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  1. Apoptosis is an important process for an organism’s innate immune system to respond to pathogens, while also allowing for cell differentiation and other essential life functions. Caspases are one of the key pr...

    Authors: Susanne Vogeler, Stefano Carboni, Xiaoxu Li and Alyssa Joyce

    Citation: BMC Genomics 2021 22:80

    Content type: Research article

    Published on:

  2. Mepiquat chloride (DPC) is a chemical that is extensively used to control internode growth and create compact canopies in cultured plants. Previous studies have suggested that DPC could also inhibit gibberelli...

    Authors: Rongfa Chen, Yegeng Fan, Huiwen Zhou, Shanping Mo, Zhongfeng Zhou, Haifeng Yan, Ting Luo, Xing Huang, Mengling Weng, Prakash Lakshmanan, Yangrui Li, Lihang Qiu and Jianming Wu

    Citation: BMC Genomics 2021 22:79

    Content type: Research article

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  3. Copy number variation (CNV) is an important source of genetic variation that has a significant influence on phenotypic diversity, economically important traits and the evolution of livestock species. In this s...

    Authors: Chao Yuan, Zengkui Lu, Tingting Guo, Yaojing Yue, Xijun Wang, Tianxiang Wang, Yajun Zhang, Fujun Hou, Chune Niu, Xiaopin Sun, Hongchang Zhao, Shaohua Zhu, Jianbin Liu and Bohui Yang

    Citation: BMC Genomics 2021 22:78

    Content type: Research article

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  4. Influenza viruses are dangerous pathogens. Seventy-Seven genomes of recently emerged genotype 4 reassortant Eurasian avian-like H1N1 virus (G4-EA-H1N1) are currently available. We investigated the presence and va...

    Authors: Václav Brázda, Otília Porubiaková, Alessio Cantara, Natália Bohálová, Jan Coufal, Martin Bartas, Miroslav Fojta and Jean-Louis Mergny

    Citation: BMC Genomics 2021 22:77

    Content type: Research article

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  5. Though interest in human simple sequence repeats (SSRs) is increasing, little is known about the exact distributional features of numerous SSRs in human Y-DNA at chromosomal level. Herein, totally 540 maps wer...

    Authors: Douyue Li, Saichao Pan, Hongxi Zhang, Yongzhuo Fu, Zhuli Peng, Liang Zhang, Shan Peng, Fei Xu, Hanrou Huang, Ruixue Shi, Heping Zheng, Yousong Peng and Zhongyang Tan

    Citation: BMC Genomics 2021 22:76

    Content type: Research article

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  6. We have previously suggested that some of the mutations defining mitochondrial DNA (mtDNA) haplogroups J and K produce an uncoupling effect on oxidative phosphorylation and thus are detrimental for elite endur...

    Authors: Jukka Kiiskilä, Jari Jokelainen, Laura Kytövuori, Ilona Mikkola, Pirjo Härkönen, Sirkka Keinänen-Kiukaanniemi and Kari Majamaa

    Citation: BMC Genomics 2021 22:75

    Content type: Research article

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  7. Toxin-antitoxin (TA) systems, abundant in prokaryotes, are composed of a toxin gene and its cognate antitoxin. Several toxins are implied to affect the physiological state and stress tolerance of bacteria in a...

    Authors: Jingyu Peng, Lindsay R. Triplett and George W. Sundin

    Citation: BMC Genomics 2021 22:74

    Content type: Research article

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  8. Although around 1% of cytosines in bees’ genomes are known to be methylated, less is known about methylation’s effect on bee behavior and fitness. Chemically altered DNA methylation levels have shown clear cha...

    Authors: María I. Pozo, Benjamin J. Hunt, Gaby Van Kemenade, Jose M. Guerra-Sanz, Felix Wäckers, Eamonn B. Mallon and Hans Jacquemyn

    Citation: BMC Genomics 2021 22:73

    Content type: Research article

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  9. Freezing injury, which is an important abiotic stress in horticultural crops, influences the growth and development and the production area of kiwifruit (Actinidia Lind1). Among Actinidia species, Actinidia argut...

    Authors: Miaomiao Lin, Shihang Sun, Jinbao Fang, Xiujuan Qi, Leiming Sun, Yunpeng Zhong, Yanxiang Sun, Gu Hong, Ran Wang and Yukuo Li

    Citation: BMC Genomics 2021 22:72

    Content type: Research article

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  10. In the light of dengue being the fastest growing transmissible disease, there is a dire need to identify the mechanisms regulating the behaviour of the main vector Aedes aegypti. Disease transmission requires the...

    Authors: Sharon Rose Hill, Tanvi Taparia and Rickard Ignell

    Citation: BMC Genomics 2021 22:71

    Content type: Research article

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  11. Pearl millet (Pennisetum glaucum) is a cereal crop that possesses the ability to withstand drought, salinity and high temperature stresses. The NAC [NAM (No Apical Meristem), ATAF1 (Arabidopsis thaliana Activatio...

    Authors: Ambika Dudhate, Harshraj Shinde, Pei Yu, Daisuke Tsugama, Shashi Kumar Gupta, Shenkui Liu and Tetsuo Takano

    Citation: BMC Genomics 2021 22:70

    Content type: Research article

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  12. Both RNA-Seq and sample freeze-thaw are ubiquitous. However, knowledge about the impact of freeze-thaw on downstream analyses is limited. The lack of common quality metrics that are sufficiently sensitive to f...

    Authors: Benjamin P. Kellman, Hratch M. Baghdassarian, Tiziano Pramparo, Isaac Shamie, Vahid Gazestani, Arjana Begzati, Shangzhong Li, Srinivasa Nalabolu, Sarah Murray, Linda Lopez, Karen Pierce, Eric Courchesne and Nathan E. Lewis

    Citation: BMC Genomics 2021 22:69

    Content type: Research article

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  13. Canine hip dysplasia (CHD) is a common disease, with a complex genetic background. Dogs with severe CHD sometimes also suffer from osteoarthritis (OA), an inflammatory, often painful and incurable condition. P...

    Authors: Lea Mikkola, Kaisa Kyöstilä, Jonas Donner, Anu K. Lappalainen, Marjo K. Hytönen, Hannes Lohi and Antti Iivanainen

    Citation: BMC Genomics 2021 22:68

    Content type: Research article

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  14. Avian infectious bronchitis virus (IBV) is a gamma coronavirus that severely affects the poultry industry worldwide. Long non-coding RNAs (lncRNAs), a subset of non-coding RNAs with a length of more than 200 n...

    Authors: Hao Li, Pengfei Cui, Xue Fu, Lan Zhang, Wenjun Yan, Yaru Zhai, Changwei Lei, Hongning Wang and Xin Yang

    Citation: BMC Genomics 2021 22:67

    Content type: Research article

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  15. Elucidation of immune populations with single-cell RNA-seq has greatly benefited the field of immunology by deepening the characterization of immune heterogeneity and leading to the discovery of new subtypes. ...

    Authors: Tracy M. Yamawaki, Daniel R. Lu, Daniel C. Ellwanger, Dev Bhatt, Paolo Manzanillo, Vanessa Arias, Hong Zhou, Oh Kyu Yoon, Oliver Homann, Songli Wang and Chi-Ming Li

    Citation: BMC Genomics 2021 22:66

    Content type: Research article

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  16. The lesser grain borer, Rhyzopertha dominica is a serious pest of stored grains. Fumigation and contact insecticides play a major role in managing this pest globally. While insects are developing genetic resistan...

    Authors: Maria K. Sakka, Maria Riga, Panagiotis Ioannidis, Georgia V. Baliota, Martha Tselika, Rajeswaran Jagadeesan, Manoj K. Nayak, John Vontas and Christos G. Athanassiou

    Citation: BMC Genomics 2021 22:65

    Content type: Research article

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  17. miRNAs play critical roles in growth and development. Various studies of chicken muscle development have focused on identifying miRNAs that are important for embryo or adult muscle development. However, littl...

    Authors: Jie Liu, Fuwei Li, Xin Hu, Dingguo Cao, Wei Liu, Haixia Han, Yan Zhou and Qiuxia Lei

    Citation: BMC Genomics 2021 22:64

    Content type: Research article

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  18. The wheat dwarfing gene increases lodging resistance, the grain number per spike and harvest index. Dwarf Polish wheat (Triticum polonicum L., 2n = 4x = 28, AABB, DPW), initially collected from Tulufan, Xinjiang,...

    Authors: Songyue Chai, Qin Yao, Xu Zhang, Xue Xiao, Xing Fan, Jian Zeng, Lina Sha, Houyang Kang, Haiqin Zhang, Jun Li, Yonghong Zhou and Yi Wang

    Citation: BMC Genomics 2021 22:63

    Content type: Research article

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  19. Next Generation Sequencing (NGS) is the fundament of various studies, providing insights into questions from biology and medicine. Nevertheless, integrating data from different experimental backgrounds can int...

    Authors: Stephan Weißbach, Stanislav Sys, Charlotte Hewel, Hristo Todorov, Susann Schweiger, Jennifer Winter, Markus Pfenninger, Ali Torkamani, Doug Evans, Joachim Burger, Karin Everschor-Sitte, Helen Louise May-Simera and Susanne Gerber

    Citation: BMC Genomics 2021 22:62

    Content type: Research article

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  20. Chinese domestic pig breeds are reputed for pork quality, but their low ratio of lean-to-fat carcass weight decreases production efficiency. A better understanding of the genetic regulation network of subcutan...

    Authors: Dawei Zhang, Wenjing Wu, Xin Huang, Ke Xu, Cheng Zheng and Jin Zhang

    Citation: BMC Genomics 2021 22:61

    Content type: Research article

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  21. Efficient regulation of bacterial genes in response to the environmental stimulus results in unique gene clusters known as operons. Lack of complete operonic reference and functional information makes the pred...

    Authors: Syed Shujaat Ali Zaidi, Masood Ur Rehman Kayani, Xuegong Zhang, Younan Ouyang and Imran Haider Shamsi

    Citation: BMC Genomics 2021 22:60

    Content type: Software

    Published on:

  22. We have previously developed a rice-based oral vaccine against cholera diarrhea, MucoRice-CTB. Using Agrobacterium-mediated co-transformation, we produced the selection marker–free MucoRice-CTB line 51A, which ha...

    Authors: Ai Sasou, Yoshikazu Yuki, Ayaka Honma, Kotomi Sugiura, Koji Kashima, Hiroko Kozuka-Hata, Masanori Nojima, Masaaki Oyama, Shiho Kurokawa, Shinichi Maruyama, Masaharu Kuroda, Shinjiro Tanoue, Narushi Takamatsu, Kohtaro Fujihashi, Eiji Goto and Hiroshi Kiyono

    Citation: BMC Genomics 2021 22:59

    Content type: Research article

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  23. The mechanism of body growth in mammals is poorly understood. Here, we investigated the regulatory networks involved in body growth through transcriptomic analysis of pituitary and epiphyseal tissues of smalle...

    Authors: Jun Fang, Dong Zhang, Jun Wei Cao, Li Zhang, Chun Xia Liu, Yan Ping Xing, Feng Wang, Hong Yang Xu, Shi Chao Wang, Yu Ling, Wei Wang, Yan Ru Zhang and Huan Min Zhou

    Citation: BMC Genomics 2021 22:58

    Content type: Research article

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  24. Body traits are generally controlled by several genes in vertebrates (i.e. polygenes), which in turn make them difficult to identify through association mapping. Increasing the power of association studies by ...

    Authors: Grazyella M. Yoshida and José M. Yáñez

    Citation: BMC Genomics 2021 22:57

    Content type: Research article

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  25. Biological functions of biomolecules rely on the cellular compartments where they are located in cells. Importantly, RNAs are assigned in specific locations of a cell, enabling the cell to implement diverse bi...

    Authors: Hao Wang, Yijie Ding, Jijun Tang, Quan Zou and Fei Guo

    Citation: BMC Genomics 2021 22:56

    Content type: Methodology article

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  26. During the bread wheat speciation by polyploidization, a series of genome rearrangement and sequence recombination occurred. Simple sequence repeat (SSR) sequences, predominately located in heterochromatic reg...

    Authors: Yingxin Zhang, Chengming Fan, Yuhong Chen, Richard R.-C. Wang, Xiangqi Zhang, Fangpu Han and Zanmin Hu

    Citation: BMC Genomics 2021 22:55

    Content type: Research article

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  27. The honey bee parasite, Varroa destructor, is a leading cause of honey bee population declines. In addition to being an obligate ectoparasitic mite, Varroa carries several viruses that infect honey bees and act a...

    Authors: Nonno Hasegawa, Maeva Techer and Alexander S. Mikheyev

    Citation: BMC Genomics 2021 22:54

    Content type: Methodology article

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  28. Genome-wide change of polyadenylation (polyA) sites (also known as alternative polyadenylation, APA) is emerging as an important strategy of gene regulation in response to stress in plants. But little is known...

    Authors: Chao Yan, Yupeng Wang, Tao Lyu, Zhikang Hu, Ning Ye, Weixin Liu, Jiyuan Li, Xiaohua Yao and Hengfu Yin

    Citation: BMC Genomics 2021 22:53

    Content type: Research article

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  29. Valsa canker is a serious disease in the stem of Malus sieversii, caused by Valsa mali. However, little is known about the global response mechanism in M. sieversii to V. mali infection.

    Authors: Xiaojie Liu, Xiaoshuang Li, Xuejing Wen, Yan Zhang, Yu Ding, Yiheng Zhang, Bei Gao and Daoyuan Zhang

    Citation: BMC Genomics 2021 22:52

    Content type: Research article

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  30. Low-temperature severely affects the growth and development of chrysanthemum which is one kind of ornamental plant well-known and widely used in the world. Lysine crotonylation is a recently identified post-tr...

    Authors: Ping Lin, Hui-ru Bai, Ling He, Qiu-xiang Huang, Qin-han Zeng, Yuan-zhi Pan, Bei-bei Jiang, Fan Zhang, Lei Zhang and Qing-Lin Liu

    Citation: BMC Genomics 2021 22:51

    Content type: Research article

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  31. Loaches of Cobitinae, widely distributed in Eurasian continent, have high economic, ornamental and scientific value. However, the phylogeny of Cobitinae fishes within genera or family level remains complex and...

    Authors: Peng Yu, Li Zhou, Wen-Tao Yang, Li-jun Miao, Zhi Li, Xiao-Juan Zhang, Yang Wang and Jian-Fang Gui

    Citation: BMC Genomics 2021 22:50

    Content type: Research article

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  32. Histone acetylation is a ubiquitous and reversible post-translational modification in eukaryotes and prokaryotes that is co-regulated by histone acetyltransferase (HAT) and histone deacetylase (HDAC). HAT acti...

    Authors: Shiqi Gao, Linzhi Li, Xiaolei Han, Tingting Liu, Peng Jin, Linna Cai, Miaoze Xu, Tianye Zhang, Fan Zhang, Jianping Chen, Jian Yang and Kaili Zhong

    Citation: BMC Genomics 2021 22:49

    Content type: Research article

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  33. With the intensification of global warming, rainbow trout (Oncorhynchus mykiss) suffer from varying degrees of thermal stimulation, leads to mass mortality, which severely restrict the development of aquaculture....

    Authors: Jinqiang Quan, Yujun Kang, Zhicheng Luo, Guiyan Zhao, Lanlan Li and Zhe Liu

    Citation: BMC Genomics 2021 22:48

    Content type: Research article

    Published on:

  35. The major pathogenesis associated with Fasciola hepatica infection results from the extensive tissue damage caused by the tunnelling and feeding activity of immature flukes during their migration, growth and deve...

    Authors: Krystyna Cwiklinski, Mark W. Robinson, Sheila Donnelly and John P. Dalton

    Citation: BMC Genomics 2021 22:46

    Content type: Research article

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  36. Aspartic proteases (APs) are a class of aspartic peptidases belonging to nine proteolytic enzyme families whose members are widely distributed in biological organisms. APs play essential functions during plant...

    Authors: Xiaqin Wang, Xinyang Yan, Shubin Li, Yun Jing, Lianfeng Gu, Shuangquan Zou, Jin Zhang and Bobin Liu

    Citation: BMC Genomics 2021 22:45

    Content type: Research article

    Published on:

  37. Chicken skeletal muscle is an important economic product. The late stages of chicken development constitute the main period that affects meat production. LncRNAs play important roles in controlling the epigene...

    Authors: Yuanfang Li, Wenjiao Jin, Bin Zhai, Yi Chen, Guoxi Li, Yanhua Zhang, Yujie Guo, Guirong Sun, Ruili Han, Zhuanjian Li, Hong Li, Yadong Tian, Xiaojun Liu and Xiangtao Kang

    Citation: BMC Genomics 2021 22:44

    Content type: Research article

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  38. Native cattle breeds are an important source of genetic variation because they might carry alleles that enable them to adapt to local environment and tough feeding conditions. Jiaxian Red, a Chinese native cat...

    Authors: Xiaoting Xia, Shunjin Zhang, Huaju Zhang, Zijing Zhang, Ningbo Chen, Zhigang Li, Hongxia Sun, Xian Liu, Shijie Lyu, Xianwei Wang, Zhiming Li, Peng Yang, Jiawei Xu, Xiaoting Ding, Qiaoting Shi, Eryao Wang…

    Citation: BMC Genomics 2021 22:43

    Content type: Research article

    Published on:

  39. RNA interference (RNAi) regulates gene expression in most multicellular organisms through binding of small RNA effectors to target transcripts. Exploiting this process is a popular strategy for genetic manipul...

    Authors: Mosharrof Mondal, Jacob Peter, Obrie Scarbrough and Alex Flynt

    Citation: BMC Genomics 2021 22:42

    Content type: Methodology article

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  40. Apple (Malus domestica Borkh.) is a popular cultivated fruit crop with high economic value in China. Apple floral transition is an important process but liable to be affected by various environmental factors. The...

    Authors: Xiya Zuo, Shixiang Wang, Wen Xiang, Huiru Yang, Muhammad Mobeen Tahir, Shangong Zheng, Na An, Mingyu Han, Caiping Zhao and Dong Zhang

    Citation: BMC Genomics 2021 22:41

    Content type: Research article

    Published on:

  41. Recently, pioneering expression quantitative trait loci (eQTL) studies on single cell RNA sequencing (scRNA-seq) data have revealed new and cell-specific regulatory single nucleotide variants (SNVs). Here, we ...

    Authors: Hongyu Liu, N. M. Prashant, Liam F. Spurr, Pavlos Bousounis, Nawaf Alomran, Helen Ibeawuchi, Justin Sein, Piotr Słowiński, Krasimira Tsaneva-Atanasova and Anelia Horvath

    Citation: BMC Genomics 2021 22:40

    Content type: Methodology article

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  42. Streptococcus pneumoniae serotype 1 remains a leading cause of invasive pneumococcal diseases, even in countries with PCV-10/PCV-13 vaccine implementation. The main objective of this study, which is part of the P...

    Authors: Néhémie Nzoyikorera, Idrissa Diawara, Pablo Fresia, Fakhreddine Maaloum, Khalid Katfy, Kaotar Nayme, Mossaab Maaloum, Jennifer Cornick, Chrispin Chaguza, Mohammed Timinouni, Houria Belabess, Khalid Zerouali and Naima Elmdaghri

    Citation: BMC Genomics 2021 22:39

    Content type: Research article

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  43. Atypical external genitalia are often a sign of reproductive organ pathologies and infertility with both environmental or genetic causes, including karyotypic abnormalities. Genome-wide association studies (GW...

    Authors: Gabriele Flossmann, Christine Wurmser, Hubert Pausch, Amabel Tenghe, Jörg Dodenhoff, Günther Dahinten, Kay-Uwe Götz, Ingolf Russ and Ruedi Fries

    Citation: BMC Genomics 2021 22:38

    Content type: Research article

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  45. DNA methylation is likely a key mechanism regulating changes in gene transcription in traits that show temporal fluctuations in response to environmental conditions. To understand the transcriptional role of D...

    Authors: Melanie Lindner, Irene Verhagen, Heidi M. Viitaniemi, Veronika N. Laine, Marcel E. Visser, Arild Husby and Kees van Oers

    Citation: BMC Genomics 2021 22:36

    Content type: Research article

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  47. The red sea urchin Mesocentrotus franciscanus is an ecologically important kelp forest herbivore and an economically valuable wild fishery species. To examine how M. franciscanus responds to its environment on a ...

    Authors: Juliet M. Wong and Gretchen E. Hofmann

    Citation: BMC Genomics 2021 22:32

    Content type: Research article

    Published on:

  49. The use of sex-sorted sperm in cattle assisted reproduction is constantly increasing. However, sperm fertility can substantially differ between unsorted (conventional) and sex-sorted semen batches of the same ...

    Authors: Esin Keles, Eleni Malama, Siyka Bozukova, Mathias Siuda, Sarah Wyck, Ulrich Witschi, Stefan Bauersachs and Heinrich Bollwein

    Citation: BMC Genomics 2021 22:30

    Content type: Research article

    Published on:

  50. Tomato plant growth is frequently hampered by a high susceptibility to pests and diseases. Traditional chemical control causes a serious impact on both the environment and human health. Therefore, seeking envi...

    Authors: Lu Zhou, Chunxu Song, Zhibo Li and Oscar P. Kuipers

    Citation: BMC Genomics 2021 22:29

    Content type: Research article

    Published on:

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