Skip to main content

Articles

Page 2 of 290

  1. Reverse Transcription quantitative polymerase chain reaction (RT-qPCR) is a sensitive and reliable method for mRNA quantification and rapid analysis of gene expression from a large number of starting templates...

    Authors: Yashu Zhang, Hongping Li, Shucheng Shang, Shuoyu Meng, Ting Lin, Yanhui Zhang and Haixing Liu

    Citation: BMC Genomics 2021 22(Suppl 5):680

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 22 Supplement 5

  2. Copy number variation is crucial in deciphering the mechanism and cure of complex disorders and cancers. The recent advancement of scDNA sequencing technology sheds light upon addressing intratumor heterogenei...

    Authors: Xikang Feng, Lingxi Chen, Yuhao Qing, Ruikang Li, Chaohui Li and Shuai Cheng Li

    Citation: BMC Genomics 2021 22(Suppl 5):651

    Content type: Methodology

    Published on:

    This article is part of a Supplement: Volume 22 Supplement 5

  3. Feed efficiency is one of the key determinants of beef industry profitability and sustainability. However, the cellular and molecular background behind feed efficiency is largely unknown. This study combines i...

    Authors: Jiyuan Li, Robert Mukiibi, Yining Wang, Graham S. Plastow and Changxi Li

    Citation: BMC Genomics 2021 22:823

    Content type: Research

    Published on:

  4. We benchmarked sequencing technology and assembly strategies for short-read, long-read, and hybrid assemblers in respect to correctness, contiguity, and completeness of assemblies in genomes of Francisella tulare...

    Authors: Kerstin Neubert, Eric Zuchantke, Robert Maximilian Leidenfrost, Roebbe Wuenschiers, Josephine Grützke, Burkhard Malorny, Holger Brendebach, Sascha Al Dahouk, Timo Homeier, Helmut Hotzel, Knut Reinert, Herbert Tomaso and Anne Busch

    Citation: BMC Genomics 2021 22:822

    Content type: Research

    Published on:

  5. The tricarboxylic acid (TCA) cycle is crucial for energy supply in animal, plant, and microbial cells. It is not only the main pathway of carbohydrate catabolism but also the final pathway of lipid and protein...

    Authors: Yongming Liu, Jingtao Qu, Ziwen Shi, Peng Zhang and Maozhi Ren

    Citation: BMC Genomics 2021 22:821

    Content type: Research

    Published on:

  6. Intragenic modifiers (in-phase, second-site variants) are known to have dramatic effects on clinical outcomes, affecting disease attributes such as severity or age of onset. However, despite their clinical imp...

    Authors: Francesca Jean, Susan Stasiuk, Tatiana Maroilley, Catherine Diao, Andrew Galbraith and Maja Tarailo-Graovac

    Citation: BMC Genomics 2021 22:820

    Content type: Research

    Published on:

  7. The transition from vegetative growth to reproductive growth involves various pathways. Vernalization is a crucial process for floral organ formation and regulation of flowering time that is widely utilized in...

    Authors: Fengyan Shi, Hezi Xu, Chuanhong Liu, Chong Tan, Jie Ren, Xueling Ye, Hui Feng and Zhiyong Liu

    Citation: BMC Genomics 2021 22:819

    Content type: Research

    Published on:

  8. Umbilical Hernia (UH) is characterized by the passage of part of the intestine through the umbilical canal forming the herniary sac. There are several potential causes that can lead to the umbilical hernia suc...

    Authors: Igor Ricardo Savoldi, Adriana Mércia Guaratini Ibelli, Maurício Egídio Cantão, Jane de Oliveira Peixoto, Michele Porto Pires, Marcos Antônio Zanella Mores, Essamai Brizola Lagos, Jader Silva Lopes, Ricardo Zanella and Mônica Corrêa Ledur

    Citation: BMC Genomics 2021 22:818

    Content type: Research article

    Published on:

  9. S-domain receptor-like kinases (SD-RLKs) are an important and multi-gene subfamily of plant receptor-like/pelle kinases (RLKs), which are known to play a significant role in the development and immune response...

    Authors: Raju Mondal, Subhankar Biswas, Akanksha Srivastava, Suvajit Basu, Maitri Trivedi, Sunil Kumar Singh and Yogesh Mishra

    Citation: BMC Genomics 2021 22:817

    Content type: Research

    Published on:

  10. The intimate association between parasitic plants and their hosts favours the exchange of genetic material, potentially leading to horizontal gene transfer (HGT) between plants. With the recent publication of ...

    Authors: Benjamin M. Anderson, Kirsten Krause and Gitte Petersen

    Citation: BMC Genomics 2021 22:816

    Content type: Research article

    Published on:

  11. Maternal mRNA provisioning of oocytes regulates early embryogenesis. Maternal transcripts are degraded as zygotic genome activation (ZGA) intensifies, a phenomenon known as the maternal-to-zygotic transition (...

    Authors: Erin Chille, Emma Strand, Mayaan Neder, Valeria Schmidt, Madeleine Sherman, Tali Mass and Hollie Putnam

    Citation: BMC Genomics 2021 22:815

    Content type: Research

    Published on:

  12. Engineered versions of adeno-associated virus (AAV) are commonly used in gene therapy but evidence revealing a potential oncogenic role of natural AAV in hepatocellular carcinoma (HCC) has raised concerns. The...

    Authors: Alejandro A. Schäffer, Dana A. Dominguez, Lesley M. Chapman, E. Michael Gertz, Anuradha Budhu, Marshonna Forgues, Jittiporn Chaisaingmongkol, Siritida Rabibhadana, Benjarath Pupacdi, Xiaolin Wu, Enkhjargal Bayarsaikhan, Curtis C. Harris, Mathuros Ruchirawat, Eytan Ruppin and Xin Wei Wang

    Citation: BMC Genomics 2021 22:814

    Content type: Research

    Published on:

  13. Many limno-terrestrial tardigrades can enter an ametabolic state, known as anhydrobiosis, upon desiccation, in which the animals can withstand extreme environments. Through genomics studies, molecular componen...

    Authors: Yumi Murai, Maho Yagi-Utsumi, Masayuki Fujiwara, Sae Tanaka, Masaru Tomita, Koichi Kato and Kazuharu Arakawa

    Citation: BMC Genomics 2021 22:813

    Content type: Research article

    Published on:

  14. Litter size is an important index of mammalian prolificacy and is determined by the ovulation rate. The ovary is a crucial organ for mammalian reproduction and is associated with follicular development, matura...

    Authors: Yufang Liu, Zuyang Zhou, Xiaoyun He, Lin Tao, Yanting Jiang, Rong Lan, Qionghua Hong and Mingxing Chu

    Citation: BMC Genomics 2021 22:812

    Content type: Research

    Published on:

  15. The aerial organs of most terrestrial plants are covered by cuticular waxes, which impart plants a glaucous appearance and play important roles in protecting against various biotic and abiotic stresses. Despit...

    Authors: Fengqing Han, Jingjing Huang, Qi Xie, Yumei Liu, Zhiyuan Fang, Limei Yang, Mu Zhuang, Yangyong Zhang, Honghao Lv, Yong Wang, Jialei Ji and Zhansheng Li

    Citation: BMC Genomics 2021 22:811

    Content type: Research

    Published on:

  16. The gut is the first barrier to infection by viruses that are internally borne and transmitted persistently by arthropod vectors to plant and animal hosts. Tomato spotted wilt virus (TSWV), a plant-pathogenic ...

    Authors: Jinlong Han and Dorith Rotenberg

    Citation: BMC Genomics 2021 22:810

    Content type: Research

    Published on:

  17. Single-cell RNA sequencing (scRNA-seq) provides new insights to address biological and medical questions, and it will benefit more from the ultralow input RNA or subcellular sequencing.

    Authors: Erteng Jia, Huajuan Shi, Ying Wang, Ying Zhou, Zhiyu Liu, Min Pan, Yunfei Bai, Xiangwei Zhao and Qinyu Ge

    Citation: BMC Genomics 2021 22:809

    Content type: Research article

    Published on:

  18. Meloidae (blister beetles) are known to synthetize cantharidin (CA), a toxic and defensive terpene mainly stored in male accessory glands (MAG) and emitted outward through reflex-bleeding. Recent progresses in...

    Authors: Emiliano Fratini, Marco Salvemini, Fabrizio Lombardo, Maurizio Muzzi, Marco Molfini, Silvia Gisondi, Elia Roma, Veronica D’Ezio, Tiziana Persichini, Tecla Gasperi, Paolo Mariottini, Andrea Di Giulio, Marco Alberto Bologna, Manuela Cervelli and Emiliano Mancini

    Citation: BMC Genomics 2021 22:808

    Content type: Research article

    Published on:

  19. Liriodendron chinense is a distinctive ornamental tree species due to its unique leaves and tulip-like flowers. The discovery of genes involved in leaf development and morphogenesis is critical for uncovering the...

    Authors: Yaxian Zong, Ziyuan Hao, Zhonghua Tu, Yufang Shen, Chengge Zhang, Shaoying Wen, Lichun Yang, Jikai Ma and Huogen Li

    Citation: BMC Genomics 2021 22:807

    Content type: Research article

    Published on:

  20. Paphiopedilum, commonly known as slipper orchid, is an important genus of orchid family with prominent horticultural value. Compared with conventional methods such as tillers and in vitro shoots multiplication, i...

    Authors: Beiyi Guo, Songjun Zeng, Yuying Yin, Lin Li, Guohua Ma, Kunlin Wu and Lin Fang

    Citation: BMC Genomics 2021 22:806

    Content type: Research article

    Published on:

  21. Intramuscular fat (IMF) content is a determining factor for meat taste. The Luchuan pig is a fat-type local breed in southern China that is famous for its desirable meat quality due to high IMF, however, the c...

    Authors: Yan Liu, Huan Long, Simin Feng, Tingting Ma, Mufeng Wang, Lizhu Niu, Xinyi Zhang, Lianni Wang, Yu Lei, Yilong Chen, Qiankun Wang and Xuewen Xu

    Citation: BMC Genomics 2021 22:805

    Content type: Research

    Published on:

  22. Xyloglucan endotransglucosylase/hydrolase (XTH) family plays an important role in cell wall reconstruction and stress resistance in plants. However, the detailed characteristics of XTH family genes and their e...

    Authors: Zihan Cheng, Xuemei Zhang, Wenjing Yao, Yuan Gao, Kai Zhao, Qing Guo, Boru Zhou and Tingbo Jiang

    Citation: BMC Genomics 2021 22:804

    Content type: Research

    Published on:

  23. Welsh onion constitutes an important crop due to its benefits in traditional medicine. Nitrogen is an important nutrient for plant growth and yield; however, little is known about its influence on the mechanis...

    Authors: Chen Zhao, Guanchu Ma, Lin Zhou, Song Zhang, Le Su, Xin Sun, Orlando Borrás-Hidalgo, Kunlun Li, Qiulin Yue and Lin Zhao

    Citation: BMC Genomics 2021 22:803

    Content type: Research article

    Published on:

  24. RNA-seq emerges as a valuable method for clinical genetics. The transcriptome is “dynamic” and tissue-specific, but typically the probed tissues to analyze (TA) are different from the tissue of interest (TI) b...

    Authors: Akhil Velluva, Maximillian Radtke, Susanne Horn, Bernt Popp, Konrad Platzer, Erind Gjermeni, Chen-Ching Lin, Johannes R. Lemke, Antje Garten, Torsten Schöneberg, Matthias Blüher, Rami Abou Jamra and Diana Le Duc

    Citation: BMC Genomics 2021 22:802

    Content type: Software

    Published on:

  25. DNA methylation and demethylation at CpG islands is one of the main regulatory factors that allow cells to respond to different stimuli. These regulatory mechanisms help in developing tissue without affecting ...

    Authors: Devender Arora, Jong-Eun Park, Dajeong Lim, Bong-Hwan Choi, In-Cheol Cho, Krishnamoorthy Srikanth, Jaebum Kim and Woncheoul Park

    Citation: BMC Genomics 2021 22:801

    Content type: Research article

    Published on:

  26. Rice (Oryza sativa L.) is a food crop for humans worldwide. However, temperature has an effect during the vegetative and reproductive stages. In high-latitude regions where rice is cultivated, cold stress is a ma...

    Authors: Jia Liu, Qinglin Meng, Hongtao Xiang, Fengmei Shi, Ligong Ma, Yichu Li, Chunlai Liu, Yu Liu and Baohua Su

    Citation: BMC Genomics 2021 22:800

    Content type: Research article

    Published on:

  27. Size of reference population is a crucial factor affecting the accuracy of prediction of the genomic estimated breeding value (GEBV). There are few studies in beef cattle that have compared accuracies achieved...

    Authors: Masayuki Takeda, Keiichi Inoue, Hidemi Oyama, Katsuo Uchiyama, Kanako Yoshinari, Nanae Sasago, Takatoshi Kojima, Masashi Kashima, Hiromi Suzuki, Takehiro Kamata, Masahiro Kumagai, Wataru Takasugi, Tatsuya Aonuma, Yuusuke Soma, Sachi Konno, Takaaki Saito…

    Citation: BMC Genomics 2021 22:799

    Content type: Research

    Published on:

  28. Treatment of wheat with the phytohormones abscisic acid (ABA) and gibberellic acid (GA) has been shown to affect Fusarium head blight (FHB) disease severity. However, the molecular mechanisms underlying the el...

    Authors: Leann M. Buhrow, Ziying Liu, Dustin Cram, Tanya Sharma, Nora A. Foroud, Youlian Pan and Michele C. Loewen

    Citation: BMC Genomics 2021 22:798

    Content type: Research article

    Published on:

  29. In July 2015, the carcasses of 11 cockatiels were submitted for disease diagnosis to the Avian Disease Division of the Animal and Plant Quarantine Agency of Korea. The cockatiels, which appeared dehydrated and...

    Authors: Si-Hyeon Kim, Yong-Kuk Kwon, Choi-Kyu Park and Hye-Ryoung Kim

    Citation: BMC Genomics 2021 22:797

    Content type: Research

    Published on:

  30. Mastitis is an economically important disease of dairy cows with Staphylococcus aureus a major cause worldwide. Challenge of Holstein-Friesian cows demonstrated that S. aureus strain MOK124, which belongs to Clon...

    Authors: Dagmara A. Niedziela, Paul Cormican, Gilles Foucras, Finola C. Leonard and Orla M. Keane

    Citation: BMC Genomics 2021 22:796

    Content type: Research

    Published on:

  31. Pathogens of the genus Phytophthora are the etiological agents of many devastating diseases in several high-value crops and forestry species such as potato, tomato, cocoa, and oak, among many others. Phytophthora...

    Authors: David A. Ayala-Usma, Martha Cárdenas, Romain Guyot, Maryam Chaib De Mares, Adriana Bernal, Alejandro Reyes Muñoz and Silvia Restrepo

    Citation: BMC Genomics 2021 22:795

    Content type: Research

    Published on:

  32. The present availability of full genome sequences of a broad range of animal species across the whole range of evolutionary history enables one to ask questions as to the distribution of genes across the chrom...

    Authors: Wilfred D. Stein and Moshe B. Hoshen

    Citation: BMC Genomics 2021 22:794

    Content type: Research

    Published on:

  33. Winter wheat requires prolonged exposure to low temperature to initiate flowering (vernalization). Shoot apical meristem of the crown is the site of cold perception, which produces leaf primordia during vegeta...

    Authors: Menglei Wang, Chenhui Yang, Kangning Wei, Miao Zhao, Liqiang Shen, Jie Ji, Li Wang, Daijing Zhang, Junqiang Guo, Yun Zheng, Juanjuan Yu, Mo Zhu, Haiying Liu and Yong-Fang Li

    Citation: BMC Genomics 2021 22(Suppl 3):793

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 22 Supplement 3

  34. The biting midge, Forcipomyia taiwana, is one of the most annoying blood-sucking pests in Taiwan. Current chemical control methods only target the adult, not the immature stages (egg to pupa), of F. taiwana. Disc...

    Authors: Mu-En Chen, Mong-Hsun Tsai, Hsiang-Ting Huang, Ching-Chu Tsai, Mei-Ju Chen, Da-Syuan Yang, Teng-Zhi Yang, John Wang and Rong-Nan Huang

    Citation: BMC Genomics 2021 22:792

    Content type: Research

    Published on:

  35. The incidence and mortality of pancreatic cancer (PC) has gradually increased. The aim of this study was to identify survival-related DNA methylation (DNAm)-driven genes and establish a nomogram to predict out...

    Authors: G.C Deng, D.C Sun, Q Zhou, Y Lv, H Yan, Q.L Han and G.H Dai

    Citation: BMC Genomics 2021 22:791

    Content type: Research

    Published on:

  36. The complexity of physical activity (PA) and DNA methylation interaction in the development of cardiovascular disease (CVD) is rarely simultaneously investigated in one study. We examined the role of DNA methy...

    Authors: Hangchuan Shi, Deborah J. Ossip, Nicole L. Mayo, Daniel A. Lopez, Robert C. Block, Wendy S. Post, Alain G. Bertoni, Jingzhong Ding, Si Chen, Chen Yan, Zidian Xie, Ina Hoeschele, Yongmei Liu and Dongmei Li

    Citation: BMC Genomics 2021 22:790

    Content type: Research

    Published on:

  37. Transposable elements (TE) comprise nearly half of the human genome and their insertions have profound effects to human genetic diversification and as well as disease. Despite their abovementioned significance...

    Authors: Matias I. Autio, Talal Bin Amin, Arnaud Perrin, Jen Yi Wong, Roger S.-Y. Foo and Shyam Prabhakar

    Citation: BMC Genomics 2021 22:789

    Content type: Methodology article

    Published on:

  38. In response to major challenges regarding the supply and sustainability of marine ingredients in aquafeeds, the aquaculture industry has made a large-scale shift toward plant-based substitutions for fish oil a...

    Authors: Carole Blay, Pierrick Haffray, Jonathan D’Ambrosio, Enora Prado, Nicolas Dechamp, Virginie Nazabal, Jérôme Bugeon, Florian Enez, David Causeur, Christophe Eklouh-Molinier, Vincent Petit, Florence Phocas, Geneviève Corraze and Mathilde Dupont-Nivet

    Citation: BMC Genomics 2021 22:788

    Content type: Research

    Published on:

  39. A new class of regulatory elements called super-enhancers, comprised of multiple neighboring enhancers, have recently been reported to be the key transcriptional drivers of cellular, developmental, and disease...

    Authors: Yueh-Hua Tu, Hsueh-Fen Juan and Hsuan-Cheng Huang

    Citation: BMC Genomics 2021 22(Suppl 3):787

    Content type: Research

    Published on:

    This article is part of a Supplement: Volume 22 Supplement 3

  40. Eggshell is a bio-ceramic material comprising columnar calcite (CaCO3) crystals and organic proteinaceous matrix. The size, shape and orientation of the CaCO3 crystals influence the microstructural properties of ...

    Authors: Quanlin Li, Zhongyi Duan, Congjiao Sun, Jiangxia Zheng, Guiyun Xu and Ning Yang

    Citation: BMC Genomics 2021 22:786

    Content type: Research

    Published on:

  41. The genetic control of sex determination in teleost species is poorly understood. This is partly because of the diversity of mechanisms that determine sex in this large group of vertebrates, including constitu...

    Authors: Andrew Catanach, Mike Ruigrok, Deepa Bowatte, Marcus Davy, Roy Storey, Noémie Valenza-Troubat, Elena López-Girona, Elena Hilario, Matthew J. Wylie, David Chagné and Maren Wellenreuther

    Citation: BMC Genomics 2021 22:785

    Content type: Research

    Published on:

  42. The Myxococcales are well known for their predatory and developmental social processes, and for the molecular complexity of regulation of these processes. Many species within this order have unusually large ge...

    Authors: Anna L. McLoon, Max E. Boeck, Marc Bruckskotten, Alexander C. Keyel and Lotte Søgaard-Andersen

    Citation: BMC Genomics 2021 22:784

    Content type: Research

    Published on:

  43. Barnacles are sessile crustaceans that attach to underwater surfaces using barnacle cement proteins. Barnacles have a calcareous or chitinous membranous base, and their substratum varies from biotic (e.g. cora...

    Authors: Hsiu-Chin Lin, Yue Him Wong, Chia-Hsuan Sung and Benny Kwok Kan Chan

    Citation: BMC Genomics 2021 22:783

    Content type: Research

    Published on:

  44. Historically, geneticists have relied on genotyping arrays and imputation to study human genetic variation. However, an underrepresentation of diverse populations has resulted in arrays that poorly capture glo...

    Authors: Anne-Katrin Emde, Amanda Phipps-Green, Murray Cadzow, C. Scott Gallagher, Tanya J. Major, Marilyn E. Merriman, Ruth K. Topless, Riku Takei, Nicola Dalbeth, Rinki Murphy, Lisa K. Stamp, Janak de Zoysa, Philip L. Wilcox, Keolu Fox, Kaja A. Wasik, Tony R. Merriman…

    Citation: BMC Genomics 2021 22:666

    Content type: Research article

    Published on:

  45. Kuruma shrimp, a major commercial shrimp species in the world, has two cryptic or sibling species, Marsupenaeus japonicus and Marsupenaeus pulchricaudatus. Codon usage analysis would contribute to our understandi...

    Authors: Panpan Wang, Yong Mao, Yongquan Su and Jun Wang

    Citation: BMC Genomics 2021 22:781

    Content type: Research article

    Published on:

  46. The molecular complexity of neural retina development remains poorly studied. Knowledge of retinal neurogenesis regulation sheds light on retinal degeneration therapy exploration. Therefore, we integrated the ...

    Authors: Gang Chen, Hong-Mei Qian, Jing Chen, Jie Wang, Ji-Tian Guan and Zai-Long Chi

    Citation: BMC Genomics 2021 22:779

    Content type: Research

    Published on:

  47. Members of the basic helix-loop-helix (bHLH) transcription factor family perform indispensable functions in various biological processes, such as plant growth, seed maturation, and abiotic stress responses. Howev...

    Authors: Yu Fan, Dili Lai, Hao Yang, Guoxing Xue, Ailing He, Long Chen, Liang Feng, Jingjun Ruan, Dabing Xiang, Jun Yan and Jianping Cheng

    Citation: BMC Genomics 2021 22:778

    Content type: Research

    Published on:

  48. Viral vectors, including adenovirus (Ad) and modified vaccinia Ankara (MVA), have gained increasing attention as vaccine platforms in recent years due to their capacity to express antigens from a wide array of...

    Authors: Dylan Sheerin, Christina Dold, Daniel O’Connor, Andrew J. Pollard and Christine S. Rollier

    Citation: BMC Genomics 2021 22:777

    Content type: Research

    Published on:

  49. Grapevine (Vitis vinifera) productivity has been severely affected by various bacterial, viral and fungal diseases worldwide. When a plant is infected with the pathogen, various defense mechanisms are subsequentl...

    Authors: Neetu Goyal, Garima Bhatia, Naina Garewal, Anuradha Upadhyay and Kashmir Singh

    Citation: BMC Genomics 2021 22:776

    Content type: Research article

    Published on:

  50. The gut microbiome is a diverse network of bacteria which inhabit our digestive tract and is crucial for efficient cellular metabolism, nutrient absorption, and immune system development. Spinal cord injury (S...

    Authors: Adam Doelman, Seth Tigchelaar, Brian McConeghy, Sunita Sinha, Martin S. Keung, Neda Manouchehri, Megan Webster, Shera Fisk, Charlotte Morrison, Femke Streijger, Corey Nislow and Brian K. Kwon

    Citation: BMC Genomics 2021 22:775

    Content type: Research

    Published on:

Featured videos

View featured videos from across the BMC-series journals

Annual Journal Metrics

Portable peer review

The editors of BMC Genomics support initiatives that expedite the peer review process and are happy to consider manuscripts that have been reviewed in Peerage of Science. Please indicate in your cover letter if this applies to your manuscript.