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  1. Sheep have developed the ability to store fat in their tails, which is a unique way of reserving energy to survive a harsh environment. However, the mechanism underlying this adaptive trait remains largely uns...

    Authors: Zhangyuan Pan, Shengdi Li, Qiuyue Liu, Zhen Wang, Zhengkui Zhou, Ran Di, Xuejiao An, Benpeng Miao, Xiangyu Wang, Wenping Hu, Xiaofei Guo, Shenjin Lv, Fukuan Li, Guohui Ding, Mingxing Chu and Yixue Li
    Citation: BMC Genomics 2019 20:261
    Content type: Research article Published on:

  2. Enhancement of crop productivity under various abiotic stresses is a major objective of agronomic research. Wheat (Triticum aestivum L.) as one of the world’s staple crops is highly sensitive to heat stress, whic...

    Authors: Shuonan Duan, Binhui Liu, Yuanyuan Zhang, Guoliang Li and Xiulin Guo
    Citation: BMC Genomics 2019 20:257
    Content type: Research article Published on:

  3. Histone methylation mainly occurs on the lysine residues and plays a crucial role during flowering and stress responses of plants, through changing the methylation status or ratio of lysine residues. Histone l...

    Authors: Yexiong Qian, Changle Chen, Lingyu Jiang, Jing Zhang and Qiaoyu Ren
    Citation: BMC Genomics 2019 20:256
    Content type: Research article Published on:

  4. An unfavorable genetic correlation between milk production and fertility makes simultaneous improvement of milk production and fertility difficult in cattle breeding. Rapid genetic improvement in milk producti...

    Authors: Zexi Cai, Bernt Guldbrandtsen, Mogens Sandø Lund and Goutam Sahana
    Citation: BMC Genomics 2019 20:255
    Content type: Research article Published on:

  5. Placental efficiency (PE) describes the relationship between placental and fetal weights (fetal wt/placental wt). Within litters, PE can vary drastically, resulting in similarly sized pigs associated with diff...

    Authors: Shanice K. Krombeen, Vijay Shankar, Rooksana E. Noorai, Christopher A. Saski, Julia L. Sharp, Matthew E. Wilson and Tiffany A. Wilmoth
    Citation: BMC Genomics 2019 20:254
    Content type: Research article Published on:

  6. Willows are widely distributed in the northern hemisphere and have good adaptability to different living environment. The increasing of genome and transcriptome data provides a chance for comparative analysis ...

    Authors: You-jie Zhao, Xin-yi Liu, Ran Guo, Kun-rong Hu, Yong Cao and Fei Dai
    Citation: BMC Genomics 2019 20:253
    Content type: Research article Published on:

  7. Continuing evolution of the Mycobacterium tuberculosis (Mtb) complex genomes associated with resistance to anti-tuberculosis drugs is threatening tuberculosis disease control efforts. Both multi- and extensively ...

    Authors: Yaa E. A. Oppong, Jody Phelan, João Perdigão, Diana Machado, Anabela Miranda, Isabel Portugal, Miguel Viveiros, Taane G. Clark and Martin L. Hibberd
    Citation: BMC Genomics 2019 20:252
    Content type: Research article Published on:

  9. The last 10 years have seen the rise of countless functional genomics studies based on Next-Generation Sequencing (NGS). In the vast majority of cases, whatever the species, whatever the experiment, the two fi...

    Authors: Mathieu Bahin, Benoit F. Noël, Valentine Murigneux, Charles Bernard, Leila Bastianelli, Hervé Le Hir, Alice Lebreton and Auguste Genovesio
    Citation: BMC Genomics 2019 20:250
    Content type: Software Published on:

  10. Epigenetic dysregulation is involved in the etiology and progression of various human diseases. Formalin-fixed paraffin-embedded (FFPE) samples represent the gold standard for archiving pathology samples, and ...

    Authors: Jian Zhong, Zhenqing Ye, Chad R. Clark, Samuel W. Lenz, Justin H. Nguyen, Huihuang Yan, Keith D. Robertson, Gianrico Farrugia, Zhiguo Zhang, Tamas Ordog and Jeong-Heon Lee
    Citation: BMC Genomics 2019 20:249
    Content type: Methodology article Published on:

  12. Functional communications between nervous, endocrine and immune systems are well established in both vertebrates and invertebrates. Circulating hemocytes act as fundamental players in this crosstalk, whose fun...

    Authors: Fuxuan Wang, Shihao Li, Jianhai Xiang and Fuhua Li
    Citation: BMC Genomics 2019 20:247
    Content type: Research article Published on:

  14. Marek’s disease virus (MDV) is an oncogenic herpesvirus that can cause T-cell lymphomas in chicken. Long noncoding RNA (lncRNA) is strongly associated with various cancers and many other diseases. In chickens,...

    Authors: Zhen You, Qinghe Zhang, Changjun Liu, Jiuzhou Song, Ning Yang and Ling Lian
    Citation: BMC Genomics 2019 20:245
    Content type: Research article Published on:

  15. Bananas (Musa spp.) are an important crop worldwide. Most modern cultivars resulted from a complex polyploidization history that comprised three whole genome duplications (WGDs) shaping the haploid Musa genome, f...

    Authors: Alberto Cenci, Yann Hueber, Yasmin Zorrilla-Fontanesi, Jelle van Wesemael, Ewaut Kissel, Marie Gislard, Julie Sardos, Rony Swennen, Nicolas Roux, Sebastien Christian Carpentier and Mathieu Rouard
    Citation: BMC Genomics 2019 20:244
    Content type: Research article Published on:

  16. Fungi are an attractive source of nutrients for predators. As part of their defense, some fungi are able to induce the production of anti-predator protein toxins in response to predation. A previous study on t...

    Authors: Annageldi Tayyrov, Claire E. Stanley, Sophie Azevedo and Markus Künzler
    Citation: BMC Genomics 2019 20:243
    Content type: Research article Published on:

  17. Brassica oleracea exhibits extensive phenotypic diversity. As an important trait, petal color varies among different B. oleracea cultivars, enabling the study of the genetic basis of this trait. In a previous stu...

    Authors: Fengqing Han, Huilin Cui, Bin Zhang, Xiaoping Liu, Limei Yang, Mu Zhuang, Honghao Lv, Zhansheng Li, Yong Wang, Zhiyuan Fang, Jianghua Song and Yangyong Zhang
    Citation: BMC Genomics 2019 20:242
    Content type: Research article Published on:

  18. Of the hundreds of Vibrio cholerae serogroups, O1 and O139 are the main epidemic-causing ones. Although non-O1/non-O139 serogroups rarely cause epidemics, the possibility exists for strains within them to have pa...

    Authors: Zhenpeng Li, Xin Lu, Duochun Wang, Wei Li Liang, Jingyun Zhang, Jie Li, Jialiang Xu, Bo Pang and Biao Kan
    Citation: BMC Genomics 2019 20:241
    Content type: Research article Published on:

  19. The most critical step in the pearl formation during aquaculture is issued to the proliferation and differentiation of outer epithelial cells of mantle graft into pearl sac. This pearl sac secretes various mat...

    Authors: Mariom, Saori Take, Yoji Igarashi, Kazutoshi Yoshitake, Shuichi Asakawa, Kaoru Maeyama, Kiyohito Nagai, Shugo Watabe and Shigeharu Kinoshita
    Citation: BMC Genomics 2019 20:240
    Content type: Research article Published on:

  20. The phytopathogenic bacterium Xylella fastidiosa was thought to be restricted to the Americas where it infects and kills numerous hosts. Its detection worldwide has been blooming since 2013 in Europe and Asia. Ge...

    Authors: Nicolas Denancé, Martial Briand, Romain Gaborieau, Sylvain Gaillard and Marie-Agnès Jacques
    Citation: BMC Genomics 2019 20:239
    Content type: Research article Published on:

  21. Common cutworm (CCW) is highly responsible for destabilizing soybean productivity. Wild soybean is a resource used by breeders to discover elite defensive genes.

    Authors: Haiping Du, Xiao Li, Lihua Ning, Rui Qin, Qing Du, Qing Wang, Haina Song, Fang Huang, Hui Wang and Deyue Yu
    Citation: BMC Genomics 2019 20:237
    Content type: Research article Published on:

  22. The human pathogen Streptococcus pyogenes, or group A Streptococcus, is responsible for mild infections to life-threatening diseases. To facilitate the characterization of regulatory networks involved in the adap...

    Authors: Isabelle Rosinski-Chupin, Elisabeth Sauvage, Agnès Fouet, Claire Poyart and Philippe Glaser
    Citation: BMC Genomics 2019 20:236
    Content type: Research article Published on:

  23. Pigeonpea has considerable extent of insect-aided natural out-crossing that impedes genetic purity of seeds. Pre-anthesis cleistogamy in pigeonpea promotes self-pollination which helps in maintaining genetic p...

    Authors: Pooja Yadav, K. B. Saxena, Anupama Hingane, C. V. Sameer Kumar, V. S. Kandalkar, Rajeev K. Varshney and Rachit K. Saxena
    Citation: BMC Genomics 2019 20:235
    Content type: Research article Published on:

  25. Lactation and associated metabolic stresses during the post-partum period have been shown to impair fertility in dairy cows. The oviduct plays key roles in embryo development and the establishment of pregnancy...

    Authors: Yann Locatelli, Niamh Forde, Helmut Blum, Alexander Graf, Benoît Piégu, Pascal Mermillod, Eckhard Wolf, Patrick Lonergan and Marie Saint-Dizier
    Citation: BMC Genomics 2019 20:233
    Content type: Research article Published on:

  26. Accumulation of protein aggregates are a major hallmark of progressive neurodegenerative disorders such as Parkinson’s disease and Alzheimer’s disease. Transgenic Caenorhabditis elegans nematodes expressing the h...

    Authors: Yiru A. Wang, Basten L. Snoek, Mark G. Sterken, Joost A. G. Riksen, Jana J. Stastna, Jan E. Kammenga and Simon C. Harvey
    Citation: BMC Genomics 2019 20:232
    Content type: Research article Published on:

  27. We recently described a method for unbiased detection of all known human papillomaviruses (HPV) types with the potential for the determination of their variant and integration from the resulting whole genome s...

    Authors: Tengguo Li, Elizabeth R. Unger and Mangalathu S. Rajeevan
    Citation: BMC Genomics 2019 20:231
    Content type: Methodology article Published on:

  28. Flowering time and maturity are among the most important adaptive traits in soybean (Glycine max (L.) Merill). Flowering Locus T (FT) family genes function as key flowering integrators, with flowering-promoting m...

    Authors: Bingjun Jiang, Shouwei Zhang, Wenwen Song, Mohammad Abdul Awal Khan, Shi Sun, Chengsheng Zhang, Tingting Wu, Cunxiang Wu and Tianfu Han
    Citation: BMC Genomics 2019 20:230
    Content type: Research article Published on:

  30. Transgenic zebrafish lines with the expression of a fluorescent reporter under the control of a cell-type specific promoter, enable transcriptome analysis of FACS sorted cell populations. RNA quality and yield...

    Authors: Siebe Loontiens, Lisa Depestel, Suzanne Vanhauwaert, Givani Dewyn, Charlotte Gistelinck, Karen Verboom, Wouter Van Loocke, Filip Matthijssens, Andy Willaert, Jo Vandesompele, Frank Speleman and Kaat Durinck
    Citation: BMC Genomics 2019 20:228
    Content type: Methodology article Published on:

  31. Abiotic stresses like drought, heat, cold and salinity cause major productivity loss in the rapeseed-mustard crops (Brassica). Major efforts have been made in the past to identify genes that provide resistance ag...

    Authors: Deepika Verma, Neha Lakhanpal and Kashmir Singh
    Citation: BMC Genomics 2019 20:227
    Content type: Research article Published on:

  32. Despite the tremendous therapeutic advances that have stemmed from somatic oncogenetics, survival of some cancers has not improved in 50 years. Osteosarcoma still has a 5-year survival rate of 66%. We propose ...

    Authors: Isain Zapata, Luis E. Moraes, Elise M. Fiala, Sara Zaldivar-Lopez, C. Guillermo Couto, Jennie L. Rowell and Carlos E. Alvarez
    Citation: BMC Genomics 2019 20:226
    Content type: Research article Published on:

  33. Large-scale genetic screening using CRISPR-Cas9 technology has emerged as a powerful approach to uncover and validate gene functions. The ability to control the timing of genetic perturbation during CRISPR scr...

    Authors: Ning Sun, Sakina Petiwala, Rui Wang, Charles Lu, Mufeng Hu, Sujana Ghosh, Yan Hao, Christopher P. Miller and Namjin Chung
    Citation: BMC Genomics 2019 20:225
    Content type: Methodology article Published on:

  34. Drosophila subobscura has long been a central model in evolutionary genetics. Presently, its use is hindered by the lack of a reference genome. To bridge this gap, here we used PacBio long-read technology, togeth...

    Authors: Charikleia Karageorgiou, Víctor Gámez-Visairas, Rosa Tarrío and Francisco Rodríguez-Trelles
    Citation: BMC Genomics 2019 20:223
    Content type: Research article Published on:

  35. Aquaporins (AQPs) facilitate transport of water and small solutes across cell membranes and play an important role in different physiological processes in plants. Despite their importance, limited data is avai...

    Authors: S. M. Shivaraj, Rupesh Deshmukh, Humira Sonah and Richard R. Bélanger
    Citation: BMC Genomics 2019 20:222
    Content type: Research article Published on:

  36. The coordination of group behaviors in bacteria is achieved by a cell-cell signaling process called quorum sensing (QS). QS is an intercellular communication system, which synchronously controls expression of ...

    Authors: Miriam Khider, Erik Hjerde, Hilde Hansen and Nils Peder Willassen
    Citation: BMC Genomics 2019 20:220
    Content type: Research article Published on:

  37. Cardiac cell fate specification occurs through progressive steps, and its gene expression regulation features are still being defined. There has been an increasing interest in understanding the coordination be...

    Authors: Isabela Tiemy Pereira, Lucia Spangenberg, Anny Waloski Robert, Rocío Amorín, Marco Augusto Stimamiglio, Hugo Naya and Bruno Dallagiovanna
    Citation: BMC Genomics 2019 20:219
    Content type: Research article Published on:

  38. Infections with helminths cause an enormous disease burden in billions of animals and plants worldwide. Large scale use of anthelmintics has driven the evolution of resistance in a number of species that infec...

    Authors: Stephen R. Doyle, Christopher J. R. Illingworth, Roz Laing, David J. Bartley, Elizabeth Redman, Axel Martinelli, Nancy Holroyd, Alison A. Morrison, Andrew Rezansoff, Alan Tracey, Eileen Devaney, Matthew Berriman, Neil Sargison, James A. Cotton and John S. Gilleard
    Citation: BMC Genomics 2019 20:218
    Content type: Research article Published on:

  39. Topologically associating domains (TADs) are considered the structural and functional units of the genome. However, there is a lack of an integrated resource for TADs in the literature where researchers can ob...

    Authors: Tong Liu, Jacob Porter, Chenguang Zhao, Hao Zhu, Nan Wang, Zheng Sun, Yin-Yuan Mo and Zheng Wang
    Citation: BMC Genomics 2019 20:217
    Content type: Database Article Published on:

  40. Target enrichment is a critical component of targeted deep next-generation sequencing for the cost-effective and sensitive detection of mutations, which is predominantly performed by either hybrid selection or...

    Authors: Jongsuk Chung, Ki-Wook Lee, Chung Lee, Seung-Ho Shin, Sungkyu Kyung, Hyo-Jeong Jeon, Sook-Young Kim, Eunjung Cho, Chang Eun Yoo, Dae-Soon Son, Woong-Yang Park and Donghyun Park
    Citation: BMC Genomics 2019 20:216
    Content type: Research article Published on:

  41. Massively-parallel-sequencing, coupled with sample multiplexing, has made genetic tests broadly affordable. However, intractable index mis-assignments (commonly exceeds 1%) were repeatedly reported on some wid...

    Authors: Qiaoling Li, Xia Zhao, Wenwei Zhang, Lin Wang, Jingjing Wang, Dongyang Xu, Zhiying Mei, Qiang Liu, Shiyi Du, Zhanqing Li, Xinming Liang, Xiaman Wang, Hanmin Wei, Pengjuan Liu, Jing Zou, Hanjie Shen…
    Citation: BMC Genomics 2019 20:215
    Content type: Research article Published on:

  42. Long noncoding RNAs (lncRNAs) have emerged as playing crucial roles in abiotic stress responsive regulation, however, the mechanism of lncRNAs underlying drought-tolerance remains largely unknown in cassava, a...

    Authors: Zehong Ding, Weiwei Tie, Lili Fu, Yan Yan, Guanghua Liu, Wei Yan, Yanan Li, Chunlai Wu, Jiaming Zhang and Wei Hu
    Citation: BMC Genomics 2019 20:214
    Content type: Research article Published on:

  43. Cupressus gigantea, a rare and endangered tree species with remarkable medicinal value, is endemic to the Tibetan Plateau. Yet, little is known about the underlying genetics of the unique ecological adaptability ...

    Authors: Shan-Shan Zhou, Zhen Xing, Hui Liu, Xian-Ge Hu, Qiong Gao, Jie Xu, Si-Qian Jiao, Kai-Hua Jia, Yu Qing Jin, Wei Zhao, Ilga Porth, Yousry A. El-Kassaby and Jian-Feng Mao
    Citation: BMC Genomics 2019 20:213
    Content type: Research article Published on:

  44. Escherichia coli is an important pathogen that causes diarrhea in both humans and animals. To determine the relationships between putative virulence factors and pathotypes or host taxa, many molecular studies on ...

    Authors: Fang Tang, Juanfang Wang, Dezhi Li, Song Gao, Jianluan Ren, Liqing Ma, Fei Liu, Xiangkai Zhuge, Genqiang Yan, Yan Lu and Jianjun Dai
    Citation: BMC Genomics 2019 20:212
    Content type: Research article Published on:

  45. Filamentous fungi have evolved to succeed in nature by efficient growth and degradation of substrates, but also due to the production of secondary metabolites including mycotoxins. For Trichoderma reesei, as a bi...

    Authors: Eva Hitzenhammer, Christoph Büschl, Michael Sulyok, Rainer Schuhmacher, Bernhard Kluger, Elisabeth Wischnitzki and Monika Schmoll
    Citation: BMC Genomics 2019 20:211
    Content type: Research article Published on:

  46. Massively parallel reporter assays (MPRAs) have emerged as a popular means for understanding noncoding variation in a variety of conditions. While a large number of experiments have been described in the liter...

    Authors: Leslie Myint, Dimitrios G. Avramopoulos, Loyal A. Goff and Kasper D. Hansen
    Citation: BMC Genomics 2019 20:209
    Content type: Methodology article Published on:

  48. Halomicronema hongdechloris was the first cyanobacterium to be identified that produces chlorophyll (Chl) f. It contains Chl a and uses phycobiliproteins as its major light-harvesting components under white light...

    Authors: Min Chen, Miguel A. Hernandez-Prieto, Patrick C. Loughlin, Yaqiong Li and Robert D. Willows
    Citation: BMC Genomics 2019 20:207
    Content type: Research article Published on:

  49. Promoter motifs in Entamoeba histolytica were earlier analysed using microarray data with lower dynamic range of gene expression. Additionally, previous transcriptomic studies did not provide information on the n...

    Authors: Sarah Naiyer, Devinder Kaur, Jamaluddin Ahamad, Shashi Shekhar Singh, Yatendra Pratap Singh, Vivek Thakur, Alok Bhattacharya and Sudha Bhattacharya
    Citation: BMC Genomics 2019 20:206
    Content type: Research article Published on:

  50. Alternative splicing (AS) may play an important role in gonadal sex determination (GSD) in mammals. The present study was designed to identify differentially expressed isoforms and AS modifications accompanyin...

    Authors: Benjamín Planells, Isabel Gómez-Redondo, Eva Pericuesta, Patrick Lonergan and Alfonso Gutiérrez-Adán
    Citation: BMC Genomics 2019 20:202
    Content type: Research article Published on:

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BMC Genomics

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