Skip to main content

Articles

Page 325 of 338

  1. The giant panda, one of the most primitive carnivores, is an endangered animal. Although it has been the subject of many interesting studies during recent years, little is known about its genome. In order to p...

    Authors: Wei Liu, Yonghui Zhao, Zhaoliang Liu, Ying Zhang, Zhengxing Lian and Ning Li
    Citation: BMC Genomics 2006 7:294
  2. Currently available vaccines against leptospirosis are of low efficacy, have an unacceptable side-effect profile, do not induce long-term protection, and provide no cross-protection against the different serov...

    Authors: Hong-Liang Yang, Yong-Zhang Zhu, Jin-Hong Qin, Ping He, Xu-Cheng Jiang, Guo-Ping Zhao and Xiao-Kui Guo
    Citation: BMC Genomics 2006 7:293
  3. Protein degradation by the ubiquitin system plays a crucial role in numerous cellular signaling pathways. Deubiquitination, a reversal of ubiquitination, has been recognized as an important regulatory step in ...

    Authors: Ju-Mi Shin, Kyong-Jai Yoo, Myung-Sun Kim, Dongku Kim and Kwang-Hyun Baek
    Citation: BMC Genomics 2006 7:292
  4. There is an imperative need for SNP genotyping technologies that are cost-effective per sample with retained high accuracy, throughput and flexibility. We have developed a microarray-based technique and compar...

    Authors: Max Käller, Emilie Hultin, Kristina Holmberg, Marie-Louise Persson, Jacob Odeberg, Joakim Lundeberg and Afshin Ahmadian
    Citation: BMC Genomics 2006 7:291
  5. Increased focus surrounds identifying patients with advanced non-small cell lung cancer (NSCLC) who will benefit from treatment with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI). EG...

    Authors: Justin M Balko, Anil Potti, Christopher Saunders, Arnold Stromberg, Eric B Haura and Esther P Black
    Citation: BMC Genomics 2006 7:289
  6. To gain insight into the evolutionary features of the huntingtin (htt) gene in Chordata, we have sequenced and characterized the full-length htt mRNA in the ascidian Ciona intestinalis, a basal chordate emerging ...

    Authors: Carmela Gissi, Graziano Pesole, Elena Cattaneo and Marzia Tartari
    Citation: BMC Genomics 2006 7:288
  7. Rhabdomyosarcoma is a highly malignant soft tissue sarcoma in childhood and arises as a consequence of regulatory disruption of the growth and differentiation pathways of myogenic precursor cells. The pathogen...

    Authors: Chiara Romualdi, Cristiano De Pittà, Lucia Tombolan, Stefania Bortoluzzi, Francesca Sartori, Angelo Rosolen and Gerolamo Lanfranchi
    Citation: BMC Genomics 2006 7:287
  8. Alzheimer's disease (AD) is a complex disorder that involves multiple biological processes. Many genes implicated in these processes may be present in low abundance in the human brain. DNA microarray analysis ...

    Authors: Qing Yan Liu, Roy R Sooknanan, Lawrence T Malek, Maria Ribecco-Lutkiewicz, Joy X Lei, Hui Shen, Boleslaw Lach, P Roy Walker, Joel Martin and Marianna Sikorska
    Citation: BMC Genomics 2006 7:286
  9. MicroRNAs (miRNAs) have been shown to play important roles in regulating gene expression. Since miRNAs are often evolutionarily conserved and their precursors can be folded into stem-loop hairpins, many miRNAs...

    Authors: Xijin Ge, Qingfa Wu and San Ming Wang
    Citation: BMC Genomics 2006 7:285
  10. Several approaches can be used to determine the order of loci on chromosomes and hence develop maps of the genome. However, all mapping approaches are prone to errors either arising from technical deficiencies...

    Authors: Oliver C Jann, Jan Aerts, Michelle Jones, Nicola Hastings, Andy Law, Stephanie McKay, Elisa Marques, Aparna Prasad, Jody Yu, Stephen S Moore, Sandrine Floriot, Marie-Françoise Mahé, André Eggen, Licia Silveri, Riccardo Negrini, Elisabetta Milanesi…
    Citation: BMC Genomics 2006 7:283
  11. The completed genome sequences of the malaria parasites P. falciparum, P. y. yoelii and P. vivax have revealed some unusual features. P. falciparum contains the most AT rich genome sequenced so far – over 90% in ...

    Authors: Pierre M Durand, Andries J Oelofse and Theresa L Coetzer
    Citation: BMC Genomics 2006 7:282
  12. The Major Histocompatibility Complex (MHC) is essential for immune function. Historically, it has been subdivided into three regions (Class I, II, and III), but a cluster of functionally related genes within t...

    Authors: Janine E Deakin, Anthony T Papenfuss, Katherine Belov, Joseph GR Cross, Penny Coggill, Sophie Palmer, Sarah Sims, Terence P Speed, Stephan Beck and Jennifer A Marshall Graves
    Citation: BMC Genomics 2006 7:281
  13. The Caenorhabditis elegans genome encodes ten proteins that share sequence similarity with the Hedgehog signaling molecule through their C-terminal autoprocessing Hint/Hog domain. These proteins contain novel N-t...

    Authors: Limin Hao, Robert Johnsen, Gilbert Lauter, David Baillie and Thomas R Bürglin
    Citation: BMC Genomics 2006 7:280
  14. The TGFβ1-induced signal transduction processes involved in growth and differentiation are only partly known. The three-dimensional epithelial differentiation model, in which T84 epithelial cells are induced t...

    Authors: Kati M Juuti-Uusitalo, Katri Kaukinen, Markku Mäki, Jarno Tuimala and Heikki Kainulainen
    Citation: BMC Genomics 2006 7:279
  15. A 70-gene tumor expression profile was established as a powerful predictor of disease outcome in young breast cancer patients. This profile, however, was generated on microarrays containing 25,000 60-mer oligo...

    Authors: Annuska M Glas, Arno Floore, Leonie JMJ Delahaye, Anke T Witteveen, Rob CF Pover, Niels Bakx, Jaana ST Lahti-Domenici, Tako J Bruinsma, Marc O Warmoes, René Bernards, Lodewyk FA Wessels and Laura J Van 't Veer
    Citation: BMC Genomics 2006 7:278
  16. Traditionally, housekeeping and tissue specific genes have been classified using direct assay of mRNA presence across different tissues, but these experiments are costly and the results not easy to compare and...

    Authors: Luna De Ferrari and Stuart Aitken
    Citation: BMC Genomics 2006 7:277
  17. Eukaryotic replication origins exhibit different initiation efficiencies and activation times within S-phase. Although local chromatin structure and function influences origin activity, the exact mechanisms re...

    Authors: Weihong Xu, Jennifer G Aparicio, Oscar M Aparicio and Simon Tavaré
    Citation: BMC Genomics 2006 7:276
  18. During the past decade, Sanger sequencing has been used to completely sequence hundreds of microbial and a few higher eukaryote genomes. In recent years, a number of alternative technologies became available, ...

    Authors: Thomas Wicker, Edith Schlagenhauf, Andreas Graner, Timothy J Close, Beat Keller and Nils Stein
    Citation: BMC Genomics 2006 7:275
  19. Body weight and length are economically important traits in foodfish species influenced by quantitative trait loci (QTL) and environmental factors. It is usually difficult to dissect the genetic and environmen...

    Authors: Chun Ming Wang, Loong Chueng Lo, Ze Yuan Zhu and Gen Hua Yue
    Citation: BMC Genomics 2006 7:274
  20. In this study, we addressed whether a single 454 Life Science GS20 sequencing run provides new gene discovery from a normalized cDNA library, and whether the short reads produced via this technology are of val...

    Authors: Foo Cheung, Brian J Haas, Susanne MD Goldberg, Gregory D May, Yongli Xiao and Christopher D Town
    Citation: BMC Genomics 2006 7:272
  21. Vertebrate genomes contain numerous duplicate genes, many of which are organised into paralagous regions indicating duplication of linked groups of genes. Comparison of genomic organisation in different lineag...

    Authors: Karl R Wotton and Sebastian M Shimeld
    Citation: BMC Genomics 2006 7:271
  22. Bacillus thuringiensis belongs to the Bacillus cereus sensu lato group of Gram-positive and spore-forming bacteria. Most isolates of B. thuringiensis can bear many endogenous plasmids, and the number and size of ...

    Authors: Junyan Huang, Suxia Guo, Jacques Mahillon, Géraldine A Van der Auwera, Li Wang, Dongmei Han, Ziniu Yu and Ming Sun
    Citation: BMC Genomics 2006 7:270
  23. The popularity of microsatellites has greatly increased in the last decade on account of their many applications. However, little is currently understood about the factors that influence their genesis and dist...

    Authors: Francesc López-Giráldez, Olga Andrés, Xavier Domingo-Roura and Montserrat Bosch
    Citation: BMC Genomics 2006 7:269
  24. A better understanding of the development of metastatic disease and the identification of molecular markers for cancer spread would be useful for the design of improved treatment strategies. This study was con...

    Authors: Heidi Lyng, Runar S Brøvig, Debbie H Svendsrud, Ruth Holm, Olav Kaalhus, Kjetil Knutstad, Halldis Oksefjell, Kolbein Sundfør, Gunnar B Kristensen and Trond Stokke
    Citation: BMC Genomics 2006 7:268
  25. Our understanding of the mechanisms that govern the cellular process of meiosis is limited in higher plants with polyploid genomes. Bread wheat is an allohexaploid that behaves as a diploid during meiosis. Chr...

    Authors: Wayne Crismani, Ute Baumann, Tim Sutton, Neil Shirley, Tracie Webster, German Spangenberg, Peter Langridge and Jason A Able
    Citation: BMC Genomics 2006 7:267
  26. Microarray normalizations typically apply methods that assume absence of global transcript shifts, or absence of changes in internal control features such as housekeeping genes. These normalization approaches ...

    Authors: Carole L Yauk, Andrew Williams, Sherri Boucher, Lynn M Berndt, Gu Zhou, Jenny L Zheng, Andrea Rowan-Carroll, Hongyan Dong, Iain B Lambert, George R Douglas and Craig L Parfett
    Citation: BMC Genomics 2006 7:266
  27. The identification of genes essential for survival is of theoretical importance in the understanding of the minimal requirements for cellular life, and of practical importance in the identification of potentia...

    Authors: Adam M Gustafson, Evan S Snitkin, Stephen CJ Parker, Charles DeLisi and Simon Kasif
    Citation: BMC Genomics 2006 7:265
  28. Little is known about the genome sequences of lepidopteran insects, although this group of insects has been studied extensively in the fields of endocrinology, development, immunity, and pathogen-host interact...

    Authors: Youping Deng, Yinghua Dong, Venkata Thodima, Rollie J Clem and A Lorena Passarelli
    Citation: BMC Genomics 2006 7:264
  29. Aplastic anemia (AA) is a bone marrow failure syndrome mostly characterized by an immune-mediated destruction of marrow hematopoietic progenitor/stem cells. The resulting hypocellularity limits a detailed anal...

    Authors: Anke Franzke, Robert Geffers, J Katrin Hunger, Susanne Pförtner, Wenji Piao, Philipp Ivanyi, Jens Grosse, Michael Probst-Kepper, Arnold Ganser and Jan Buer
    Citation: BMC Genomics 2006 7:263
  30. TILLING (T argeting I nduced L ocal L esions i n G enomes) is a reverse genetic technique based on the use of a mismatch-specific enzyme that identifies mutations in a target gene through heteroduplex analysis. W...

    Authors: Erin J Gilchrist, Nigel J O'Neil, Ann M Rose, Monique C Zetka and George W Haughn
    Citation: BMC Genomics 2006 7:262
  31. The multi-step process of carcinogenesis can be more fully understood by characterizing gene expression changes induced in cells by carcinogens. In this study, expression microarrays were used to monitor the a...

    Authors: Sarah L Hockley, Volker M Arlt, Daniel Brewer, Ian Giddings and David H Phillips
    Citation: BMC Genomics 2006 7:260
  32. Post-segregational killing systems are present in a large variety of microorganisms. When found on plasmids, they are described as addiction systems that act to maintain the plasmid during the partitioning of ...

    Authors: Sarah Fico and Jacques Mahillon
    Citation: BMC Genomics 2006 7:259
  33. Quantitative variation in gene expression has been proposed to underlie phenotypic variation among human individuals. A facilitating step towards understanding the basis for gene expression variability is asso...

    Authors: Vineet K Sharma, Anu Sharma, Naveen Kumar, Mamta Khandelwal, Kiran Kumar Mandapati, Shirley Horn-Saban, Liora Strichman-Almashanu, Doron Lancet, Samir K Brahmachari and Srinivasan Ramachandran
    Citation: BMC Genomics 2006 7:258
  34. The ability to rapidly characterize an unknown microorganism is critical in both responding to infectious disease and biodefense. To do this, we need some way of anticipating an organism's phenotype based on t...

    Authors: Chern-Sing Goh, Tara A Gianoulis, Yang Liu, Jianrong Li, Alberto Paccanaro, Yves A Lussier and Mark Gerstein
    Citation: BMC Genomics 2006 7:257
  35. Dermatophytes are the primary causative agent of dermatophytoses, a disease that affects billions of individuals worldwide. Trichophyton rubrum is the most common of the superficial fungi. Although T. rubrum is a...

    Authors: Lingling Wang, Li Ma, Wenchuan Leng, Tao Liu, Lu Yu, Jian Yang, Li Yang, Wenliang Zhang, Qian Zhang, Jie Dong, Ying Xue, Yafang Zhu, Xingye Xu, Zhe Wan, Guohui Ding, Fudong Yu…
    Citation: BMC Genomics 2006 7:255
  36. Cross-species primers have been used with moderate success to address a variety of questions concerning genome structure, evolution, and gene function. However, the factors affecting their success have never b...

    Authors: Donna JE Housley, Zachary A Zalewski, Stephanie E Beckett and Patrick J Venta
    Citation: BMC Genomics 2006 7:253
  37. RNA amplification is necessary for profiling gene expression from small tissue samples. Previous studies have shown that the T7 based amplification techniques are reproducible but may distort the true abundanc...

    Authors: Ilhem Diboun, Lorenz Wernisch, Christine Anne Orengo and Martin Koltzenburg
    Citation: BMC Genomics 2006 7:252
  38. Allergy is a common debilitating and occasionally life threatening condition. The fungal kingdom contains a number of species that produce a wide range of well defined protein allergens although the vast major...

    Authors: Paul Bowyer, Marcin Fraczek and David W Denning
    Citation: BMC Genomics 2006 7:251
  39. Leishmania major is a protozoan parasite with a highly polarised cell shape that depends upon endocytosis and exocytosis from a single area of the plasma membrane, the flagellar pocket. SNAREs (soluble N-ethylmal...

    Authors: Sébastien Besteiro, Graham H Coombs and Jeremy C Mottram
    Citation: BMC Genomics 2006 7:250
  40. Pigment epithelium derived factor (PEDF), a member of the serpin family, regulates cell proliferation, promotes survival of neurons, and blocks growth of new blood vessels in mammals. Defining the molecular ph...

    Authors: Xuming Xu, Samuel Shao-Min Zhang, Colin J Barnstable and Joyce Tombran-Tink
    Citation: BMC Genomics 2006 7:248
  41. Chemostat cultures are commonly used in production of cellular material for systems-wide biological studies. We have used the novel TRAC (transcript analysis with aid of affinity capture) method to study expre...

    Authors: Jari J Rautio, Bart A Smit, Marilyn Wiebe, Merja Penttilä and Markku Saloheimo
    Citation: BMC Genomics 2006 7:247
  42. High throughput sequencing-by-synthesis is an emerging technology that allows the rapid production of millions of bases of data. Although the sequence reads are short, they can readily be used for re-sequencin...

    Authors: Matthew N Bainbridge, René L Warren, Martin Hirst, Tammy Romanuik, Thomas Zeng, Anne Go, Allen Delaney, Malachi Griffith, Matthew Hickenbotham, Vincent Magrini, Elaine R Mardis, Marianne D Sadar, Asim S Siddiqui, Marco A Marra and Steven JM Jones
    Citation: BMC Genomics 2006 7:246
  43. Members of the genus Phytophthora are notorious pathogens with world-wide distribution. The most devastating species include P. infestans, P. ramorum and P. sojae. In order to develop molecular methods for routin...

    Authors: Diana P Garnica, Andrés M Pinzón, Lina M Quesada-Ocampo, Adriana J Bernal, Emiliano Barreto, Niklaus J Grünwald and Silvia Restrepo
    Citation: BMC Genomics 2006 7:245

Featured videos

View featured videos from across the BMC-series journals

Annual Journal Metrics

  • Citation Impact 2023
    Journal Impact Factor: 3.5
    5-year Journal Impact Factor: 4.1
    Source Normalized Impact per Paper (SNIP): 1.083
    SCImago Journal Rank (SJR): 1.047

    Speed 2023
    Submission to first editorial decision (median days): 21
    Submission to acceptance (median days): 137

    Usage 2023
    Downloads: 7,167,242
    Altmetric mentions: 4,454

Sign up for article alerts and news from this journal