserve...

    Authors: Maud Vallée, Claude Robert, Steve Méthot, Marie-France Palin and Marc-André Sirard

    Citation: BMC Genomics 2006 7:113

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  38. Content type: Research article

    Staphylococcus epidermidis, long regarded as an innocuous commensal bacterium of the human skin, is the most frequent cause of nosocomial infections associated with implanted medical devices. This conditional pat...

    Authors: Wu Wei, ZhiWei Cao, Yu-Li Zhu, XiaoJing Wang, GuoHui Ding, Hao Xu, PeiLin Jia, Di Qu, Antoine Danchin and YiXue Li

    Citation: BMC Genomics 2006 7:112

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  39. Content type: Research article

    The MRP 1 gene encodes the 190 kDa multidrug resistance-associated protein 1 (MRP1/ABCC1) and effluxes diverse drugs and xenobiotics. Sequence variations within this gene might account for differences in drug res...

    Authors: Zihua Wang, Pui-Hoon Sew, Helen Ambrose, Stephen Ryan, Samuel S Chong, Edmund JD Lee and Caroline GL Lee

    Citation: BMC Genomics 2006 7:111

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