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  1. Content type: Research article

    Uncoupling protein 2 (UCP2) belongs to the superfamily of mitochondrial anion carriers that dissociate the respiratory chain from ATP synthesis. It has been determined that UCP2 plays a role in several physiol...

    Authors: Issa Coulibaly, Scott A Gahr, Yniv Palti, Jianbo Yao and Caird E Rexroad III

    Citation: BMC Genomics 2006 7:203

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  2. Content type: Research article

    The Aβ-binding alcohol dehydrogenase/17β-hydroxysteroid dehydrogenase type 10 (ABAD/HSD10) is an enzyme involved in pivotal metabolic processes and in the mitochondrial dysfunction seen in the Alzheimer's dise...

    Authors: Alexandra T Marques, Agostinho Antunes, Pedro A Fernandes and Maria J Ramos

    Citation: BMC Genomics 2006 7:202

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  3. Content type: Research article

    For holometabolous insects there has been an explosion of proteomic and peptidomic information thanks to large genome sequencing projects. Heterometabolous insects, although comprising many important species, ...

    Authors: Elke Clynen, Jurgen Huybrechts, Peter Verleyen, Arnold De Loof and Liliane Schoofs

    Citation: BMC Genomics 2006 7:201

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  4. Content type: Research article

    With the completion of the genome sequence for rice (Oryza sativa L.), the focus of rice genomics research has shifted to the comparison of the rice genome with genomes of other species for gene cloning, breeding...

    Authors: Barbara L Hass-Jacobus, Montona Futrell-Griggs, Brian Abernathy, Rick Westerman, Jose-Luis Goicoechea, Joshua Stein, Patricia Klein, Bonnie Hurwitz, Bin Zhou, Fariborz Rakhshan, Abhijit Sanyal, Navdeep Gill, Jer-Young Lin, Jason G Walling, Mei Zhong Luo, Jetty Siva S Ammiraju…

    Citation: BMC Genomics 2006 7:199

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  5. Content type: Research article

    Mucins are large glycoproteins that cover epithelial surfaces of the body. All mucins contain at least one PTS domain, a region rich in proline, threonine and serine. Mucins are also characterized by von Wille...

    Authors: Tiange Lang, Gunnar C Hansson and Tore Samuelsson

    Citation: BMC Genomics 2006 7:197

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  6. Content type: Research article

    The major royal jelly proteins/yellow (MRJP/YELLOW) family possesses several physiological and chemical functions in the development of Apis mellifera and Drosophila melanogaster. Each protein of the family has a...

    Authors: Ai-Hua Xia, Qing-Xiang Zhou, Lin-Lin Yu, Wei-Guo Li, Yong-Zhu Yi, Yao-Zhou Zhang and Zhi-Fang Zhang

    Citation: BMC Genomics 2006 7:195

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  7. Content type: Research article

    Comparative mapping provides new insights into the evolutionary history of genomes. In particular, recent studies in mammals have suggested a role for segmental duplication in genome evolution. In some species...

    Authors: Laurent Schibler, Anne Roig, Marie-Françoise Mahe, Pascal Laurent, Hélène Hayes, François Rodolphe and Edmond P Cribiu

    Citation: BMC Genomics 2006 7:194

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  8. Content type: Research article

    The filamentous fungus Trichoderma harzianum is used as biological control agent of several plant-pathogenic fungi. In order to study the genome of this fungus, a functional genomics project called "TrichoEST" wa...

    Authors: Juan Antonio Vizcaíno, Francisco Javier González, M Belén Suárez, José Redondo, Julian Heinrich, Jesús Delgado-Jarana, Rosa Hermosa, Santiago Gutiérrez, Enrique Monte, Antonio Llobell and Manuel Rey

    Citation: BMC Genomics 2006 7:193

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  9. Content type: Methodology article

    Single nucleotide polymorphisms (SNPs) represent the most abundant type of DNA variation in the vertebrate genome, and their applications as genetic markers in numerous studies of molecular ecology and conserv...

    Authors: Heikki J Ryynänen and Craig R Primmer

    Citation: BMC Genomics 2006 7:192

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  10. Content type: Research article

    Helicobacter pylori is presumed to be co-evolved with its human host and is a highly diverse gastric pathogen at genetic levels. Ancient origins of H. pylori in the New World are still debatable. It is not clear ...

    Authors: S Manjulata Devi, Irshad Ahmed, Aleem A Khan, Syed Asad Rahman, Ayesha Alvi, Leonardo A Sechi and Niyaz Ahmed

    Citation: BMC Genomics 2006 7:191

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  11. Content type: Methodology article

    Although microscopic diagnosis has been playing the decisive role in cancer diagnostics, there have been cases in which it does not satisfy the clinical need. Differential diagnosis of malignant and benign thy...

    Authors: Naoto Yukinawa, Shigeyuki Oba, Kikuya Kato, Kazuya Taniguchi, Kyoko Iwao-Koizumi, Yasuhiro Tamaki, Shinzaburo Noguchi and Shin Ishii

    Citation: BMC Genomics 2006 7:190

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  12. Content type: Research article

    Alternative polyadenylation is a widespread mechanism contributing to transcript diversity in eukaryotes. Over half of mammalian genes are alternatively polyadenylated. Our understanding of poly(A) site evolut...

    Authors: Takeshi Ara, Fabrice Lopez, William Ritchie, Philippe Benech and Daniel Gautheret

    Citation: BMC Genomics 2006 7:189

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  13. Content type: Research article

    Doublecortin (DCX) domains serve as protein-interaction platforms. Mutations in members of this protein superfamily are linked to several genetic diseases. Mutations in the human DCX gene result in abnormal neuro...

    Authors: Orly Reiner, Frédéric M Coquelle, Bastian Peter, Talia Levy, Anna Kaplan, Tamar Sapir, Irit Orr, Naama Barkai, Gregor Eichele and Sven Bergmann

    Citation: BMC Genomics 2006 7:188

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  14. Content type: Research article

    Accurate evaluation of the quality of genomic or proteomic data and computational methods is vital to our ability to use them for formulating novel biological hypotheses and directing further experiments. Ther...

    Authors: Chad L Myers, Daniel R Barrett, Matthew A Hibbs, Curtis Huttenhower and Olga G Troyanskaya

    Citation: BMC Genomics 2006 7:187

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  15. Content type: Research article

    Nanoarchaeum equitans, the only known hyperthermophilic archaeon exhibiting parasitic life style, has raised some new questions about the evolution of the Archaea and provided a model of choice to study the genom...

    Authors: Sabyasachi Das, Sandip Paul, Sumit K Bag and Chitra Dutta

    Citation: BMC Genomics 2006 7:186

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  16. Content type: Research article

    Nuclear mitochondrial pseudogenes (numts) are a potential source of contamination during mitochondrial DNA PCR amplification. This possibility warrants careful experimental design and cautious interpretation o...

    Authors: Ryan L Parr, Jennifer Maki, Brian Reguly, Gabriel D Dakubo, Andrea Aguirre, Roy Wittock, Kerry Robinson, John P Jakupciak and Robert E Thayer

    Citation: BMC Genomics 2006 7:185

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  17. Content type: Research article

    In the recent years a strong resemblance has been observed between the insect immune system and the mammalian innate immune mechanisms suggesting their common origin. Among the insects, only the dipterans (Drosop...

    Authors: Archana S Gandhe, K P Arunkumar, Serene H John and J Nagaraju

    Citation: BMC Genomics 2006 7:184

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  18. Content type: Research article

    DNA methylation and histone deacetylation are epigenetic mechanisms that play major roles in eukaryotic gene regulation. We hypothesize that many genes in the human hepatoma cell line HepG2 are regulated by DN...

    Authors: Luke O Dannenberg and Howard J Edenberg

    Citation: BMC Genomics 2006 7:181

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  19. Content type: Research article

    Currently most pastoral farmers rely on anthelmintic drenches to control gastrointestinal parasitic nematodes in sheep. Resistance to anthelmintics is rapidly increasing in nematode populations such that on so...

    Authors: Allan M Crawford, Korena A Paterson, Ken G Dodds, Cristina Diez Tascon, Penny A Williamson, Meredith Roberts Thomson, Stewart A Bisset, Anne E Beattie, Gordon J Greer, Richard S Green, Roger Wheeler, Richard J Shaw, Kevin Knowler and John C McEwan

    Citation: BMC Genomics 2006 7:178

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  20. Content type: Research article

    Cleavage of messenger RNA (mRNA) precursors is an essential step in mRNA maturation. The signal recognized by the cleavage enzyme complex has been characterized as an A rich region upstream of the cleavage sit...

    Authors: Dorota Retelska, Christian Iseli, Philipp Bucher, C Victor Jongeneel and Felix Naef

    Citation: BMC Genomics 2006 7:176

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  21. Content type: Research article

    Transcriptomic techniques are now being applied in ecotoxicology and toxicology to measure the impact of stressors and develop understanding of mechanisms of toxicity. Microarray technology in particular offer...

    Authors: Lars-Henrik Heckmann, Richard Connon, Thomas H Hutchinson, Steve J Maund, Richard M Sibly and Amanda Callaghan

    Citation: BMC Genomics 2006 7:175

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  22. Content type: Research article

    High-throughput genotyping technologies represent a highly efficient way to accelerate genetic mapping and enable association studies. As a first step toward this goal, we aimed to develop a resource of candid...

    Authors: Nathalie Pavy, Lee S Parsons, Charles Paule, John MacKay and Jean Bousquet

    Citation: BMC Genomics 2006 7:174

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  23. Content type: Research article

    Shigella bacteria cause dysentery, which remains a significant threat to public health. Shigella flexneri is the most common species in both developing and developed countries. Five Shigella genomes have been seq...

    Authors: Huan Nie, Fan Yang, Xiaobing Zhang, Jian Yang, Lihong Chen, Jing Wang, Zhaohui Xiong, Junping Peng, Lilian Sun, Jie Dong, Ying Xue, Xingye Xu, Shuxia Chen, Zhijian Yao, Yan Shen and Qi Jin

    Citation: BMC Genomics 2006 7:173

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  24. Content type: Research article

    The sheep is an important model animal for testing novel fracture treatments and other medical applications. Despite these medical uses and the well known economic and cultural importance of the sheep, relativ...

    Authors: Jochen Hecht, Heiner Kuhl, Stefan A Haas, Sebastian Bauer, Albert J Poustka, Jasmin Lienau, Hanna Schell, Asita C Stiege, Volkhard Seitz, Richard Reinhardt, Georg N Duda, Stefan Mundlos and Peter N Robinson

    Citation: BMC Genomics 2006 7:172

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  25. Content type: Research article

    Mature saturated brine (crystallizers) communities are largely dominated (>80% of cells) by the square halophilic archaeon "Haloquadratum walsbyi". The recent cultivation of the strain HBSQ001 and thesequencing o...

    Authors: Boris A Legault, Arantxa Lopez-Lopez, Jose Carlos Alba-Casado, W Ford Doolittle, Henk Bolhuis, Francisco Rodriguez-Valera and R Thane Papke

    Citation: BMC Genomics 2006 7:171

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  26. Content type: Research article

    Prediction of secondary structures in the expressed sequences of bacterial genomes allows to investigate spontaneous folding of the corresponding RNA. This is particularly relevant in untranslated mRNA regions...

    Authors: Mauro Petrillo, Giustina Silvestro, Pier Paolo Di Nocera, Angelo Boccia and Giovanni Paolella

    Citation: BMC Genomics 2006 7:170

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  27. Content type: Research article

    The square halophilic archaeon Haloquadratum walsbyi dominates NaCl-saturated and MgCl2 enriched aquatic ecosystems, which imposes a serious desiccation stress, caused by the extremely low water activity. The gen...

    Authors: Henk Bolhuis, Peter Palm, Andy Wende, Michaela Falb, Markus Rampp, Francisco Rodriguez-Valera, Friedhelm Pfeiffer and Dieter Oesterhelt

    Citation: BMC Genomics 2006 7:169

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  28. Content type: Research article

    Pollen of the European white birch (Betula pendula, syn. B. verrucosa) is an important cause of hay fever. The main allergen is Bet v 1, member of the pathogenesis-related class 10 (PR-10) multigene family. To es...

    Authors: Martijn F Schenk, Ludovicus JWJ Gilissen, Gerhard D Esselink and Marinus JM Smulders

    Citation: BMC Genomics 2006 7:168

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  29. Content type: Research article

    NCI60 cell lines are derived from cancers of 9 tissue origins and have been invaluable in vitro models for cancer research and anti-cancer drug screen. Although extensive studies have been carried out to assess t...

    Authors: Huixia Wang, Shuguang Huang, Jianyong Shou, Eric W Su, Jude E Onyia, Birong Liao and Shuyu Li

    Citation: BMC Genomics 2006 7:166

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  30. Content type: Research article

    Pseudomonas aeruginosa is a genetically complex bacterium which can adopt and switch between a free-living or biofilm lifestyle, a versatility that enables it to thrive in many different environments and contribu...

    Authors: Richard D Waite, Alberto Paccanaro, Anastasia Papakonstantinopoulou, Jacob M Hurst, Mansoor Saqi, Eddie Littler and Michael A Curtis

    Citation: BMC Genomics 2006 7:162

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  31. Content type: Research article

    Genomic approaches provide unique opportunities to study interactions of insects with their pathogens. We developed a cDNA microarray to analyze the gene transcription profile of the lepidopteran pest Spodoptera ...

    Authors: M Barat-Houari, F Hilliou, F-X Jousset, L Sofer, E Deleury, J Rocher, M Ravallec, L Galibert, P Delobel, R Feyereisen, P Fournier and A-N Volkoff

    Citation: BMC Genomics 2006 7:160

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  32. Content type: Research article

    The purpose of this work was to study the gene expression of transient receptor potential (TRP) channels in the mouse. The application of a standardized and quantitative technique, TaqMan RT-PCR, should give i...

    Authors: Christiane Kunert-Keil, Frederike Bisping, Jana Krüger and Heinrich Brinkmeier

    Citation: BMC Genomics 2006 7:159

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  33. Content type: Research article

    The maize INDETERMINATE1 gene, ID1, is a key regulator of the transition to flowering and the founding member of a transcription factor gene family that encodes a protein with a distinct arrangement of zinc finge...

    Authors: Joseph Colasanti, Reynald Tremblay, Ada YM Wong, Viktoriya Coneva, Akiko Kozaki and Barbara K Mable

    Citation: BMC Genomics 2006 7:158

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  34. Content type: Research article

    The nematode Strongyloides ratti has two adult phases in its lifecycle: one obligate, female and parasitic and one facultative, dioecious and free-living. The molecular control of the development of this free-liv...

    Authors: Fiona J Thompson, Gary LA Barker, Louise Hughes, Clare P Wilkes, Jane Coghill and Mark E Viney

    Citation: BMC Genomics 2006 7:157

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  35. Content type: Research article

    Trisomy of human chromosome 21 (Chr21) results in Down's syndrome, a complex developmental and neurodegenerative disease. Molecular analysis of Down's syndrome, however, poses a particular challenge, because t...

    Authors: Yu-Hui Hu, Hans-Jörg Warnatz, Dominique Vanhecke, Florian Wagner, Andrea Fiebitz, Sabine Thamm, Pascal Kahlem, Hans Lehrach, Marie-Laure Yaspo and Michal Janitz

    Citation: BMC Genomics 2006 7:155

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