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  1. The quail and chicken major histocompatibility complex (Mhc) genomic regions have a similar overall organization but differ markedly in that the quail has an expanded number of duplicated class I, class IIB, natu...

    Authors: Kazuyoshi Hosomichi, Takashi Shiina, Shingo Suzuki, Masayuki Tanaka, Sayoko Shimizu, Shigehisa Iwamoto, Hiromi Hara, Yutaka Yoshida, Jerzy K Kulski, Hidetoshi Inoko and Kei Hanzawa

    Citation: BMC Genomics 2006 7:322

    Content type: Research article

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  2. Up to now, microarray data are mostly assessed in context with only one or few parameters characterizing the experimental conditions under study. More explicit experiment annotations, however, are highly usefu...

    Authors: Kurt Fellenberg, Christian H Busold, Olaf Witt, Andrea Bauer, Boris Beckmann, Nicole C Hauser, Marcus Frohme, Stefan Winter, Jürgen Dippon and Jörg D Hoheisel

    Citation: BMC Genomics 2006 7:319

    Content type: Methodology article

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  3. Many marketed therapeutic agents have been developed to modulate the function of G protein-coupled receptors (GPCRs). The regulators of G-protein signaling (RGS proteins) are also being examined as potential d...

    Authors: Yu-Ching Fang, Wei-Hsin Sun, Li-Cheng Wu, Hsien-Da Huang, Hsueh-Fen Juan and Jorng-Tzong Horng

    Citation: BMC Genomics 2006 7:317

    Content type: Database

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  4. Maturation of spermatozoa, including development of motility and the ability to fertilize the oocyte, occurs during transit through the microenvironment of the epididymis. Comprehensive understanding of sperm ...

    Authors: Jungsu Oh, Jiae Lee, Jong-Min Woo, Eunyoung Choi, Inju Park, Cecil Han, Namhoe Baek, Hoyong Lee, Do Han Kim and Chunghee Cho

    Citation: BMC Genomics 2006 7:314

    Content type: Research article

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  5. Upon exposure to agents that damage DNA, Saccharomyces cerevisiae undergo widespread reprogramming of gene expression. Such a vast response may be due not only to damage to DNA but also damage to proteins, RNA, a...

    Authors: Rebecca C Fry, Michael S DeMott, Joseph P Cosgrove, Thomas J Begley, Leona D Samson and Peter C Dedon

    Citation: BMC Genomics 2006 7:313

    Content type: Research article

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  6. Formalin-fixed paraffin-embedded (FFPE) tissues represent the largest source of archival biological material available for genomic studies of human cancer. Therefore, it is desirable to develop methods that en...

    Authors: Sarit Aviel-Ronen, Chang Qi Zhu, Bradley P Coe, Ni Liu, Spencer K Watson, Wan L Lam and Ming Sound Tsao

    Citation: BMC Genomics 2006 7:312

    Content type: Methodology article

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  7. The signals that determine the specificity and efficiency of splicing are multiple and complex, and are not fully understood. Among other factors, the relative contributions of different mechanisms appear to d...

    Authors: Colin N Dewey, Igor B Rogozin and Eugene V Koonin

    Citation: BMC Genomics 2006 7:311

    Content type: Research article

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  8. Rice blast, caused by the fungal pathogen Magnaporthe grisea, is a devastating disease causing tremendous yield loss in rice production. The public availability of the complete genome sequence of M. grisea provid...

    Authors: Malali Gowda, RC Venu, Mohan B Raghupathy, Kan Nobuta, Huameng Li, Rod Wing, Eric Stahlberg, Sean Couglan, Christian D Haudenschild, Ralph Dean, Baek-Hie Nahm, Blake C Meyers and Guo-Liang Wang

    Citation: BMC Genomics 2006 7:310

    Content type: Research article

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  9. One of the most crucial tasks for a cell to ensure its long term survival is preserving the integrity of its genetic heritage via maintenance of DNA structure and sequence. While the DNA damage response in the...

    Authors: Michael G Benton, Swetha Somasundaram, Jeremy D Glasner and Sean P Palecek

    Citation: BMC Genomics 2006 7:305

    Content type: Research article

    Published on:

  10. Repetitive elements comprise ~45% of mammalian genomes and are increasingly known to impact genomic function by contributing to the genomic architecture, by direct regulation of gene expression and by affectin...

    Authors: Ralph T Wiedmann, Dan J Nonneman and John W Keele

    Citation: BMC Genomics 2006 7:304

    Content type: Research article

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  11. Fission yeast cells undergo sexual differentiation in response to nitrogen starvation. In this process haploid M and P cells first mate to form diploid zygotes, which then enter meiosis and sporulate. Prior to...

    Authors: Yongtao Xue-Franzén, Søren Kjærulff, Christian Holmberg, Anthony Wright and Olaf Nielsen

    Citation: BMC Genomics 2006 7:303

    Content type: Research article

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  12. The development of large genomic resources has become a prerequisite to elucidate the wide-scale evolution of genomes and the molecular basis of complex traits. Linkage maps represent a first level of integrat...

    Authors: René Guyomard, Stéphane Mauger, Kamila Tabet-Canale, Sylvain Martineau, Carine Genet, Francine Krieg and Edwige Quillet

    Citation: BMC Genomics 2006 7:302

    Content type: Research article

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  13. The replication of mammalian genomic DNA during the S phase is a highly coordinated process that occurs in a programmed manner. Recent studies have begun to elucidate the pattern of replication timing on a gen...

    Authors: Stephanie M Cohen, Terrence S Furey, Norman A Doggett and David G Kaufman

    Citation: BMC Genomics 2006 7:301

    Content type: Research article

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  14. Esophageal squamous cell carcinoma (ESCC) is a common malignancy worldwide. Comprehensive genomic characterization of ESCC will further our understanding of the carcinogenesis process in this disease.

    Authors: Nan Hu, Chaoyu Wang, Ying Hu, Howard H Yang, Li-Hui Kong, Ning Lu, Hua Su, Quan-Hong Wang, Alisa M Goldstein, Kenneth H Buetow, Michael R Emmert-Buck, Philip R Taylor and Maxwell P Lee

    Citation: BMC Genomics 2006 7:299

    Content type: Research article

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  15. Single nucleotide polymorphisms (SNPs) are an abundant form of genetic variation in the genome of every species and are useful for gene mapping and association studies. Of particular interest are non-synonymou...

    Authors: Michael A Lee, Orla M Keane, Belinda C Glass, Tim R Manley, Neil G Cullen, Ken G Dodds, Alan F McCulloch, Chris A Morris, Mark Schreiber, Jonathan Warren, Amonida Zadissa, Theresa Wilson and John C McEwan

    Citation: BMC Genomics 2006 7:298

    Content type: Research article

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  16. Peridinin-containing dinoflagellates have a highly reduced chloroplast genome, which is unlike that found in other chloroplast containing organisms. Genome reduction appears to be the result of extensive trans...

    Authors: Adrian C Barbrook, Nicole Santucci, Lindsey J Plenderleith, Roger G Hiller and Christopher J Howe

    Citation: BMC Genomics 2006 7:297

    Content type: Research article

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  17. To unravel molecular targets involved in glycopeptide resistance, three isogenic strains of Staphylococcus aureus with different susceptibility levels to vancomycin or teicoplanin were subjected to whole-genome m...

    Authors: Alexander Scherl, Patrice François, Yvan Charbonnier, Jacques M Deshusses, Thibaud Koessler, Antoine Huyghe, Manuela Bento, Jianru Stahl-Zeng, Adrien Fischer, Alexandre Masselot, Alireza Vaezzadeh, Francesca Gallé, Adriana Renzoni, Pierre Vaudaux, Daniel Lew, Catherine G Zimmermann-Ivol…

    Citation: BMC Genomics 2006 7:296

    Content type: Research article

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  18. The development and outcome of cerebral malaria (CM) reflects a complex interplay between parasite-expressed virulence factors and host response to infection. The murine CM model, Plasmodium berghei ANKA (PbA), w...

    Authors: Fiona E Lovegrove, Lourdes Peña-Castillo, Naveed Mohammad, W Conrad Liles, Timothy R Hughes and Kevin C Kain

    Citation: BMC Genomics 2006 7:295

    Content type: Research article

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  19. The giant panda, one of the most primitive carnivores, is an endangered animal. Although it has been the subject of many interesting studies during recent years, little is known about its genome. In order to p...

    Authors: Wei Liu, Yonghui Zhao, Zhaoliang Liu, Ying Zhang, Zhengxing Lian and Ning Li

    Citation: BMC Genomics 2006 7:294

    Content type: Research article

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  20. Currently available vaccines against leptospirosis are of low efficacy, have an unacceptable side-effect profile, do not induce long-term protection, and provide no cross-protection against the different serov...

    Authors: Hong-Liang Yang, Yong-Zhang Zhu, Jin-Hong Qin, Ping He, Xu-Cheng Jiang, Guo-Ping Zhao and Xiao-Kui Guo

    Citation: BMC Genomics 2006 7:293

    Content type: Research article

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  21. Protein degradation by the ubiquitin system plays a crucial role in numerous cellular signaling pathways. Deubiquitination, a reversal of ubiquitination, has been recognized as an important regulatory step in ...

    Authors: Ju-Mi Shin, Kyong-Jai Yoo, Myung-Sun Kim, Dongku Kim and Kwang-Hyun Baek

    Citation: BMC Genomics 2006 7:292

    Content type: Research article

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  22. There is an imperative need for SNP genotyping technologies that are cost-effective per sample with retained high accuracy, throughput and flexibility. We have developed a microarray-based technique and compar...

    Authors: Max Käller, Emilie Hultin, Kristina Holmberg, Marie-Louise Persson, Jacob Odeberg, Joakim Lundeberg and Afshin Ahmadian

    Citation: BMC Genomics 2006 7:291

    Content type: Methodology article

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  23. Increased focus surrounds identifying patients with advanced non-small cell lung cancer (NSCLC) who will benefit from treatment with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI). EG...

    Authors: Justin M Balko, Anil Potti, Christopher Saunders, Arnold Stromberg, Eric B Haura and Esther P Black

    Citation: BMC Genomics 2006 7:289

    Content type: Research article

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  24. To gain insight into the evolutionary features of the huntingtin (htt) gene in Chordata, we have sequenced and characterized the full-length htt mRNA in the ascidian Ciona intestinalis, a basal chordate emerging ...

    Authors: Carmela Gissi, Graziano Pesole, Elena Cattaneo and Marzia Tartari

    Citation: BMC Genomics 2006 7:288

    Content type: Research article

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  25. Rhabdomyosarcoma is a highly malignant soft tissue sarcoma in childhood and arises as a consequence of regulatory disruption of the growth and differentiation pathways of myogenic precursor cells. The pathogen...

    Authors: Chiara Romualdi, Cristiano De Pittà, Lucia Tombolan, Stefania Bortoluzzi, Francesca Sartori, Angelo Rosolen and Gerolamo Lanfranchi

    Citation: BMC Genomics 2006 7:287

    Content type: Research article

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  26. Alzheimer's disease (AD) is a complex disorder that involves multiple biological processes. Many genes implicated in these processes may be present in low abundance in the human brain. DNA microarray analysis ...

    Authors: Qing Yan Liu, Roy R Sooknanan, Lawrence T Malek, Maria Ribecco-Lutkiewicz, Joy X Lei, Hui Shen, Boleslaw Lach, P Roy Walker, Joel Martin and Marianna Sikorska

    Citation: BMC Genomics 2006 7:286

    Content type: Methodology article

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  27. MicroRNAs (miRNAs) have been shown to play important roles in regulating gene expression. Since miRNAs are often evolutionarily conserved and their precursors can be folded into stem-loop hairpins, many miRNAs...

    Authors: Xijin Ge, Qingfa Wu and San Ming Wang

    Citation: BMC Genomics 2006 7:285

    Content type: Research article

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  28. Several approaches can be used to determine the order of loci on chromosomes and hence develop maps of the genome. However, all mapping approaches are prone to errors either arising from technical deficiencies...

    Authors: Oliver C Jann, Jan Aerts, Michelle Jones, Nicola Hastings, Andy Law, Stephanie McKay, Elisa Marques, Aparna Prasad, Jody Yu, Stephen S Moore, Sandrine Floriot, Marie-Françoise Mahé, André Eggen, Licia Silveri, Riccardo Negrini, Elisabetta Milanesi…

    Citation: BMC Genomics 2006 7:283

    Content type: Research article

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  29. The completed genome sequences of the malaria parasites P. falciparum, P. y. yoelii and P. vivax have revealed some unusual features. P. falciparum contains the most AT rich genome sequenced so far – over 90% in ...

    Authors: Pierre M Durand, Andries J Oelofse and Theresa L Coetzer

    Citation: BMC Genomics 2006 7:282

    Content type: Research article

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  30. The Major Histocompatibility Complex (MHC) is essential for immune function. Historically, it has been subdivided into three regions (Class I, II, and III), but a cluster of functionally related genes within t...

    Authors: Janine E Deakin, Anthony T Papenfuss, Katherine Belov, Joseph GR Cross, Penny Coggill, Sophie Palmer, Sarah Sims, Terence P Speed, Stephan Beck and Jennifer A Marshall Graves

    Citation: BMC Genomics 2006 7:281

    Content type: Research article

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  31. The Caenorhabditis elegans genome encodes ten proteins that share sequence similarity with the Hedgehog signaling molecule through their C-terminal autoprocessing Hint/Hog domain. These proteins contain novel N-t...

    Authors: Limin Hao, Robert Johnsen, Gilbert Lauter, David Baillie and Thomas R Bürglin

    Citation: BMC Genomics 2006 7:280

    Content type: Research article

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  32. The TGFβ1-induced signal transduction processes involved in growth and differentiation are only partly known. The three-dimensional epithelial differentiation model, in which T84 epithelial cells are induced t...

    Authors: Kati M Juuti-Uusitalo, Katri Kaukinen, Markku Mäki, Jarno Tuimala and Heikki Kainulainen

    Citation: BMC Genomics 2006 7:279

    Content type: Research article

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  33. A 70-gene tumor expression profile was established as a powerful predictor of disease outcome in young breast cancer patients. This profile, however, was generated on microarrays containing 25,000 60-mer oligo...

    Authors: Annuska M Glas, Arno Floore, Leonie JMJ Delahaye, Anke T Witteveen, Rob CF Pover, Niels Bakx, Jaana ST Lahti-Domenici, Tako J Bruinsma, Marc O Warmoes, René Bernards, Lodewyk FA Wessels and Laura J Van 't Veer

    Citation: BMC Genomics 2006 7:278

    Content type: Methodology article

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  34. Traditionally, housekeeping and tissue specific genes have been classified using direct assay of mRNA presence across different tissues, but these experiments are costly and the results not easy to compare and...

    Authors: Luna De Ferrari and Stuart Aitken

    Citation: BMC Genomics 2006 7:277

    Content type: Research article

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  35. Eukaryotic replication origins exhibit different initiation efficiencies and activation times within S-phase. Although local chromatin structure and function influences origin activity, the exact mechanisms re...

    Authors: Weihong Xu, Jennifer G Aparicio, Oscar M Aparicio and Simon Tavaré

    Citation: BMC Genomics 2006 7:276

    Content type: Research article

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  36. During the past decade, Sanger sequencing has been used to completely sequence hundreds of microbial and a few higher eukaryote genomes. In recent years, a number of alternative technologies became available, ...

    Authors: Thomas Wicker, Edith Schlagenhauf, Andreas Graner, Timothy J Close, Beat Keller and Nils Stein

    Citation: BMC Genomics 2006 7:275

    Content type: Research article

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  37. Body weight and length are economically important traits in foodfish species influenced by quantitative trait loci (QTL) and environmental factors. It is usually difficult to dissect the genetic and environmen...

    Authors: Chun Ming Wang, Loong Chueng Lo, Ze Yuan Zhu and Gen Hua Yue

    Citation: BMC Genomics 2006 7:274

    Content type: Research article

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  38. Vertebrate genomes contain numerous duplicate genes, many of which are organised into paralagous regions indicating duplication of linked groups of genes. Comparison of genomic organisation in different lineag...

    Authors: Karl R Wotton and Sebastian M Shimeld

    Citation: BMC Genomics 2006 7:271

    Content type: Research article

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