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  1. Head and neck squamous cell carcinoma (HNSCC) is a common cancer characterized by late diagnosis and poor prognosis. The aim of this study was to identify a novel ferroptosis-related DNA methylation signature ...

    Authors: Yuanyuan Xu, Min Hong, Deyu Kong, Jun Deng, Zhaoming Zhong and Jin Liang

    Citation: BMC Genomics 2022 23:63

    Content type: Research

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  2. In preimplantation genetic testing for aneuploidy (PGT-A), appropriate evaluation of mosaic embryos is important because of the adverse implications of transferring embryos with high-level mosaicism or discard...

    Authors: Dongjia Chen, Yan Xu, Chenhui Ding, Yali Wang, Yu Fu, Bing Cai, Jing Wang, Rong Li, Jing Guo, Jiafu Pan, Yanhong Zeng, Yiping Zhong, Xiaoting Shen and Canquan Zhou

    Citation: BMC Genomics 2022 23:62

    Content type: Research

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  3. Lysine succinylation (Ksu) exists in both eukaryotes and prokaryotes, and influences a variety of metabolism processes. However, little attention has been paid to Ksu in insects, especially the notorious invas...

    Authors: Jingwen Ye and Jun Li

    Citation: BMC Genomics 2022 23:61

    Content type: Research

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  4. Salt damage is an important abiotic stress that affects the growth and yield of maize worldwide. As an important member of the salt overly sensitive (SOS) signal transduction pathway, the SOS3 gene family part...

    Authors: Yunying Cao, Tingyu Shan, Hui Fang, Kangtai Sun, Wen Shi, Bei Tang, Junping Wu, Kai Wang, Ping Li and Baohua Wang

    Citation: BMC Genomics 2022 23:60

    Content type: Research

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  5. Ischemic stroke (IS) is a principal contributor to long-term disability in adults. A new cell death mediated by iron is ferroptosis, characterized by lethal aggregation of lipid peroxidation. However, a paucit...

    Authors: Jiaxin Fan, Mengying Chen, Shuai Cao, Qingling Yao, Xiaodong Zhang, Shuang Du, Huiyang Qu, Yuxuan Cheng, Shuyin Ma, Meijuan Zhang, Yizhou Huang, Nan Zhang, Kaili Shi and Shuqin Zhan

    Citation: BMC Genomics 2022 23:59

    Content type: Research

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  6. Circadian clocks allow organisms to anticipate daily fluctuations in their environment by driving rhythms in physiology and behavior. Inter-organismal differences in daily rhythms, called chronotypes, exist an...

    Authors: Biplabendu Das and Charissa de Bekker

    Citation: BMC Genomics 2022 23:57

    Content type: Research article

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  7. Lung carcinoma is a common geriatric disease. The development of genotype-targeted therapies greatly improved the management of lung carcinoma. However, the treatment for old patients can be more complex than ...

    Authors: Sixian Chen, Aizhen Fu, Yuan Lu, Wei Lu, Yongfeng Chen, Shuiqiang Hong, Suli Zhou, Tianmin Xiang, Zhenzhen Zhang and Yongguang Cai

    Citation: BMC Genomics 2022 23:55

    Content type: Research

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  8. The characterization of genetic diversity and population differentiation for maize inbred lines from breeding programs is of great value in assisting breeders in maintaining and potentially increasing the rate...

    Authors: Sirlene Viana de Faria, Leandro Tonello Zuffo, Wemerson Mendonça Rezende, Diego Gonçalves Caixeta, Hélcio Duarte Pereira, Camila Ferreira Azevedo and Rodrigo Oliveira DeLima

    Citation: BMC Genomics 2022 23:54

    Content type: Research

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  9. Small non-coding (s)RNAs are involved in the negative regulation of gene expression, playing critical roles in genome integrity, development and metabolic pathways. Targeting of RNAs by ribonucleoprotein compl...

    Authors: Chenna Swetha, Anushree Narjala, Awadhesh Pandit, Varsha Tirumalai and P. V. Shivaprasad

    Citation: BMC Genomics 2022 23:53

    Content type: Research

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  10. Plants are attacked by diverse insect and mammalian herbivores and respond with different physical and chemical defences. Transcriptional changes underlie these phenotypic changes. Simulated herbivory has been...

    Authors: J. S. Nantongo, B. M. Potts, T. Frickey, E. Telfer, H. Dungey, H. Fitzgerald and J. M. O’Reilly-Wapstra

    Citation: BMC Genomics 2022 23:52

    Content type: Research

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  11. High-grade serous ovarian carcinoma is highly heterogeneous, and although many studies have been conducted to identify high-grade serous ovarian carcinoma molecular subtypes that are sensitive to immunotherapy...

    Authors: Ping Liu, Ruoxu Chen, Xudong Zhang, Ruiting Fu, Lin Tao and Wei Jia

    Citation: BMC Genomics 2022 23:51

    Content type: Research

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  12. Long non-coding RNAs (lncRNAs) play important roles in response to abiotic stresses in plants, by acting as cis- or trans-acting regulators of protein-coding genes. As a widely cultivated crop worldwide, maize...

    Authors: Peng Liu, Yinchao Zhang, Chaoying Zou, Cong Yang, Guangtang Pan, Langlang Ma and Yaou Shen

    Citation: BMC Genomics 2022 23:50

    Content type: Research

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  13. MicroRNAs (miRNAs) are endogenous, non-coding small functional RNAs that govern the post-transcriptional regulatory system of gene expression and control the growth and development of plants. Ginger is an herb...

    Authors: Haitao Xing, Yuan Li, Yun Ren, Ying Zhao, Xiaoli Wu and Hong-Lei Li

    Citation: BMC Genomics 2022 23:49

    Content type: Research

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  14. Proteases catalyze the hydrolysis of peptide bonds of proteins, thereby improving dietary protein digestibility, nutrient availability, as well as flavor and texture of fermented food and feed products. The la...

    Authors: Binbin Chen, Bryan Zong Lin Loo, Ying Ying Cheng, Peng Song, Huan Fan, Oleg Latypov and Sandra Kittelmann

    Citation: BMC Genomics 2022 23:48

    Content type: Research

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  15. Cardiomyopathy is a complex type of myocardial disease, and its incidence has increased significantly in recent years. Dilated cardiomyopathy (DCM) and ischemic cardiomyopathy (ICM) are two common and indistin...

    Authors: Zherou Rong, Hongwei Chen, Zihan Zhang, Yue Zhang, Luanfeng Ge, Zhengyu Lv, Yuqing Zou, Junjie Lv, Yuehan He, Wan Li and Lina Chen

    Citation: BMC Genomics 2022 23:47

    Content type: Research

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  16. Drug resistant Mycobacterium tuberculosis is complicating the effective treatment and control of tuberculosis disease (TB). With the adoption of whole genome sequencing as a diagnostic tool, machine learning appr...

    Authors: Wouter Deelder, Gary Napier, Susana Campino, Luigi Palla, Jody Phelan and Taane G. Clark

    Citation: BMC Genomics 2022 23:46

    Content type: Research

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  17. Orius laevigatus, a minute pirate bug, is a highly effective beneficial predator of crop pests including aphids, spider mites and thrips in integrated pest management (IPM) programmes. No genomic information is ...

    Authors: Emma Bailey, Linda Field, Christopher Rawlings, Rob King, Fady Mohareb, Keywan-Hassani Pak, David Hughes, Martin Williamson, Eric Ganko, Benjamin Buer and Ralf Nauen

    Citation: BMC Genomics 2022 23:45

    Content type: Research

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  18. Small RNAs (sRNAs) regulate numerous plant processes directly related to yield, such as disease resistance and plant growth. To exploit this yield-regulating potential of sRNAs, the sRNA profile of one of the ...

    Authors: Anikó Meijer, Tim De Meyer, Klaas Vandepoele and Tina Kyndt

    Citation: BMC Genomics 2022 23:44

    Content type: Research

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  19. Miscanthus, which is a leading dedicated-energy grass in Europe and in parts of Asia, is expected to play a key role in the development of the future bioeconomy. However, due to its complex genetic background, it...

    Authors: Zhiyong Chen, Yancen He, Yasir Iqbal, Yanlan Shi, Hongmei Huang and Zili Yi

    Citation: BMC Genomics 2022 23:43

    Content type: Research article

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  20. Alternative splicing is a key mechanism underlying cellular differentiation and a driver of complexity in mammalian neuronal tissues. However, understanding of which isoforms are differentially used or express...

    Authors: David J. Wright, Nicola A. L. Hall, Naomi Irish, Angela L. Man, Will Glynn, Arne Mould, Alejandro De Los Angeles, Emily Angiolini, David Swarbreck, Karim Gharbi, Elizabeth M. Tunbridge and Wilfried Haerty

    Citation: BMC Genomics 2022 23:42

    Content type: Research article

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  21. The early death and health problems of calves caused substantial economic losses in the dairy industry. As the immune system of neonates has not been fully developed, the absorption of maternal immunoglobulin ...

    Authors: Shan Lin, Cuncun Ke, Lin Liu, Yahui Gao, Lingna Xu, Bo Han, Yaofeng Zhao, Shengli Zhang and Dongxiao Sun

    Citation: BMC Genomics 2022 23:41

    Content type: Research article

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  22. RADIALIS (RAD), belongs to the MYB gene family and regulates a variety of functions including floral dorsoventral asymmetry in Antirrhinum majus and development of fruit proteins in Solanum lycopersicum. RAD gene...

    Authors: Nosheen Kabir, Xin Zhang, Le Liu, Ghulam Qanmber, Lian Zhang, Yu Xuan Wang, Zhuojing Sun, Na Zhao and Gang Wang

    Citation: BMC Genomics 2022 23:40

    Content type: Research

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  23. The coronatine insensitive 1 (COI1) gene is the core member of jasmonate signaling pathway, which is closely related to plant biotic and abiotic resistance. However, there have been no reports on COI1 in sugarcan...

    Authors: Tingting Sun, Yintian Meng, Guangli Cen, Aoyin Feng, Weihua Su, Yanling Chen, Chuihuai You, Youxiong Que and Yachun Su

    Citation: BMC Genomics 2022 23:38

    Content type: Research

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  24. Carbapenem-resistant hypervirulent K. pneumoniae (CR-hvKP) causes serious infections with significant morbidity and mortality. However, the epidemiology and transmission mechanisms of CR-hvKP and the correspondin...

    Authors: Yanxian Yang, Yongqiang Yang, Mohamed Abd El-Gawad El-Sayed Ahmed, Mingyang Qin, Ruowen He, Yiping Wu, Xiaoxue Liang, Lan-Lan Zhong, Ping Chen, Baoguo Deng, Reem Mostafa Hassan, Weihong Wen, Lingqing Xu, Xubin Huang, Lin Xu and Guo-Bao Tian

    Citation: BMC Genomics 2022 23:20

    Content type: Research

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  25. Chromatin accessibility is essential for transcriptional activation of genomic regions. It is well established that transcription factors (TFs) and histone modifications (HMs) play critical roles in chromatin ...

    Authors: Yanding Zhao, Yadong Dong, Wei Hong, Chongming Jiang, Kevin Yao and Chao Cheng

    Citation: BMC Genomics 2022 23:19

    Content type: Research

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  26. Schisandra chinensis, an ancient member of the most basal angiosperm lineage which is known as the ANITA, is a fruit-bearing vine with the pharmacological effects of a multidrug system, such as antioxidant, anti...

    Authors: Chang Pyo Hong, Chang-Kug Kim, Dong Jin Lee, Hee Jeong Jeong, Yi Lee, Sin-Gi Park, Hyo-Jin Kim, Ji-Nam Kang, Hojin Ryu, Soo-Jin Kwon and Sang-Ho Kang

    Citation: BMC Genomics 2022 23:17

    Content type: Research

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  27. Advances in DNA sequencing technologies have transformed our capacity to perform life science research, decipher the dynamics of complex soil microbial communities and exploit them for plant disease management...

    Authors: Guoshun Xu, Liwen Zhang, Xiaoqing Liu, Feifei Guan, Yuquan Xu, Haitao Yue, Jin-Qun Huang, Jieyin Chen, Ningfeng Wu and Jian Tian

    Citation: BMC Genomics 2022 23:37

    Content type: Research

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  28. Bioassessment and biomonitoring of meat products are aimed at identifying and quantifying adulterants and contaminants, such as meat from unexpected sources and microbes. Several methods for determining the bi...

    Authors: Mei Jiang, Shu-Fei Xu, Tai-Shan Tang, Li Miao, Bao-Zheng Luo, Yang Ni, Fan-De Kong and Chang Liu

    Citation: BMC Genomics 2022 23:36

    Content type: Research

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  29. Gene expression is regulated by transcription factors, cofactors, and epigenetic mechanisms. Coexpressed genes indicate similar functional categories and gene networks. Detecting gene-gene coexpression is impo...

    Authors: Heng Xu, Ying Hu, Xinyu Zhang, Bradley E. Aouizerat, Chunhua Yan and Ke Xu

    Citation: BMC Genomics 2022 23:35

    Content type: Research

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  30. Pathogens have evolved diverse lifestyles and adopted pivotal new roles in both natural ecosystems and human environments. However, the molecular mechanisms underlying their adaptation to new lifestyles are ob...

    Authors: Yansu Wang, Jie Wu, Jiacheng Yan, Ming Guo, Lei Xu, Liping Hou and Quan Zou

    Citation: BMC Genomics 2022 23:34

    Content type: Research

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  31. Long non-coding RNAs (lncRNAs) play a critical role in the pathogenesis of hypoxic pulmonary hypertension (HPH). The role of N7-methylguanosine (m7G) modification in lncRNAs has received increased attentions i...

    Authors: Huan Wang, Ren Biao Chen, Si Ni Zhang and Rui Feng Zhang

    Citation: BMC Genomics 2022 23:33

    Content type: Research

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  32. The composition of intramuscular fat depends on genetic and environmental factors, including the diet. In pigs, we identified a haplotype of three SNP mutations in the stearoyl-coA desaturase (SCD) gene promoter ...

    Authors: Emma Solé, Rayner González-Prendes, Yelyzaveta Oliinychenko, Marc Tor, Roger Ros-Freixedes, Joan Estany and Ramona N. Pena

    Citation: BMC Genomics 2022 23:16

    Content type: Research

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  33. Interferon regulatory factor-8 (IRF8) and nuclear factor-activated T cells c1 (NFATc1) are two transcription factors that have an important role in osteoclast differentiation. Thanks to ChIP-seq technology, sc...

    Authors: Honglin Wang, Pujan Joshi, Seung-Hyun Hong, Peter F. Maye, David W. Rowe and Dong-Guk Shin

    Citation: BMC Genomics 2022 23:14

    Content type: Research

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  34. Extreme complexity in the Human Leukocyte Antigens (HLA) system and its nomenclature makes it difficult to interpret and integrate relevant information for HLA associations with diseases, Adverse Drug Reaction...

    Authors: Dhwani Dholakia, Ankit Kalra, Bishnu Raman Misir, Uma Kanga and Mitali Mukerji

    Citation: BMC Genomics 2022 23:10

    Content type: Database

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  35. Brassinosteroids (BRs) are a type of sterol plant hormone that play an important role in various biochemical and physiological reactions such as promoting cell growth, increasing biomass, and improving stress ...

    Authors: Qifang Jin, Zhong Wang, Yanni Chen, Yiping Luo, Na Tian, Zhonghua Liu, Jianan Huang and Shuoqian Liu

    Citation: BMC Genomics 2022 23:29

    Content type: Research

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  36. Histone deacetylases (HDACs) play an important role in the regulation of gene expression, which is indispensable in plant growth, development, and responses to environmental stresses. In Arabidopsis and rice, the...

    Authors: Qiaoli Du, Yuanpeng Fang, Junmei Jiang, Meiqing Chen, Xiaodong Fu, Zaifu Yang, Liting Luo, Qijiao Wu, Qian Yang, Lujie Wang, Zhiguang Qu, Xiangyang Li and Xin Xie

    Citation: BMC Genomics 2022 23:28

    Content type: Research

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  37. Handeliodendron Rehder and Eurycorymbus Hand.-Mazz. are the monotypic genera in the Sapindaceae family. The phylogenetic relationship of these endangered species Handeliodendron bodinieri (Lévl.) Rehd. and Euryc...

    Authors: Jiaxin Yang, Guoxiong Hu and Guangwan Hu

    Citation: BMC Genomics 2022 23:27

    Content type: Research

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  38. Valgus-varus deformity (VVD) is a lateral or middle deviation of the tibiotarsus or tarsometatarsus, which is associated with compromised growth, worse bone quality and abnormal changes in serum indicators in ...

    Authors: Yaping Guo, Hetian Huang, Zhenzhen Zhang, Yanchao Ma, Jianzeng Li, Hehe Tang, Haoxiang Ma, Zhuanjian Li, Wenting Li, Xiaojun Liu, Xiangtao Kang and Ruili Han

    Citation: BMC Genomics 2022 23:26

    Content type: Research

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  39. Migration of neuroblasts and neurons from their birthplace is central to the formation of neural circuits and networks. ETR-1 is the Caenorhabditis elegans homolog of the CELF1 (CUGBP, ELAV-like family 1) RNA-pro...

    Authors: Matthew E. Ochs, Rebecca M. McWhirter, Robert L. Unckless, David M. Miller III and Erik A. Lundquist

    Citation: BMC Genomics 2022 23:13

    Content type: Research

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  40. Zebrafish have practical features that make them a useful model for higher-throughput tests of gene function using CRISPR/Cas9 editing to create ‘knockout’ models. In particular, the use of G0 mosaic mutants has ...

    Authors: José M. Uribe-Salazar, Gulhan Kaya, Aadithya Sekar, KaeChandra Weyenberg, Cole Ingamells and Megan Y. Dennis

    Citation: BMC Genomics 2022 23:12

    Content type: Research

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  41. Neonicotinoids are widely applied in the control of the destructive agricultural pest Bemisia tabaci, and resistance against these chemicals has become a common, severe problem in the control of whiteflies. To in...

    Authors: Cheng Song Zhou, Huan Huan Lv, Xiao Hu Guo, Qian Cao, Rui Xingyue Zhang and De Ying Ma

    Citation: BMC Genomics 2022 23:15

    Content type: Research

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  42. Oil palm (Elaeis guineensis, Jacq.) is an important vegetable oil-yielding plant. Somatic embryogenesis is a promising method to produce large-scale elite clones to meet the demand for palm oil. The epigenetic me...

    Authors: Lixia Zhou, Rajesh Yarra, Longfei Jin, Yaodong Yang, Hongxing Cao and Zhihao Zhao

    Citation: BMC Genomics 2022 23:11

    Content type: Research

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  43. Aspergillus flavus, one of the causative agents of human fungal keratitis, can be phagocytosed by human corneal epithelial (HCE) cells and the conidia containing phagosomes mature into phagolysosomes. But the imm...

    Authors: Divya Arunachalam, Shruthi Mahalakshmi Ramanathan, Athul Menon, Lekshmi Madhav, Gopalakrishna Ramaswamy, Venkatesh Prajna Namperumalsamy, Lalitha Prajna and Dharmalingam Kuppamuthu

    Citation: BMC Genomics 2022 23:5

    Content type: Research

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