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  1. The treatment of microbial infections is becoming increasingly challenging because of limited therapeutic options and the growing number of pathogenic strains that are resistant to current antibiotics. There i...

    Authors: Haoxin Li, Andrew Cowie, John A. Johnson, Duncan Webster, Christopher J. Martyniuk and Christopher A. Gray
    Citation: BMC Genomics 2016 17:621
  2. Many species of bivalves exhibit a unique system of mtDNA transmission named Doubly Uniparental Inheritance (DUI). Under this system, species have two distinct, sex-linked mitochondrial genomes: the M-type mtD...

    Authors: Alyssa Mitchell, Davide Guerra, Donald Stewart and Sophie Breton
    Citation: BMC Genomics 2016 17:597
  3. Clenbuterol, a beta2-adrenergic receptor agonist, is used therapeutically to treat respiratory conditions in the horse. However, by virtue of its mechanism of action it has been suggested that clenbuterol may ...

    Authors: Heather K. Knych, Linda M. Harrison, Stacy J. Steinmetz, Nadira Chouicha and Phil H. Kass
    Citation: BMC Genomics 2016 17:596
  4. The RNA-seq technique is applied for the investigation of transcriptional behaviour. The reduction in sequencing costs has led to an unprecedented trove of gene expression data from diverse biological systems....

    Authors: Deepak Karthik, Gil Stelzer, Sivan Gershanov, Danny Baranes and Mali Salmon-Divon
    Citation: BMC Genomics 2016 17:595
  5. Residual feed intake (RFI) is a powerful indicator for energy utilization efficiency and responds to selection. Low RFI selection enables a reduction in feed intake without affecting growth performance. Howeve...

    Authors: Zhenqiang Xu, Congliang Ji, Yan Zhang, Zhe Zhang, Qinghua Nie, Jiguo Xu, Dexiang Zhang and Xiquan Zhang
    Citation: BMC Genomics 2016 17:594
  6. Target capture sequencing is an efficient approach to directly identify the causative mutations of genetic disorders. To apply this strategy to laboratory rats exhibiting various phenotypes, we developed a nov...

    Authors: Minako Yoshihara, Daisuke Saito, Tetsuya Sato, Osamu Ohara, Takashi Kuramoto and Mikita Suyama
    Citation: BMC Genomics 2016 17:593
  7. Feed efficient cattle consume less feed and produce less environmental waste than inefficient cattle. Many factors are known to contribute to differences in feed efficiency, however the underlying molecular me...

    Authors: Rebecca S. G. Kong, Guanxiang Liang, Yanhong Chen, Paul Stothard and Le Luo Guan
    Citation: BMC Genomics 2016 17:592
  8. G1 + HBP is a male sterile cybrid line with nuclear genome from Hirado Buntan pummelo (C. grandis Osbeck) (HBP) and mitochondrial genome from “Guoqing No.1” (G1, Satsuma mandarin), which provides a good opportuni...

    Authors: Yan-Ni Fang, Bei-Bei Zheng, Lun Wang, Wei Yang, Xiao-Meng Wu, Qiang Xu and Wen-Wu Guo
    Citation: BMC Genomics 2016 17:591
  9. Meiotic recombination is a fundamental evolutionary process. It not only generates diversity, but influences the efficacy of natural selection and genome evolution. There can be significant heterogeneity in re...

    Authors: Jean-Marc Gion, Corey J. Hudson, Isabelle Lesur, René E. Vaillancourt, Brad M. Potts and Jules S. Freeman
    Citation: BMC Genomics 2016 17:590
  10. The primary cause of morbidity and mortality in cystic fibrosis (CF) patients is lung infection by Pseudomonas aeruginosa. Therefore much work has been done to understand the adaptation and evolution of P. aerugi...

    Authors: Lea M. Sommer, Rasmus L. Marvig, Adela Luján, Anna Koza, Tacjana Pressler, Søren Molin and Helle K. Johansen
    Citation: BMC Genomics 2016 17:589
  11. Only 2 % of the human genome code for proteins. Among the remaining 98 %, transposable elements (TEs) represent millions of sequences. TEs have an impact on genome evolution by promoting mutations. Especially,...

    Authors: Laura Grégoire, Annabelle Haudry and Emmanuelle Lerat
    Citation: BMC Genomics 2016 17:588
  12. The giant freshwater prawn, Macrobrachium rosenbergii, is a decapod crustacean that is commercially important as a food source. Farming of commercial crustaceans requires an efficient management strategy because ...

    Authors: Saowaros Suwansa-ard, Wilairat Kankuan, Tipsuda Thongbuakaew, Jirawat Saetan, Napamanee Kornthong, Thanapong Kruangkum, Kanjana Khornchatri, Scott F. Cummins, Ciro Isidoro and Prasert Sobhon
    Citation: BMC Genomics 2016 17:587
  13. Most fungi, including entomopathogenic fungi, have two different conidiation patterns, normal and microcycle conidiation, under different culture conditions, eg, in media containing different nutrients. Howeve...

    Authors: Zhenglong Wang, Kai Jin and Yuxian Xia
    Citation: BMC Genomics 2016 17:586
  14. Cross breeding is the most commonly used method in chrysanthemum (Chrysanthemum morifolium) breeding; however, cross barriers always exist in these combinations. Many studies have shown that paternal chromosome d...

    Authors: Fengjiao Zhang, Lichun Hua, Jiangsong Fei, Fan Wang, Yuan Liao, Weimin Fang, Fadi Chen and Nianjun Teng
    Citation: BMC Genomics 2016 17:585

    The Erratum to this article has been published in BMC Genomics 2016 17:714

  15. Ramularia collo-cygni is a newly important, foliar fungal pathogen of barley that causes the disease Ramularia leaf spot. The fungus exhibits a prolonged endophytic growth stage before...

    Authors: Graham R. D. McGrann, Ambrose Andongabo, Elisabet Sjökvist, Urmi Trivedi, Francois Dussart, Maciej Kaczmarek, Ashleigh Mackenzie, James M. Fountaine, Jeanette M. G. Taylor, Linda J. Paterson, Kalina Gorniak, Fiona Burnett, Kostya Kanyuka, Kim E. Hammond-Kosack, Jason J. Rudd, Mark Blaxter…
    Citation: BMC Genomics 2016 17:584
  16. During long dives, the brain of whales and seals experiences a reduced supply of oxygen (hypoxia). The brain neurons of the hooded seal (Cystophora cristata) are more tolerant towards low-oxygen conditions than t...

    Authors: Andrej Fabrizius, Mariana Leivas Müller Hoff, Gerhard Engler, Lars P. Folkow and Thorsten Burmester
    Citation: BMC Genomics 2016 17:583
  17. Non-coding RNAs (ncRNAs) play crucial roles in many biological processes, such as post-transcription of gene regulation. ncRNAs mainly function through interaction with RNA binding proteins (RBPs). To understa...

    Authors: Xiaoyong Pan, Yong-Xian Fan, Junchi Yan and Hong-Bin Shen
    Citation: BMC Genomics 2016 17:582
  18. Bacillus cereus group isolates that produce diarrheal or emetic toxins are frequently isolated from raw milk and, in spore form, can survive pasteurization. Several species within the

    Authors: Jasna Kovac, Rachel A. Miller, Laura M. Carroll, David J. Kent, Jiahui Jian, Sarah M. Beno and Martin Wiedmann
    Citation: BMC Genomics 2016 17:581
  19. Wild rice (Oryza rufipogon) constitutes a primary gene source for rice breed improvement. Chromosome segment substitution line (CSSL) for O. rufipogon is a powerful tool for fine mapping of quantitative traits, n...

    Authors: Weihua Qiao, Lan Qi, Zhijun Cheng, Long Su, Jing Li, Yan Sun, Junfang Ren, Xiaoming Zheng and Qingwen Yang
    Citation: BMC Genomics 2016 17:580
  20. Next-generation sequencing (NGS) provides many possibilities for plant virology research. In this study, we performed integrated analyses using plant transcriptome data for plant virus identification using Apple ...

    Authors: Yeonhwa Jo, Hoseong Choi, Sang-Min Kim, Sun-Lim Kim, Bong Choon Lee and Won Kyong Cho
    Citation: BMC Genomics 2016 17:579
  21. Phylogenetic footprinting is an important computational technique for identifying cis-regulatory motifs in orthologous regulatory regions from multiple genomes, as motifs tend to evolve slower than their surround...

    Authors: Bingqiang Liu, Hanyuan Zhang, Chuan Zhou, Guojun Li, Anne Fennell, Guanghui Wang, Yu Kang, Qi Liu and Qin Ma
    Citation: BMC Genomics 2016 17:578
  22. Although the toxicological impacts of the xenoestrogen bisphenol-A (BPA) have been studied extensively, but the mechanism of action is poorly understood. Eventually, no standard method exists for evaluating th...

    Authors: Md Saidur Rahman, Woo-Sung Kwon, Sung-Jae Yoon, Yoo-Jin Park, Buom-Yong Ryu and Myung-Geol Pang
    Citation: BMC Genomics 2016 17:577
  23. The gastrointestinal tract is the primary site of toxin interaction, an interface between the organism and its surroundings. In this study, we assessed the alteration of intestinal mRNA profile in the case of ...

    Authors: Cornelia Braicu, Sonia Selicean, Roxana Cojocneanu-Petric, Raduly Lajos, Ovidiu Balacescu, Ionelia Taranu, Daniela Eliza Marin, Monica Motiu, Ancuta Jurj, Patriciu Achimas-Cadariu and Ioana Berindan-Neagoe
    Citation: BMC Genomics 2016 17:576
  24. Ornamental peaches cv. ‘Yaguchi’ (Prunus persica (L.) Batsch) can be propagated via seeds. The establishment of efficient seed treatments for early germination and seedling growth is required to shorten nursery a...

    Authors: Worarad Kanjana, Tomohiro Suzuki, Kazuo Ishii, Toshinori Kozaki, Masayuki Iigo and Kenji Yamane
    Citation: BMC Genomics 2016 17:575
  25. Transcriptome analysis may provide means to investigate the underlying genetic causes of shared and divergent phenotypes in different populations and help to identify potential targets of adaptive evolution. A...

    Authors: Korbinian von Heckel, Wolfgang Stephan and Stephan Hutter
    Citation: BMC Genomics 2016 17:574
  26. Many genes involved in responses to photoperiod and vernalization have been characterized or predicted in Arabidopsis (Arabidopsis thaliana), Brachypodium (Brachypodium distachyon), wheat (Triticum aestivum) and ...

    Authors: Fred Y. Peng, Zhiqiu Hu and Rong-Cai Yang
    Citation: BMC Genomics 2016 17:573
  27. Fear/anxiety and anger/aggression greatly influence health, quality of life and social interactions. They are a huge burden to wellbeing, and personal and public economics. However, while much is known about t...

    Authors: Isain Zapata, James A. Serpell and Carlos E. Alvarez
    Citation: BMC Genomics 2016 17:572
  28. Prior to egg laying the parasitoid wasp Nasonia vitripennis envenomates its pupal host with a complex mixture of venom peptides. This venom induces several dramatic changes in the host, including developmental ar...

    Authors: Andre D. Sim and David Wheeler
    Citation: BMC Genomics 2016 17:571
  29. Echinocandins are nonribosomal lipopeptides produced by ascommycete fungi. Due to their strong inhibitory effect on fungal cell wall biosynthesis and lack of human toxicity, they have been developed to an impo...

    Authors: Wolfgang Hüttel, Loubna Youssar, Björn A. Grüning, Stefan Günther and Katharina G. Hugentobler
    Citation: BMC Genomics 2016 17:570
  30. The Leucine-responsive Regulatory Protein (Lrp) family is a widespread family of regulatory transcription factors in prokaryotes. BarR is an Lrp-like transcription factor in the model archaeon Sulfolobus acidocal...

    Authors: Han Liu, Kun Wang, Ann-Christin Lindås and Eveline Peeters
    Citation: BMC Genomics 2016 17:569
  31. Automatically generated bacterial metabolic models, and even some curated models, lack accuracy in predicting energy yields due to poor representation of key pathways in energy biosynthesis and the electron tr...

    Authors: Janaka N. Edirisinghe, Pamela Weisenhorn, Neal Conrad, Fangfang Xia, Ross Overbeek, Rick L. Stevens and Christopher S. Henry
    Citation: BMC Genomics 2016 17:568
  32. The southern root-knot nematode (Meloidogyne incognita; RKN) is one of the most important economic pests of Upland cotton (Gossypium hirsutum L.). Host plant resistance, the ability of a plant to suppress nematod...

    Authors: Pawan Kumar, Yajun He, Rippy Singh, Richard F. Davis, Hui Guo, Andrew H. Paterson, Daniel G. Peterson, Xinlian Shen, Robert L. Nichols and Peng W. Chee
    Citation: BMC Genomics 2016 17:567
  33. miRNAs are small noncoding RNA molecules that play an important role in post-transcriptional regulation of gene expression. Length and/or sequence variants of the same miRNA are termed isomiRs. While most isom...

    Authors: Omar Salem, Nese Erdem, Janine Jung, Ewald Münstermann, Angelika Wörner, Heike Wilhelm, Stefan Wiemann and Cindy Körner
    Citation: BMC Genomics 2016 17:566
  34. S. aureus is one of the major etiological agents causing bovine subclinical mastitis. The regulatory effects of H3K27me3 on gene expression in subclinical S. aureus mastitis cows are u...

    Authors: Yanghua He, Minyan Song, Yi Zhang, Xizhi Li, Jiuzhou Song, Yuan Zhang and Ying Yu
    Citation: BMC Genomics 2016 17:565
  35. Acipenser baeri, one of the critically endangered animals on the verge of extinction, is a key species for evolutionary, developmental, physiology and conservation studies and a stando...

    Authors: Wei Song, Keji Jiang, Fengying Zhang, Yu Lin and Lingbo Ma
    Citation: BMC Genomics 2016 17:564
  36. Plant transcriptome profiling has provided a tool for understanding the mechanisms by which plants respond to stress conditions. Analysis of genome-wide transcriptome will provides a useful dataset of drought ...

    Authors: Pil Joong Chung, Harin Jung, Dong-Hoon Jeong, Sun-Hwa Ha, Yang Do Choi and Ju-Kon Kim
    Citation: BMC Genomics 2016 17:563
  37. Zoysia matrella, widely used in lawns and sports fields, is of great economic and ecological value. Z. matrella is an allotetraploid species (2n = 4x = 40) in the genus zoysia under th...

    Authors: Xiaoen Huang, Fangfang Wang, Ratnesh Singh, James A. Reinert, M. C. Engelke, Anthony D. Genovesi, Ambika Chandra and Qingyi Yu
    Citation: BMC Genomics 2016 17:562
  38. Iron metabolism and regulation is an indispensable part of species survival, most importantly for blood feeding insects. Iron regulatory proteins are central regulators of iron homeostasis, whose binding to ir...

    Authors: Zahra Jalali Sefid Dashti, Junaid Gamieldien and Alan Christoffels
    Citation: BMC Genomics 2016 17:561
  39. The heat shock response, induced by cytoplasmic proteotoxic stress, is one of the most highly conserved transcriptional responses. This response, driven by the heat shock transcription factor HSF1, restores pr...

    Authors: Jessica Brunquell, Stephanie Morris, Yin Lu, Feng Cheng and Sandy D. Westerheide
    Citation: BMC Genomics 2016 17:559
  40. Black extrinsic discoloration in primary dentition is a common clinical and aesthetic problem that can co-occur with dental caries, the most common oral diseases in childhood. Although the role of bacteria in ...

    Authors: Yanhui Li, Cheng-Gang Zou, Yu Fu, Yanhong Li, Qing Zhou, Bo Liu, Zhigang Zhang and Juan Liu
    Citation: BMC Genomics 2016 17:558
  41. Microsatellite markers are one of the most informative and versatile DNA-based markers used in plant genetic research, but their development has traditionally been difficult and costly. The whole genome sequen...

    Authors: Huayu Zhu, Pengyao Song, Dal-Hoe Koo, Luqin Guo, Yanman Li, Shouru Sun, Yiqun Weng and Luming Yang
    Citation: BMC Genomics 2016 17:557
  42. Population genetic analyses based on genome-wide sequencing data have been carried out for Sinorhizobium medicae and S. meliloti, two closely related bacterial species forming nitrogen-fixing symbioses with plant...

    Authors: Nicolás Toro, Francisco Martínez-Abarca and Manuel Fernández-López
    Citation: BMC Genomics 2016 17:556
  43. Many species belonging to the genus Colletotrichum cause anthracnose disease on a wide range of plant species. In addition to their economic impact, the genus Colletotrichum is a useful model for the study of the...

    Authors: Riccardo Baroncelli, Daniel Buchvaldt Amby, Antonio Zapparata, Sabrina Sarrocco, Giovanni Vannacci, Gaétan Le Floch, Richard J. Harrison, Eric Holub, Serenella A. Sukno, Surapareddy Sreenivasaprasad and Michael R. Thon
    Citation: BMC Genomics 2016 17:555
  44. Methylmecury (MeHg) is a widely distributed environmental pollutant with considerable risk to both human health and wildlife. To gain better insight into the underlying mechanisms of MeHg-mediated toxicity, we...

    Authors: Fekadu Yadetie, Silje Bjørneklett, Hilde Kristin Garberg, Eystein Oveland, Frode Berven, Anders Goksøyr and Odd André Karlsen
    Citation: BMC Genomics 2016 17:554
  45. Mycobacterium abscessus subsp. abscessus (MAB) is a highly drug resistant mycobacterium and the most common respiratory pathogen among the rapidly growing non-tuberculous mycobacteria....

    Authors: Aleksandra A. Miranda-CasoLuengo, Patrick M. Staunton, Adam M. Dinan, Amanda J. Lohan and Brendan J. Loftus
    Citation: BMC Genomics 2016 17:553
  46. The spiral cleavage mode of early development is utilized in over one-third of all animal phyla and generates embryonic cells of different size, position, and fate through a conserved set of stereotypic and in...

    Authors: Hsien-Chao Chou, Margaret M. Pruitt, Benjamin R. Bastin and Stephan Q. Schneider
    Citation: BMC Genomics 2016 17:552
  47. Flixweed (Descurainia sophia L.) is a troublesome and widespread broadleaf weed in winter fields in China, and has evolved high level resistance to acetolactate synthase (ALS)-inhibiting sulfonylurea herbicide tr...

    Authors: Qian Yang, Wei Deng, Xuefeng Li, Qin Yu, Lianyang Bai and Mingqi Zheng
    Citation: BMC Genomics 2016 17:551
  48. Pichia pastoris has emerged as an important alternative host for producing recombinant biopharmaceuticals, owing to its high cultivation density, low host cell protein burden, and the ...

    Authors: Kerry R. Love, Kartik A. Shah, Charles A. Whittaker, Jie Wu, M. Catherine Bartlett, Duanduan Ma, Rachel L. Leeson, Margaret Priest, Jonathan Borowsky, Sarah K. Young and J. Christopher Love
    Citation: BMC Genomics 2016 17:550

    The Erratum to this article has been published in BMC Genomics 2016 17:762

  49. The CRISPR/Cas9 system has become a regularly used tool for editing the genome of many model organisms at specific sites. However, two limiting steps arise in the process of validating guide RNA target sites i...

    Authors: Éric Samarut, Alexandra Lissouba and Pierre Drapeau
    Citation: BMC Genomics 2016 17:547

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