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  1. Pyropia haitanensis is an economically important mariculture crop in China and is also valuable in life science research. However, the lack of genetic information of this organism hinders the understanding of the...

    Authors: Chaotian Xie, Bing Li, Yan Xu, Dehua Ji and Changsheng Chen
    Citation: BMC Genomics 2013 14:107
  2. The core promoter is the region flanking the transcription start site (TSS) that directs formation of the pre-initiation complex. Core promoters have been studied intensively in mammals and yeast, but not in m...

    Authors: Sourav Roy, Laetitia Poidevin, Tao Jiang and Howard S Judelson
    Citation: BMC Genomics 2013 14:106
  3. For safe clinical application of engineered cartilage made from mesenchymal stem cells (MSCs), molecular mechanisms for chondrogenic differentiation must be known in detail. Changes in gene expression and extr...

    Authors: Sarah R Herlofsen, Jan Christian Bryne, Torill Høiby, Li Wang, Robbyn Issner, Xiaolan Zhang, Michael J Coyne, Patrick Boyle, Hongcang Gu, Leonardo A Meza-Zepeda, Philippe Collas, Tarjei S Mikkelsen and Jan E Brinchmann
    Citation: BMC Genomics 2013 14:105
  4. MicroRNAs (miRNAs) are short non-coding regulatory RNAs that control gene expression usually producing translational repression and gene silencing. High-throughput sequencing technologies have revealed heterog...

    Authors: Franc Llorens, Mónica Bañez-Coronel, Lorena Pantano, Jose Antonio del Río, Isidre Ferrer, Xavier Estivill and Eulàlia Martí
    Citation: BMC Genomics 2013 14:104
  5. Tandem repeats (TRs) in the mitochondrial (mt) genome control region have been documented in a wide variety of vertebrate species. The mechanism by which repeated tracts originate and undergo duplication and d...

    Authors: Wei Shi, Xiao-Yu Kong, Zhong-Ming Wang, Shan-Shan Yu, Hai-Xia Chen and Elizabeth A De Stasio
    Citation: BMC Genomics 2013 14:103
  6. Detection of significant differentially expressed genes (DEGs) from DNA microarray datasets is a common routine task conducted in biomedical research. For the detection of DEGs, numerous methods are proposed. ...

    Authors: Koki Tsuyuzaki, Daisuke Tominaga, Yeondae Kwon and Satoru Miyazaki
    Citation: BMC Genomics 2013 14(Suppl 2):S9

    This article is part of a Supplement: Volume 14 Supplement 2

  7. Biological data acquisition is raising new challenges, both in data analysis and handling. Not only is it proving hard to analyze the data at the rate it is generated today, but simply reading and transferring...

    Authors: Konstantin Tretyakov, Sven Laur, Geert Smant, Jaak Vilo and Pjotr Prins
    Citation: BMC Genomics 2013 14(Suppl 2):S8

    This article is part of a Supplement: Volume 14 Supplement 2

  8. Long intergenic non-coding RNAs (lincRNAs) are emerging as a novel class of non-coding RNAs and potent gene regulators. High-throughput RNA-sequencing combined with de novo assembly promises quantity discovery of...

    Authors: Kun Sun, Xiaona Chen, Peiyong Jiang, Xiaofeng Song, Huating Wang and Hao Sun
    Citation: BMC Genomics 2013 14(Suppl 2):S7

    This article is part of a Supplement: Volume 14 Supplement 2

  9. Classification is the problem of assigning each input object to one of a finite number of classes. This problem has been extensively studied in machine learning and statistics, and there are numerous applicati...

    Authors: Mark Menor, Kyungim Baek and Guylaine Poisson
    Citation: BMC Genomics 2013 14(Suppl 2):S6

    This article is part of a Supplement: Volume 14 Supplement 2

  10. Haplotype information is useful for various genetic analyses, including genome-wide association studies. Determining haplotypes experimentally is difficult and there are several computational approaches that i...

    Authors: Hirotaka Matsumoto and Hisanori Kiryu
    Citation: BMC Genomics 2013 14(Suppl 2):S5

    This article is part of a Supplement: Volume 14 Supplement 2

  11. Investigation of conformational changes in a protein is a prerequisite to understand its biological function. To explore these conformational changes in proteins we developed a strategy with the combination of...

    Authors: MNV Prasad Gajula, KP Vogel, Anil Rai, Franziska Dietrich and HJ Steinhoff
    Citation: BMC Genomics 2013 14(Suppl 2):S4

    This article is part of a Supplement: Volume 14 Supplement 2

  12. microRNAs (miRNAs) are tiny endogenous RNAs that have been discovered in animals and plants, and direct the post-transcriptional regulation of target mRNAs for degradation or translational repression via bindi...

    Authors: Toyofumi Fujiwara and Tetsushi Yada
    Citation: BMC Genomics 2013 14(Suppl 2):S3

    This article is part of a Supplement: Volume 14 Supplement 2

  13. Single nucleotide polymorphisms (SNPs) are the most common form of genetic variation in human DNA. The sequence of SNPs in each of the two copies of a given chromosome in a diploid organism is referred to as a...

    Authors: Fei Deng, Wenjuan Cui and Lusheng Wang
    Citation: BMC Genomics 2013 14(Suppl 2):S2

    This article is part of a Supplement: Volume 14 Supplement 2

  14. Protein structure comparison and classification is an effective method for exploring protein structure-function relations. This problem is computationally challenging. Many different computational approaches f...

    Authors: Cody Ashby, Daniel Johnson, Karl Walker, Iyad A Kanj, Ge Xia and Xiuzhen Huang
    Citation: BMC Genomics 2013 14(Suppl 2):S1

    This article is part of a Supplement: Volume 14 Supplement 2

  15. Many studies have revealed correlations between breast tumour phenotypes, variations in gene expression, and patient survival outcomes. The molecular heterogeneity between breast tumours revealed by these stud...

    Authors: Yi Kan Wang, Cristin G Print and Edmund J Crampin
    Citation: BMC Genomics 2013 14:102
  16. Due to the rapid progress of next-generation sequencing (NGS) facilities, an explosion of human whole genome data will become available in the coming years. These data can be used to optimize and to increase t...

    Authors: Anneleen Van Geystelen, Ronny Decorte and Maarten HD Larmuseau
    Citation: BMC Genomics 2013 14:101
  17. White clover (Trifolium repens L.) is an allotetraploid species possessing two highly collinear ancestral sub-genomes. The apparent existence of highly similar homeolog copies for the majority of genes in white c...

    Authors: Istvan Nagy, Susanne Barth, Jeanne Mehenni-Ciz, Michael T Abberton and Dan Milbourne
    Citation: BMC Genomics 2013 14:100
  18. The Nuclear Factor I (NFI) family of DNA binding proteins (also called CCAAT box transcription factors or CTF) is involved in both DNA replication and gene expression regulation. Using chromatin immuno-precipi...

    Authors: Milos Pjanic, Christoph D Schmid, Armelle Gaussin, Giovanna Ambrosini, Jozef Adamcik, Petar Pjanic, Genta Plasari, Jan Kerschgens, Giovani Dietler, Philipp Bucher and Nicolas Mermod
    Citation: BMC Genomics 2013 14:99
  19. Most studies on the origin and evolution of microRNA in the human genome have been focused on its relationship with repetitive elements and segmental duplications. However, duplication events at a smaller scal...

    Authors: Zhi-Qiang Du, Cai-Xia Yang, Max F Rothschild and Jason W Ross
    Citation: BMC Genomics 2013 14:98
  20. Cotton (Gossypium hirsutum) anther development involves a diverse range of gene interactions between sporophytic and gametophytic tissues. However, only a small number of genes are known to be specifically involv...

    Authors: Mingming Wei, Meizhen Song, Shuli Fan and Shuxun Yu
    Citation: BMC Genomics 2013 14:97
  21. High throughput sequencing is beginning to make a transformative impact in the area of viral evolution. Deep sequencing has the potential to reveal the mutant spectrum within a viral sample at high resolution,...

    Authors: Haiyin Chen-Harris, Monica K Borucki, Clinton Torres, Tom R Slezak and Jonathan E Allen
    Citation: BMC Genomics 2013 14:96
  22. A classical example of repeated speciation coupled with ecological diversification is the evolution of 14 closely related species of Darwin’s (Galápagos) finches (Thraupidae, Passeriformes). Their adaptive rad...

    Authors: Chris M Rands, Aaron Darling, Matthew Fujita, Lesheng Kong, Matthew T Webster, Céline Clabaut, Richard D Emes, Andreas Heger, Stephen Meader, Michael Brent Hawkins, Michael B Eisen, Clotilde Teiling, Jason Affourtit, Benjamin Boese, Peter R Grant, Barbara Rosemary Grant…
    Citation: BMC Genomics 2013 14:95
  23. Genome scale annotation of regulatory interactions and reconstruction of regulatory networks are the crucial problems in bacterial genomics. The Lactobacillales order of bacteria collates various microorganisms h...

    Authors: Dmitry A Ravcheev, Aaron A Best, Natalia V Sernova, Marat D Kazanov, Pavel S Novichkov and Dmitry A Rodionov
    Citation: BMC Genomics 2013 14:94
  24. Every year, substantial crop loss occurs globally, as a result of bacterial, fungal, parasite and viral infections in rice. Here, we present an in-depth investigation of the transcriptomic response to infectio...

    Authors: Reena Narsai, Chuang Wang, Jie Chen, Jianli Wu, Huixia Shou and James Whelan
    Citation: BMC Genomics 2013 14:93
  25. The oxidative burst is one of the major antimicrobial mechanisms adopted by macrophages. The WKY rat strain is uniquely susceptible to experimentally induced macrophage-dependent crescentic glomerulonephritis ...

    Authors: Richard P Hull, Prashant K Srivastava, Zelpha D’Souza, Santosh S Atanur, Fatima Mechta-Grigoriou, Laurence Game, Enrico Petretto, H Terence Cook, Timothy J Aitman and Jacques Behmoaras
    Citation: BMC Genomics 2013 14:92
  26. The ascomycete fungus Ceratocystis cacaofunesta is the causal agent of wilt disease in cacao, which results in significant economic losses in the affected producing areas. Despite the economic importance of the C...

    Authors: Alinne Batista Ambrosio, Leandro Costa do Nascimento, Bruno V Oliveira, Paulo José P L Teixeira, Ricardo A Tiburcio, Daniela P Toledo Thomazella, Adriana F P Leme, Marcelo F Carazzolle, Ramon O Vidal, Piotr Mieczkowski, Lyndel W Meinhardt, Gonçalo A G Pereira and Odalys G Cabrera
    Citation: BMC Genomics 2013 14:91
  27. The throughput of next-generation sequencing machines has increased dramatically over the last few years; yet the cost and time for library preparation have not changed proportionally, thus representing the ma...

    Authors: Stefan Wilkening, Manu M Tekkedil, Gen Lin, Emilie S Fritsch, Wu Wei, Julien Gagneur, David W Lazinski, Andrew Camilli and Lars M Steinmetz
    Citation: BMC Genomics 2013 14:90
  28. The human KIR genes are arranged in at least six major gene-content haplotypes, all of which are combinations of four centromeric and two telomeric motifs. Several less frequent or minor haplotypes also exist, in...

    Authors: Chul-Woo Pyo, Ruihan Wang, Quyen Vu, Nezih Cereb, Soo Young Yang, Fuh-Mei Duh, Steven Wolinsky, Maureen P Martin, Mary Carrington and Daniel E Geraghty
    Citation: BMC Genomics 2013 14:89
  29. The theoretical basis of genome-wide association studies (GWAS) is statistical inference of linkage disequilibrium (LD) between any polymorphic marker and a putative disease locus. Most methods widely implemen...

    Authors: Minghui Wang, Lin Wang, Ning Jiang, Tianye Jia and Zewei Luo
    Citation: BMC Genomics 2013 14:88
  30. Anguillicola crassus is an economically and ecologically important parasitic nematode of eels. The native range of A. crassus is in East Asia, where it infects Anguilla japonica, the Japanese eel. A. crassus was ...

    Authors: Emanuel Heitlinger, Stephen Bridgett, Anna Montazam, Horst Taraschewski and Mark Blaxter
    Citation: BMC Genomics 2013 14:87
  31. Polymorphism is key to the evolutionary potential of populations. Understanding which factors shape levels of genetic diversity within genomes forms a central question in evolutionary genomics and is of import...

    Authors: Carina F Mugal, Benoit Nabholz and Hans Ellegren
    Citation: BMC Genomics 2013 14:86
  32. The regenerative response of Schwann cells after peripheral nerve injury is a critical process directly related to the pathophysiology of a number of neurodegenerative diseases. This SC injury response is depe...

    Authors: Li-Wei Chang, Andreu Viader, Nobish Varghese, Jacqueline E Payton, Jeffrey Milbrandt and Rakesh Nagarajan
    Citation: BMC Genomics 2013 14:84
  33. Whereas temporal gene expression in mammalian herpesviruses has been studied extensively, little is known about gene expression in fish herpesviruses. Here we report a genome-wide transcription analysis of a f...

    Authors: Steven J van Beurden, Ben PH Peeters, Peter JM Rottier, Andrew J Davison and Marc Y Engelsma
    Citation: BMC Genomics 2013 14:83
  34. Tissues and their component cells have unique DNA methylation profiles comprising DNA methylation patterns of tissue-dependent and differentially methylated regions (T-DMRs). Previous studies reported that DNA...

    Authors: Keiji Hirabayashi, Kunio Shiota and Shintaro Yagi
    Citation: BMC Genomics 2013 14:82
  35. Despite being one of the most intensely studied model organisms, many questions still remain about the evolutionary biology and ecology of Escherichia coli. An important step toward achieving a more complete unde...

    Authors: Eric J de Muinck, Karin Lagesen, Jan Egil Afset, Xavier Didelot, Kjersti S Rønningen, Knut Rudi, Nils Chr Stenseth and Pål Trosvik
    Citation: BMC Genomics 2013 14:81
  36. Mycoplasma hyopneumoniae is the causative agent of porcine enzootic pneumonia (EP), a mild, chronic pneumonia of swine. Despite presenting with low direct mortality, EP is responsible for major economic losses in...

    Authors: Wei Liu, Shaobo Xiao, Mao Li, Shaohua Guo, Sha Li, Rui Luo, Zhixin Feng, Bin Li, Zhemin Zhou, Guoqing Shao, Huanchun Chen and Liurong Fang
    Citation: BMC Genomics 2013 14:80
  37. The narrow-leafed lupin, Lupinus angustifolius L., is a grain legume species with a relatively compact genome. The species has 2n = 40 chromosomes and its genome size is 960 Mbp/1C. During the last decade, L. ang...

    Authors: Michał Książkiewicz, Katarzyna Wyrwa, Anna Szczepaniak, Sandra Rychel, Karolina Majcherkiewicz, Łucja Przysiecka, Wojciech Karlowski, Bogdan Wolko and Barbara Naganowska
    Citation: BMC Genomics 2013 14:79
  38. Although banana (Musa sp.) is an important edible crop, contributing towards poverty alleviation and food security, limited transcriptome datasets are available for use in accelerated molecular-based breeding in ...

    Authors: Marco A N Passos, Viviane Oliveira de Cruz, Flavia L Emediato, Cristiane Camargo de Teixeira, Vânia C Rennó Azevedo, Ana C M Brasileiro, Edson P Amorim, Claudia F Ferreira, Natalia F Martins, Roberto C Togawa, Georgios J Pappas Júnior, Orzenil Bonfim da Silva Jr and Robert NG Miller
    Citation: BMC Genomics 2013 14:78
  39. Phosphorus (P) is an essential macronutrient for plant growth and development. To modulate their P homeostasis, plants must balance P uptake, mobilisation, and partitioning to various organs. Despite the world...

    Authors: Youko Oono, Fuminori Kobayashi, Yoshihiro Kawahara, Takayuki Yazawa, Hirokazu Handa, Takeshi Itoh and Takashi Matsumoto
    Citation: BMC Genomics 2013 14:77
  40. Among repetitive genomic sequence, the class of tri-nucleotide repeats has received much attention due to their association with human diseases. Tri-nucleotide repeat diseases are caused by excessive sequence ...

    Authors: Kai Willadsen, Minh Duc Cao, Janet Wiles, Sureshkumar Balasubramanian and Mikael Bodén
    Citation: BMC Genomics 2013 14:76
  41. Hevea brasiliensis, a member of the Euphorbiaceae family, is the major commercial source of natural rubber (NR). NR is a latex polymer with high elasticity, flexibility, and resilience that has played a critical ...

    Authors: Ahmad Yamin Abdul Rahman, Abhilash O Usharraj, Biswapriya B Misra, Gincy P Thottathil, Kandakumar Jayasekaran, Yun Feng, Shaobin Hou, Su Yean Ong, Fui Ling Ng, Ling Sze Lee, Hock Siew Tan, Muhd Khairul Luqman Muhd Sakaff, Beng Soon Teh, Bee Feong Khoo, Siti Suriawati Badai, Nurohaida Ab Aziz…
    Citation: BMC Genomics 2013 14:75
  42. Tuberculosis (TB) continues to cause a high toll of disease and death among children worldwide. The diagnosis of childhood TB is challenged by the paucibacillary nature of the disease and the difficulties in o...

    Authors: Lilly M Verhagen, Aldert Zomer, Mailis Maes, Julian A Villalba, Berenice del Nogal, Marc Eleveld, Sacha AFT van Hijum, Jacobus H de Waard and Peter WM Hermans
    Citation: BMC Genomics 2013 14:74
  43. Buchnera aphidicola is an obligate symbiotic bacterium, associated with most of the aphididae, whose genome has drastically shrunk during intracellular evolution. Gene regulation in Buchnera has been a matter of ...

    Authors: Lilia Brinza, Federica Calevro and Hubert Charles
    Citation: BMC Genomics 2013 14:73
  44. Polyploidy is an important evolutionary mechanism in flowering plants that often induces immediate extensive changes in gene expression through genomic merging and doubling. Brassica napus L. is one of the most e...

    Authors: Jinjin Jiang, Yanlin Shao, Kun Du, Liping Ran, Xiaoping Fang and Youping Wang
    Citation: BMC Genomics 2013 14:72
  45. An emerging Hi-C protocol has the ability to probe three-dimensional (3D) architecture and capture chromatin interactions in a genome-wide scale. It provides informative results to address how chromatin organi...

    Authors: Junbai Wang, Xun Lan, Pei-Yin Hsu, Hang-Kai Hsu, Kun Huang, Jeffrey Parvin, Tim H-M Huang and Victor X Jin
    Citation: BMC Genomics 2013 14:70
  46. Alzheimer’s disease (AD) is intimately tied to amyloid-β (Aβ) peptide. Extraneuronal brain plaques consisting primarily of Aβ aggregates are a hallmark of AD. Intraneuronal Aβ subunits are strongly implicated ...

    Authors: Debomoy K Lahiri, Bryan Maloney, Jack T Rogers and Yuan-Wen Ge
    Citation: BMC Genomics 2013 14:68
  47. Meiotic recombination events are not randomly located, but rather cluster at hotspot regions. Recently, the fine-scale mapping of genome-wide human recombination hotspots was performed. Here, we systematically...

    Authors: Tao Zhou, Zhibin Hu, Zuomin Zhou, Xuejiang Guo and Jiahao Sha
    Citation: BMC Genomics 2013 14:67
  48. Phosphorus (P) plays important roles in plant growth and development. MicroRNAs involved in P signaling have been identified in Arabidopsis and rice, but P-responsive microRNAs and their targets in soybean lea...

    Authors: Feng Xu, Qian Liu, Luying Chen, Jiebin Kuang, Thomas Walk, Jinxiang Wang and Hong Liao
    Citation: BMC Genomics 2013 14:66
  49. The genomic basis of teleost phenotypic complexity remains obscure, despite increasing availability of genome and transcriptome sequence data. Fish-specific genome duplication cannot provide sufficient explana...

    Authors: Liandong Yang, Ming Zou, Beide Fu and Shunping He
    Citation: BMC Genomics 2013 14:65

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