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  1. Because biotechnological uses of bacteriophage gene products as alternatives to conventional antibiotics will require a thorough understanding of their genomic context, we sequenced and analyzed the genomes of...

    Authors: Brian B Oakley, Eldin Talundzic, Cesar A Morales, Kelli L Hiett, Gregory R Siragusa, Nikolay V Volozhantsev and Bruce S Seal
    Citation: BMC Genomics 2011 12:282
    Content type: Research article Published on:

  2. Glucagon is an important hormone in the regulation of glucose homeostasis, particularly in the maintenance of euglycemia and prevention of hypoglycemia. In type 2 Diabetes Mellitus (T2DM), glucagon levels are ...

    Authors: Jianxin Yang, Margit L MacDougall, Michael T McDowell, Li Xi, Ru Wei, William J Zavadoski, Mark P Molloy, John D Baker, Max Kuhn, Over Cabrera and Judith L Treadway
    Citation: BMC Genomics 2011 12:281
    Content type: Research article Published on:

  3. In animals, signaling of Bone Morphogenetic Proteins (BMPs) is essential for dorsoventral (DV) patterning of the embryo, but how BMP signaling evolved with changes in embryonic DV differentiation is largely un...

    Authors: Steffen Lemke, Dionysios A Antonopoulos, Folker Meyer, Marc H Domanus and Urs Schmidt-Ott
    Citation: BMC Genomics 2011 12:278
    Content type: Research article Published on:

  4. In an important model for neuroscience, songbirds learn to discriminate songs they hear during tape-recorded playbacks, as demonstrated by song-specific habituation of both behavioral and neurogenomic response...

    Authors: Preethi H Gunaratne, Ya-Chi Lin, Ashley L Benham, Jenny Drnevich, Cristian Coarfa, Jayantha B Tennakoon, Chad J Creighton, Jong H Kim, Aleksandar Milosavljevic, Michael Watson, Sam Griffiths-Jones and David F Clayton
    Citation: BMC Genomics 2011 12:277
    Content type: Research article Published on:

  5. MicroRNAs (miRNAs) play important roles in embryonic stem cell (ESC) self-renewal and pluripotency. Numerous studies have revealed human and mouse ESC miRNA profiles. As a model for human-related study, the rh...

    Authors: Zhenghua Sun, Qiang Wei, Yanfeng Zhang, Xiechao He, Weizhi Ji and Bing Su
    Citation: BMC Genomics 2011 12:276
    Content type: Research article Published on:

  6. Entamoeba histolytica, an enteric protozoan parasite, causes amebic colitis and extra intestinal abscesses in millions of inhabitants of endemic areas. E. histolytica completely lacks glutathione metabolism but p...

    Authors: Afzal Husain, Ghulam Jeelani, Dan Sato and Tomoyoshi Nozaki
    Citation: BMC Genomics 2011 12:275
    Content type: Research article Published on:

  7. In livestock species like the chicken, high throughput single nucleotide polymorphism (SNP) genotyping assays are increasingly being used for whole genome association studies and as a tool in breeding (referre...

    Authors: Martien AM Groenen, Hendrik-Jan Megens, Yalda Zare, Wesley C Warren, LaDeana W Hillier, Richard PMA Crooijmans, Addie Vereijken, Ron Okimoto, William M Muir and Hans H Cheng
    Citation: BMC Genomics 2011 12:274
    Content type: Research article Published on:

  9. Despite the fact that the organization of the ciliate mitochondrial genome is exceptional, only few ciliate mitochondrial genomes have been sequenced until today. All ciliate mitochondrial genomes are linear. ...

    Authors: Dana Barth and Thomas U Berendonk
    Citation: BMC Genomics 2011 12:272
    Content type: Research article Published on:

  10. Chemosensory signal transduction guides the behavior of many insects, including Anopheles gambiae, the major vector for human malaria in sub-Saharan Africa. To better understand the molecular basis of mosquito ch...

    Authors: R Jason Pitts, David C Rinker, Patrick L Jones, Antonis Rokas and Laurence J Zwiebel
    Citation: BMC Genomics 2011 12:271
    Content type: Research article Published on:

  12. The identification and characterization of the transcriptional regulatory networks governing the physiology and adaptation of microbial cells is a key step in understanding their behaviour. One such wide-domai...

    Authors: Thomas Portnoy, Antoine Margeot, Rita Linke, Lea Atanasova, Erzsébet Fekete, Erzsébet Sándor, Lukas Hartl, Levente Karaffa, Irina S Druzhinina, Bernhard Seiboth, Stéphane Le Crom and Christian P Kubicek
    Citation: BMC Genomics 2011 12:269
    Content type: Research article Published on:

  13. A deficiency in phaseolin and phytohemagglutinin is associated with a near doubling of sulfur amino acid content in genetically related lines of common bean (Phaseolus vulgaris), particularly cysteine, elevated b...

    Authors: Fuqiang Yin, Agnieszka Pajak, Ralph Chapman, Andrew Sharpe, Shangzhi Huang and Frédéric Marsolais
    Citation: BMC Genomics 2011 12:268
    Content type: Research article Published on:

  14. Entamoeba histolytica and Entamoeba dispar are closely related protistan parasites but while E. histolytica can be invasive, E. dispar is completely non pathogenic. Transposable elements constitute a significant ...

    Authors: Vandana Kumari, Rahul Sharma, Vijay P Yadav, Abhishek K Gupta, Alok Bhattacharya and Sudha Bhattacharya
    Citation: BMC Genomics 2011 12:267
    Content type: Research article Published on:

  15. Cassava (Manihot esculenta Crantz) can produce cyanide, a toxic compound, without self-injury. That ability was called the cyanogenic potential (CN). This project aimed to identify quantitative trait loci (QTL) a...

    Authors: Sukhuman Whankaew, Supannee Poopear, Supanath Kanjanawattanawong, Sithichoke Tangphatsornruang, Opas Boonseng, David A Lightfoot and Kanokporn Triwitayakorn
    Citation: BMC Genomics 2011 12:266
    Content type: Research article Published on:

  16. Lentil (Lens culinaris Medik.) is a cool-season grain legume which provides a rich source of protein for human consumption. In terms of genomic resources, lentil is relatively underdeveloped, in comparison to oth...

    Authors: Sukhjiwan Kaur, Noel OI Cogan, Luke W Pembleton, Maiko Shinozuka, Keith W Savin, Michael Materne and John W Forster
    Citation: BMC Genomics 2011 12:265
    Content type: Research article Published on:

  17. Global transcriptional analysis of loblolly pine (Pinus taeda L.) is challenging due to limited molecular tools. PtGen2, a 26,496 feature cDNA microarray, was fabricated and used to assess drought-induced gene ex...

    Authors: W Walter Lorenz, Rob Alba, Yuan-Sheng Yu, John M Bordeaux, Marta Simões and Jeffrey FD Dean
    Citation: BMC Genomics 2011 12:264
    Content type: Research article Published on:

  18. Populations of Atlantic killifish (Fundulus heteroclitus) have evolved resistance to the embryotoxic effects of polychlorinated biphenyls (PCBs) and other halogenated and nonhalogenated aromatic hydrocarbons that...

    Authors: Marjorie F Oleksiak, Sibel I Karchner, Matthew J Jenny, Diana G Franks, David B Mark Welch and Mark E Hahn
    Citation: BMC Genomics 2011 12:263
    Content type: Research article Published on:

  19. Age-related gene expression patterns of Homo sapiens as well as of model organisms such as Mus musculus, Saccharomyces cerevisiae, Caenorhabditis elegans and Drosophila melanogaster are a basis for understanding ...

    Authors: Edith Hofer, Gerhard T Laschober, Matthias Hackl, Gerhard G Thallinger, Günter Lepperdinger, Johannes Grillari, Pidder Jansen-Dürr and Zlatko Trajanoski
    Citation: BMC Genomics 2011 12:262
    Content type: Database Published on:

  21. Transposable elements (TEs) are DNA sequences, present in the genome of most eukaryotic organisms that hold the key characteristic of being able to mobilize and increase their copy number within chromosomes. T...

    Authors: Rita D Fernández-Medina, Cláudio J Struchiner and José MC Ribeiro
    Citation: BMC Genomics 2011 12:260
    Content type: Research article Published on:

  22. A long term research goal of venomics, of applied importance for improving current antivenom therapy, but also for drug discovery, is to understand the pharmacological potential of venoms. Individually or comb...

    Authors: Jordi Durban, Paula Juárez, Yamileth Angulo, Bruno Lomonte, Marietta Flores-Diaz, Alberto Alape-Girón, Mahmood Sasa, Libia Sanz, José M Gutiérrez, Joaquín Dopazo, Ana Conesa and Juan J Calvete
    Citation: BMC Genomics 2011 12:259
    Content type: Research article Published on:

  24. The total number of miRNA genes in a genome, expression of which is responsible for the miRNA repertoire of an organism, is not precisely known. Moreover, the question of how new miRNA genes arise during evolu...

    Authors: Stefan Lehnert, Vladimir Kapitonov, Pushpike J Thilakarathne and Frans C Schuit
    Citation: BMC Genomics 2011 12:257
    Content type: Research article Published on:

  25. Phenotype-driven forward genetic experiments are powerful approaches for linking phenotypes to genomic elements but they still involve a laborious positional cloning process. Although sequencing of complete ge...

    Authors: Michal Mokry, Isaäc J Nijman, Anja van Dijken, Rene Benjamins, Renze Heidstra, Ben Scheres and Edwin Cuppen
    Citation: BMC Genomics 2011 12:256
    Content type: Methodology article Published on:

  26. Expansion of aquaculture is seriously limited by reductions in fish oil (FO) supply for aquafeeds. Terrestrial alternatives such as vegetable oils (VO) have been investigated and recently a strategy combining ...

    Authors: Sofia Morais, Jarunan Pratoomyot, John B Taggart, James E Bron, Derrick R Guy, J Gordon Bell and Douglas R Tocher
    Citation: BMC Genomics 2011 12:255
    Content type: Research article Published on:

  27. Phytophthora species are oomycete plant pathogens with such major social and economic impact that genome sequences have been determined for Phytophthora infestans, P. sojae and P. ramorum. Pepsin-like aspartic pr...

    Authors: John Kay, Harold JG Meijer, Arjen ten Have and Jan AL van Kan
    Citation: BMC Genomics 2011 12:254
    Content type: Research article Published on:

  28. Streptococcus suis serotype 2 (S. suis 2) is an important pathogen of pigs. S suis 2 infections have high mortality rates and are characterized by meningitis, septicemia and pneumonia. S. suis 2 is also an emergi...

    Authors: Manli Liu, Liurong Fang, Chen Tan, Tiansi Long, Huanchun Chen and Shaobo Xiao
    Citation: BMC Genomics 2011 12:253
    Content type: Research article Published on:

  29. Melon (Cucumis melo), an economically important vegetable crop, belongs to the Cucurbitaceae family which includes several other important crops such as watermelon, cucumber, and pumpkin. It has served as a model...

    Authors: Christian Clepet, Tarek Joobeur, Yi Zheng, Delphine Jublot, Mingyun Huang, Veronica Truniger, Adnane Boualem, Maria Elena Hernandez-Gonzalez, Ramon Dolcet-Sanjuan, Vitaly Portnoy, Albert Mascarell-Creus, Ana I Caño-Delgado, Nurit Katzir, Abdelhafid Bendahmane, James J Giovannoni, Miguel A Aranda…
    Citation: BMC Genomics 2011 12:252
    Content type: Research article Published on:

  30. In vitro cell systems together with omics methods represent promising alternatives to conventional animal models for toxicity testing. Transcriptomic and proteomic approaches have been widely applied in vitro but...

    Authors: Ainhoa Ruiz-Aracama, Ad Peijnenburg, Jos Kleinjans, Danyel Jennen, Joost van Delft, Caroline Hellfrisch and Arjen Lommen
    Citation: BMC Genomics 2011 12:251
    Content type: Research article Published on:

  32. Sequence related amplified polymorphism (SRAP) is commonly used to construct high density genetic maps, map genes and QTL of important agronomic traits in crops and perform genetic diversity analysis without k...

    Authors: Wei Li, Jiefu Zhang, Yanglong Mou, Jianfeng Geng, Peter BE McVetty, Shengwu Hu and Genyi Li
    Citation: BMC Genomics 2011 12:249
    Content type: Research article Published on:

  33. The domesticated silkworm, Bombyx mori, is the model insect for the order Lepidoptera, has economically important values, and has gained some representative behavioral characteristics compared to its wild ancesto...

    Authors: Bo Zhu, Miao-Miao Lou, Guan-Lin Xie, Guo-Qing Zhang, Xue-Ping Zhou, Bin Li and Gu-Lei Jin
    Citation: BMC Genomics 2011 12:248
    Content type: Research article Published on:

  34. Although second generation sequencing (2GS) technologies allow re-sequencing of previously gold-standard-sequenced genomes, whole genome shotgun sequencing and de novo assembly of large and complex eukaryotic gen...

    Authors: Daniela Schulte, Ruvini Ariyadasa, Bujun Shi, Delphine Fleury, Chris Saski, Michael Atkins, Pieter deJong, Cheng-Cang Wu, Andreas Graner, Peter Langridge and Nils Stein
    Citation: BMC Genomics 2011 12:247
    Content type: Research article Published on:

  35. Genome sequencing of barley has been delayed due to its large genome size (ca. 5,000Mbp). Among the fast sequencing systems, 454 liquid phase pyrosequencing provides the longest reads and is the most promising...

    Authors: Kazuhiro Sato, Yuka Motoi, Nami Yamaji and Hideya Yoshida
    Citation: BMC Genomics 2011 12:246
    Content type: Research article Published on:

  36. The rapid evolution of 454 GS-FLX sequencing technology has not been accompanied by a reassessment of the quality and accuracy of the sequences obtained. Current strategies for decision-making and error-correc...

    Authors: André Gilles, Emese Meglécz, Nicolas Pech, Stéphanie Ferreira, Thibaut Malausa and Jean-François Martin
    Citation: BMC Genomics 2011 12:245
    Content type: Research article Published on:

  38. In highly copy number variable (CNV) regions such as the human defensin gene locus, comprehensive assessment of sequence variations is challenging. PCR approaches are practically restricted to tiny fractions, ...

    Authors: Stefan Taudien, Karol Szafranski, Marius Felder, Marco Groth, Klaus Huse, Francesca Raffaelli, Andreas Petzold, Xinmin Zhang, Philip Rosenstiel, Jochen Hampe, Stefan Schreiber and Matthias Platzer
    Citation: BMC Genomics 2011 12:243
    Content type: Research article Published on:

  39. The black tiger shrimp (Penaeus monodon) is one of the most important aquaculture species in the world, representing the crustacean lineage which possesses the greatest species diversity among marine invertebrate...

    Authors: Shiao-Wei Huang, You-Yu Lin, En-Min You, Tze-Tze Liu, Hung-Yu Shu, Keh-Ming Wu, Shih-Feng Tsai, Chu-Fang Lo, Guang-Hsiung Kou, Gwo-Chin Ma, Ming Chen, Dongying Wu, Takashi Aoki, Ikuo Hirono and Hon-Tsen Yu
    Citation: BMC Genomics 2011 12:242
    Content type: Research article Published on:

  40. G protein-coupled receptors (GPCRs) are major players in cell communication, regulate a whole range of physiological functions during development and throughout adult life, are affected in numerous pathologica...

    Authors: Benjamin Maurel, Anne Le Digarcher, Christelle Dantec and Laurent Journot
    Citation: BMC Genomics 2011 12:241
    Content type: Methodology article Published on:

  41. Most disease-resistance (R) genes in plants encode NBS-LRR proteins and belong to one of the largest and most variable gene families among plant genomes. However, the specific evolutionary routes of NBS-LRR en...

    Authors: Alessandra F Ribas, Alberto Cenci, Marie-Christine Combes, Hervé Etienne and Philippe Lashermes
    Citation: BMC Genomics 2011 12:240
    Content type: Research article Published on:

  42. Brassica rapa is an economically important crop and a model plant for studies concerning polyploidization and the evolution of extreme morphology. The multinational B. rapa Genome Sequencing Project (BrGSP) was l...

    Authors: Yan Wang, Silong Sun, Bo Liu, Hui Wang, Jie Deng, Yongcui Liao, Qian Wang, Feng Cheng, Xiaowu Wang and Jian Wu
    Citation: BMC Genomics 2011 12:239
    Content type: Research article Published on:

  43. Studies on bacterial signal transduction systems have revealed complex networks of functional interactions, where the response regulators play a pivotal role. The AtoSC system of E. coli activates the expression ...

    Authors: Eleftherios Pilalis, Aristotelis A Chatziioannou, Asterios I Grigoroudis, Christos A Panagiotidis, Fragiskos N Kolisis and Dimitrios A Kyriakidis
    Citation: BMC Genomics 2011 12:238
    Content type: Research article Published on:

  45. BAHD acyltransferases are involved in the synthesis and elaboration of a wide variety of secondary metabolites. Previous research has shown that characterized proteins from this family fall broadly into five m...

    Authors: Lindsey K Tuominen, Virgil E Johnson and Chung-Jui Tsai
    Citation: BMC Genomics 2011 12:236
    Content type: Research article Published on:

  46. Sinorhizobium meliloti is a model system for the studies of symbiotic nitrogen fixation. An extensive polymorphism at the genetic and phenotypic level is present in natural populations of this species, especially...

    Authors: Marco Galardini, Alessio Mengoni, Matteo Brilli, Francesco Pini, Antonella Fioravanti, Susan Lucas, Alla Lapidus, Jan-Fang Cheng, Lynne Goodwin, Samuel Pitluck, Miriam Land, Loren Hauser, Tanja Woyke, Natalia Mikhailova, Natalia Ivanova, Hajnalka Daligault…
    Citation: BMC Genomics 2011 12:235
    Content type: Research article Published on:

  47. The Manila clam, Ruditapes philippinarum, is one of the major aquaculture species in the world and a potential sentinel organism for monitoring the status of marine ecosystems. However, genomic resources for R. p...

    Authors: Massimo Milan, Alessandro Coppe, Richard Reinhardt, Leonor M Cancela, Ricardo B Leite, Carlos Saavedra, Claudio Ciofi, Guido Chelazzi, Tomaso Patarnello, Stefania Bortoluzzi and Luca Bargelloni
    Citation: BMC Genomics 2011 12:234
    Content type: Research article Published on:

  48. Resistance of soybean (Glycine max L. Merr.) cultivars to populations of cyst nematode (SCN; Heterodera glycines I.) was complicated by the diversity of HG Types (biotypes), the multigenic nature of resistance an...

    Authors: Wei Chang, Limin Dong, Zizhen Wang, Haibo Hu, Yingpeng Han, Weili Teng, Hongxia Zhang, Maozu Guo and Wenbin Li
    Citation: BMC Genomics 2011 12:233
    Content type: Research article Published on:

  50. Diapause, a state of arrested development accompanied by a marked decrease of metabolic rate, helps insects to overcome unfavorable seasons. Helicoverpa armigera (Har) undergoes pupal diapause, but the molecular ...

    Authors: Bin Bao and Wei-Hua Xu
    Citation: BMC Genomics 2011 12:224
    Content type: Research article Published on:

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BMC Genomics

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