Poole DC: Current concepts of oxygen transport during exercise. Equine and Comparative Exercise Physiology. 2004, 1 (1): 5-22. 10.1079/ECP20036.
Google Scholar
Young LE, Marlin DJ, Deaton C, Brown-Feltner H, Roberts CA, Wood JL: Heart size estimated by echocardiography correlates with maximal oxygen uptake. Equine Vet J Suppl. 2002, 467-471. 34
Guthrie AJ, Lund RJ: Thermoregulation. Base mechanisms and hyperthermia. Vet Clin North Am Equine Pract. 1998, 14 (1): 45-59.
CAS
PubMed
Google Scholar
Gunn HM: Muscle, bone and fat proportions and muscle distribution of Thoroughbreds and other horses. Equine exercise physiology 2 Davis, ICEEP, CA 1987. Edited by: Gillespie JR, Robinson NE. 1987, 253-264.
Google Scholar
Booth FW, Tseng BS, Fluck M, Carson JA: Molecular and cellular adaptation of muscle in response to physical training. Acta Physiol Scand. 1998, 162 (3): 343-350. 10.1046/j.1365-201X.1998.0326e.x.
CAS
PubMed
Google Scholar
Martineau LC, Gardiner PF: Insight into skeletal muscle mechanotransduction: MAPK activation is quantitatively related to tension. J Appl Physiol. 2001, 91 (2): 693-702.
CAS
PubMed
Google Scholar
Sahlin K, Tonkonogi M, Soderlund K: Energy supply and muscle fatigue in humans. Acta Physiol Scand. 1998, 162 (3): 261-266. 10.1046/j.1365-201X.1998.0298f.x.
CAS
PubMed
Google Scholar
Pilegaard H, Ordway GA, Saltin B, Neufer PD: Transcriptional regulation of gene expression in human skeletal muscle during recovery from exercise. Am J Physiol Endocrinol Metab. 2000, 279 (4): E806-814.
CAS
PubMed
Google Scholar
Jeukendrup AE: Modulation of carbohydrate and fat utilization by diet, exercise and environment. Biochem Soc Trans. 2003, 31 (Pt 6): 1270-1273. 10.1042/BST0311270.
CAS
PubMed
Google Scholar
Ji LL: Exercise-induced modulation of antioxidant defense. Ann N Y Acad Sci. 2002, 959: 82-92.
CAS
PubMed
Google Scholar
Green HJ: Membrane excitability, weakness, and fatigue. Can J Appl Physiol. 2004, 29 (3): 291-307.
CAS
PubMed
Google Scholar
Richter EA, Derave W, Wojtaszewski JF: Glucose, exercise and insulin: emerging concepts. J Physiol. 2001, 535 (Pt 2): 313-322. 10.1111/j.1469-7793.2001.t01-2-00313.x.
PubMed Central
CAS
PubMed
Google Scholar
Adhihetty PJ, Irrcher I, Joseph AM, Ljubicic V, Hood DA: Plasticity of skeletal muscle mitochondria in response to contractile activity. Exp Physiol. 2003, 88 (1): 99-107. 10.1113/eph8802505.
CAS
PubMed
Google Scholar
Carter SL, Rennie C, Tarnopolsky MA: Substrate utilization during endurance exercise in men and women after endurance training. Am J Physiol Endocrinol Metab. 2001, 280 (6): E898-907.
CAS
PubMed
Google Scholar
Fluck M, Hoppeler H: Molecular basis of skeletal muscle plasticity--from gene to form and function. Rev Physiol Biochem Pharmacol. 2003, 146: 159-216. full_text.
CAS
PubMed
Google Scholar
Booth FW, Baldwin KM: Muscle plasticity: energy demanding and supply processes. Handbook of physiology. Edited by: Rowell LB, Shepherd JT. 1996, Oxford University Press, New York, Chap 24 (Sect 12): 1075-1123.
Hood DA: Invited Review: contractile activity-induced mitochondrial biogenesis in skeletal muscle. J Appl Physiol. 2001, 90 (3): 1137-1157.
CAS
PubMed
Google Scholar
Neufer PD, Ordway GA, Hand GA, Shelton JM, Richardson JA, Benjamin IJ, Williams RS: Continuous contractile activity induces fiber type specific expression of HSP70 in skeletal muscle. Am J Physiol. 1996, 271 (6 Pt 1): C1828-1837.
CAS
PubMed
Google Scholar
Mahoney DJ, Parise G, Melov S, Safdar A, Tarnopolsky MA: Analysis of global mRNA expression in human skeletal muscle during recovery from endurance exercise. FASEB J. 2005, 19 (11): 1498-1500.
CAS
PubMed
Google Scholar
Hoppeler H, Klossner S, Fluck M: Gene expression in working skeletal muscle. Adv Exp Med Biol. 2007, 618: 245-254. full_text.
PubMed
Google Scholar
Gibala MJ, McGee SL, Garnham AP, Howlett KF, Snow RJ, Hargreaves M: Brief intense interval exercise activates AMPK and p38 MAPK signaling and increases the expression of PGC-1alpha in human skeletal muscle. J Appl Physiol. 2009, 106 (3): 929-934. 10.1152/japplphysiol.90880.2008.
CAS
PubMed
Google Scholar
Ikeda S, Kizaki T, Haga S, Ohno H, Takemasa T: Acute exercise induces biphasic increase in respiratory mRNA in skeletal muscle. Biochem Biophys Res Commun. 2008, 368 (2): 323-328. 10.1016/j.bbrc.2008.01.095.
CAS
PubMed
Google Scholar
Louis E, Raue U, Yang Y, Jemiolo B, Trappe S: Time course of proteolytic, cytokine, and myostatin gene expression after acute exercise in human skeletal muscle. J Appl Physiol. 2007, 103 (5): 1744-1751. 10.1152/japplphysiol.00679.2007.
CAS
PubMed
Google Scholar
Puntschart A, Wey E, Jostarndt K, Vogt M, Wittwer M, Widmer HR, Hoppeler H, Billeter R: Expression of fos and jun genes in human skeletal muscle after exercise. Am J Physiol. 1998, 274 (1 Pt 1): C129-137.
CAS
PubMed
Google Scholar
Rose RJ: Poor performance: a clinical and physiological perspective. Proceedings of the nineteenth American College of Veterinary Internal Medicine Forum: 2001; Denver, Colo. 2001, 224-225.
Google Scholar
Rose RJ, Hendrickson DK, Knight PK: Clinical exercise testing in the normal thoroughbred racehorse. Australian veterinary journal. 1990, 67 (10): 345-348. 10.1111/j.1751-0813.1990.tb07394.x.
CAS
PubMed
Google Scholar
Woodie JB, Ducharme NG, Hackett RP, Erb HN, Mitchell LM, Soderholm LV: Can an external device prevent dorsal displacement of the soft palate during strenuous exercise?. Equine veterinary journal. 2005, 37 (5): 425-429. 10.2746/042516405774480003.
CAS
PubMed
Google Scholar
Huang da W, Sherman BT, Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 2009, 4 (1): 44-57. 10.1038/nprot.2008.211.
PubMed
Google Scholar
Dennis G, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, Lempicki RA: DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol. 2003, 4 (5): P3-10.1186/gb-2003-4-5-p3.
PubMed
Google Scholar
Puntschart A, Vogt M, Widmer HR, Hoppeler H, Billeter R: Hsp70 expression in human skeletal muscle after exercise. Acta Physiol Scand. 1996, 157 (4): 411-417. 10.1046/j.1365-201X.1996.512270000.x.
CAS
PubMed
Google Scholar
Simon P, Fehrenbach E, Niess AM: Regulation of immediate early gene expression by exercise: short cuts for the adaptation of immune function. Exerc Immunol Rev. 2006, 12: 112-131.
PubMed
Google Scholar
McArdle F, Spiers S, Aldemir H, Vasilaki A, Beaver A, Iwanejko L, McArdle A, Jackson MJ: Preconditioning of skeletal muscle against contraction-induced damage: the role of adaptations to oxidants in mice. J Physiol. 2004, 561 (Pt 1): 233-244. 10.1113/jphysiol.2004.069914.
PubMed Central
CAS
PubMed
Google Scholar
Broome CS, Kayani AC, Palomero J, Dillmann WH, Mestril R, Jackson MJ, McArdle A: Effect of lifelong overexpression of HSP70 in skeletal muscle on age-related oxidative stress and adaptation after nondamaging contractile activity. FASEB J. 2006, 20 (9): 1549-1551. 10.1096/fj.05-4935fje.
CAS
PubMed
Google Scholar
Marber MS, Mestril R, Chi SH, Sayen MR, Yellon DM, Dillmann WH: Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury. J Clin Invest. 1995, 95 (4): 1446-1456. 10.1172/JCI117815.
PubMed Central
CAS
PubMed
Google Scholar
Gething MJ, Sambrook J: Protein folding in the cell. Nature. 1992, 355 (6355): 33-45. 10.1038/355033a0.
CAS
PubMed
Google Scholar
Tupling AR, Gramolini AO, Duhamel TA, Kondo H, Asahi M, Tsuchiya SC, Borrelli MJ, Lepock JR, Otsu K, Hori M, et al: HSP70 binds to the fast-twitch skeletal muscle sarco(endo)plasmic reticulum Ca2+ -ATPase (SERCA1a) and prevents thermal inactivation. J Biol Chem. 2004, 279 (50): 52382-52389. 10.1074/jbc.M409336200.
CAS
PubMed
Google Scholar
Senf SM, Dodd SL, McClung JM, Judge AR: Hsp70 overexpression inhibits NF-kappaB and Foxo3a transcriptional activities and prevents skeletal muscle atrophy. FASEB J. 2008, 22 (11): 3836-3845. 10.1096/fj.08-110163.
CAS
PubMed
Google Scholar
Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES: Negative regulation of the Apaf-1 apoptosome by Hsp70. Nat Cell Biol. 2000, 2 (8): 476-483. 10.1038/35019510.
CAS
PubMed
Google Scholar
Moresi V, Garcia-Alvarez G, Pristera A, Rizzuto E, Albertini MC, Rocchi M, Marazzi G, Sassoon D, Adamo S, Coletti D: Modulation of caspase activity regulates skeletal muscle regeneration and function in response to vasopressin and tumor necrosis factor. PLoS ONE. 2009, 4 (5): e5570-10.1371/journal.pone.0005570.
PubMed Central
PubMed
Google Scholar
Yun H, Lee M, Kim SS, Ha J: Glucose deprivation increases mRNA stability of vascular endothelial growth factor through activation of AMP-activated protein kinase in DU145 prostate carcinoma. J Biol Chem. 2005, 280 (11): 9963-9972. 10.1074/jbc.M412994200.
CAS
PubMed
Google Scholar
Minchenko O, Opentanova I, Minchenko D, Ogura T, Esumi H: Hypoxia induces transcription of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase-4 gene via hypoxia-inducible factor-1alpha activation. FEBS Lett. 2004, 576 (1-2): 14-20. 10.1016/j.febslet.2004.08.053.
CAS
PubMed
Google Scholar
Van Schaftingen E, Jett MF, Hue L, Hers HG: Control of liver 6-phosphofructokinase by fructose 2,6-bisphosphate and other effectors. Proc Natl Acad Sci USA. 1981, 78 (6): 3483-3486. 10.1073/pnas.78.6.3483.
PubMed Central
CAS
PubMed
Google Scholar
Eivers SS, McGivney BA, Fonseca RG, Machugh DE, Menson K, Park SD, Rivero JL, Taylor CT, Katz LM, Hill EW: Alterations in oxidative gene expression in equine skeletal muscle following exercise and training. Physiol Genomics. 2009,
Google Scholar
Wittwer M, Billeter R, Hoppeler H, Fluck M: Regulatory gene expression in skeletal muscle of highly endurance-trained humans. Acta Physiol Scand. 2004, 180 (2): 217-227. 10.1046/j.0001-6772.2003.01242.x.
CAS
PubMed
Google Scholar
Arden C, Hampson LJ, Huang GC, Shaw JA, Aldibbiat A, Holliman G, Manas D, Khan S, Lange AJ, Agius L: A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic beta-cells. Biochem J. 2008, 411 (1): 41-51. 10.1042/BJ20070962.
CAS
PubMed
Google Scholar
Jiao H, Kaaman M, Dungner E, Kere J, Arner P, Dahlman I: Association analysis of positional obesity candidate genes based on integrated data from transcriptomics and linkage analysis. Int J Obes (Lond). 2008, 32 (5): 816-825. 10.1038/sj.ijo.0803789.
CAS
Google Scholar
Obach M, Navarro-Sabate A, Caro J, Kong X, Duran J, Gomez M, Perales JC, Ventura F, Rosa JL, Bartrons R: 6-Phosphofructo-2-kinase (pfkfb3) gene promoter contains hypoxia-inducible factor-1 binding sites necessary for transactivation in response to hypoxia. J Biol Chem. 2004, 279 (51): 53562-53570. 10.1074/jbc.M406096200.
CAS
PubMed
Google Scholar
Wu Z, Huang X, Feng Y, Handschin C, Gullicksen PS, Bare O, Labow M, Spiegelman B, Stevenson SC: Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1alpha transcription and mitochondrial biogenesis in muscle cells. Proc Natl Acad Sci USA. 2006, 103 (39): 14379-14384. 10.1073/pnas.0606714103.
PubMed Central
CAS
PubMed
Google Scholar
Liu Y, Dentin R, Chen D, Hedrick S, Ravnskjaer K, Schenk S, Milne J, Meyers DJ, Cole P, Yates J, et al: A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange. Nature. 2008, 456 (7219): 269-273. 10.1038/nature07349.
PubMed Central
CAS
PubMed
Google Scholar
Price NT, Jackson VN, Halestrap AP: Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Biochem J. 1998, 329 (Pt 2): 321-328.
PubMed Central
CAS
PubMed
Google Scholar
Snow DH, Guy PS: Muscle fibre type composition of a number of limb muscles in different types of horse. Res Vet Sci. 1980, 28 (2): 137-144.
CAS
PubMed
Google Scholar
Koho NM, Hyyppa S, Poso AR: Monocarboxylate transporters (MCT) as lactate carriers in equine muscle and red blood cells. Equine Vet J Suppl. 2006, 354-358. 36
Wang Q, Morris ME: The role of monocarboxylate transporter 2 and 4 in the transport of gamma-hydroxybutyric acid in mammalian cells. Drug Metab Dispos. 2007, 35 (8): 1393-1399. 10.1124/dmd.107.014852.
CAS
PubMed
Google Scholar
Lyon RC, Johnston SM, Panopoulos A, Alzeer S, McGarvie G, Ellis EM: Enzymes involved in the metabolism of gamma-hydroxybutyrate in SH-SY5Y cells: identification of an iron-dependent alcohol dehydrogenase ADHFe1. Chem Biol Interact. 2009, 178 (1-3): 283-287. 10.1016/j.cbi.2008.10.025.
CAS
PubMed
Google Scholar
Gu J, Orr N, Park SD, Katz LM, Sulimova G, MacHugh DE, Hill EW: A genome scan for positive selection in thoroughbred horses. PLoS ONE. 2009, 4 (6): e5767-10.1371/journal.pone.0005767.
PubMed Central
PubMed
Google Scholar
Al-Shahrour F, Arbiza L, Dopazo H, Huerta-Cepas J, Minguez P, Montaner D, Dopazo J: From genes to functional classes in the study of biological systems. BMC Bioinformatics. 2007, 8: 114-10.1186/1471-2105-8-114.
PubMed Central
PubMed
Google Scholar
Dohm GL, Kasperek GJ, Tapscott EB, Beecher GR: Effect of exercise on synthesis and degradation of muscle protein. Biochem J. 1980, 188 (1): 255-262.
PubMed Central
CAS
PubMed
Google Scholar
Gautsch TA, Anthony JC, Kimball SR, Paul GL, Layman DK, Jefferson LS: Availability of eIF4E regulates skeletal muscle protein synthesis during recovery from exercise. Am J Physiol. 1998, 274 (2 Pt 1): C406-414.
CAS
PubMed
Google Scholar
Williamson DL, Kubica N, Kimball SR, Jefferson LS: Exercise-induced alterations in extracellular signal-regulated kinase 1/2 and mammalian target of rapamycin (mTOR) signalling to regulatory mechanisms of mRNA translation in mouse muscle. J Physiol. 2006, 573 (Pt 2): 497-510. 10.1113/jphysiol.2005.103481.
PubMed Central
CAS
PubMed
Google Scholar
Hunt CR, Parsian AJ, Goswami PC, Kozak CA: Characterization and expression of the mouse Hsc70 gene. Biochim Biophys Acta. 1999, 1444 (3): 315-325.
CAS
PubMed
Google Scholar
Humphries AD, Streimann IC, Stojanovski D, Johnston AJ, Yano M, Hoogenraad NJ, Ryan MT: Dissection of the mitochondrial import and assembly pathway for human Tom40. J Biol Chem. 2005, 280 (12): 11535-11543. 10.1074/jbc.M413816200.
CAS
PubMed
Google Scholar
Takahashi M, Chesley A, Freyssenet D, Hood DA: Contractile activity-induced adaptations in the mitochondrial protein import system. Am J Physiol. 1998, 274 (5 Pt 1): C1380-1387.
CAS
PubMed
Google Scholar
Bolender N, Sickmann A, Wagner R, Meisinger C, Pfanner N: Multiple pathways for sorting mitochondrial precursor proteins. EMBO Rep. 2008, 9 (1): 42-49. 10.1038/sj.embor.7401126.
PubMed Central
CAS
PubMed
Google Scholar
Neupert W, Herrmann JM: Translocation of proteins into mitochondria. Annu Rev Biochem. 2007, 76: 723-749. 10.1146/annurev.biochem.76.052705.163409.
CAS
PubMed
Google Scholar
Vissing K, Bayer ML, Overgaard K, Schjerling P, Raastad T: Heat shock protein translocation and expression response is attenuated in response to repeated eccentric exercise. Acta Physiol (Oxf). 2009, 196 (3): 283-293. 10.1111/j.1748-1716.2008.01940.x.
CAS
Google Scholar
Paulsen G, Vissing K, Kalhovde JM, Ugelstad I, Bayer ML, Kadi F, Schjerling P, Hallen J, Raastad T: Maximal eccentric exercise induces a rapid accumulation of small heat shock proteins on myofibrils and a delayed HSP70 response in humans. Am J Physiol Regul Integr Comp Physiol. 2007, 293 (2): R844-853.
CAS
PubMed
Google Scholar
Ikeda T, Abe K, Ota A, Ikenoue T: Heat shock protein 70 and heat shock cognate protein 70 messenger ribonucleic acid induction in the brains, hearts, and livers of neonatal rats after hypoxic stress. Am J Obstet Gynecol. 1999, 180 (2 Pt 1): 457-461. 10.1016/S0002-9378(99)70232-2.
CAS
PubMed
Google Scholar
Su CY, Chong KY, Edelstein K, Lille S, Khardori R, Lai CC: Constitutive hsp70 attenuates hydrogen peroxide-induced membrane lipid peroxidation. Biochem Biophys Res Commun. 1999, 265 (2): 279-284. 10.1006/bbrc.1999.1649.
CAS
PubMed
Google Scholar
Ryhanen T, Hyttinen JM, Kopitz J, Rilla K, Kuusisto E, Mannermaa E, Viiri J, Holmberg CI, Immonen I, Meri S, et al: Crosstalk between Hsp70 molecular chaperone, lysosomes and proteasomes in autophagy-mediated proteolysis in human retinal pigment epithelial cells. J Cell Mol Med. 2008,
Google Scholar
Vlahovich N, Schevzov G, Nair-Shaliker V, Ilkovski B, Artap ST, Joya JE, Kee AJ, North KN, Gunning PW, Hardeman EC: Tropomyosin 4 defines novel filaments in skeletal muscle associated with muscle remodelling/regeneration in normal and diseased muscle. Cell Motil Cytoskeleton. 2008, 65 (1): 73-85. 10.1002/cm.20245.
CAS
PubMed
Google Scholar
Klip A: The many ways to regulate glucose transporter 4. Appl Physiol Nutr Metab. 2009, 34 (3): 481-487. 10.1139/H09-047.
CAS
PubMed
Google Scholar
Boden G: Pathogenesis of type 2 diabetes. Insulin resistance. Endocrinol Metab Clin North Am. 2001, 30 (4): 801-815. 10.1016/S0889-8529(05)70216-4.
CAS
PubMed
Google Scholar
Reynolds THt, Bodine SC, Lawrence JC: Control of Ser2448 phosphorylation in the mammalian target of rapamycin by insulin and skeletal muscle load. J Biol Chem. 2002, 277 (20): 17657-17662. 10.1074/jbc.M201142200.
CAS
PubMed
Google Scholar
Wretman C, Lionikas A, Widegren U, Lannergren J, Westerblad H, Henriksson J: Effects of concentric and eccentric contractions on phosphorylation of MAPK(erk1/2) and MAPK(p38) in isolated rat skeletal muscle. J Physiol. 2001, 535 (Pt 1): 155-164. 10.1111/j.1469-7793.2001.00155.x.
PubMed Central
CAS
PubMed
Google Scholar
Johnson GL, Lapadat R: Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science. 2002, 298 (5600): 1911-1912. 10.1126/science.1072682.
CAS
PubMed
Google Scholar
Osorio-Fuentealba C, Valdes JA, Riquelme D, Hidalgo J, Hidalgo C, Carrasco MA: Hypoxia stimulates via separate pathways ERK phosphorylation and NF-kappaB activation in skeletal muscle cells in primary culture. J Appl Physiol. 2009, 106 (4): 1301-1310. 10.1152/japplphysiol.91224.2008.
CAS
PubMed
Google Scholar
Carson JA, Wei L: Integrin signaling's potential for mediating gene expression in hypertrophying skeletal muscle. J Appl Physiol. 2000, 88 (1): 337-343.
CAS
PubMed
Google Scholar
Kuppuswamy D: Importance of integrin signaling in myocyte growth and survival. Circ Res. 2002, 90 (12): 1240-1242. 10.1161/01.RES.0000025080.78636.23.
CAS
PubMed
Google Scholar
Fluck M, Mund SI, Schittny JC, Klossner S, Durieux AC, Giraud MN: Mechano-regulated tenascin-C orchestrates muscle repair. Proc Natl Acad Sci USA. 2008, 105 (36): 13662-13667. 10.1073/pnas.0805365105.
PubMed Central
CAS
PubMed
Google Scholar
Klossner S, Durieux AC, Freyssenet D, Flueck M: Mechano-transduction to muscle protein synthesis is modulated by FAK. Eur J Appl Physiol. 2009, 106 (3): 389-398. 10.1007/s00421-009-1032-7.
CAS
PubMed
Google Scholar
Spangenburg EE: Changes in muscle mass with mechanical load: possible cellular mechanisms. Appl Physiol Nutr Metab. 2009, 34 (3): 328-335. 10.1139/H09-010.
CAS
PubMed
Google Scholar
Durieux AC, D'Antona G, Desplanches D, Freyssenet D, Klossner S, Bottinelli R, Fluck M: Focal adhesion kinase is a load-dependent governor of the slow contractile and oxidative muscle phenotype. J Physiol. 2009, 587 (Pt 14): 3703-3717. 10.1113/jphysiol.2009.171355.
PubMed Central
CAS
PubMed
Google Scholar
Yang R, Amir J, Liu H, Chaqour B: Mechanical strain activates a program of genes functionally involved in paracrine signaling of angiogenesis. Physiol Genomics. 2008, 36 (1): 1-14. 10.1152/physiolgenomics.90291.2008.
PubMed Central
PubMed
Google Scholar
Saleem A, Adhihetty PJ, Hood DA: Role of p53 in mitochondrial biogenesis and apoptosis in skeletal muscle. Physiol Genomics. 2009, 37 (1): 58-66. 10.1152/physiolgenomics.90346.2008.
CAS
PubMed
Google Scholar
Matoba S, Kang JG, Patino WD, Wragg A, Boehm M, Gavrilova O, Hurley PJ, Bunz F, Hwang PM: p53 regulates mitochondrial respiration. Science. 2006, 312 (5780): 1650-1653. 10.1126/science.1126863.
CAS
PubMed
Google Scholar
Irrcher I, Ljubicic V, Kirwan AF, Hood DA: AMP-activated protein kinase-regulated activation of the PGC-1alpha promoter in skeletal muscle cells. PLoS ONE. 2008, 3 (10): e3614-10.1371/journal.pone.0003614.
PubMed Central
PubMed
Google Scholar
Boland LM, Drzewiecki MM: Polyunsaturated fatty acid modulation of voltage-gated ion channels. Cell Biochem Biophys. 2008, 52 (2): 59-84. 10.1007/s12013-008-9027-2.
CAS
PubMed
Google Scholar
Ispirlidis I, Fatouros IG, Jamurtas AZ, Nikolaidis MG, Michailidis I, Douroudos I, Margonis K, Chatzinikolaou A, Kalistratos E, Katrabasas I, et al: Time-course of changes in inflammatory and performance responses following a soccer game. Clin J Sport Med. 2008, 18 (5): 423-431. 10.1097/JSM.0b013e3181818e0b.
PubMed
Google Scholar
Amantea D, Nappi G, Bernardi G, Bagetta G, Corasaniti MT: Post-ischemic brain damage: pathophysiology and role of inflammatory mediators. FEBS J. 2009, 276 (1): 13-26. 10.1111/j.1742-4658.2008.06766.x.
CAS
PubMed
Google Scholar
Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Zeller KI, Dang CV, Semenza GL: HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell. 2007, 11 (5): 407-420. 10.1016/j.ccr.2007.04.001.
CAS
PubMed
Google Scholar
Kondo K, Klco J, Nakamura E, Lechpammer M, Kaelin WG: Inhibition of HIF is necessary for tumor suppression by the von Hippel-Lindau protein. Cancer Cell. 2002, 1 (3): 237-246. 10.1016/S1535-6108(02)00043-0.
CAS
PubMed
Google Scholar
Tavaria M, Gabriele T, Kola I, Anderson RL: A hitchhiker's guide to the human Hsp70 family. Cell Stress Chaperones. 1996, 1 (1): 23-28. 10.1379/1466-1268(1996)001<0023:AHSGTT>2.3.CO;2.
PubMed Central
CAS
PubMed
Google Scholar
Huang WJ, Xia LM, Zhu F, Huang B, Zhou C, Zhu HF, Wang B, Chen B, Lei P, Shen GX: Transcriptional upregulation of HSP70-2 by HIF-1 in cancer cells in response to hypoxia. Int J Cancer. 2009, 124 (2): 298-305. 10.1002/ijc.23906.
CAS
PubMed
Google Scholar
Ivanova AV, Ivanov SV, Danilkovitch-Miagkova A, Lerman MI: Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway. J Biol Chem. 2001, 276 (18): 15306-15315. 10.1074/jbc.M010516200.
CAS
PubMed
Google Scholar
Miyazaki K, Kawamoto T, Tanimoto K, Nishiyama M, Honda H, Kato Y: Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes. J Biol Chem. 2002, 277 (49): 47014-47021. 10.1074/jbc.M204938200.
CAS
PubMed
Google Scholar
Means AR, Dedman JR: Calmodulin--an intracellular calcium receptor. Nature. 1980, 285 (5760): 73-77. 10.1038/285073a0.
CAS
PubMed
Google Scholar
Wright NT, Prosser BL, Varney KM, Zimmer DB, Schneider MF, Weber DJ: S100A1 and calmodulin compete for the same binding site on ryanodine receptor. J Biol Chem. 2008, 283 (39): 26676-26683. 10.1074/jbc.M804432200.
PubMed Central
CAS
PubMed
Google Scholar
Jeyasingham MD, Artigues A, Nadeau OW, Carlson GM: Structural evidence for co-evolution of the regulation of contraction and energy production in skeletal muscle. J Mol Biol. 2008, 377 (3): 623-629. 10.1016/j.jmb.2007.12.072.
PubMed Central
CAS
PubMed
Google Scholar
Lindholm A, Piehl K: Fibre composition, enzyme activity and concentrations of metabolites and electrolytes in muscles of standardbred horses. Acta Vet Scand. 1974, 15 (3): 287-309.
CAS
PubMed
Google Scholar
Dingboom EG, Dijkstra G, Enzerink E, van Oudheusden HC, Weijs WA: Postnatal muscle fibre composition of the gluteus medius muscle of Dutch Warmblood foals; maturation and the influence of exercise. Equine Vet J Suppl. 1999, 95-100. 31
MacLeod JN: Equine articular cartilage microarray abstract. Plant & Animal Genome Conference XIII: 2005; San Diego, CA, USA. 2005
Google Scholar
Coleman SJ, Gong G, Gaile DP, Chowdhary BP, Bailey E, Liu L, MacLeod JN: Evaluation of Compass as a comparative mapping tool for ESTs using horse radiation hybrid maps. Anim Genet. 2007, 38 (3): 294-302. 10.1111/j.1365-2052.2007.01603.x.
CAS
PubMed
Google Scholar
Band MR, Olmstead C, Everts RE, Liu ZL, Lewin HA: A 3800 gene microarray for cattle functional genomics: comparison of gene expression in spleen, placenta, and brain. Anim Biotechnol. 2002, 13 (1): 163-172. 10.1081/ABIO-120005779.
PubMed
Google Scholar
Smit A, Hubley R, Green P: RepeatMasker Open-3.0. 1996
Google Scholar
Team RDC: R: A language and environment for statistical computing. 2005, Vienna, Austria: R Foundation for Statistical Computing
Google Scholar
Gentleman RC, Carey VJ, Bates DM, Bolstad B, Dettling M, Dudoit S, Ellis B, Gautier L, Ge Y, Gentry J, et al: Bioconductor: open software development for computational biology and bioinformatics. Genome Biol. 2004, 5 (10): R80-10.1186/gb-2004-5-10-r80.
PubMed Central
PubMed
Google Scholar
Irizarry RA, Hobbs B, Collin F, Beazer-Barclay YD, Antonellis KJ, Scherf U, Speed TP: Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics. 2003, 4 (2): 249-264. 10.1093/biostatistics/4.2.249.
PubMed
Google Scholar
Bolstad BM, Irizarry RA, Astrand M, Speed TP: A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics. 2003, 19 (2): 185-193. 10.1093/bioinformatics/19.2.185.
CAS
PubMed
Google Scholar
Cleveland WS: Robust locally weighted regression and smoothing scatterplots. Journal of the American Statistical Association. 1979, 74 (368): 829-836. 10.2307/2286407.
Google Scholar
Smyth GK, Michaud J, Scott HS: Use of within-array replicate spots for assessing differential expression in microarray experiments. Bioinformatics. 2005, 21 (9): 2067-2075. 10.1093/bioinformatics/bti270.
CAS
PubMed
Google Scholar
Smyth GK: Linear models and empirical bayes methods for assessing differential expression in microarray experiments. Stat Appl Genet Mol Biol. 2004, 3: Article3-
PubMed
Google Scholar
Benjamini Y, Hochberg Y: Controlling the false discovery rate - a practical and powerful approach to multiple testing. J R Stat Soc Ser B-Methodol. 1995, 57 (1): 289-300.
Google Scholar
Hosack DA, Dennis G, Sherman BT, Lane HC, Lempicki RA: Identifying biological themes within lists of genes with EASE. Genome Biol. 2003, 4 (10): R70-10.1186/gb-2003-4-10-r70.
PubMed Central
PubMed
Google Scholar
Al-Shahrour F, Minguez P, Tarraga J, Montaner D, Alloza E, Vaquerizas JM, Conde L, Blaschke C, Vera J, Dopazo J: BABELOMICS: a systems biology perspective in the functional annotation of genome-scale experiments. Nucleic Acids Res. 2006, W472-476. 10.1093/nar/gkl172. 34 Web Server
Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F: Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 2002, 3 (7): RESEARCH0034-10.1186/gb-2002-3-7-research0034.
PubMed Central
PubMed
Google Scholar
Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001, 25 (4): 402-408. 10.1006/meth.2001.1262.
CAS
PubMed
Google Scholar