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  1. Content type: Research article

    Enterohemorrhagic Escherichia coli (E. coli) are intestinal pathogenic bacteria that cause life-threatening disease in humans. Their cardinal virulence factor is Shiga toxin (Stx), which is encoded on lambdoid ph...

    Authors: Petya Berger, Ivan U. Kouzel, Michael Berger, Nadja Haarmann, Ulrich Dobrindt, Gerald B. Koudelka and Alexander Mellmann

    Citation: BMC Genomics 2019 20:504

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  2. Content type: Research article

    Accurate classification of breast cancer using gene expression profiles has contributed to a better understanding of the biological mechanisms behind the disease and has paved the way for better prognosticatio...

    Authors: Rolf Søkilde, Helena Persson, Anna Ehinger, Anna Chiara Pirona, Mårten Fernö, Cecilia Hegardt, Christer Larsson, Niklas Loman, Martin Malmberg, Lisa Rydén, Lao Saal, Åke Borg, Johan Vallon-Christerson and Carlos Rovira

    Citation: BMC Genomics 2019 20:503

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  3. Content type: Research article

    We present results from a computational analysis developed to integrate transcriptome and metabolomic data in order to explore the heat stress response in the liver of the modern broiler chicken. Heat stress i...

    Authors: Allen H. Hubbard, Xiaoke Zhang, Sara Jastrebski, Abhyudai Singh and Carl Schmidt

    Citation: BMC Genomics 2019 20:502

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  4. Content type: Research article

    Feed efficiency is one of the most important parameters that affect beef production costs. The energy metabolism of skeletal muscle greatly contributes to variations in feed efficiency. However, information re...

    Authors: Elisa B. Carvalho, Mateus P. Gionbelli, Rafael T. S. Rodrigues, Sarah F. M. Bonilha, Charles J. Newbold, Simone E. F. Guimarães, Walmir Silva, Lucas L. Verardo, Fabyano F. Silva, Edenio Detmann and Marcio S. Duarte

    Citation: BMC Genomics 2019 20:501

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  5. Content type: Methodology article

    The wide variety of specialized permissive and repressive mechanisms by which germ cells regulate developmental gene expression are not well understood genome-wide. Isolation of germ cells with high integrity ...

    Authors: Mei Han, Guifeng Wei, Catherine E. McManus, LaDeana W. Hillier and Valerie Reinke

    Citation: BMC Genomics 2019 20:500

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  6. Content type: Research article

    Seed aging in soybean is a serious challenge for agronomic production and germplasm preservation. However, its genetic basis remains largely unclear in soybean. Unraveling the genetic mechanism involved in see...

    Authors: Xi Zhang, Aiman Hina, Shiyu Song, Jiejie Kong, Javaid Akhter Bhat and Tuanjie Zhao

    Citation: BMC Genomics 2019 20:499

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  7. Content type: Research article

    The date palm is one of the oldest cultivated fruit trees. The tree can withstand high temperatures and low water and the fruit can be stored dry offering nutrition across the year. The first region of cultiva...

    Authors: Yasmin A. Mohamoud, Lisa S. Mathew, Maria F. Torres, Shameem Younuskunju, Robert Krueger, Karsten Suhre and Joel A. Malek

    Citation: BMC Genomics 2019 20:498

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  8. Content type: Methodology article

    The introduction of genome-wide shRNA and CRISPR libraries has facilitated cell-based screens to identify loss-of-function mutations associated with a phenotype of interest. Approaches to perform analogous gai...

    Authors: Charlotte R. Feddersen, Lexy S. Wadsworth, Eliot Y. Zhu, Hayley R. Vaughn, Andrew P. Voigt, Jesse D. Riordan and Adam J. Dupuy

    Citation: BMC Genomics 2019 20:497

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  9. Content type: Software

    Modern metagenomic analysis of complex microbial communities produces large amounts of sequence data containing information on the microbiome in terms of bacterial, archaeal, viral and eukaryotic composition. ...

    Authors: Matteo Soverini, Silvia Turroni, Elena Biagi, Patrizia Brigidi, Marco Candela and Simone Rampelli

    Citation: BMC Genomics 2019 20:496

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  10. Content type: Research article

    Puccinia graminis f. sp. tritici (Pgt) race TTKSK and its lineage pose a threat to barley production world-wide justifying the extensive efforts to identify, clone, and characterize the rpg4-mediated resistance l...

    Authors: Shyam Solanki, Jonathan Richards, Gazala Ameen, Xue Wang, Atiya Khan, Harris Ali, Alex Stangel, Prabin Tamang, Thomas Gross, Patrick Gross, Thomas G. Fetch and Robert S. Brueggeman

    Citation: BMC Genomics 2019 20:495

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  11. Content type: Research article

    Understanding the population structure and genetic bases of well-adapted cattle breeds to local environments is one of the most essential tasks to develop appropriate genetic improvement programs.

    Authors: Lingyang Xu, Liu Yang, Bo Zhu, Wengang Zhang, Zezhao Wang, Yan Chen, Lupei Zhang, Xue Gao, Huijiang Gao, George E. Liu and Junya Li

    Citation: BMC Genomics 2019 20:494

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  12. Content type: Research article

    Limited accessibility to intestinal epithelial tissue in wild animals and humans makes it challenging to study patterns of intestinal gene regulation, and hence to monitor physiological status and health in fi...

    Authors: Ashok Kumar Sharma, Barbora Pafčo, Klára Vlčková, Barbora Červená, Jakub Kreisinger, Samuel Davison, Karen Beeri, Terence Fuh, Steven R. Leigh, Michael B. Burns, Ran Blekhman, Klára J. Petrželková and Andres Gomez

    Citation: BMC Genomics 2019 20:493

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  13. Content type: Research article

    Epigenetic variation may result from selection for complex traits related to metabolic processes or appear in the course of adaptation to mediate responses to exogenous stressors. Moreover epigenetic marks, in...

    Authors: Siriluck Ponsuksili, Nares Trakooljul, Sajjanar Basavaraj, Frieder Hadlich, Eduard Murani and Klaus Wimmers

    Citation: BMC Genomics 2019 20:492

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  14. Content type: Research article

    Mycobacterium avium subsp. paratuberculosis (MAP), the etiologic agent of Johne’s disease is spread between cattle via the fecal-oral route, yet the functional changes in the salivary gland associated with infect...

    Authors: Sanjay Mallikarjunappa, Mounir Adnane, Paul Cormican, Niel A. Karrow and Kieran G. Meade

    Citation: BMC Genomics 2019 20:491

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  15. Content type: Research article

    Salmonella enterica possess several iron acquisition systems, encoded on the chromosome and plasmids. Recently, we demonstrated that incompatibility group (Inc) FIB plasmid-encoded iron acquisition systems (Sit a...

    Authors: Bijay K. Khajanchi, Joshua Xu, Christopher J. Grim, Andrea R. Ottesen, Padmini Ramachandran and Steven L. Foley

    Citation: BMC Genomics 2019 20:490

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  16. Content type: Research article

    Juncus effusus L. (family: Juncaceae; order: Poales) is a helophytic rush growing in temperate damp or wet terrestrial habitats and is of almost cosmopolitan distribution. The species has been studied intensively...

    Authors: Muhammad Arslan, Upendra Kumar Devisetty, Martin Porsch, Ivo Große, Jochen A. Müller and Stefan G. Michalski

    Citation: BMC Genomics 2019 20:489

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  17. Content type: Research article

    With rising global temperature, understanding plants’ adaptation to heat stress has implications in plant breeding. MicroRNAs (miRNAs) are small, non-coding, regulatory RNAs guiding gene expression at the post...

    Authors: Sridhar Ravichandran, Raja Ragupathy, Tara Edwards, Michael Domaratzki and Sylvie Cloutier

    Citation: BMC Genomics 2019 20:488

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  18. Content type: Research article

    Apomixis is considered an evolutionary deviation of the sexual reproductive pathway leading to the generation of clonal maternal progenies by seeds. Recent evidence from model and non-model species suggested t...

    Authors: Juan Pablo A. Ortiz, Olivier Leblanc, Cristian Rohr, Mauricio Grisolia, Lorena A. Siena, Maricel Podio, Carolina Colono, Celeste Azzaro and Silvina C. Pessino

    Citation: BMC Genomics 2019 20:487

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  19. Content type: Research article

    Pectobacterium carotovorum subsp. brasiliense is a broad host range bacterial pathogen, which causes blackleg of potatoes and bacterial soft rot of vegetables worldwide. Production of plant cell wall degrading en...

    Authors: Lei Li, Lifang Yuan, Yanxia Shi, Xuewen Xie, Ali Chai, Qi Wang and Baoju Li

    Citation: BMC Genomics 2019 20:486

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  20. Content type: Research

    Single-cell gene expression measurements offer opportunities in deriving mechanistic understanding of complex diseases, including cancer. However, due to the complex regulatory machinery of the cell, gene regu...

    Authors: Ehsan Hajiramezanali, Mahdi Imani, Ulisses Braga-Neto, Xiaoning Qian and Edward R. Dougherty

    Citation: BMC Genomics 2019 20(Suppl 6):435

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    This article is part of a Supplement: Volume 20 Supplement 6

  21. Content type: Research

    Biological networks describes the mechanisms which govern cellular functions. Temporal networks show how these networks evolve over time. Studying the temporal progression of network topologies is of utmost im...

    Authors: Rasha Elhesha, Aisharjya Sarkar, Christina Boucher and Tamer Kahveci

    Citation: BMC Genomics 2019 20(Suppl 6):434

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    This article is part of a Supplement: Volume 20 Supplement 6

  22. Content type: Research article

    The growing importance of the ubiquitous fungal genus Trichoderma (Hypocreales, Ascomycota) requires understanding of its biology and evolution. Many Trichoderma species are used as biofertilizers and biofungicid...

    Authors: Christian P. Kubicek, Andrei S. Steindorff, Komal Chenthamara, Gelsomina Manganiello, Bernard Henrissat, Jian Zhang, Feng Cai, Alexey G. Kopchinskiy, Eva M. Kubicek, Alan Kuo, Riccardo Baroncelli, Sabrina Sarrocco, Eliane Ferreira Noronha, Giovanni Vannacci, Qirong Shen, Igor V. Grigoriev…

    Citation: BMC Genomics 2019 20:485

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  23. Content type: Research article

    It is hypothesized that the highly conserved inverted repeats (IR) structure of land plant plastid genomes (plastomes) is beneficial for stabilizing plastome organization, whereas the mechanism of the occurren...

    Authors: Hong-Rui Zhang, Xian-Chun Zhang and Qiao-Ping Xiang

    Citation: BMC Genomics 2019 20:484

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  24. Content type: Research article

    In reported plants, the bZIP family is one of the largest transcription factor families. bZIP genes play roles in the light signal, seed maturation, flower development, cell elongation, seed accumulation protein,...

    Authors: Moyang Liu, Yongdi Wen, Wenjun Sun, Zhaotang Ma, Li Huang, Qi Wu, Zizhong Tang, Tongliang Bu, Chenglei Li and Hui Chen

    Citation: BMC Genomics 2019 20:483

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  25. Content type: Research article

    Global biodiversity is decreasing at an alarming rate and amphibians are at the forefront of this crisis. Understanding the factors that negatively impact amphibian populations and effectively monitoring their...

    Authors: Timothy A. Clay, Michael A. Steffen, Michael L. Treglia, Carolyn D. Torres, Ana Lilia Trujano-Alvarez and Ronald M. Bonett

    Citation: BMC Genomics 2019 20:482

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  26. Content type: Research article

    Due to the recent domestication of peanut from a single tetraploidization event, relatively little genetic diversity underlies the extensive morphological and agronomic diversity in peanut cultivars today. To ...

    Authors: Paul I. Otyama, Andrew Wilkey, Roshan Kulkarni, Teshale Assefa, Ye Chu, Josh Clevenger, Dan J. O’Connor, Graeme C. Wright, Stanley W. Dezern, Gregory E. MacDonald, Noelle L. Anglin, Ethalinda K. S. Cannon, Peggy Ozias-Akins and Steven B. Cannon

    Citation: BMC Genomics 2019 20:481

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  27. Content type: Research article

    Plasmids play an vital role in driving the rapid global spread of antimicrobial resistance and adaptation to changing ambient conditions. It has been suggested that the presence of plasmids can pose tremendous...

    Authors: Dan Long, Lan-lan Zhu, Fang-ling Du, Tian-xin Xiang, La-Gen Wan, Dan-dan Wei, Wei Zhang and Yang Liu

    Citation: BMC Genomics 2019 20:480

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  28. Content type: Research article

    The mammalian major histocompatibility complex (MHC) harbours clusters of genes associated with the immunological defence of animals against infectious pathogens. At present, no complete MHC physical map is av...

    Authors: Chaokun Li, Longxin Chen, Xuefeng Liu, Xiaoqian Shi, Yu Guo, Rui Huang, Fangyuan Nie, Changming Zheng, Chenglin Zhang and Runlin Z. Ma

    Citation: BMC Genomics 2019 20:479

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  29. Content type: Research article

    Salt pond restoration aims to recover the environmental damages that accumulated over the long history of salt production. Of the restoration strategies, phytoremediation that utilizes salt-tolerant plants and...

    Authors: Huyen-Trang Tran, Hao-Chu Wang, Tsai-Wen Hsu, Rakesh Sarkar, Chao-Li Huang and Tzen-Yuh Chiang

    Citation: BMC Genomics 2019 20:478

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  30. Content type: Research article

    Global RNA sequencing technologies have revealed widespread RNA polymerase II (Pol II) transcription outside of gene promoters. Small 5′-capped RNA sequencing (Start-seq) originally developed for the detection...

    Authors: Adam Scheidegger, Carissa J. Dunn, Ann Samarakkody, Nii Koney-Kwaku Koney, Danielle Perley, Ramendra N. Saha and Sergei Nechaev

    Citation: BMC Genomics 2019 20:477

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  31. Content type: Research article

    The redundancy of genomic resources, including transcript and molecular markers, and their uncertain position in the genome have dramatically hindered the study of traits in ramie, an important natural fiber c...

    Authors: Yanzhou Wang, Zheng Zeng, Fu Li, Xiufeng Yang, Xinyue Gao, Yonghong Ma, Jing Rao, Hengyun Wang and Touming Liu

    Citation: BMC Genomics 2019 20:476

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  32. Content type: Research article

    When puberty starts before males reach harvest size, animal welfare and sustainability issues occur in Atlantic salmon (Salmo salar) aquaculture. Hallmarks of male puberty are an increased proliferation activity ...

    Authors: Diego Crespo, Jan Bogerd, Elisabeth Sambroni, Florence LeGac, Eva Andersson, Rolf B. Edvardsen, Elisabeth Jönsson Bergman, Björn Thrandur Björnsson, Geir Lasse Taranger and Rüdiger W. Schulz

    Citation: BMC Genomics 2019 20:475

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  33. Content type: Research article

    Extracellular vesicles (EVs) are small membrane vesicles secreted by the cells that mediate intercellular transfer of molecules and contribute to transduction of various signals. Viral infection and action of ...

    Authors: Andrii Slonchak, Brian Clarke, Jason Mackenzie, Alberto Anastacio Amarilla, Yin Xiang Setoh and Alexander A. Khromykh

    Citation: BMC Genomics 2019 20:474

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  34. Content type: Research article

    Reliable indicators for the onset of flowering are not available for most perennial monocarpic species, representing a drawback for crops such as bamboo, agave and banana. The ability to predict and control th...

    Authors: Emmanuel Avila de Dios, Luis Delaye and June Simpson

    Citation: BMC Genomics 2019 20:473

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  36. Content type: Research article

    Puddled transplanted system of rice cultivation despite having several benefits, is a highly labor, water and energy intensive system. In the face of changing climatic conditions, a successful transition from ...

    Authors: Sushil Raj Subedi, Nitika Sandhu, Vikas Kumar Singh, Pallavi Sinha, Santosh Kumar, S. P. Singh, Surya Kant Ghimire, Madhav Pandey, Ram Baran Yadaw, Rajeev K. Varshney and Arvind Kumar

    Citation: BMC Genomics 2019 20:471

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  37. Content type: Research article

    A critical goal in biology is to relate the phenotype to the genotype, that is, to find the genetic determinants of various traits. However, while simple monofactorial determinants are relatively easy to ident...

    Authors: George S. Long, Mohammed Hussen, Jonathan Dench and Stéphane Aris-Brosou

    Citation: BMC Genomics 2019 20:470

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  38. Content type: Research article

    The pearl oyster Pinctada fucata martensii (Pfu.), widely cultured in the South China Sea, is a precious source of sea pearls and calcifying materials. A yellow shell variety of Pfu. was obtained after years of a...

    Authors: Meng Xu, Jing Huang, Yu Shi, Hua Zhang and Maoxian He

    Citation: BMC Genomics 2019 20:469

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  41. Content type: Research article

    The causes and consequences of genome size variation across Eukaryotes, which spans five orders of magnitude, have been hotly debated since before the advent of genome sequencing. Previous studies have mostly ...

    Authors: J. Blommaert, S. Riss, B. Hecox-Lea, D. B. Mark Welch and C. P. Stelzer

    Citation: BMC Genomics 2019 20:466

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  42. Content type: Research article

    The Neotropical fruit fly Drosophila paulistorum (Diptera: Drosophilidae) is a species complex in statu nascendi comprising six reproductively isolated semispecies, each harboring mutualistic Wolbachia strains. A...

    Authors: Guilherme C. Baião, Daniela I. Schneider, Wolfgang J. Miller and Lisa Klasson

    Citation: BMC Genomics 2019 20:465

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  43. Content type: Research article

    The WRKY gene family is one of the most important families in higher plants. As transcription factors, they actively respond to biotic and abiotic stress and are also involved in plant development. Chinese juj...

    Authors: Chaoling Xue, Hongtai Li, Zhiguo Liu, Lili Wang, Yitong Zhao, Ximeng Wei, Hu Fang, Mengjun Liu and Jin Zhao

    Citation: BMC Genomics 2019 20:464

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  44. Content type: Research article

    The diamondback moth (DBM), Plutella xylostella (L.), is a major pest of cruciferous crops worldwide. While the species has become a model for genomics, post-transcriptional mechanisms associated with development...

    Authors: Qian Zhao, Weimin Zhong, Weiyi He, Yiying Li, Yaqing Li, Tianpu Li, Liette Vasseur and Minsheng You

    Citation: BMC Genomics 2019 20:463

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  45. Content type: Research article

    Isopods constitute a particular group of crustaceans that has successfully colonized all environments including marine, freshwater and terrestrial habitats. Their ability to use various food sources, especiall...

    Authors: Marius Bredon, Benjamin Herran, Baptiste Lheraud, Joanne Bertaux, Pierre Grève, Bouziane Moumen and Didier Bouchon

    Citation: BMC Genomics 2019 20:462

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  46. Content type: Research article

    Hibernation is a physiological state exploited by many animals exposed to prolonged adverse environmental conditions associated with winter. Large changes in metabolism and cellular function occur, with many s...

    Authors: Alexander Capraro, Denis O’Meally, Shafagh A. Waters, Hardip R. Patel, Arthur Georges and Paul D. Waters

    Citation: BMC Genomics 2019 20:460

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  47. Content type: Research article

    Chinese bayberry (Myrica rubra Sieb. & Zucc.) is an economically important fruit tree characterized by its juicy fruits rich in antioxidant compounds. Elucidating the genetic basis of the biosynthesis of active a...

    Authors: Haiying Ren, Haiyan Yu, Shuwen Zhang, Senmiao Liang, Xiliang Zheng, Shujian Zhang, Pu Yao, Hongkun Zheng and Xingjiang Qi

    Citation: BMC Genomics 2019 20:458

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  49. Content type: Research

    Closing gaps in draft genomes is an important post processing step in genome assembly. It leads to more complete genomes, which benefits downstream genome analysis such as annotation and genotyping. Several to...

    Authors: Chong Chu, Xin Li and Yufeng Wu

    Citation: BMC Genomics 2019 20(Suppl 5):426

    Published on:

    This article is part of a Supplement: Volume 20 Supplement 5

  50. Content type: Research

    High throughput sequencing has spurred the development of metagenomics, which involves the direct analysis of microbial communities in various environments such as soil, ocean water, and the human body. Many e...

    Authors: Nathan LaPierre, Serghei Mangul, Mohammed Alser, Igor Mandric, Nicholas C. Wu, David Koslicki and Eleazar Eskin

    Citation: BMC Genomics 2019 20(Suppl 5):423

    Published on:

    This article is part of a Supplement: Volume 20 Supplement 5

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