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  1. Molecular markers serve three important functions in physical map assembly. First, they provide anchor points to genetic maps facilitating functional genomic studies. Second, they reduce the overlap required f...

    Authors: Young-Sun Yim, Patricia Moak, Hector Sanchez-Villeda, Theresa A Musket, Pamela Close, Patricia E Klein, John E Mullet, Michael D McMullen, Zheiwei Fang, Mary L Schaeffer, Jack M Gardiner, Edward H Coe Jr and Georgia L Davis
    Citation: BMC Genomics 2007 8:47
    Content type: Research article Published on:

  2. Human stem cells are viewed as a possible source of neurons for a cell-based therapy of neurodegenerative disorders, such as Parkinson's disease. Several protocols that generate different types of neurons from...

    Authors: Sergey V Anisimov, Nicolaj S Christophersen, Ana S Correia, Jia-Yi Li and Patrik Brundin
    Citation: BMC Genomics 2007 8:46
    Content type: Methodology article Published on:

  3. Var genes encode a family of virulence factors known as PfEMP1 (Plasmodium falciparum erythrocyte membrane protein 1) which are responsible for both antigenic variation and cytoadherence of infected erythrocytes....

    Authors: Susan M Kraemer, Sue A Kyes, Gautam Aggarwal, Amy L Springer, Siri O Nelson, Zoe Christodoulou, Leia M Smith, Wendy Wang, Emily Levin, Christopher I Newbold, Peter J Myler and Joseph D Smith
    Citation: BMC Genomics 2007 8:45
    Content type: Research article Published on:

  4. Comparative teleost studies are of great interest since they are important in aquaculture and in evolutionary issues. Comparing genomes of fully sequenced model fish species with those of farmed fish species t...

    Authors: Elena Sarropoulou, Rafaella Franch, Bruno Louro, Deborah M Power, Luca Bargelloni, Antonios Magoulas, Fabrice Senger, Matina Tsalavouta, Tomaso Patarnello, Francis Galibert, Georgios Kotoulas and Robert Geisler
    Citation: BMC Genomics 2007 8:44
    Content type: Research article Published on:

  5. Rhesus macaques serve a critical role in the study of human biomedical research. While both Indian and Chinese rhesus macaques are commonly used, genetic differences between these two subspecies affect aspects...

    Authors: Betsy Ferguson, Summer L Street, Hollis Wright, Carlo Pearson, Yibing Jia, Shaun L Thompson, Patrick Allibone, Christopher J Dubay, Eliot Spindel and Robert B Norgren Jr
    Citation: BMC Genomics 2007 8:43
    Content type: Research article Published on:

  7. Many lines of evidence suggest that poly(ADP-ribose) polymerase-1 (Parp-1) is involved in transcriptional regulation of various genes as a coactivator or a corepressor by modulating chromatin structure. Howeve...

    Authors: Hideki Ogino, Tadashige Nozaki, Akemi Gunji, Miho Maeda, Hiroshi Suzuki, Tsutomu Ohta, Yasufumi Murakami, Hitoshi Nakagama, Takashi Sugimura and Mitsuko Masutani
    Citation: BMC Genomics 2007 8:41
    Content type: Research article Published on:

  9. Noncoding RNA species play a diverse set of roles in the eukaryotic cell. While much recent attention has focused on smaller RNA species, larger noncoding transcripts are also thought to be highly abundant in ...

    Authors: John N Hutchinson, Alexander W Ensminger, Christine M Clemson, Christopher R Lynch, Jeanne B Lawrence and Andrew Chess
    Citation: BMC Genomics 2007 8:39
    Content type: Research article Published on:

  10. Human myelogenous leukemia characterized by either the non random t(8; 21)(q22; q22) or t(16; 21)(q24; q22) chromosome translocations differ for both their biological and clinical features. Some of these featu...

    Authors: Stefano Rossetti, André T Hoogeveen, Ping Liang, Cornel Stanciu, Peter van der Spek and Nicoletta Sacchi
    Citation: BMC Genomics 2007 8:38
    Content type: Research article Published on:

  11. The midgut of hematophagous insects, such as disease transmitting mosquitoes, carries out a variety of essential functions that mostly relate to blood feeding. The midgut of the female malaria vector mosquito Ano...

    Authors: Emma Warr, Ruth Aguilar, Yuemei Dong, Vassiliki Mahairaki and George Dimopoulos
    Citation: BMC Genomics 2007 8:37
    Content type: Research article Published on:

  13. Neisseria gonorrhoeae can survive during oxygen starvation by reducing nitrite to nitrous oxide catalysed by the nitrite and nitric oxide reductases, AniA and NorB. The oxygen-sensing transcription factor, FNR, i...

    Authors: Rebekah N Whitehead, Tim W Overton, Lori AS Snyder, Simon J McGowan, Harry Smith, Jeff A Cole and Nigel J Saunders
    Citation: BMC Genomics 2007 8:35
    Content type: Research article Published on:

  14. Pyrethroid resistance in Anopheles funestus populations has led to an increase in malaria transmission in southern Africa. Resistance has been attributed to elevated activities of cytochrome P450s but the molecul...

    Authors: Charles S Wondji, John Morgan, Maureen Coetzee, Richard H Hunt, Keith Steen, William C Black IV, Janet Hemingway and Hilary Ranson
    Citation: BMC Genomics 2007 8:34
    Content type: Research article Published on:

  16. Prostate cancer is the most frequently diagnosed cancer in American men, and few effective treatment options are available to patients who develop hormone-refractory prostate cancer. The molecular changes that...

    Authors: Steven N Quayle, Heidi Hare, Allen D Delaney, Martin Hirst, Dorothy Hwang, Jacqueline E Schein, Steven JM Jones, Marco A Marra and Marianne D Sadar
    Citation: BMC Genomics 2007 8:32
    Content type: Research article Published on:

  17. Improvement of Citrus, the most economically important fruit crop in the world, is extremely slow and inherently costly because of the long-term nature of tree breeding and an unusual combination of reproductive ...

    Authors: Javier Terol, Ana Conesa, Jose M Colmenero, Manuel Cercos, Francisco Tadeo, Javier Agustí, Enriqueta Alós, Fernando Andres, Guillermo Soler, Javier Brumos, Domingo J Iglesias, Stefan Götz, Francisco Legaz, Xavier Argout, Brigitte Courtois, Patrick Ollitrault…
    Citation: BMC Genomics 2007 8:31
    Content type: Research article Published on:

  18. Rapid progress in high-throughput biotechnologies (e.g. microarrays) and exponential accumulation of gene functional knowledge make it promising for systematic understanding of complex human diseases at functi...

    Authors: Jing Zhu, Jing Wang, Zheng Guo, Min Zhang, Da Yang, Yanhui Li, Dong Wang and Guohua Xiao
    Citation: BMC Genomics 2007 8:30
    Content type: Software Published on:

  19. An important mechanism for gene regulation utilizes small non-coding RNAs called microRNAs (miRNAs). These small RNAs play important roles in tissue development, cell differentiation and proliferation, lipid a...

    Authors: Yang Wang, Tingting Weng, Deming Gou, Zhongming Chen, Narendranath Reddy Chintagari and Lin Liu
    Citation: BMC Genomics 2007 8:29
    Content type: Research article Published on:

  20. Until recently, few genomic reagents specific for non-human primate research have been available. To address this need, we have constructed a macaque-specific high-density oligonucleotide microarray by using h...

    Authors: James C Wallace, Marcus J Korth, Bryan Paeper, Sean C Proll, Matthew J Thomas, Charles L Magness, Shawn P Iadonato, Charles Nelson and Michael G Katze
    Citation: BMC Genomics 2007 8:28
    Content type: Research article Published on:

  21. The C. elegans Promoterome is a powerful resource for revealing the regulatory mechanisms by which transcription is controlled pan-genomically. Transcription factors will form the core of any systems biology mode...

    Authors: John S Reece-Hoyes, Jane Shingles, Denis Dupuy, Christian A Grove, Albertha JM Walhout, Marc Vidal and Ian A Hope
    Citation: BMC Genomics 2007 8:27
    Content type: Research article Published on:

  22. Amyotrophic lateral sclerosis (ALS) is a fatal disorder caused by the progressive degeneration of motoneurons in brain and spinal cord. Despite identification of disease-linked mutations, the diversity of proc...

    Authors: Carsten W Lederer, Antonietta Torrisi, Maria Pantelidou, Niovi Santama and Sebastiano Cavallaro
    Citation: BMC Genomics 2007 8:26
    Content type: Research article Published on:

  23. Regulatory networks often employ the model that attributes changes in gene expression levels, as observed across different cellular conditions, to changes in the activity of transcription factors (TFs). Althou...

    Authors: Theo A Knijnenburg, Johannes H de Winde, Jean-Marc Daran, Pascale Daran-Lapujade, Jack T Pronk, Marcel JT Reinders and Lodewyk FA Wessels
    Citation: BMC Genomics 2007 8:25
    Content type: Research article Published on:

  25. Nuclear receptors are hormone-regulated transcription factors whose signaling controls numerous aspects of development and physiology. Many receptors recognize DNA hormone response elements formed by direct re...

    Authors: David Laperriere, Tian-Tian Wang, John H White and Sylvie Mader
    Citation: BMC Genomics 2007 8:23
    Content type: Research article Published on:

  26. Cell-wall digestibility is the major target for improving the feeding value of forage maize. An understanding of the molecular basis for cell-wall digestibility is crucial towards breeding of highly digestible...

    Authors: Chun Shi, Anna Uzarowska, Milena Ouzunova, Matthias Landbeck, Gerhard Wenzel and Thomas Lübberstedt
    Citation: BMC Genomics 2007 8:22
    Content type: Research article Published on:

  27. Transcription regulatory networks are composed of protein-DNA interactions between transcription factors and their target genes. A long-term goal in genome biology is to map protein-DNA interaction networks of...

    Authors: M Inmaculada Barrasa, Philippe Vaglio, Fabien Cavasino, Laurent Jacotot and Albertha JM Walhout
    Citation: BMC Genomics 2007 8:21
    Content type: Database Published on:

  29. Dystrophins and dystrobrevins are distantly related proteins with important but poorly understood roles in the function of metazoan muscular and neuronal tissues. Defects in them and their associated proteins ...

    Authors: Hong Jin, Sipin Tan, Jane Hermanowski, Sabrina Böhm, Sabrina Pacheco, Joanna M McCauley, Marc J Greener, Yaniv Hinits, Simon M Hughes, Paul T Sharpe and Roland G Roberts
    Citation: BMC Genomics 2007 8:19
    Content type: Research article Published on:

  30. Several lines of evidence support the existence of novel genes and other transcribed units which have not yet been annotated in the Arabidopsis genome. Two gene prediction programs which make use of comparativ...

    Authors: William A Moskal Jr, Hank C Wu, Beverly A Underwood, Wei Wang, Christopher D Town and Yongli Xiao
    Citation: BMC Genomics 2007 8:18
    Content type: Research article Published on:

  31. The normalization of DNA microarrays allows comparison among samples by adjusting for individual hybridization intensities. The approaches most commonly used are global normalization methods that are based on ...

    Authors: Paolo Fardin, Stefano Moretti, Barbara Biasotti, Annamaria Ricciardi, Stefano Bonassi and Luigi Varesio
    Citation: BMC Genomics 2007 8:17
    Content type: Research article Published on:

  32. Meningiomas are the most common intracranial neoplasias, representing a clinically and histopathologically heterogeneous group of tumors. The neurofibromatosis type 2 (NF2) tumor suppressor is the only gene known...

    Authors: Caisa M Hansson, Patrick G Buckley, Giedre Grigelioniene, Arkadiusz Piotrowski, Anders R Hellström, Kiran Mantripragada, Caroline Jarbo, Tiit Mathiesen and Jan P Dumanski
    Citation: BMC Genomics 2007 8:16
    Content type: Research article Published on:

  34. Copy number variants (CNVs) account for a significant proportion of normal phenotypic variation and may have an important role in human pathological variation. The α-defensin cluster on human chromosome 8p23.1...

    Authors: Ester Ballana, Juan Ramón González, Nina Bosch and Xavier Estivill
    Citation: BMC Genomics 2007 8:14
    Content type: Research article Published on:

  35. Cryptosporidium parvum is a unicellular eukaryote in the phylum Apicomplexa. It is an obligate intracellular parasite that causes diarrhea and is a significant AIDS-related pathogen. Cryptosporidium parvum is not...

    Authors: Nandita Mullapudi, Cheryl A Lancto, Mitchell S Abrahamsen and Jessica C Kissinger
    Citation: BMC Genomics 2007 8:13
    Content type: Research article Published on:

  36. The establishment of C4 photosynthesis in maize is associated with differential accumulation of gene transcripts and proteins between bundle sheath and mesophyll photosynthetic cell types. We have physically sepa...

    Authors: Ruairidh JH Sawers, Peng Liu, Katya Anufrikova, JT Gene Hwang and Thomas P Brutnell
    Citation: BMC Genomics 2007 8:12
    Content type: Research article Published on:

  37. Large-scale mutagenesis screens in the zebrafish employing the mutagen ENU have isolated several hundred mutant loci that represent putative developmental control genes. In order to realize the potential of su...

    Authors: Robert Geisler, Gerd-Jörg Rauch, Silke Geiger-Rudolph, Andrea Albrecht, Frauke van Bebber, Andrea Berger, Elisabeth Busch-Nentwich, Ralf Dahm, Marcus PS Dekens, Christopher Dooley, Alexandra F Elli, Ines Gehring, Horst Geiger, Maria Geisler, Stefanie Glaser, Scott Holley…
    Citation: BMC Genomics 2007 8:11
    Content type: Research article Published on:

  38. Many of the most effective high-throughput protocols for SNP genotyping employ microarrays. Genotypes are assessed by comparing the signal intensities that derive from the hybridization of different allele-spe...

    Authors: Arianna Cozza, Francesco Morandin, Silvia Giulia Galfrè, Veronica Mariotti, Roberto Marangoni and Silvia Pellegrini
    Citation: BMC Genomics 2007 8:10
    Content type: Methodology article Published on:

  39. The Ashbya Genome Database (AGD) 3.0 is an innovative cross-species genome and transcriptome browser based on release 40 of the Ensembl developer environment.

    Authors: Alexandre Gattiker, Riccarda Rischatsch, Philippe Demougin, Sylvia Voegeli, Fred S Dietrich, Peter Philippsen and Michael Primig
    Citation: BMC Genomics 2007 8:9
    Content type: Database Published on:

  41. In higher eukaryotes DNA methylation regulates important biological functions including silencing of gene expression and protection from adverse effects of retrotransposons. In the protozoan parasite Entamoeba hi...

    Authors: Ibne Karim M Ali, Gretchen M Ehrenkaufer, Jason A Hackney and Upinder Singh
    Citation: BMC Genomics 2007 8:7
    Content type: Research article Published on:

  42. Saliva of blood-sucking arthropods contains a cocktail of antihemostatic agents and immunomodulators that help blood feeding. Mosquitoes additionally feed on sugar meals and have specialized regions of their g...

    Authors: José MC Ribeiro, Bruno Arcà, Fabrizio Lombardo, Eric Calvo, Van My Phan, Prafulla K Chandra and Stephen K Wikel
    Citation: BMC Genomics 2007 8:6
    Content type: Research article Published on:

  43. Single nucleotide polymorphisms (SNPs) are the most common source of genetic variation in eukaryotic species and have become an important marker for genetic studies. The mosquito Anopheles funestus is one of the ...

    Authors: Charles S Wondji, Janet Hemingway and Hilary Ranson
    Citation: BMC Genomics 2007 8:5
    Content type: Research article Published on:

  44. Corynebacterium glutamicum is a gram-positive soil bacterium widely used for the industrial production of amino acids. There is great interest in the examination of the molecular mechanism of transcription contro...

    Authors: Christof Larisch, Diana Nakunst, Andrea T Hüser, Andreas Tauch and Jörn Kalinowski
    Citation: BMC Genomics 2007 8:4
    Content type: Research article Published on:

  45. The low-shear microgravity environment, modeled by rotating suspension culture bioreactors called high aspect ratio vessels (HARVs), allows investigation in ground-based studies of the effects of microgravity ...

    Authors: Kathy B Sheehan, Kate McInnerney, Boloroo Purevdorj-Gage, Sara D Altenburg and Linda E Hyman
    Citation: BMC Genomics 2007 8:3
    Content type: Research article Published on:

  46. A promising application of the huge amounts of genetic data currently available lies in developing a better understanding of complex diseases, such as cancer. Analysis of publicly available databases can help ...

    Authors: Abdel Aouacheria, Vincent Navratil, Ricardo López-Pérez, Norma C Gutiérrez, Alexander Churkin, Danny Barash, Dominique Mouchiroud and Christian Gautier
    Citation: BMC Genomics 2007 8:2
    Content type: Research article Published on:

  47. The homologues of human disease genes are expected to contribute to better understanding of physiological and pathogenic processes. We made use of the present availability of vertebrate genomic sequences, and ...

    Authors: Marko Premzl and Vera Gamulin
    Citation: BMC Genomics 2007 8:1
    Content type: Research article Published on:

  48. Recently, several high-resolution methods of chromosome analysis have been developed. It is important to compare these methods and to select reliable combinations of techniques to analyze complex chromosomal r...

    Authors: Eva Darai-Ramqvist, Teresita Diaz de Ståhl, Agneta Sandlund, Kiran Mantripragada, George Klein, Jan Dumanski, Stefan Imreh and Maria Kost-Alimova
    Citation: BMC Genomics 2006 7:330
    Content type: Methodology article Published on:

  49. The local environment of single nucleotide polymorphisms (SNPs) contains abundant genetic information for the study of mechanisms of mutation, genome evolution, and causes of diseases. Recent studies revealed ...

    Authors: Daekwan Seo, Cizhong Jiang and Zhongming Zhao
    Citation: BMC Genomics 2006 7:329
    Content type: Methodology article Published on:

  50. The strong linkage disequilibrium (LD) recently found in genic or exonic regions of the human genome demonstrated that LD can be increased by evolutionary mechanisms that select for functionally important loci...

    Authors: Mamoru Kato, Akihiro Sekine, Yozo Ohnishi, Todd A Johnson, Toshihiro Tanaka, Yusuke Nakamura and Tatsuhiko Tsunoda
    Citation: BMC Genomics 2006 7:326
    Content type: Research article Published on:

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BMC Genomics

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