Skip to main content

Articles

121 result(s) for 'gene editing in the context of an increasingly complex genome ' within BMC Genomics

Page 3 of 3

  1. The drug discovery and development pipeline is a long and arduous process that inevitably hampers rapid drug development. Therefore, strategies to improve the efficiency of drug development are urgently needed...

    Authors: Bernard Kok Bang Lee, Kai Hung Tiong, Jit Kang Chang, Chee Sun Liew, Zainal Ariff Abdul Rahman, Aik Choon Tan, Tsung Fei Khang and Sok Ching Cheong
    Citation: BMC Genomics 2017 18(Suppl 1):934
    Content type: Research Published on:

    This article is part of a Supplement: Volume 18 Supplement 1

  2. Human leukocyte antigen matching at allelic resolution is proven clinically significant in hematopoietic stem cell transplantation, lowering the risk of graft-versus-host disease and mortality. However, due to...

    Authors: Martin Danzer, Norbert Niklas, Stephanie Stabentheiner, Katja Hofer, Johannes Pröll, Christina Stückler, Edeltraud Raml, Helene Polin and Christian Gabriel
    Citation: BMC Genomics 2013 14:221
    Content type: Methodology article Published on:

  3. Mosquitoes are important vectors for a range of diseases, contributing to high rates of morbidity and mortality in the human population. Culex pipiens pallens is dominant species of Culex mosquito in northern Chi...

    Authors: Chuanhui Zang, Xuejun Wang, Peng Cheng, Lijuan Liu, Xiuxia Guo, Haifang Wang, Ziwei Lou, Jingjing Lei, Wenqian Wang, Yiting Wang, Maoqing Gong and Hongmei Liu
    Citation: BMC Genomics 2023 24:145
    Content type: Research Published on:

  4. Enteromyxosis caused by the intestinal myxozoan parasite Enteromyxum scophthalmi is a serious threat for turbot (Scophthalmus maximus, L.) aquaculture, causing severe catarrhal enteritis leading to a cachectic sy...

    Authors: Diego Robledo, Paolo Ronza, Peter W Harrison, Ana Paula Losada, Roberto Bermúdez, Belén G Pardo, María José Redondo, Ariadna Sitjà-Bobadilla, María Isabel Quiroga and Paulino Martínez
    Citation: BMC Genomics 2014 15:1149
    Content type: Research article Published on:

  5. In cellular activities, essential proteins play a vital role and are instrumental in comprehending fundamental biological necessities and identifying pathogenic genes. Current deep learning approaches for pred...

    Authors: Chen Ye, Qi Wu, Shuxia Chen, Xuemei Zhang, Wenwen Xu, Yunzhi Wu, Youhua Zhang and Yi Yue
    Citation: BMC Genomics 2024 25:117
    Content type: Research Published on:

  6. Finding a source from which high-energy-density biofuels can be derived at an industrial scale has become an urgent challenge for renewable energy production. Some microorganisms can produce free fatty acids (...

    Authors: Olaa Motwalli, Magbubah Essack, Boris R. Jankovic, Boyang Ji, Xinyao Liu, Hifzur Rahman Ansari, Robert Hoehndorf, Xin Gao, Stefan T. Arold, Katsuhiko Mineta, John A. C. Archer, Takashi Gojobori, Ivan Mijakovic and Vladimir B. Bajic
    Citation: BMC Genomics 2017 18:33
    Content type: Methodology article Published on:

  7. Despite continuous research efforts, bacterio(phages) infecting Lactococcus lactis starter strains persist as a major threat to dairy fermentations. The lactococcal P335 phages, which are currently classified int...

    Authors: Jennifer Mahony, Joana Oliveira, Barry Collins, Laurens Hanemaaijer, Gabriele Andrea Lugli, Horst Neve, Marco Ventura, Thijs R. Kouwen, Christian Cambillau and Douwe van Sinderen
    Citation: BMC Genomics 2017 18:146
    Content type: Research article Published on:

  8. Darjeeling tea is a globally renowned beverage, which faces numerous obstacles in sexual reproduction, such as self-incompatibility, poor seed germination, and viability, as well as issues with vegetative prop...

    Authors: Vivek Kumar Awon, Debabrata Dutta, Saptadipa Banerjee, Soumili Pal and Gaurab Gangopadhyay
    Citation: BMC Genomics 2024 25:207
    Content type: Research Published on:

  9. The products of cyp19, dax, foxl2, mis, sf1 and sox9 have each been associated with sex-determining processes among vertebrates. We provide evidence for expression of these regulators very early in salmonid devel...

    Authors: Kristian R von Schalburg, Motoshige Yasuike, Ryosuke Yazawa, Johan G de Boer, Linda Reid, Stacy So, Adrienne Robb, Eric B Rondeau, Ruth B Phillips, William S Davidson and Ben F Koop
    Citation: BMC Genomics 2011 12:31
    Content type: Research article Published on:

  10. Molecular marker technologies are undergoing a transition from largely serial assays measuring DNA fragment sizes to hybridization-based technologies with high multiplexing levels. Diversity Arrays Technology ...

    Authors: Peter Wenzl, Haobing Li, Jason Carling, Meixue Zhou, Harsh Raman, Edie Paul, Phillippa Hearnden, Christina Maier, Ling Xia, Vanessa Caig, Jaroslava Ovesná, Mehmet Cakir, David Poulsen, Junping Wang, Rosy Raman, Kevin P Smith…
    Citation: BMC Genomics 2006 7:206
    Content type: Research article Published on:

  11. Single-cell (sc) sequencing performs unbiased profiling of individual cells and enables evaluation of less prevalent cellular populations, often missed using bulk sequencing. However, the scale and the complex...

    Authors: Namit Kumar, Ryan Golhar, Kriti Sen Sharma, James L. Holloway, Srikant Sarangi, Isaac Neuhaus, Alice M. Walsh and Zachary W. Pitluk
    Citation: BMC Genomics 2021 22:5
    Content type: Database Published on:

  12. We introduce Iterative Feature Removal (IFR) as an unbiased approach for selecting features with diagnostic capacity from large data sets. The algorithm is based on recently developed tools in machine learning...

    Authors: Stephen O’Hara, Kun Wang, Richard A Slayden, Alan R Schenkel, Greg Huber, Corey S O’Hern, Mark D Shattuck and Michael Kirby
    Citation: BMC Genomics 2013 14:832
    Content type: Methodology article Published on:

  13. RNA binding proteins (RBPs) play a vital role in post-transcriptional processes in all eukaryotes, such as splicing regulation, mRNA transport, and modulation of mRNA translation and decay. The identification ...

    Authors: Lei Deng, Youzhi Liu, Yechuan Shi, Wenhao Zhang, Chun Yang and Hui Liu
    Citation: BMC Genomics 2020 21(Suppl 13):866
    Content type: Research Published on:

    This article is part of a Supplement: Volume 21 Supplement 13

  14. Transcription factors are essential regulators of gene expression and play critical roles in development, differentiation, and in many cancers. To carry out their regulatory programs, they must cooperate in ne...

    Authors: Zachary B. Abrams, Mark Zucker, Min Wang, Amir Asiaee Taheri, Lynne V. Abruzzo and Kevin R. Coombes
    Citation: BMC Genomics 2018 19:738
    Content type: Research article Published on:

  15. Classically, models of DNA-transcription factor binding sites (TFBSs) have been based on relatively few known instances and have treated them as sites of fixed length using position weight matrices (PWMs). Var...

    Authors: John E Reid, Kenneth J Evans, Nigel Dyer, Lorenz Wernisch and Sascha Ott
    Citation: BMC Genomics 2010 11:30
    Content type: Research article Published on:

  16. RNA-Seq measures gene expression by counting sequence reads belonging to unique cDNA fragments. Molecular barcodes commonly in the form of random nucleotides were recently introduced to improve gene expression...

    Authors: Billy T. Lau and Hanlee P. Ji
    Citation: BMC Genomics 2017 18:745
    Content type: Methodology article Published on:

  18. In livestock, residual variance has been studied because of the interest to improve uniformity of production. Several studies have provided evidence that residual variance is partially under genetic control; h...

    Authors: Laiza Helena de Souza Iung, Herman Arend Mulder, Haroldo Henrique de Rezende Neves and Roberto Carvalheiro
    Citation: BMC Genomics 2018 19:619
    Content type: Research article Published on:

  20. Most biological processes are influenced by protein post-translational modifications (PTMs). Identifying novel PTM sites in different organisms, including humans and model organisms, has expedited our understa...

    Authors: Rima Chaudhuri, Arash Sadrieh, Nolan J. Hoffman, Benjamin L. Parker, Sean J. Humphrey, Jacqueline Stöckli, Adam P. Hill, David E. James and Jean Yee Hwa Yang
    Citation: BMC Genomics 2015 16:617
    Content type: Software Published on:

  21. With the rise of precision medicine efforts worldwide, our study objective was to describe and map the emerging precision medicine landscape. A Google search was conducted between June 19, 2017 to July 20, 201...

    Authors: Jasmine Lee, Dina Hamideh and Camille Nebeker
    Citation: BMC Genomics 2019 20:868
    Content type: Research article Published on:

Featured videos

View featured videos from across the BMC-series journals

Submit manuscript

Annual Journal Metrics

  • 2022 Citation Impact
    4.4 - 2-year Impact Factor
    4.7 - 5-year Impact Factor
    1.189 - SNIP (Source Normalized Impact per Paper)
    1.107 - SJR (SCImago Journal Rank)

    2023 Speed
    23 days submission to first editorial decision for all manuscripts (Median)
    137 days submission to accept (Median)

    2023 Usage
    7,167,242 downloads
    4,454 Altmetric mentions

Follow

Sign up for article alerts and news from this journal

BMC Genomics

ISSN: 1471-2164

Contact us