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  1. The pond snail, Lymnaea stagnalis (L. stagnalis), has served as a valuable model organism for neurobiology studies due to its simple and easily accessible central nervous system (CNS). L. stagnalis has been widel...

    Authors: Martina Rosato, Brittany Hoelscher, Zhenguo Lin, Chidera Agwu and Fenglian Xu

    Citation: BMC Genomics 2021 22:637

    Content type: Research

    Published on:

  2. Association mapping studies of quantitative trait loci (QTL) for canine hip dysplasia (CHD) can contribute to the understanding of the genetic background of this common and debilitating disease and might contr...

    Authors: Shizhi Wang, Erling Strandberg, Per Arvelius, Dylan N. Clements, Pamela Wiener and Juliane Friedrich

    Citation: BMC Genomics 2021 22:636

    Content type: Research

    Published on:

  3. Brine shrimp Artemia have an unequalled ability to endure extreme salinity and complete anoxia. This study aims to elucidate its strategies to cope with these stressors.

    Authors: Stephanie De Vos, Stephane Rombauts, Louis Coussement, Wannes Dermauw, Marnik Vuylsteke, Patrick Sorgeloos, James S. Clegg, Ziro Nambu, Filip Van Nieuwerburgh, Parisa Norouzitallab, Thomas Van Leeuwen, Tim De Meyer, Gilbert Van Stappen, Yves Van de Peer and Peter Bossier

    Citation: BMC Genomics 2021 22:635

    Content type: Research

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  4. The gut microbiota provides health benefits in humans by producing short-chain fatty acids (SCFAs), whose deficiency causes multiple disorders and inflammatory diseases. However, gut bacteria producing SCFAs i...

    Authors: Jing Zhang, Kun Zuo, Chen Fang, Xiandong Yin, Xiaoqing Liu, Jiuchang Zhong, Kuibao Li, Jing Li, Li Xu and Xinchun Yang

    Citation: BMC Genomics 2021 22:634

    Content type: Research

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  5. Halogenation is a recurring feature in natural products, especially those from marine organisms. The selectivity with which halogenating enzymes act on their substrates renders halogenases interesting targets ...

    Authors: Nadia Eusebio, Adriana Rego, Nathaniel R. Glasser, Raquel Castelo-Branco, Emily P. Balskus and Pedro N. Leão

    Citation: BMC Genomics 2021 22:633

    Content type: Research

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  6. As an important group of the multidrug efflux transporter family, the multidrug and toxic compound extrusion (MATE) family has a wide range of functions and is distributed in all kingdoms of living organisms. ...

    Authors: Weihan Zhang, Liao Liao, Jinsheng Xu, Yuepeng Han and Li Li

    Citation: BMC Genomics 2021 22:632

    Content type: Research article

    Published on:

  7. There exist few, if any, practical guidelines for predictive and falsifiable multi-omic data integration that systematically integrate existing knowledge. Disease modules are popular concepts for interpreting ...

    Authors: Tejaswi V. S. Badam, Hendrik A. de Weerd, David Martínez-Enguita, Tomas Olsson, Lars Alfredsson, Ingrid Kockum, Maja Jagodic, Zelmina Lubovac-Pilav and Mika Gustafsson

    Citation: BMC Genomics 2021 22:631

    Content type: Research article

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  8. Fusarium culmorum is an important pathogen causing head blight of cereals in Europe. This disease is of worldwide importance leading to reduced yield, grain quality, and contamination by mycotoxins. These mycotox...

    Authors: Thomas Miedaner, Andrea Vasquez, Valheria Castiblanco, Hilda Elena Castillo, Nora Foroud, Tobias Würschum and Willmar Leiser

    Citation: BMC Genomics 2021 22:630

    Content type: Research article

    Published on:

  9. It is believed that natural selection acts on the phenotypical changes caused by mutations. Phenotypically, from fishes to amphibians to reptiles, the emergence of limbs greatly facilitates the landing of anci...

    Authors: Yankai Jiang, Xinyue Cao and Haibin Wang

    Citation: BMC Genomics 2021 22:629

    Content type: Research article

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  10. Streptococcus agalactiae (Group B Streptococcus, GBS) is one of the major bacterial pathogens responsible for neonatal sepsis. Whole genome sequencing has, in recent years, emerged as a reliable tool for capsular...

    Authors: Mienye Bob-Manuel, Lesley McGee, Jeremiah A Igunma, Mary A Alex-Wele, Orikomaba K Obunge and Kennedy T Wariso

    Citation: BMC Genomics 2021 22:627

    Content type: Research

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  11. Long-read sequencing has great promise in enabling portable, rapid molecular-assisted cancer diagnoses. A key challenge in democratizing long-read sequencing technology in the biomedical and clinical community...

    Authors: Shishir Reddy, Ling-Hong Hung, Olga Sala-Torra, Jerald P. Radich, Cecilia CS Yeung and Ka Yee Yeung

    Citation: BMC Genomics 2021 22:626

    Content type: Software

    Published on:

  12. Genome-wide data are invaluable to characterize differentiation and adaptation of natural populations. Reduced representation sequencing (RRS) subsamples a genome repeatedly across many individuals. However, R...

    Authors: Henrik Christiansen, Franz M. Heindler, Bart Hellemans, Quentin Jossart, Francesca Pasotti, Henri Robert, Marie Verheye, Bruno Danis, Marc Kochzius, Frederik Leliaert, Camille Moreau, Tasnim Patel, Anton P. Van de Putte, Ann Vanreusel, Filip A. M. Volckaert and Isa Schön

    Citation: BMC Genomics 2021 22:625

    Content type: Research

    Published on:

  13. Finding meaningful gene-gene interaction and the main Transcription Factors (TFs) in co-expression networks is one of the most important challenges in gene expression data mining.

    Authors: Carlos Alberto Oliveira de Biagi Jr, Ricardo Perecin Nociti, Danielle Barbosa Brotto, Breno Osvaldo Funicheli, Patrícia de Cássia Ruy, João Paulo Bianchi Ximenez, David Livingstone Alves Figueiredo and Wilson Araújo Silva Jr

    Citation: BMC Genomics 2021 22:624

    Content type: Software

    Published on:

  14. The low cost and rapidity of microsatellite analysis have led to the development of several markers for many species. Because in non-invasive genetics it is recommended to genotype individuals using few loci, ...

    Authors: Erminia Scarpulla, Alessio Boattini, Mario Cozzo, Patrizia Giangregorio, Paolo Ciucci, Nadia Mucci, Ettore Randi and Francesca Davoli

    Citation: BMC Genomics 2021 22:623

    Content type: Methodology article

    Published on:

  15. Sugarcane (Saccharum) is the most critical sugar crop worldwide. As one of the most enriched transcription factor families in plants, MYB genes display a great potential to contribute to sugarcane improvement by ...

    Authors: Yuan Yuan, Xiping Yang, Mengfan Feng, Hongyan Ding, Muhammad Tahir Khan, Jisen Zhang and Muqing Zhang

    Citation: BMC Genomics 2021 22:622

    Content type: Research

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  16. Grass carp (Ctenopharyngodon idella) is one of the most widely cultivated fishes in China. High stocking density can reportedly affect fish growth and immunity. Herein we performed PacBio long-read single-molecul...

    Authors: Yan He, Hongyan Yu, Honggang Zhao, Hua Zhu, Qingjing Zhang, Anqi Wang, Yubang Shen, Xiaoyan Xu and Jiale Li

    Citation: BMC Genomics 2021 22:620

    Content type: Research

    Published on:

  17. Babesia rossi is a leading cause of morbidity and mortality among the canine population of sub-Saharan Africa, but pathogenesis remains poorly understood. Previous studies of B. rossi infection were derived from ...

    Authors: Rachel L. Smith, Amelia Goddard, Arun Boddapati, Steven Brooks, Johan P. Schoeman, Justin Lack, Andrew Leisewitz and Hans Ackerman

    Citation: BMC Genomics 2021 22:619

    Content type: Research

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  18. Chestnut seeds are important kinds of edible nuts rich in starch and protein. The characteristics and nutrient contents of chestnut have been found to show obvious metaxenia effects in previous studies. To imp...

    Authors: Shengxing Li, Zhuogong Shi, Qiurong Zhu, Liang Tao, Wenhui Liang and Zhiheng Zhao

    Citation: BMC Genomics 2021 22:617

    Content type: Research article

    Published on:

  19. The endosymbiont Wolbachia can manipulate arthropod reproduction and invade host populations by inducing cytoplasmic incompatibility (CI). Some host species are coinfected with multiple Wolbachia strains which ma...

    Authors: Jennifer L. Morrow and Markus Riegler

    Citation: BMC Genomics 2021 22:616

    Content type: Research

    Published on:

  20. Disease resilience, which is the ability of an animal to maintain performance under disease, is important for pigs in commercial herds, where they are exposed to various pathogens. Our objective was to investi...

    Authors: Kyu-Sang Lim, Jian Cheng, Austin Putz, Qian Dong, Xuechun Bai, Hamid Beiki, Christopher K. Tuggle, Michael K. Dyck, Pig Gen Canada, Frederic Fortin, John C. S. Harding, Graham S. Plastow and Jack C. M. Dekkers

    Citation: BMC Genomics 2021 22:614

    Content type: Research article

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  21. Hypertrophic scar (HTS) is a fibroproliferative skin disorder characterized by excessive cell proliferation, migration, and extracellular matrix (ECM) deposition. The CUB and Sushi multiple domains 1 (CSMD1) h...

    Authors: Shuchen Gu, Xin Huang, Xiangwen Xu, Yunhan Liu, Yimin Khoong, Zewei Zhang, Haizhou Li, Yashan Gao and Tao Zan

    Citation: BMC Genomics 2021 22:613

    Content type: Research

    Published on:

  22. Soil salinization represents a serious threat to global rice production. Although significant research has been conducted to understand salt stress at the genomic, transcriptomic and proteomic levels, few stud...

    Authors: Xiaoyu Yang, Bo Song, Jie Cui, Lina Wang, Shuoshuo Wang, Linlin Luo, Lei Gao, Beixin Mo, Yu Yu and Lin Liu

    Citation: BMC Genomics 2021 22:612

    Content type: Research article

    Published on:

  23. Potato cyst nematodes belong to the most harmful pathogens in potato, and durable management of these parasites largely depends on host-plant resistances. These resistances are pathotype specific. The current Glo...

    Authors: Joris J.M. van Steenbrugge, Sven van den Elsen, Martijn Holterman, Mark G. Sterken, Peter Thorpe, Aska Goverse, Geert Smant and Johannes Helder

    Citation: BMC Genomics 2021 22:611

    Content type: Research article

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  24. Since the domestication of chicken, various breeds have been developed for food production, entertainment, and so on. Compared to indigenous chicken breeds which generally do not show elite production performa...

    Authors: Xiurong Zhao, Changsheng Nie, Jinxin Zhang, Xinghua Li, Tao Zhu, Zi Guan, Yu Chen, Liang Wang, Xue Ze Lv, Weifang Yang, Yaxiong Jia, Zhonghua Ning, Haiying Li, Changqing Qu, Huie Wang and Lujiang Qu

    Citation: BMC Genomics 2021 22:610

    Content type: Research

    Published on:

  25. In the animal kingdom, mollusca is an important phylum of the Lophotrochozoa. However, few studies have investigated the molecular cascade of sex determination/early gonadal differentiation within this phylum....

    Authors: Coralie Broquard, Suwansa-ard Saowaros, Mélanie Lepoittevin, Lionel Degremont, Jean-Baptiste Lamy, Benjamin Morga, Abigail Elizur and Anne-Sophie Martinez

    Citation: BMC Genomics 2021 22:609

    Content type: Research article

    Published on:

  26. The degree to which adaptation to same environment is determined by similar molecular mechanisms, is a topic of broad interest in evolutionary biology, as an indicator of evolutionary predictability. We wished...

    Authors: Sylvie Gimenez, Imène Seninet, Marion Orsucci, Philippe Audiot, Nicolas Nègre, Kiwoong Nam, Réjane Streiff and Emmanuelle d’Alençon

    Citation: BMC Genomics 2021 22:606

    Content type: Research

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  27. Seisonidea (also Seisonacea or Seisonidae) is a group of small animals living on marine crustaceans (Nebalia spec.) with only four species described so far. Its monophyletic origin with mostly free-living wheel a...

    Authors: Katharina M. Mauer, Hanno Schmidt, Marco Dittrich, Andreas C. Fröbius, Sören Lukas Hellmann, Hans Zischler, Thomas Hankeln and Holger Herlyn

    Citation: BMC Genomics 2021 22:604

    Content type: Research

    Published on:

  28. Alfalfa, the “queen of forage”, is the most extensively cultivated forage legume in the world. The development and yield of alfalfa are seriously limited by abiotic stress. MADS-box transcription factors are o...

    Authors: Xueming Dong, Hao Deng, Wenxue Ma, Qiang Zhou and Zhipeng Liu

    Citation: BMC Genomics 2021 22:603

    Content type: Research

    Published on:

  29. Grain weight and grain shape are important agronomic traits that affect the grain yield potential and grain quality of rice. Both grain weight and grain shape are controlled by multiple genes. The 3,000 Rice G...

    Authors: Yanan Niu, Tianxiao Chen, Chunchao Wang, Kai Chen, Congcong Shen, Huizhen Chen, Shuangbing Zhu, Zhichao Wu, Tianqing Zheng, Fan Zhang and Jianlong Xu

    Citation: BMC Genomics 2021 22:602

    Content type: Research article

    Published on:

  30. While recent advances in genomics has enabled vast improvements in the quantification of genome-wide diversity and the identification of adaptive and deleterious alleles in model species, wildlife and non-mode...

    Authors: Georgina Samaha, Claire M. Wade, Hamutal Mazrier, Catherine E. Grueber and Bianca Haase

    Citation: BMC Genomics 2021 22:601

    Content type: Research article

    Published on:

  31. Nucleotide excision repair is the primary DNA repair mechanism that removes bulky DNA adducts such as UV-induced pyrimidine dimers. Correspondingly, genome-wide mapping of nucleotide excision repair with eXcis...

    Authors: Umit Akkose, Veysel Ogulcan Kaya, Laura Lindsey-Boltz, Zeynep Karagoz, Adam D. Brown, Peter A. Larsen, Anne D. Yoder, Aziz Sancar and Ogun Adebali

    Citation: BMC Genomics 2021 22:600

    Content type: Research article

    Published on:

  32. Experimental proof of gene function assignments in plants is based on mutant analyses. T-DNA insertion lines provided an invaluable resource of mutants and enabled systematic reverse genetics-based investigati...

    Authors: Boas Pucker, Nils Kleinbölting and Bernd Weisshaar

    Citation: BMC Genomics 2021 22:599

    Content type: Research article

    Published on:

  33. The typical single-chromosome mitochondrial (mt) genome of animals has fragmented into multiple minichromosomes in the lineage Mitodivisia, which contains most of the parasitic lice of eutherian mammals. These...

    Authors: Wen-Ge Dong, Yalun Dong, Xian-Guo Guo and Renfu Shao

    Citation: BMC Genomics 2021 22:598

    Content type: Research

    Published on:

  34. Bread wheat (Triticum aestivum L.) is one of the most important cereal food crops for the global population. Spike-layer uniformity (the consistency of the spike distribution in the vertical space)-related traits...

    Authors: Parveen Malik, Jitendra Kumar, Shiveta Sharma, Rajiv Sharma and Shailendra Sharma

    Citation: BMC Genomics 2021 22:597

    Content type: Research article

    Published on:

  35. The eating and cooking qualities (ECQs) of rice (Oryza sativa L.) are key characteristics affecting variety adoption and market value. Starch viscosity profiles tested by a rapid visco analyzer (RVA) offer a dire...

    Authors: Ling Zhao, Chunfang Zhao, Lihui Zhou, Qingyong Zhao, Zhen Zhu, Tao Chen, Shu Yao, Yadong Zhang and Cailin Wang

    Citation: BMC Genomics 2021 22:596

    Content type: Research article

    Published on:

  36. Cannabis sativa L., a dioecious plant derived from China, demonstrates important medicinal properties and economic value worldwide. Cannabis properties have been usually harnessed depending on the sex of the plan...

    Authors: Gen Pan, Zheng Li, Siqi Huang, Jie Tao, Yaliang Shi, Anguo Chen, Jianjun Li, Huijuan Tang, Li Chang, Yong Deng, Defang Li and Lining Zhao

    Citation: BMC Genomics 2021 22:595

    Content type: Research

    Published on:

    The Correction to this article has been published in BMC Genomics 2021 22:657

  37. Annual molt is a critical stage in the life cycle of birds. Although the most extensively documented aspects of molt are the renewing of plumage and the remodeling of the reproductive tract in laying hens, in ...

    Authors: Clémentine Charton, Dong-Jae Youm, Byung June Ko, Donghyeok Seol, Bongsang Kim, Han-Ha Chai, Dajeong Lim and Heebal Kim

    Citation: BMC Genomics 2021 22:594

    Content type: Research

    Published on:

  38. The mutation of insulin-like growth factor 2 (IGF2 mutation) that a single-nucleotide substitution (G→A) in the third intron of IGF2 abrogates the interaction with zinc finger BED-type containing 6 (ZBED6) and le...

    Authors: Dandan Wang, Yabin Pu, Yefang Li, Dengke Pan, Shengnan Wang, Wenjie Tian, Yuehui Ma and Lin Jiang

    Citation: BMC Genomics 2021 22:593

    Content type: Research

    Published on:

  39. Genetic aberrations in hepatocellular carcinoma (HCC) are well known, but the functional consequences of such aberrations remain poorly understood.

    Authors: Christos Dimitrakopoulos, Sravanth Kumar Hindupur, Marco Colombi, Dritan Liko, Charlotte K. Y. Ng, Salvatore Piscuoglio, Jonas Behr, Ariane L. Moore, Jochen Singer, Hans-Joachim Ruscheweyh, Matthias S. Matter, Dirk Mossmann, Luigi M. Terracciano, Michael N. Hall and Niko Beerenwinkel

    Citation: BMC Genomics 2021 22:592

    Content type: Research article

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  40. Fusarium head blight is a disease of global concern that reduces crop yields and renders grains unfit for consumption due to mycotoxin contamination. Fusarium poae is frequently associated with cereal crops showi...

    Authors: Thomas E. Witte, Linda J. Harris, Hai D. T. Nguyen, Anne Hermans, Anne Johnston, Amanda Sproule, Jeremy R. Dettman, Christopher N. Boddy and David P. Overy

    Citation: BMC Genomics 2021 22:591

    Content type: Research

    Published on:

  41. To investigate whether copy number variations (CNVs) are implicated in molecular mechanisms underlying primary open-angle glaucoma (POAG), we used genotype data of POAG individuals and healthy controls from tw...

    Authors: Valeria Lo Faro, Jacoline B. ten Brink, Harold Snieder, Nomdo M. Jansonius and Arthur A. Bergen

    Citation: BMC Genomics 2021 22:590

    Content type: Research

    Published on:

  42. The Botryosphaeriaceae are important plant pathogens, but also have the ability to establish asymptomatic infections that persist for extended periods in a latent state. In this study, we used comparative genome ...

    Authors: Jan H. Nagel, Michael J. Wingfield and Bernard Slippers

    Citation: BMC Genomics 2021 22:589

    Content type: Research

    Published on:

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